CR20120254A - Células madre multipotenciales en el árbol de billary extrahepática y métodos de aislamiento del mismo - Google Patents

Células madre multipotenciales en el árbol de billary extrahepática y métodos de aislamiento del mismo

Info

Publication number
CR20120254A
CR20120254A CR20120254A CR20120254A CR20120254A CR 20120254 A CR20120254 A CR 20120254A CR 20120254 A CR20120254 A CR 20120254A CR 20120254 A CR20120254 A CR 20120254A CR 20120254 A CR20120254 A CR 20120254A
Authority
CR
Costa Rica
Prior art keywords
extrahepathic
billary
multipotential
tree
same
Prior art date
Application number
CR20120254A
Other languages
English (en)
Spanish (es)
Inventor
Lola M Reid
Yunfang Wang
Vicenzo Cardinale
Eugenio Gaudio
Guido Carpino
Domenico Alvaro
Cai-Bin Cui
Original Assignee
Univ North Carolina
Sapienza Uni Di Roma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43922533&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20120254(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ North Carolina, Sapienza Uni Di Roma filed Critical Univ North Carolina
Publication of CR20120254A publication Critical patent/CR20120254A/es

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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/413Gall bladder; Bile
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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CR20120254A 2009-10-30 2012-05-17 Células madre multipotenciales en el árbol de billary extrahepática y métodos de aislamiento del mismo CR20120254A (es)

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US25684609P 2009-10-30 2009-10-30

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CR20120254A true CR20120254A (es) 2012-09-24

