JP2014516036A5 - - Google Patents
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- Publication number
- JP2014516036A5 JP2014516036A5 JP2014511553A JP2014511553A JP2014516036A5 JP 2014516036 A5 JP2014516036 A5 JP 2014516036A5 JP 2014511553 A JP2014511553 A JP 2014511553A JP 2014511553 A JP2014511553 A JP 2014511553A JP 2014516036 A5 JP2014516036 A5 JP 2014516036A5
- Authority
- JP
- Japan
- Prior art keywords
- beta
- acid
- phe
- peptide product
- tic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161487636P | 2011-05-18 | 2011-05-18 | |
| US201161487638P | 2011-05-18 | 2011-05-18 | |
| US61/487,638 | 2011-05-18 | ||
| US61/487,636 | 2011-05-18 | ||
| US201161543721P | 2011-10-05 | 2011-10-05 | |
| US201161543725P | 2011-10-05 | 2011-10-05 | |
| US61/543,721 | 2011-10-05 | ||
| US61/543,725 | 2011-10-05 | ||
| PCT/US2012/038429 WO2012158962A2 (en) | 2011-05-18 | 2012-05-17 | Improved peptide pharmaceuticals |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017008902A Division JP6883912B2 (ja) | 2011-05-18 | 2017-01-20 | 改善されたペプチド製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014516036A JP2014516036A (ja) | 2014-07-07 |
| JP2014516036A5 true JP2014516036A5 (enExample) | 2015-07-09 |
| JP6148228B2 JP6148228B2 (ja) | 2017-06-14 |
Family
ID=47177640
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014511553A Active JP6148228B2 (ja) | 2011-05-18 | 2012-05-17 | 改善されたペプチド製剤 |
| JP2017008902A Active JP6883912B2 (ja) | 2011-05-18 | 2017-01-20 | 改善されたペプチド製剤 |
| JP2019103108A Active JP6929610B2 (ja) | 2011-05-18 | 2019-05-31 | 改善されたペプチド製剤 |
| JP2020174102A Pending JP2021020925A (ja) | 2011-05-18 | 2020-10-15 | 改善されたペプチド製剤 |
| JP2022177489A Pending JP2023022045A (ja) | 2011-05-18 | 2022-11-04 | 改善されたペプチド製剤 |
| JP2024205047A Pending JP2025043342A (ja) | 2011-05-18 | 2024-11-25 | 改善されたペプチド製剤 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017008902A Active JP6883912B2 (ja) | 2011-05-18 | 2017-01-20 | 改善されたペプチド製剤 |
| JP2019103108A Active JP6929610B2 (ja) | 2011-05-18 | 2019-05-31 | 改善されたペプチド製剤 |
| JP2020174102A Pending JP2021020925A (ja) | 2011-05-18 | 2020-10-15 | 改善されたペプチド製剤 |
| JP2022177489A Pending JP2023022045A (ja) | 2011-05-18 | 2022-11-04 | 改善されたペプチド製剤 |
| JP2024205047A Pending JP2025043342A (ja) | 2011-05-18 | 2024-11-25 | 改善されたペプチド製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10010617B2 (enExample) |
| EP (3) | EP4286400A3 (enExample) |
| JP (6) | JP6148228B2 (enExample) |
| KR (2) | KR102512178B1 (enExample) |
| CN (2) | CN103796666B (enExample) |
| AU (4) | AU2012255116B2 (enExample) |
| CA (1) | CA2836573C (enExample) |
| WO (2) | WO2012158962A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4286400A3 (en) * | 2011-05-18 | 2024-06-05 | Eumederis Pharmaceuticals, Inc. | Improved peptide pharmaceuticals |
| CA3134906A1 (en) * | 2011-05-18 | 2012-11-22 | Mederis Diabetes, Llc | Improved peptide pharmaceuticals for insulin resistance |
| MX354705B (es) | 2011-09-23 | 2018-03-16 | Novo Nordisk As | Analogos de glucagon novedosos. |
| MX349035B (es) | 2012-05-17 | 2017-07-07 | Extend Biosciences Inc | Portadores para el suministro mejorado de farmaco. |
| WO2014081872A1 (en) | 2012-11-20 | 2014-05-30 | Mederis Diabetes, Llc | Improved peptide pharmaceuticals for insulin resistance |
