JP2016501204A5 - - Google Patents

Info

Publication number

JP2016501204A5

JP2016501204A5 JP2015543145A JP2015543145A JP2016501204A5 JP 2016501204 A5 JP2016501204 A5 JP 2016501204A5 JP 2015543145 A JP2015543145 A JP 2015543145A JP 2015543145 A JP2015543145 A JP 2015543145A JP 2016501204 A5 JP2016501204 A5 JP 2016501204A5

Authority

JP

Japan

Prior art keywords

absent

aib

beta

lys

alkyl

Prior art date

2013-11-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 claims 53
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 34
• -1 linker amino acid Chemical class 0.000 claims 34
• 108090000765 processed proteins & peptides Proteins 0.000 claims 23
• 125000000217 alkyl group Chemical group 0.000 claims 22
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 21
• ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 10
• 239000002253 acid Substances 0.000 claims 8
• 239000004094 surface-active agent Substances 0.000 claims 8
• 125000006239 protecting group Chemical group 0.000 claims 6
• IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 5
• 150000001413 amino acids Chemical class 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 5
• WNTGYJSOUMFZEP-UHFFFAOYSA-N 2-(4-chloro-2-methylphenoxy)propanoic acid Chemical compound OC(=O)C(C)OC1=CC=C(Cl)C=C1C WNTGYJSOUMFZEP-UHFFFAOYSA-N 0.000 claims 4
• SCIFESDRCALIIM-VIFPVBQESA-N N-methyl-L-phenylalanine Chemical compound C[NH2+][C@H](C([O-])=O)CC1=CC=CC=C1 SCIFESDRCALIIM-VIFPVBQESA-N 0.000 claims 4
• 150000001720 carbohydrates Chemical class 0.000 claims 4
• 238000009472 formulation Methods 0.000 claims 4
• 125000000923 (C1-C30) alkyl group Chemical group 0.000 claims 3
• 125000004171 alkoxy aryl group Chemical group 0.000 claims 3
• 125000003710 aryl alkyl group Chemical group 0.000 claims 3
• 150000003431 steroids Chemical class 0.000 claims 3
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 2
• 208000024172 Cardiovascular disease Diseases 0.000 claims 2
• QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 2
• 125000000998 L-alanino group Chemical group [H]N([*])[C@](C([H])([H])[H])([H])C(=O)O[H] 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 125000000524 functional group Chemical group 0.000 claims 2
• 108010087791 pyroglutamylhistidine Proteins 0.000 claims 2
• 150000008135 α-glycosides Chemical class 0.000 claims 2
• SHCMCJLNUOZJOR-YXISZKLHSA-N (2s,3s,4s,5r,6r)-6-dodecyl-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound CCCCCCCCCCCC[C@@]1(O)O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O SHCMCJLNUOZJOR-YXISZKLHSA-N 0.000 claims 1
• MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims 1
• SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 1
• 239000004471 Glycine Substances 0.000 claims 1
• 206010022489 Insulin Resistance Diseases 0.000 claims 1
• 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 claims 1
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
• 125000002252 acyl group Chemical group 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229930182470 glycoside Natural products 0.000 claims 1
• 230000000302 ischemic effect Effects 0.000 claims 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
• 230000004580 weight loss Effects 0.000 claims 1