JP2014516036A5 - - Google Patents

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Publication number
JP2014516036A5
JP2014516036A5 JP2014511553A JP2014511553A JP2014516036A5 JP 2014516036 A5 JP2014516036 A5 JP 2014516036A5 JP 2014511553 A JP2014511553 A JP 2014511553A JP 2014511553 A JP2014511553 A JP 2014511553A JP 2014516036 A5 JP2014516036 A5 JP 2014516036A5
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JP
Japan
Prior art keywords
beta
acid
phe
peptide product
tic
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Application number
JP2014511553A
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English (en)
Japanese (ja)
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JP2014516036A (ja
JP6148228B2 (ja
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Priority claimed from PCT/US2012/038429 external-priority patent/WO2012158962A2/en
Publication of JP2014516036A publication Critical patent/JP2014516036A/ja
Publication of JP2014516036A5 publication Critical patent/JP2014516036A5/ja
Application granted granted Critical
Publication of JP6148228B2 publication Critical patent/JP6148228B2/ja
Active legal-status Critical Current
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JP2014511553A 2011-05-18 2012-05-17 改善されたペプチド製剤 Active JP6148228B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161487636P 2011-05-18 2011-05-18
US201161487638P 2011-05-18 2011-05-18
US61/487,636 2011-05-18
US61/487,638 2011-05-18
US201161543725P 2011-10-05 2011-10-05
US201161543721P 2011-10-05 2011-10-05
US61/543,725 2011-10-05
US61/543,721 2011-10-05
PCT/US2012/038429 WO2012158962A2 (en) 2011-05-18 2012-05-17 Improved peptide pharmaceuticals

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017008902A Division JP6883912B2 (ja) 2011-05-18 2017-01-20 改善されたペプチド製剤

Publications (3)

Publication Number Publication Date
JP2014516036A JP2014516036A (ja) 2014-07-07
JP2014516036A5 true JP2014516036A5 (enExample) 2015-07-09
JP6148228B2 JP6148228B2 (ja) 2017-06-14

Family

ID=47177640

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2014511553A Active JP6148228B2 (ja) 2011-05-18 2012-05-17 改善されたペプチド製剤
JP2017008902A Active JP6883912B2 (ja) 2011-05-18 2017-01-20 改善されたペプチド製剤
JP2019103108A Active JP6929610B2 (ja) 2011-05-18 2019-05-31 改善されたペプチド製剤
JP2020174102A Pending JP2021020925A (ja) 2011-05-18 2020-10-15 改善されたペプチド製剤
JP2022177489A Pending JP2023022045A (ja) 2011-05-18 2022-11-04 改善されたペプチド製剤
JP2024205047A Pending JP2025043342A (ja) 2011-05-18 2024-11-25 改善されたペプチド製剤

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2017008902A Active JP6883912B2 (ja) 2011-05-18 2017-01-20 改善されたペプチド製剤
JP2019103108A Active JP6929610B2 (ja) 2011-05-18 2019-05-31 改善されたペプチド製剤
JP2020174102A Pending JP2021020925A (ja) 2011-05-18 2020-10-15 改善されたペプチド製剤
JP2022177489A Pending JP2023022045A (ja) 2011-05-18 2022-11-04 改善されたペプチド製剤
JP2024205047A Pending JP2025043342A (ja) 2011-05-18 2024-11-25 改善されたペプチド製剤

Country Status (8)