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US (1) US20110135610A1 (cg-RX-API-DMAC7.html)
EP (2) EP3725874A1 (cg-RX-API-DMAC7.html)
JP (2) JP5936547B2 (cg-RX-API-DMAC7.html)
KR (4) KR102016870B1 (cg-RX-API-DMAC7.html)
CN (2) CN102918145B (cg-RX-API-DMAC7.html)
AR (2) AR078849A1 (cg-RX-API-DMAC7.html)
AU (1) AU2016210783B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012009848B1 (cg-RX-API-DMAC7.html)
CA (2) CA2779144C (cg-RX-API-DMAC7.html)
CL (1) CL2012001117A1 (cg-RX-API-DMAC7.html)
CR (1) CR20120254A (cg-RX-API-DMAC7.html)
ES (1) ES2819028T3 (cg-RX-API-DMAC7.html)
IL (2) IL219454A (cg-RX-API-DMAC7.html)
MX (1) MX2012005087A (cg-RX-API-DMAC7.html)
NZ (3) NZ622427A (cg-RX-API-DMAC7.html)
PH (1) PH12012500845A1 (cg-RX-API-DMAC7.html)
RU (2) RU2756584C2 (cg-RX-API-DMAC7.html)
SG (2) SG10201407102QA (cg-RX-API-DMAC7.html)
TW (3) TWI740180B (cg-RX-API-DMAC7.html)
WO (1) WO2011053690A1 (cg-RX-API-DMAC7.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201407102QA (en) * 2009-10-30 2014-11-27 Univ North Carolina Multipotent stem cells from the extrahepatic billary tree and methods of isolating same
JP2014519854A (ja) 2011-06-23 2014-08-21 ザ チルドレンズ ホスピタル オブ フィラデルフィア ヒト多能性幹細胞から生じる自己複製する内胚葉前駆細胞株とその使用方法
US9533013B2 (en) 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
CN103266084B (zh) * 2013-05-27 2015-03-04 刘卫辉 富集干细胞的三步分离法
EP3120151A4 (en) * 2014-03-17 2017-08-09 Agency For Science, Technology And Research METHOD FOR PREDICTING TOXICITY OF A COMPOUND BASED ON NUCLEAR FACTOR-kB TRANSLOCATION
GB201507894D0 (en) * 2015-05-08 2015-06-24 Imagen Biotech Ltd Personalised media
GB201510950D0 (en) 2015-06-22 2015-08-05 Cambridge Entpr Ltd In vitro Production of Cholangiocytes
EP3368657B1 (en) * 2015-10-30 2021-06-30 Biolamina AB Methods for producing hepatocytes
GB201521179D0 (en) 2015-12-01 2016-01-13 Univ Leuven Kath Methods for differentiating cells into hepatic stellate cells
CN105807053B (zh) * 2016-04-15 2019-04-02 苏州药明康德新药开发股份有限公司 一种肿瘤解离试剂在流式细胞检测中的应用
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
CN110913691A (zh) * 2017-04-06 2020-03-24 北卡罗来纳大学教堂山分校 低温保存方法
JP7562416B2 (ja) * 2018-03-29 2024-10-07 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 十二指腸ブルンナー腺由来の幹/前駆細胞ならびにそれらの単離および使用方法
CN112126618B (zh) * 2019-06-24 2023-09-12 上海拜羡生物科技有限公司 一种人胆囊干细胞的获取和长期体外培养的方法
CN113388569B (zh) * 2020-08-28 2022-05-17 广东乾晖生物科技有限公司 肝脏类器官的制备方法
JP2024525215A (ja) * 2021-06-30 2024-07-10 ポルビオニカ スポルカ ジー オグラニクゾナ オドパウイエドジアルノシア 単離膵島を保存するための培地及び単離膵島の保存方法
CN115975913B (zh) * 2023-02-03 2024-06-04 北京中医药大学深圳医院(龙岗) 一种利用多能干细胞诱导分化胆囊祖细胞的方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3646197A (en) * 1969-05-14 1972-02-29 Zaidan Hojin Biseibutsu Novel process for removing copper from copper-containing bleomycin
US6069005A (en) * 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
US5660207A (en) * 1994-12-29 1997-08-26 Tylan General, Inc. Flow controller, parts of flow controller, and related method
US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
GB9605808D0 (en) * 1996-03-20 1996-05-22 Isis Innovation CFTR gene regulator
US5830850A (en) * 1996-08-28 1998-11-03 Mount Sinai School Of Medicine Of The City Of New York Methods for the treatment of bone resorption disorders, including osteoporosis
US20020182188A1 (en) * 1999-01-19 2002-12-05 Reid Lola M. Human liver progenitors
US7456017B2 (en) * 1999-10-01 2008-11-25 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells
EP1285057B1 (en) * 2000-04-28 2006-05-31 Children's Medical Center Corporation Isolation of mesenchymal stem cells and use thereof
US6828145B2 (en) * 2000-05-10 2004-12-07 Cedars-Sinai Medical Center Method for the isolation of stem cells by immuno-labeling with HLA/MHC gene product marker
JP3602038B2 (ja) * 2000-07-24 2004-12-15 株式会社日立グローバルストレージテクノロジーズ 磁気ヘッドおよび磁気記録再生装置
DE10064804C2 (de) * 2000-12-22 2003-03-20 Schott Glas Alkalifreie Aluminoborosilicatgläser und ihre Verwendung
EP1425388A2 (en) 2001-09-12 2004-06-09 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung A method for isolating, culturing and differentiating intestinal stem cells for therapeutic use
US7150990B2 (en) * 2002-03-06 2006-12-19 Reprocell, Inc. Self-renewing pluripotent hepatic stem cells
CA2479510C (en) * 2002-03-15 2019-10-29 University Of North Carolina At Chapel Hill Primitive and proximal hepatic stem cells
WO2004071464A2 (en) * 2003-02-12 2004-08-26 Johns Hopkins University School Of Medicine Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells
DE10336152B4 (de) * 2003-08-06 2007-02-15 Nephrogen LLC, Salt Lake City Aufreinigungsverfahren für humane mesenchymale Stammzellen
US8119774B2 (en) * 2003-10-09 2012-02-21 Martin Pera Cell marker for hepatic and pancreatic stem cells and progenitor cells
KR20070007030A (ko) * 2003-10-28 2007-01-12 카리타스 세인트 엘리자베스 메디칼 센터 오브 보스톤, 인코포레이티드 신규한 다능성 줄기세포 및 그의 용도
US7081582B2 (en) * 2004-06-30 2006-07-25 Microsoft Corporation System and method for aligning and mixing songs of arbitrary genres
JP4824036B2 (ja) 2004-12-23 2011-11-24 ヴィアサイト,インコーポレイテッド 胚体内胚葉細胞の増殖
JP4773777B2 (ja) * 2005-08-30 2011-09-14 グローバル・オーエルイーディー・テクノロジー・リミテッド・ライアビリティ・カンパニー アクティブマトリクス型表示装置
EP1941032A2 (en) * 2005-10-14 2008-07-09 Regents Of The University Of Minnesota Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype
RU2008124158A (ru) * 2005-11-16 2010-01-10 Юниверсити Оф Норт Каролина Эт Чепел Хилл (Us) Внеклеточные матриксные компоненты для экспансии и дифференцировки гепатических клеток-предшественников
AU2007321928A1 (en) * 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
EP2132303A2 (en) * 2007-03-06 2009-12-16 University Of North Carolina At Chapel Hill Complexes of hyaluronans, other matrix components, hormones and growth factors for maintenance, expansion and/or differentiation of cells
EP2171040A4 (en) * 2007-06-15 2010-08-04 Univ North Carolina PARACRIC SIGNALS FROM MESENCHYMAL FEEDER CELLS AND REGULATION OF THE EXPANSION AND DIFFERENTIATION OF PRECURSOR LIVER CELLS USING THEREOF
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
CA2695225C (en) * 2007-07-31 2021-06-01 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic endocrine
SG10201407102QA (en) * 2009-10-30 2014-11-27 Univ North Carolina Multipotent stem cells from the extrahepatic billary tree and methods of isolating same
US10135700B2 (en) 2014-03-10 2018-11-20 Softphone SRL Enterprise application integration on client computing devices
US10387547B2 (en) 2014-09-09 2019-08-20 Intentional Software Corporation Layout engine for creating a visual layout tree for a document

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