JP2016199549A5 - - Google Patents
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- JP2016199549A5 JP2016199549A5 JP2016095779A JP2016095779A JP2016199549A5 JP 2016199549 A5 JP2016199549 A5 JP 2016199549A5 JP 2016095779 A JP2016095779 A JP 2016095779A JP 2016095779 A JP2016095779 A JP 2016095779A JP 2016199549 A5 JP2016199549 A5 JP 2016199549A5
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- 102100033625 Killer cell immunoglobulin-like receptor 2DS3 Human genes 0.000 claims description 133
- 108010077854 Natural Killer Cell Receptors Proteins 0.000 claims description 133
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 90
- 239000012634 fragment Substances 0.000 claims description 88
- 150000001875 compounds Chemical class 0.000 claims description 78
- 208000004346 Smoldering Multiple Myeloma Diseases 0.000 claims description 44
- 208000010721 smoldering plasma cell myeloma Diseases 0.000 claims description 44
- 208000014951 hematologic disease Diseases 0.000 claims description 33
- 230000003211 malignant effect Effects 0.000 claims description 33
- 208000019838 Blood disease Diseases 0.000 claims description 32
- 208000018706 hematopoietic system disease Diseases 0.000 claims description 32
- 210000004027 cell Anatomy 0.000 claims description 31
- 230000003902 lesion Effects 0.000 claims description 30
- 101001027081 Homo sapiens Killer cell immunoglobulin-like receptor 2DL1 Proteins 0.000 claims description 29
- 102100037363 Killer cell immunoglobulin-like receptor 2DL1 Human genes 0.000 claims description 29
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 27
- 230000002159 abnormal effect Effects 0.000 claims description 23
- 210000001185 bone marrow Anatomy 0.000 claims description 21
- 101710085938 Matrix protein Proteins 0.000 claims description 20
- 101710127721 Membrane protein Proteins 0.000 claims description 20
- 229920001184 polypeptide Polymers 0.000 claims description 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 18
- 201000009295 smoldering myeloma Diseases 0.000 claims description 18
- 101000945371 Homo sapiens Killer cell immunoglobulin-like receptor 2DL2 Proteins 0.000 claims description 17
- 102100033599 Killer cell immunoglobulin-like receptor 2DL2 Human genes 0.000 claims description 17
- 210000002966 serum Anatomy 0.000 claims description 17
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 16
- 210000004180 plasmocyte Anatomy 0.000 claims description 16
- 101000945333 Homo sapiens Killer cell immunoglobulin-like receptor 2DL3 Proteins 0.000 claims description 14
- 102100033634 Killer cell immunoglobulin-like receptor 2DL3 Human genes 0.000 claims description 14
- 210000000822 natural killer cell Anatomy 0.000 claims description 14
- 208000032839 leukemia Diseases 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 208000034578 Multiple myelomas Diseases 0.000 claims description 10
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 9
- 208000031404 Chromosome Aberrations Diseases 0.000 claims description 9
- 230000035772 mutation Effects 0.000 claims description 9
- 102000039446 nucleic acids Human genes 0.000 claims description 9
- 108020004707 nucleic acids Proteins 0.000 claims description 9
- 150000007523 nucleic acids Chemical class 0.000 claims description 9
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 8
- 239000002955 immunomodulating agent Substances 0.000 claims description 8
- 230000002584 immunomodulator Effects 0.000 claims description 8
- 229940121354 immunomodulator Drugs 0.000 claims description 8
- 230000002068 genetic effect Effects 0.000 claims description 7
- 230000008707 rearrangement Effects 0.000 claims description 7
- 108010043610 KIR Receptors Proteins 0.000 claims description 6
- 102000002698 KIR Receptors Human genes 0.000 claims description 6
- 239000002246 antineoplastic agent Substances 0.000 claims description 6
- 229940127089 cytotoxic agent Drugs 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 6
- 229940124597 therapeutic agent Drugs 0.000 claims description 6
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 5
- 206010067477 Cytogenetic abnormality Diseases 0.000 claims description 5
- 206010060880 Monoclonal gammopathy Diseases 0.000 claims description 5
- 230000006378 damage Effects 0.000 claims description 5
- 239000003550 marker Substances 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108010069149 HLA-C*04 antigen Proteins 0.000 claims description 4
