JP2016183128A - 液状口腔用組成物 - Google Patents
液状口腔用組成物 Download PDFInfo
- Publication number
- JP2016183128A JP2016183128A JP2015064356A JP2015064356A JP2016183128A JP 2016183128 A JP2016183128 A JP 2016183128A JP 2015064356 A JP2015064356 A JP 2015064356A JP 2015064356 A JP2015064356 A JP 2015064356A JP 2016183128 A JP2016183128 A JP 2016183128A
- Authority
- JP
- Japan
- Prior art keywords
- allantoin
- oral composition
- liquid
- liquid oral
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Description
項1. (A)アラントイン及びその誘導体よりなる群から選択される少なくとも1種、(B)ポリビニルピロリドン及びその誘導体よりなる群から選択される少なくとも1種、並びに(C)水を含有することを特徴とする、液状口腔用組成物。
項2. pHが4〜6である、項1に記載の液状口腔用組成物。
項3. 前記(B)成分の重量平均分子量が5千〜300万である、項1又は2に記載の液状口腔用組成物。
項4. 前記(B)成分の含有量が0.1〜20重量%である、項1〜3のいずれかに記載の液状口腔用組成物。
項5. 前記(A)成分の含有量が0.001〜1重量%である、項1〜4のいずれかに記載の液状口腔用組成物。
項6.更に、クエン酸、及びその塩よりなる群から選択される少なくとも1種を含む、請求項1〜5のいずれかに記載の液状口腔用組成物。
項7. 液体歯磨剤である、項1〜6のいずれかに記載の液状口腔用組成物。
項8. (A)アラントイン及びその誘導体よりなる群から選択される少なくとも1種、並びに(C)水を含有する液状口腔用組成物に、(B)ポリビニルピロリドン及びその誘導体よりなる群から選択される少なくとも1種を配合することを特徴とする、当該液状口腔用組成物中のアラントイン及び/又はその誘導体を安定化する方法。
項9. (A)アラントイン及びその誘導体よりなる群から選択される少なくとも1種、並びに(C)水を含有する液状口腔用組成物に、(B)ポリビニルピロリドン及びその誘導体よりなる群から選択される少なくとも1種を配合することを特徴とする、当該液状口腔用組成物の口腔内での滞留性を向上させる方法。
本発明の液状口腔用組成物は、アラントイン及びその誘導体よりなる群から選択される少なくとも1種(以下、(A)成分と表記することもある)、ポリビニルピロリドン及びその誘導体よりなる群から選択される少なくとも1種(以下、(B)成分と表記することもある)、並びに水(以下、(C)成分と表記することもある)を含有することを特徴とする。以下、本発明の液状口腔用組成物について詳述する。
本発明の液状口腔用組成物は、(A)成分として、アラントイン及びその誘導体よりなる群から選択される少なくとも1種を含有する。アラントイン及び/又はその誘導体には、安定性が劣るという欠点があるが、本発明によれば、後述する(B)成分を配合することによって、水存在下でのアラントイン及び/又はその誘導体の安定性の向上を図りながら、口腔内でのべたつきを抑制しつつ滞留性を向上させることが可能になる。
本発明の液状口腔用組成物は、(B)成分としてポリビニルピロリドン及びその誘導体よりなる群から選択される少なくとも1種を含有する。本発明の液状口腔用組成物において、ポリビニルピロリドン及び/又はその誘導体は、水存在下でのアラントイン及び/又はその誘導体の安定性の向上に寄与すると共に、口腔内でのべたつきを抑制しつつ滞留性を向上させる役割をも果たす。
本発明の液状口腔用組成物は、(C)成分として水を含有する。アラントイン及び/又はその誘導体は、水との共存下で安定性が低下する傾向を示すが、本発明の液状口腔用組成物によれば、水との共存下で引き起こされるアラントイン及び/又はその誘導体の安定性の低下を効果的に抑制することができる。
