JP2016127847A5 - - Google Patents
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- JP2016127847A5 JP2016127847A5 JP2016014732A JP2016014732A JP2016127847A5 JP 2016127847 A5 JP2016127847 A5 JP 2016127847A5 JP 2016014732 A JP2016014732 A JP 2016014732A JP 2016014732 A JP2016014732 A JP 2016014732A JP 2016127847 A5 JP2016127847 A5 JP 2016127847A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- pluripotent stem
- stem
- marker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000000130 stem cell Anatomy 0.000 claims 48
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 23
- 238000000034 method Methods 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 16
- 239000003550 marker Substances 0.000 claims 16
- 210000001900 endoderm Anatomy 0.000 claims 11
- 210000003494 hepatocyte Anatomy 0.000 claims 7
- 210000003445 biliary tract Anatomy 0.000 claims 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 6
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 5
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 5
- 210000000232 gallbladder Anatomy 0.000 claims 5
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 4
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 4
- 108091023040 Transcription factor Proteins 0.000 claims 4
- 102000040945 Transcription factor Human genes 0.000 claims 4
- 210000000013 bile duct Anatomy 0.000 claims 4
- 239000002458 cell surface marker Substances 0.000 claims 4
- 102000004877 Insulin Human genes 0.000 claims 3
- 108090001061 Insulin Proteins 0.000 claims 3
- -1 N-CAM Proteins 0.000 claims 3
- 239000007640 basal medium Substances 0.000 claims 3
- 210000004907 gland Anatomy 0.000 claims 3
- 229940125396 insulin Drugs 0.000 claims 3
- 108010005465 AC133 Antigen Proteins 0.000 claims 2
- 102000005908 AC133 Antigen Human genes 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 102100029284 Hepatocyte nuclear factor 3-beta Human genes 0.000 claims 2
- 102100029087 Hepatocyte nuclear factor 6 Human genes 0.000 claims 2
- 101001002170 Homo sapiens Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial Proteins 0.000 claims 2
- 101001062347 Homo sapiens Hepatocyte nuclear factor 3-beta Proteins 0.000 claims 2
- 101000988619 Homo sapiens Hepatocyte nuclear factor 6 Proteins 0.000 claims 2
- 101000603702 Homo sapiens Neurogenin-3 Proteins 0.000 claims 2
- 101001069749 Homo sapiens Prospero homeobox protein 1 Proteins 0.000 claims 2
- 101000843556 Homo sapiens Transcription factor HES-1 Proteins 0.000 claims 2
- 101000711846 Homo sapiens Transcription factor SOX-9 Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 108010069196 Neural Cell Adhesion Molecules Proteins 0.000 claims 2
- 102100023616 Neural cell adhesion molecule L1-like protein Human genes 0.000 claims 2
- 102100038553 Neurogenin-3 Human genes 0.000 claims 2
- 102100033880 Prospero homeobox protein 1 Human genes 0.000 claims 2
- 102100020949 Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial Human genes 0.000 claims 2
- 102100034204 Transcription factor SOX-9 Human genes 0.000 claims 2
- 210000000941 bile Anatomy 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 210000001953 common bile duct Anatomy 0.000 claims 2
- 210000003459 common hepatic duct Anatomy 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 238000000684 flow cytometry Methods 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 2
- 229940099552 hyaluronan Drugs 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 210000004153 islets of langerhan Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 239000012679 serum free medium Substances 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102100023635 Alpha-fetoprotein Human genes 0.000 claims 1