Country Link
US (4) US10010617B2 (enExample)
EP (3) EP2709645B1 (enExample)
JP (6) JP6148228B2 (enExample)
KR (2) KR102126484B1 (enExample)
CN (2) CN103796666B (enExample)
AU (4) AU2012255116B2 (enExample)
CA (1) CA2836573C (enExample)
WO (2) WO2012158962A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012158965A2 (en) * 2011-05-18 2012-11-22 Mederis Diabetes, Llc Improved peptide pharmaceuticals for insulin resistance
CN103796666B (zh) 2011-05-18 2018-07-06 欧莫德里斯制药公司 改良的肽药物
TWI596110B (zh) 2011-09-23 2017-08-21 諾佛 儂迪克股份有限公司 新穎升糖素類似物
KR102238317B1 (ko) 2012-05-17 2021-04-12 익스텐드 바이오사이언시즈, 인크. 개선된 약물 전달용 캐리어
ES2906975T3 (es) 2012-11-20 2022-04-21 Eumederis Pharmaceuticals Inc Productos farmacéuticos de péptidos mejorados
CA2891931A1 (en) * 2012-11-20 2014-05-30 Mederis Diabetes, Llc Improved peptide pharmaceuticals for insulin resistance
CA2909581A1 (en) 2013-04-18 2014-10-23 Novo Nordisk A/S Stable, protracted glp-1/glucagon receptor co-agonists for medical use
KR20250007694A (ko) * 2014-05-28 2025-01-14 메더리스 다이어비티즈, 엘엘씨 인슐린 저항성에 대한 개선된 펩티드 약제
WO2015185640A1 (en) 2014-06-04 2015-12-10 Novo Nordisk A/S Glp-1/glucagon receptor co-agonists for medical use
JP2017532292A (ja) * 2014-08-11 2017-11-02 オルバニー メディカル カレッジ ミリストイル化レプチン関連ペプチド及びその使用
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
WO2016065042A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
WO2018139991A1 (en) 2017-01-24 2018-08-02 Macregen, Inc. Treatment of age-related degeneration and other eye diseases with apolipoprotein mimetics
AU2018226872A1 (en) 2017-03-03 2019-09-05 Macregen, Inc. Treatment of age-related macular degeneration and other eye diseases with one or more therapeutic agents
CN111615517B (zh) * 2017-11-27 2024-01-09 香港大学 Yeats抑制剂及其使用方法
KR20250043579A (ko) * 2018-01-03 2025-03-28 메더리스 다이어비티즈, 엘엘씨 Nash 및 다른 질병의 치료를 위한 개선된 펩티드 약제
EP3743092A4 (en) 2018-01-23 2021-10-20 Gila Therapeutics, Inc. PHARMACEUTICAL PEPTIDE-YY FORMULATIONS, COMPOSITIONS, AND PROCEDURES
TWI764248B (zh) * 2019-08-23 2022-05-11 大陸商四川海思科製藥有限公司 肽醯胺類組合物及其製備
IL295744A (en) * 2020-02-21 2022-10-01 Spitfire Pharma Llc glp-1r and gcgr agonists, formulations and methods of use
US12171806B2 (en) 2021-09-28 2024-12-24 Spitfire Pharma Llc Therapeutic regimens and methods for lowering blood glucose and/or body weight using GLP-1R and GCGR balanced agonists
WO2022270482A1 (ja) * 2021-06-24 2022-12-29 国立大学法人茨城大学 糖鎖固定化ポリマー粒子及びその製造方法
KR102844771B1 (ko) * 2022-07-22 2025-08-12 주식회사 아이큐어비앤피 테리파라타이드를 포함하는 골다공증 예방 또는 치료를 위한 경구용 약학적 조성물 및 이의 제조방법
EP4593867A2 (en) 2022-09-30 2025-08-06 Extend Biosciences, Inc. Long-acting parathyroid hormone