本発明の液状口腔用組成物は、前記(A)〜(C)成分に加えて、必要に応じて1価の低級アルコールが含まれていてもよい。このような1価の低級アルコールとしては、具体的には、エタノール、プロパノール、ブタノール、ペンタノール、ヘキサノール、イソプロパノール等の炭素数1〜6の1価アルコールが挙げられる。これらの1価の低級アルコールは、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。
更に、本発明の液状口腔用組成物は、前述する成分に加えて、クエン酸及び/又はその塩が含まれていてもよい。クエン酸及び/又はその塩を含有することにより、水存在下でのアラントイン及び/又はその誘導体の安定化効果を増強させることが可能になる。
本発明の液状口腔用組成物は、前述する成分以外に、本発明の効果を損なわない範囲で、口腔用組成物の製剤形態に応じて、当該技術分野で通常使用される成分を含有していてもよい。このような成分としては、例えば、防腐剤、殺菌剤、抗菌剤、消炎剤、グルコシルトランスフェラーゼ(GTase)阻害剤、プラーク抑制剤、知覚過敏抑制剤、歯石予防剤、歯質強化/再石灰化剤、増粘剤、湿潤剤、賦形剤、香料、甘味剤、清涼化剤、色素、消臭剤、界面活性剤、pH調整剤等が挙げられる。
本発明の液状口腔用組成物の粘度については、特に制限されないが、例えば、25℃での粘度として、5〜100mPa・Sが挙げられる。より一層効果的べたつき抑制及び滞留性の向上を図るという観点から本発明の液状口腔用組成物の25℃での粘度として、好ましくは7〜70mPa・S、更に好ましくは18〜40mPa・Sが挙げられる。ここで、25℃での粘度とは、B型回転粘度計(スピンドル:LVスピンドルNo.2、回転数60rpm)にて測定される25℃での粘度を意味する。
本発明の液状口腔用組成物の製剤形態は、液状であり、口腔内に適用されて口腔内で一定時間滞留し得るものである限り制限されないが、例えば、液体歯磨剤、液状歯磨剤、洗口液(液体歯磨剤、洗口液は、一般にマウスリンス、マウスウォッシュ、デンタルリンス等と呼称されることがある)、口中清涼剤(マウススプレー等)等の口腔衛生剤が挙げられる。これらの中でも、好ましくは液体歯磨剤、液状歯磨剤、洗口液、更に好ましくは液体歯磨剤、洗口液が挙げられる。
前述するように、アラントイン及び/又はその誘導体と水とを含む液状口腔用組成物に、ポリビニルピロリドン及び/又はその誘導体を配合することによって、当該液状口腔用組成物中のアラントイン及び/又はその誘導体を安定化させ、保存安定性を向上させることができる。
前述するように、アラントイン及び/又はその誘導体と水とを含む液状口腔用組成物に、ポリビニルピロリドン及び/又はその誘導体を配合することによって、当該液状口腔用組成物の口腔内での滞留性を向上させることができる。
1.試験方法
表1及び2に示す組成の液体歯磨剤(実施例1〜16及び比較例1〜7)を調製し、以下に示す方法で、pH、粘度、使用感(口腔内での滞留性及びべたつき)、保存後のアラントインの安定性及び外観性状について評価を行った。
25℃の各液体歯磨剤のpHについて、pHメーター(型式:F−53、株式会社堀場製作所製)を用いて測定した。
各液体歯磨剤の粘度について、B型回転粘度計(機種:LVT、ブルックフィールド社製)を用いて、下記の条件で測定した。
スピンドル:LVスピンドルNo.2
回転速度:60rpm
LVスピンドルフィルター:5
測定時間:回転開始から30秒経過後
測定温度:25℃
各液体歯磨剤10mlを口に含み、30秒間、口をすすいで吐出した後に、以下の方法で口腔内での滞留性及びべたつきを評価した。なお、本試験は、5名のパネラーによって行った。
(口腔内での滞留性)
以下の判定基準に従って、口腔内での滞留性を評点化した。
判定基準
3点:液体歯磨剤を吐出した後に、液体歯磨剤の残留性を十分に感じる。
2点:液体歯磨剤を吐出した後に、液体歯磨剤の残留性を感じる。
1点:液体歯磨剤を吐出した後に、液体歯磨剤の残留性を僅かに感じる。
0点:液体歯磨剤を吐出した後に、液体歯磨剤の残留性を感じない。
評価分類
◎:評点の合計点が12〜15点
○:評点の合計点が9〜11点