| EP2922877B1 (en) * | 2012-11-20 | 2018-09-05 | Eumederis Pharmaceuticals, Inc. | Improved peptide pharmaceuticals |
| BR112015025464A2 (pt) | 2013-04-18 | 2017-10-10 | Novo Nordisk As | coagonistas do receptor de glp-1/glucagon estáveis, prolongados para uso médico |
| CN117582516A (zh) * | 2014-05-28 | 2024-02-23 | 梅德瑞斯糖尿病有限责任公司 | 针对胰岛素抵抗的改良肽药物 |
| JP2017525656A (ja) | 2014-06-04 | 2017-09-07 | ノヴォ ノルディスク アー/エス | 医療用のglp−1/グルカゴン受容体コアゴニスト |
| EP3180021A4 (en) * | 2014-08-11 | 2018-04-18 | Albany Medical College | Myristoylated leptin-related peptides and uses thereof |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| CN110545836A (zh) | 2017-01-24 | 2019-12-06 | 马克雷根有限公司 | 用载脂蛋白模拟物治疗与年龄有关的黄斑变性和其他眼部疾病 |
| EP3570888A1 (en) | 2017-03-03 | 2019-11-27 | MacRegen, Inc. | Treatment of age-related macular degeneration and other eye diseases with one or more therapeutic agents |
| US11512111B2 (en) * | 2017-11-27 | 2022-11-29 | The University Of Hong Kong | Yeats inhibitors and methods of use thereof |
| AU2019205905B2 (en) * | 2018-01-03 | 2024-12-12 | Mederis Diabetes, Llc | Improved peptide pharmaceuticals for treatment of NASH and other disorders |
| US11911445B2 (en) | 2018-01-23 | 2024-02-27 | Gila Therapeutics, Inc. | Peptide YY pharmaceutical formulations, compositions, and methods |
| TWI764248B (zh) * | 2019-08-23 | 2022-05-11 | 大陸商四川海思科製藥有限公司 | 肽醯胺類組合物及其製備 |
| CA3168001A1 (en) * | 2020-02-21 | 2021-08-26 | Spitfire Pharma Llc | Glp-1r and gcgr agonists, formulations, and methods of use |
| CN117202924A (zh) | 2020-12-07 | 2023-12-08 | 斯皮特弗尔制药有限责任公司 | 使用glp-1r和gcgr平衡激动剂降低血糖和/或体重的治疗方案和方法 |
| WO2022270482A1 (ja) * | 2021-06-24 | 2022-12-29 | 国立大学法人茨城大学 | 糖鎖固定化ポリマー粒子及びその製造方法 |
| KR102844771B1 (ko) * | 2022-07-22 | 2025-08-12 | 주식회사 아이큐어비앤피 | 테리파라타이드를 포함하는 골다공증 예방 또는 치료를 위한 경구용 약학적 조성물 및 이의 제조방법 |
| US12233115B2 (en) | 2022-09-30 | 2025-02-25 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
Family Cites Families (53)
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|---|---|---|---|---|
| FR18245E (fr) | 1913-01-10 | 1914-02-28 | Gedeon Guibal | Flotteur avec index indicateur de niveau, pour chaudières à vapeur et autres appareils, permettant de connaitre le niveau d'un liquide quelconque à une hauteur inférieur au niveau lui-meme |
| US3219656A (en) | 1963-08-12 | 1965-11-23 | Rohm & Haas | Alkylpolyalkoxyalkyl glucosides and process of preparation therefor |
| US3839318A (en) | 1970-09-27 | 1974-10-01 | Rohm & Haas | Process for preparation of alkyl glucosides and alkyl oligosaccharides |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| ATE37552T1 (de) * | 1982-10-18 | 1988-10-15 | Ici Plc | Peptid- und pseudopeptid-derivate. |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| DK149776C (da) | 1984-01-06 | 1987-04-21 | Orion Yhtymae Oy | Antibiotisk virksom erytromycinforbindelse og praeparat indeholdende forbindelsen |
| AT382381B (de) | 1984-10-02 | 1987-02-25 | Oesterr Zuckerfab Evidenz | Verfahren zur herstellung neuer grenzfl|chenaktiver kohlenhydrat-derivate |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| JPS63152393A (ja) * | 1986-07-03 | 1988-06-24 | Takeda Chem Ind Ltd | グリコシル誘導体 |