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR18245E (fr) 1913-01-10 1914-02-28 Gedeon Guibal Flotteur avec index indicateur de niveau, pour chaudières à vapeur et autres appareils, permettant de connaitre le niveau d'un liquide quelconque à une hauteur inférieur au niveau lui-meme
US3219656A (en) 1963-08-12 1965-11-23 Rohm & Haas Alkylpolyalkoxyalkyl glucosides and process of preparation therefor
US3839318A (en) 1970-09-27 1974-10-01 Rohm & Haas Process for preparation of alkyl glucosides and alkyl oligosaccharides
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
DE3378121D1 (de) * 1982-10-18 1988-11-03 Ici Plc Peptide and pseudopeptide derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
DK149776C (da) 1984-01-06 1987-04-21 Orion Yhtymae Oy Antibiotisk virksom erytromycinforbindelse og praeparat indeholdende forbindelsen
AT382381B (de) 1984-10-02 1987-02-25 Oesterr Zuckerfab Evidenz Verfahren zur herstellung neuer grenzfl|chenaktiver kohlenhydrat-derivate
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
JPS63152393A (ja) * 1986-07-03 1988-06-24 Takeda Chem Ind Ltd グリコシル誘導体
US5252318A (en) 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5661130A (en) 1993-06-24 1997-08-26 The Uab Research Foundation Absorption enhancers for drug administration
SE9401596D0 (sv) * 1994-05-06 1994-05-06 Astra Ab New compounds
JPH1160598A (ja) 1997-08-15 1999-03-02 Asahi Glass Co Ltd オピオイド様ペプチド
US20010010919A1 (en) * 1998-10-13 2001-08-02 David K. Grandy Opioid antagonists and methods of their use
US6924264B1 (en) 1999-04-30 2005-08-02 Amylin Pharmaceuticals, Inc. Modified exendins and exendin agonists
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
RU2181729C1 (ru) * 2000-09-20 2002-04-27 Калюжин Олег Витальевич Производные мурамовой кислоты
US6858580B2 (en) 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6864069B2 (en) 2001-10-05 2005-03-08 Bayer Pharmaceuticals Corporation Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use
NZ532027A (en) 2001-10-10 2008-09-26 Neose Technologies Inc Remodeling and glycoconjugation of peptides
US20050255038A1 (en) * 2002-04-12 2005-11-17 A And D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents and uses thereof
US6881829B2 (en) * 2002-04-26 2005-04-19 Chimeracom, L.L.C. Chimeric hybrid analgesics
WO2004093902A1 (en) * 2003-03-19 2004-11-04 The General Hospital Corporation CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH α-HELIX STABILIZERS
US20110257096A1 (en) 2004-08-25 2011-10-20 Aegis Therapeutics, Inc. Compositions for drug administration
US20060046962A1 (en) * 2004-08-25 2006-03-02 Aegis Therapeutics Llc Absorption enhancers for drug administration
ITRM20040607A1 (it) * 2004-12-15 2005-03-15 Biogen S R L Analoghi della dermorfina ad attivita' analgesica.
US7776819B2 (en) * 2005-03-03 2010-08-17 The Board Of Trustees Of The University Of Illinois Targeted drug delivery of pain and addiction therapies using opioid receptor-mediated internalization
JP2008539735A (ja) 2005-05-06 2008-11-20 バイエル・フアーマシユーチカルズ・コーポレーシヨン グルカゴン様ペプチド１（ｇｌｐ−１）受容体アンタゴニストおよびそれらの薬理学的使用方法
WO2007002465A2 (en) 2005-06-23 2007-01-04 Rapid Pharmaceuticals, Llc Stabilizing alkylglycoside compositions and methods thereof
DK1912671T3 (da) * 2005-07-18 2017-11-27 Seattle Genetics Inc Beta-glucuronid-linker-lægemiddelkonjugater
WO2007060692A2 (en) 2005-11-24 2007-05-31 Brain N' Beyond Biotech Pvt. Ltd. Compositions for increasing bioavailability of peptides or proteins and method thereof
US7425542B2 (en) 2006-06-23 2008-09-16 Aegis Therapeutics, Inc. Stabilizing alkylglycoside compositions and methods thereof
US7998927B2 (en) 2006-06-23 2011-08-16 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
US8173594B2 (en) * 2006-06-23 2012-05-08 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
JP6017754B2 (ja) 2007-02-15 2016-11-02 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ グルカゴン／ｇｌｐ−１受容体コアゴニスト
CN104072606B (zh) * 2007-08-01 2017-09-22 总医院有限公司 利用g蛋白偶联受体和相关组合物的筛选方法
EP2052736A1 (en) * 2007-10-26 2009-04-29 Nycomed Danmark ApS Parathyroid hormone formulations und uses thereof
EA019203B9 (ru) 2008-06-17 2014-03-31 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Коагонисты глюкагонового рецептора/glp-1-рецептора
WO2012158965A2 (en) 2011-05-18 2012-11-22 Mederis Diabetes, Llc Improved peptide pharmaceuticals for insulin resistance
CN103796666B (zh) * 2011-05-18 2018-07-06 欧莫德里斯制药公司 改良的肽药物
CA2891931A1 (en) 2012-11-20 2014-05-30 Mederis Diabetes, Llc Improved peptide pharmaceuticals for insulin resistance
ES2906975T3 (es) 2012-11-20 2022-04-21 Eumederis Pharmaceuticals Inc Productos farmacéuticos de péptidos mejorados
KR20250007694A (ko) * 2014-05-28 2025-01-14 메더리스 다이어비티즈, 엘엘씨 인슐린 저항성에 대한 개선된 펩티드 약제
KR20250043579A (ko) * 2018-01-03 2025-03-28 메더리스 다이어비티즈, 엘엘씨 Nash 및 다른 질병의 치료를 위한 개선된 펩티드 약제
IL295744A (en) * 2020-02-21 2022-10-01 Spitfire Pharma Llc glp-1r and gcgr agonists, formulations and methods of use

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