△:評点の合計点が6〜8点
×:評点の合計点が0〜5点
液体歯磨剤を吐出した後に、「口腔内にべたつきを感じる」を0点、「口腔内にべたつきを感じない」を10点として、VAS(visual analogue Scale)法にて評点化した。次いで、各洗口剤について、5名のパネラーによる評点の平均値を算出し、以下の評価分類に従って、べたつきについて評価した。
評価分類
◎:評点の平均点が9〜10点
○:評点の平均点が7〜8点
△:評点の平均点が3〜6点
×:評点の平均点が0〜2点
各液体歯磨剤60mlを80ml容のガラス容器に充填し、蓋をして密封し、60℃の暗所で2週間保存した。
評価分類
◎:保存後に残存しているアラントインが95%以上である。
○:保存後に残存しているアラントインが91%以上95%未満である。
△:保存後に残存しているアラントインが90%以上91%未満である。
×:保存後に残存しているアラントインが88%以上90%未満である。
××:保存後に残存しているアラントインが88未満である。
評価分類
◎:成分の析出や濁りが全く認められず、澄明である。
△:成分の析出や濁りが僅かに認められる。
×:成分の析出と濁りが明らかに認められる。
得られた結果を表1及び2に示す。表1から明らかなように、アラントイン、ポリビニルピロリドン、及び水を含む液体歯磨剤では、60℃で2週間保存した後でも、アラントインが安定に維持され、良好な外観性状を備えていた(実施例1〜15)。特に、アラントイン、ポリビニルピロリドン、及び水を含む場合には、エタノールを含んでいなくても、アラントインを安定化できていた。
表3〜5に記載の組成の液体歯磨剤(洗口液)を調製した。得られた各液体歯磨剤(洗口液)について、前記試験例と同様の方法で、使用感(口腔内での滞留性、べたつき)、60℃2週間保存後のアラントインの安定性と外観性状を評価したところ、いずれも良好であった。
Claims (9)
- (A)アラントイン及びその誘導体よりなる群から選択される少なくとも1種、(B)ポリビニルピロリドン及びその誘導体よりなる群から選択される少なくとも1種、並びに(C)水を含有することを特徴とする、液状口腔用組成物。
- pHが4〜6である、請求項1に記載の液状口腔用組成物。
- 前記(B)成分の重量平均分子量が5千〜300万である、請求項1又は2に記載の液状口腔用組成物。
- 前記(B)成分の含有量が0.1〜20重量%である、請求項1〜3のいずれかに記載の液状口腔用組成物。
- 前記(A)成分の含有量が0.001〜1重量%である、請求項1〜4のいずれかに記載の液状口腔用組成物。
- 更に、クエン酸、及びその塩よりなる群から選択される少なくとも1種を含む、請求項1〜5のいずれかに記載の液状口腔用組成物。
- 液体歯磨剤である、請求項1〜6のいずれかに記載の液状口腔用組成物。
- (A)アラントイン及びその誘導体よりなる群から選択される少なくとも1種、並びに(C)水を含有する液状口腔用組成物に、(B)ポリビニルピロリドン及びその誘導体よりなる群から選択される少なくとも1種を配合することを特徴とする、当該液状口腔用組成物中のアラントイン及び/又はその誘導体を安定化する方法。
- (A)アラントイン及びその誘導体よりなる群から選択される少なくとも1種、並びに(C)水を含有する液状口腔用組成物に、(B)ポリビニルピロリドン及びその誘導体よりなる群から選択される少なくとも1種を配合することを特徴とする、当該液状口腔用組成物の口腔内での滞留性を向上させる方法。
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JP2006182699A (ja) * | 2004-12-27 | 2006-07-13 | Lion Corp | 口腔用組成物 |
CN102198126A (zh) * | 2011-05-04 | 2011-09-28 | 刘布鸣 | 治疗口腔及牙齿疾病的涂抹剂及其涂抹器 |
JP2013001651A (ja) * | 2011-06-13 | 2013-01-07 | Kao Corp | 透明液体口腔用組成物 |
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