- 239000004382 Amylase Substances 0.000 claims 1
- 102000013142 Amylases Human genes 0.000 claims 1
- 108010065511 Amylases Proteins 0.000 claims 1
- 102000010637 Aquaporins Human genes 0.000 claims 1
- 108010063290 Aquaporins Proteins 0.000 claims 1
- 102000001187 Collagen Type III Human genes 0.000 claims 1
- 108010069502 Collagen Type III Proteins 0.000 claims 1
- 102000004266 Collagen Type IV Human genes 0.000 claims 1
- 108010042086 Collagen Type IV Proteins 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 102000051325 Glucagon Human genes 0.000 claims 1
- 108060003199 Glucagon Proteins 0.000 claims 1
- 102000015779 HDL Lipoproteins Human genes 0.000 claims 1
- 108010010234 HDL Lipoproteins Proteins 0.000 claims 1
- 108010049606 Hepatocyte Nuclear Factors Proteins 0.000 claims 1
- 102000008088 Hepatocyte Nuclear Factors Human genes 0.000 claims 1
- 101000998011 Homo sapiens Keratin, type I cytoskeletal 19 Proteins 0.000 claims 1
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 1
- 101000652324 Homo sapiens Transcription factor SOX-17 Proteins 0.000 claims 1
- 101710123134 Ice-binding protein Proteins 0.000 claims 1
- 101710082837 Ice-structuring protein Proteins 0.000 claims 1
- 102100033420 Keratin, type I cytoskeletal 19 Human genes 0.000 claims 1
- 102000007547 Laminin Human genes 0.000 claims 1
- 108010085895 Laminin Proteins 0.000 claims 1
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 1
- 101710183548 Pyridoxal 5'-phosphate synthase subunit PdxS Proteins 0.000 claims 1
- 102100035459 Pyruvate dehydrogenase protein X component, mitochondrial Human genes 0.000 claims 1
- 239000012980 RPMI-1640 medium Substances 0.000 claims 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 102000005157 Somatostatin Human genes 0.000 claims 1
- 108010056088 Somatostatin Proteins 0.000 claims 1
- 108010017842 Telomerase Proteins 0.000 claims 1
- 102100030243 Transcription factor SOX-17 Human genes 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 101710107540 Type-2 ice-structuring protein Proteins 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 235000019418 amylase Nutrition 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 235000021588 free fatty acids Nutrition 0.000 claims 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 1
- 229960004666 glucagon Drugs 0.000 claims 1
- 239000000859 incretin Substances 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 230000009996 pancreatic endocrine effect Effects 0.000 claims 1
- 238000004091 panning Methods 0.000 claims 1
- 238000007747 plating Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000011669 selenium Substances 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 1
- 229960000553 somatostatin Drugs 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25684609P | 2009-10-30 | 2009-10-30 | |
| US61/256,846 | 2009-10-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012537054A Division JP5936547B2 (ja) | 2009-10-30 | 2010-10-28 | 肝外胆樹からの多能性幹細胞およびそれらを単離する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016127847A JP2016127847A (ja) | 2016-07-14 |
| JP2016127847A5 true JP2016127847A5 (cg-RX-API-DMAC7.html) | 2016-12-01 |
| JP6356165B2 JP6356165B2 (ja) | 2018-07-11 |
Family
ID=43922533
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012537054A Active JP5936547B2 (ja) | 2009-10-30 | 2010-10-28 | 肝外胆樹からの多能性幹細胞およびそれらを単離する方法 |
| JP2016014732A Active JP6356165B2 (ja) | 2009-10-30 | 2016-01-28 | 肝外胆樹からの多能性幹細胞およびそれらを単離する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012537054A Active JP5936547B2 (ja) | 2009-10-30 | 2010-10-28 | 肝外胆樹からの多能性幹細胞およびそれらを単離する方法 |