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 230000001684 chronic effect Effects 0.000 claims description 4
- 238000010494 dissociation reaction Methods 0.000 claims description 4
- 230000005593 dissociations Effects 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 230000004083 survival effect Effects 0.000 claims description 4
- 102100029382 CMRF35-like molecule 6 Human genes 0.000 claims description 3
- 101000990034 Homo sapiens CMRF35-like molecule 6 Proteins 0.000 claims description 3
- 101001109508 Homo sapiens NKG2-A/NKG2-B type II integral membrane protein Proteins 0.000 claims description 3
- 101000971513 Homo sapiens Natural killer cells antigen CD94 Proteins 0.000 claims description 3
- 206010025323 Lymphomas Diseases 0.000 claims description 3
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 claims description 3
- 102100021462 Natural killer cells antigen CD94 Human genes 0.000 claims description 3
- 108700042075 T-Cell Receptor Genes Proteins 0.000 claims description 3
- 239000004037 angiogenesis inhibitor Substances 0.000 claims description 3
- 239000013059 antihormonal agent Substances 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000012636 effector Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 238000000684 flow cytometry Methods 0.000 claims description 3
- 230000013595 glycosylation Effects 0.000 claims description 3
- 238000006206 glycosylation reaction Methods 0.000 claims description 3
- 210000003714 granulocyte Anatomy 0.000 claims description 3
- 230000005764 inhibitory process Effects 0.000 claims description 3
- 230000001404 mediated effect Effects 0.000 claims description 3
- 238000010837 poor prognosis Methods 0.000 claims description 3
- 230000017854 proteolysis Effects 0.000 claims description 3
- 238000001959 radiotherapy Methods 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- 208000024891 symptom Diseases 0.000 claims description 3
- 230000009885 systemic effect Effects 0.000 claims description 3
- 210000001519 tissue Anatomy 0.000 claims description 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 239000003112 inhibitor Substances 0.000 claims 8
- 230000005856 abnormality Effects 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 2
- 238000011443 conventional therapy Methods 0.000 claims 2
- 206010064571 Gene mutation Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 101150010487 are gene Proteins 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 210000004324 lymphatic system Anatomy 0.000 claims 1
- 230000008816 organ damage Effects 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 230000000392 somatic effect Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 131
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 74
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 74
- 239000000203 mixture Substances 0.000 description 21
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 3
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000036210 malignancy Effects 0.000 description 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41597310P | 2010-11-22 | 2010-11-22 | |
| US61/415,973 | 2010-11-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013541022A Division JP6224457B2 (ja) | 2010-11-22 | 2011-11-22 | Ｎｋ細胞調節治療及び悪性血液疾患の治療方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016199549A JP2016199549A (ja) | 2016-12-01 |
| JP2016199549A5 true JP2016199549A5 (cg-RX-API-DMAC7.html) | 2017-03-09 |
Family
ID=46146390
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013541022A Expired - Fee Related JP6224457B2 (ja) | 2010-11-22 | 2011-11-22 | Ｎｋ細胞調節治療及び悪性血液疾患の治療方法 |
| JP2016095779A Pending JP2016199549A (ja) | 2010-11-22 | 2016-05-12 | Ｎｋ細胞調節治療及び悪性血液疾患の治療方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013541022A Expired - Fee Related JP6224457B2 (ja) | 2010-11-22 | 2011-11-22 | Ｎｋ細胞調節治療及び悪性血液疾患の治療方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9844593B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2643350A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6224457B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN106963947A (cg-RX-API-DMAC7.html) |
| AR (1) | AR083957A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013012138B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2818684C (cg-RX-API-DMAC7.html) |
| EA (1) | EA035033B1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX355483B (cg-RX-API-DMAC7.html) |