| US5252318A (en) | 1990-06-15 | 1993-10-12 | Allergan, Inc. | Reversible gelation compositions and methods of use |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| US5661130A (en) | 1993-06-24 | 1997-08-26 | The Uab Research Foundation | Absorption enhancers for drug administration |
| SE9401596D0 (sv) * | 1994-05-06 | 1994-05-06 | Astra Ab | New compounds |
| JPH1160598A (ja) * | 1997-08-15 | 1999-03-02 | Asahi Glass Co Ltd | オピオイド様ペプチド |
| US20010010919A1 (en) * | 1998-10-13 | 2001-08-02 | David K. Grandy | Opioid antagonists and methods of their use |
| US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| US6309633B1 (en) * | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
| RU2181729C1 (ru) * | 2000-09-20 | 2002-04-27 | Калюжин Олег Витальевич | Производные мурамовой кислоты |
| US6858580B2 (en) | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| US6864069B2 (en) | 2001-10-05 | 2005-03-08 | Bayer Pharmaceuticals Corporation | Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use |
| EP2292273A3 (en) | 2001-10-10 | 2011-11-23 | BioGeneriX AG | Remodeling and glycoconjugation of peptides |
| WO2003086475A1 (en) * | 2002-04-12 | 2003-10-23 | A & D Bioscience, Inc. | Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof |
| US6881829B2 (en) * | 2002-04-26 | 2005-04-19 | Chimeracom, L.L.C. | Chimeric hybrid analgesics |
| AU2003220380A1 (en) * | 2003-03-19 | 2004-11-19 | Bristol-Myers Squibb Company | CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH Alpha-HELIX STABILIZERS |
| US20060046962A1 (en) * | 2004-08-25 | 2006-03-02 | Aegis Therapeutics Llc | Absorption enhancers for drug administration |
| US20110257096A1 (en) | 2004-08-25 | 2011-10-20 | Aegis Therapeutics, Inc. | Compositions for drug administration |
| ITRM20040607A1 (it) | 2004-12-15 | 2005-03-15 | Biogen S R L | Analoghi della dermorfina ad attivita' analgesica. |
| US7776819B2 (en) * | 2005-03-03 | 2010-08-17 | The Board Of Trustees Of The University Of Illinois | Targeted drug delivery of pain and addiction therapies using opioid receptor-mediated internalization |
| CA2607566A1 (en) | 2005-05-06 | 2006-11-16 | Bayer Pharmaceuticals Corporation | Glucagon-like peptide 1 (glp-1) receptor agonists and their pharmacological methods of use |
| WO2007002465A2 (en) | 2005-06-23 | 2007-01-04 | Rapid Pharmaceuticals, Llc | Stabilizing alkylglycoside compositions and methods thereof |
| HUE035853T2 (en) * | 2005-07-18 | 2018-05-28 | Seattle Genetics Inc | Beta-glucuronide-linker-drug conjugates |
| WO2007060692A2 (en) | 2005-11-24 | 2007-05-31 | Brain N' Beyond Biotech Pvt. Ltd. | Compositions for increasing bioavailability of peptides or proteins and method thereof |
| US7425542B2 (en) | 2006-06-23 | 2008-09-16 | Aegis Therapeutics, Inc. | Stabilizing alkylglycoside compositions and methods thereof |
| US8173594B2 (en) * | 2006-06-23 | 2012-05-08 | Aegis Therapeutics, Llc | Stabilizing alkylglycoside compositions and methods thereof |
| US7998927B2 (en) | 2006-06-23 | 2011-08-16 | Aegis Therapeutics, Llc | Stabilizing alkylglycoside compositions and methods thereof |
| EP1961765A1 (en) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