Country Status (20)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201407102QA (en) * | 2009-10-30 | 2014-11-27 | Univ North Carolina | Multipotent stem cells from the extrahepatic billary tree and methods of isolating same |
| JP2014519854A (ja) | 2011-06-23 | 2014-08-21 | ザ チルドレンズ ホスピタル オブ フィラデルフィア | ヒト多能性幹細胞から生じる自己複製する内胚葉前駆細胞株とその使用方法 |
| US9533013B2 (en) | 2013-03-13 | 2017-01-03 | University Of North Carolina At Chapel Hill | Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree |
| CN103266084B (zh) * | 2013-05-27 | 2015-03-04 | 刘卫辉 | 富集干细胞的三步分离法 |
| EP3120151A4 (en) * | 2014-03-17 | 2017-08-09 | Agency For Science, Technology And Research | METHOD FOR PREDICTING TOXICITY OF A COMPOUND BASED ON NUCLEAR FACTOR-kB TRANSLOCATION |
| GB201507894D0 (en) * | 2015-05-08 | 2015-06-24 | Imagen Biotech Ltd | Personalised media |
| GB201510950D0 (en) | 2015-06-22 | 2015-08-05 | Cambridge Entpr Ltd | In vitro Production of Cholangiocytes |
| EP3368657B1 (en) * | 2015-10-30 | 2021-06-30 | Biolamina AB | Methods for producing hepatocytes |
| GB201521179D0 (en) | 2015-12-01 | 2016-01-13 | Univ Leuven Kath | Methods for differentiating cells into hepatic stellate cells |
| CN105807053B (zh) * | 2016-04-15 | 2019-04-02 | 苏州药明康德新药开发股份有限公司 | 一种肿瘤解离试剂在流式细胞检测中的应用 |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| CN110913691A (zh) * | 2017-04-06 | 2020-03-24 | 北卡罗来纳大学教堂山分校 | 低温保存方法 |
| JP7562416B2 (ja) * | 2018-03-29 | 2024-10-07 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 十二指腸ブルンナー腺由来の幹／前駆細胞ならびにそれらの単離および使用方法 |
| CN112126618B (zh) * | 2019-06-24 | 2023-09-12 | 上海拜羡生物科技有限公司 | 一种人胆囊干细胞的获取和长期体外培养的方法 |
| CN113388569B (zh) * | 2020-08-28 | 2022-05-17 | 广东乾晖生物科技有限公司 | 肝脏类器官的制备方法 |
| JP2024525215A (ja) * | 2021-06-30 | 2024-07-10 | ポルビオニカ スポルカ ジー オグラニクゾナ オドパウイエドジアルノシア | 単離膵島を保存するための培地及び単離膵島の保存方法 |
| CN115975913B (zh) * | 2023-02-03 | 2024-06-04 | 北京中医药大学深圳医院(龙岗) | 一种利用多能干细胞诱导分化胆囊祖细胞的方法 |
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| US3646197A (en) * | 1969-05-14 | 1972-02-29 | Zaidan Hojin Biseibutsu | Novel process for removing copper from copper-containing bleomycin |
| US6069005A (en) * | 1991-08-07 | 2000-05-30 | Albert Einstein College Of Medicine Of Yeshwa University | Hapatoblasts and method of isolating same |
| US5660207A (en) * | 1994-12-29 | 1997-08-26 | Tylan General, Inc. | Flow controller, parts of flow controller, and related method |
| US5861313A (en) * | 1995-06-07 | 1999-01-19 | Ontogeny, Inc. | Method of isolating bile duct progenitor cells |
| GB9605808D0 (en) * | 1996-03-20 | 1996-05-22 | Isis Innovation | CFTR gene regulator |
| US5830850A (en) * | 1996-08-28 | 1998-11-03 | Mount Sinai School Of Medicine Of The City Of New York | Methods for the treatment of bone resorption disorders, including osteoporosis |
| US20020182188A1 (en) * | 1999-01-19 | 2002-12-05 | Reid Lola M. | Human liver progenitors |
| US7456017B2 (en) * | 1999-10-01 | 2008-11-25 | University Of North Carolina At Chapel Hill | Processes for clonal growth of hepatic progenitor cells |
| EP1285057B1 (en) * | 2000-04-28 | 2006-05-31 | Children's Medical Center Corporation | Isolation of mesenchymal stem cells and use thereof |
| US6828145B2 (en) * | 2000-05-10 | 2004-12-07 | Cedars-Sinai Medical Center | Method for the isolation of stem cells by immuno-labeling with HLA/MHC gene product marker |
| JP3602038B2 (ja) * | 2000-07-24 | 2004-12-15 | 株式会社日立グローバルストレージテクノロジーズ | 磁気ヘッドおよび磁気記録再生装置 |
| DE10064804C2 (de) * | 2000-12-22 | 2003-03-20 | Schott Glas | Alkalifreie Aluminoborosilicatgläser und ihre Verwendung |