| TW (1) | TWI664191B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012071411A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20090191213A9 (en) * | 2003-07-02 | 2009-07-30 | Novo Nordisk A/S | Compositions and methods for regulating NK cell activity |
| ES2732623T3 (es) * | 2005-01-06 | 2019-11-25 | Innate Pharma Sa | Tratamientos y métodos de combinación anti-KIR |
| CA2837184C (en) * | 2011-05-25 | 2021-09-21 | Innate Pharma, S.A. | Anti-kir antibodies for the treatment of inflammatory and autoimmune disorders |
| WO2014037422A1 (en) * | 2012-09-04 | 2014-03-13 | Inven2 As | Selective and controlled expansion of educated nk cells |
| CA2887027C (en) | 2012-10-02 | 2021-11-16 | Bristol-Myers Squibb Company | Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer |
| CA2893977C (en) | 2012-12-21 | 2024-02-13 | Seattle Genetics, Inc. | Anti-ntb-a antibodies and related compositions and methods |
| EP2948544A4 (en) | 2013-01-28 | 2016-08-03 | St Jude Childrens Res Hospital | CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES |
| KR102098985B1 (ko) * | 2013-05-03 | 2020-04-09 | 오하이오 스테이트 이노베이션 파운데이션 | Cs1-특이적 키메라 항원 수용체 가공된 면역 작동체 세포 |
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| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| WO2015195555A1 (en) * | 2014-06-16 | 2015-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Blocking cd38 using anti-cd38 antibody conjugated to protein g to protect nk cells |
| US10617757B2 (en) | 2014-08-08 | 2020-04-14 | The Regents Of The University Of California | Methods for treating multiple myeloma |
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| RU2571551C1 (ru) * | 2015-04-16 | 2015-12-20 | Закрытое акционерное общество "ПЕПТЕК" | Специфическая сочетанная терапия злокачественных опухолей цитостатиком и его модификатором |
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| SG10202002131PA (en) | 2015-05-21 | 2020-05-28 | Harpoon Therapeutics Inc | Trispecific binding proteins and methods of use |
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| KR101926166B1 (ko) * | 2016-05-24 | 2018-12-06 | 재단법인 아산사회복지재단 | 수용체 시너지 활성을 이용한 nk 세포의 활성도 검사 방법 및 이를 이용한 nk 세포의 활성도가 관련된 질환의 진단 방법 |
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| BR112019006041A2 (pt) | 2016-09-27 | 2019-09-03 | Board Of Regents, The University Of Texas System | métodos para aprimorar a terapia de bloqueio do ponto de verificação imunológico por modulação do microbioma |
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| RU2019128544A (ru) | 2017-03-27 | 2021-04-28 | Нэшнл Юниверсити Оф Сингапур | Линии стимулирующих клеток для ex vivo размножения и активации клеток-натуральных киллеров |
| CN117384929A (zh) | 2017-03-27 | 2024-01-12 | 新加坡国立大学 | 一种编码由细胞表达的嵌合受体的多核苷酸 |
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| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| AU2023393653A1 (en) | 2022-12-14 | 2025-05-22 | Astellas Pharma Europe Bv | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors |
| WO2025038763A1 (en) | 2023-08-15 | 2025-02-20 | Bristol-Myers Squibb Company | Ceramic hydroxyapatite chromatography flow through method |
| WO2025121445A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025120866A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
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| US20030105294A1 (en) | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| WO2003097040A1 (en) * | 2002-05-17 | 2003-11-27 | Celgene Corporation | Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases |
| US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| EP1639013B1 (en) | 2003-07-02 | 2012-09-12 | Innate Pharma | Pan-kir2dl NK-receptor antibodies and their use in diagnostic and therapy |
| CN1852924A (zh) * | 2003-07-02 | 2006-10-25 | 依奈特制药公司 | Pan－kir2dl nk－受体的抗体及其在诊断及治疗中的应用 |
| KR101299599B1 (ko) * | 2003-07-24 | 2013-08-23 | 위니베르시따 데글리 스뚜디 디 뻬루지아 | Ｎｋ 세포 강화 화합물을 사용하여 치료용 항체의 효율을 높이는 방법 및 조성물 |
| AU2005259221B2 (en) | 2004-07-01 | 2011-02-10 | Innate Pharma | Antibodies binding to receptors KIR2DL1, -2, 3 but not KIR2DS4 and their therapeutic use |
| ES2732623T3 (es) * | 2005-01-06 | 2019-11-25 | Innate Pharma Sa | Tratamientos y métodos de combinación anti-KIR |
| CN101103043A (zh) * | 2005-01-06 | 2008-01-09 | 诺和诺德公司 | Kir结合剂和使用其的方法 |
| US20100189723A1 (en) * | 2007-01-11 | 2010-07-29 | Peter Andreas Nicolai Reumert Wagtmann | Anti-kir antibodies, formulations, and uses thereof |
| US20100099084A1 (en) | 2008-10-17 | 2010-04-22 | Maher Albitar | Detection of npm1 nucleic acid in acellular body fluids |
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