| NZ578948A (en) | 2007-02-15 | 2012-03-30 | Univ Indiana Res & Tech Corp | Glucagon/glp-1 receptor co-agonists |
| BRPI0814962B8 (pt) * | 2007-08-01 | 2021-05-25 | Chugai Pharmaceutical Co Ltd | métodos in vitro para determinar se um composto candidato é um agonista de longa duração ou de curta duração de um receptor acoplado à proteína g, polipeptídeo, seu uso e composição farmacêutica |
| EP2052736A1 (en) * | 2007-10-26 | 2009-04-29 | Nycomed Danmark ApS | Parathyroid hormone formulations und uses thereof |
| CA2728284C (en) | 2008-06-17 | 2019-09-10 | Richard D. Dimarchi | Glucagon/glp-1 receptor co-agonists |
| EP4286400A3 (en) * | 2011-05-18 | 2024-06-05 | Eumederis Pharmaceuticals, Inc. | Improved peptide pharmaceuticals |
| CA3134906A1 (en) | 2011-05-18 | 2012-11-22 | Mederis Diabetes, Llc | Improved peptide pharmaceuticals for insulin resistance |
| EP2922877B1 (en) | 2012-11-20 | 2018-09-05 | Eumederis Pharmaceuticals, Inc. | Improved peptide pharmaceuticals |
| WO2014081872A1 (en) | 2012-11-20 | 2014-05-30 | Mederis Diabetes, Llc | Improved peptide pharmaceuticals for insulin resistance |
| CN117582516A (zh) | 2014-05-28 | 2024-02-23 | 梅德瑞斯糖尿病有限责任公司 | 针对胰岛素抵抗的改良肽药物 |
| AU2019205905B2 (en) * | 2018-01-03 | 2024-12-12 | Mederis Diabetes, Llc | Improved peptide pharmaceuticals for treatment of NASH and other disorders |
| CA3168001A1 (en) * | 2020-02-21 | 2021-08-26 | Spitfire Pharma Llc | Glp-1r and gcgr agonists, formulations, and methods of use |
-
2012
- 2012-05-17 EP EP23168618.9A patent/EP4286400A3/en active Pending
- 2012-05-17 JP JP2014511553A patent/JP6148228B2/ja active Active
- 2012-05-17 CA CA2836573A patent/CA2836573C/en active Active
- 2012-05-17 CN CN201280035528.1A patent/CN103796666B/zh active Active
- 2012-05-17 AU AU2012255116A patent/AU2012255116B2/en active Active
- 2012-05-17 CN CN201810595590.5A patent/CN108892709A/zh active Pending
- 2012-05-17 WO PCT/US2012/038429 patent/WO2012158962A2/en not_active Ceased
- 2012-05-17 KR KR1020207017489A patent/KR102512178B1/ko active Active
- 2012-05-17 WO PCT/US2012/038433 patent/WO2012158964A2/en not_active Ceased
- 2012-05-17 US US14/118,546 patent/US10010617B2/en active Active
- 2012-05-17 EP EP19176297.0A patent/EP3566711A1/en not_active Withdrawn
- 2012-05-17 KR KR1020137033672A patent/KR102126484B1/ko active Active
- 2012-05-17 EP EP12784971.9A patent/EP2709645B1/en active Active
-
2017
- 2017-01-20 JP JP2017008902A patent/JP6883912B2/ja active Active
- 2017-08-17 AU AU2017216533A patent/AU2017216533B2/en active Active
-
2018
- 2018-03-06 US US15/913,845 patent/US10420844B2/en active Active
-
2019
- 2019-05-31 JP JP2019103108A patent/JP6929610B2/ja active Active
- 2019-09-23 US US16/579,799 patent/US20210077629A1/en not_active Abandoned
- 2019-12-05 AU AU2019275610A patent/AU2019275610A1/en not_active Abandoned
-
2020
- 2020-03-21 US US16/826,208 patent/US20200289653A1/en active Pending
- 2020-10-15 JP JP2020174102A patent/JP2021020925A/ja active Pending
-
2021
- 2021-11-01 AU AU2021258101A patent/AU2021258101B2/en active Active
-
2022
- 2022-11-04 JP JP2022177489A patent/JP2023022045A/ja active Pending
-
2024
- 2024-11-25 JP JP2024205047A patent/JP2025043342A/ja active Pending
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