| EP1425388A2 (en) | 2001-09-12 | 2004-06-09 | DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung | A method for isolating, culturing and differentiating intestinal stem cells for therapeutic use |
| US7150990B2 (en) * | 2002-03-06 | 2006-12-19 | Reprocell, Inc. | Self-renewing pluripotent hepatic stem cells |
| CA2479510C (en) * | 2002-03-15 | 2019-10-29 | University Of North Carolina At Chapel Hill | Primitive and proximal hepatic stem cells |
| WO2004071464A2 (en) * | 2003-02-12 | 2004-08-26 | Johns Hopkins University School Of Medicine | Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells |
| DE10336152B4 (de) * | 2003-08-06 | 2007-02-15 | Nephrogen LLC, Salt Lake City | Aufreinigungsverfahren für humane mesenchymale Stammzellen |
| US8119774B2 (en) * | 2003-10-09 | 2012-02-21 | Martin Pera | Cell marker for hepatic and pancreatic stem cells and progenitor cells |
| KR20070007030A (ko) * | 2003-10-28 | 2007-01-12 | 카리타스 세인트 엘리자베스 메디칼 센터 오브 보스톤, 인코포레이티드 | 신규한 다능성 줄기세포 및 그의 용도 |
| US7081582B2 (en) * | 2004-06-30 | 2006-07-25 | Microsoft Corporation | System and method for aligning and mixing songs of arbitrary genres |
| JP4824036B2 (ja) | 2004-12-23 | 2011-11-24 | ヴィアサイト，インコーポレイテッド | 胚体内胚葉細胞の増殖 |
| JP4773777B2 (ja) * | 2005-08-30 | 2011-09-14 | グローバル・オーエルイーディー・テクノロジー・リミテッド・ライアビリティ・カンパニー | アクティブマトリクス型表示装置 |
| EP1941032A2 (en) * | 2005-10-14 | 2008-07-09 | Regents Of The University Of Minnesota | Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype |
| RU2008124158A (ru) * | 2005-11-16 | 2010-01-10 | Юниверсити Оф Норт Каролина Эт Чепел Хилл (Us) | Внеклеточные матриксные компоненты для экспансии и дифференцировки гепатических клеток-предшественников |
| AU2007321928A1 (en) * | 2006-11-24 | 2008-05-29 | Regents Of The University Of Minnesota | Endodermal progenitor cells |
| EP2132303A2 (en) * | 2007-03-06 | 2009-12-16 | University Of North Carolina At Chapel Hill | Complexes of hyaluronans, other matrix components, hormones and growth factors for maintenance, expansion and/or differentiation of cells |
| EP2171040A4 (en) * | 2007-06-15 | 2010-08-04 | Univ North Carolina | PARACRIC SIGNALS FROM MESENCHYMAL FEEDER CELLS AND REGULATION OF THE EXPANSION AND DIFFERENTIATION OF PRECURSOR LIVER CELLS USING THEREOF |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| CA2695225C (en) * | 2007-07-31 | 2021-06-01 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| SG10201407102QA (en) * | 2009-10-30 | 2014-11-27 | Univ North Carolina | Multipotent stem cells from the extrahepatic billary tree and methods of isolating same |
| US10135700B2 (en) | 2014-03-10 | 2018-11-20 | Softphone SRL | Enterprise application integration on client computing devices |
| US10387547B2 (en) | 2014-09-09 | 2019-08-20 | Intentional Software Corporation | Layout engine for creating a visual layout tree for a document |
-
2010
- 2010-10-28 SG SG10201407102QA patent/SG10201407102QA/en unknown
- 2010-10-28 KR KR1020187013924A patent/KR102016870B1/ko not_active Expired - Fee Related
- 2010-10-28 US US12/926,161 patent/US20110135610A1/en not_active Abandoned
- 2010-10-28 JP JP2012537054A patent/JP5936547B2/ja active Active
- 2010-10-28 ES ES10827464T patent/ES2819028T3/es active Active
- 2010-10-28 NZ NZ622427A patent/NZ622427A/en not_active IP Right Cessation
- 2010-10-28 EP EP20178369.3A patent/EP3725874A1/en active Pending
- 2010-10-28 MX MX2012005087A patent/MX2012005087A/es not_active Application Discontinuation
- 2010-10-28 BR BR112012009848-9A patent/BR112012009848B1/pt not_active IP Right Cessation
- 2010-10-28 KR KR1020127013498A patent/KR20120117758A/ko not_active Ceased
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