JP2016102111A - 補助化療薬品とされる医薬組成物その用途 - Google Patents
補助化療薬品とされる医薬組成物その用途 Download PDFInfo
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- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 description 1
- 230000008786 sensory perception of smell Effects 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
- DVORYMAGXQGBQK-QCMFUGJUSA-N zhankuic acid A Chemical compound C([C@@]12C)CC(=O)[C@@H](C)[C@@H]1CC(=O)C1=C2C(=O)C[C@]2(C)[C@@H]([C@@H](CCC(=C)C(C)C(O)=O)C)CC[C@H]21 DVORYMAGXQGBQK-QCMFUGJUSA-N 0.000 description 1
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Abstract
Description
R1が、−OHや=O或いは−O−グリコシル基(単糖や二糖或いは多糖類である)やC1−3エステル基であり、
R2が、−Hや−OH或いは−O−グリコシル基(単糖や二糖或いは多糖類である)やC1−3エステル基であり、
R3が、−OHや=O或いは−O−グリコシル基(単糖や二糖或いは多糖類である)やC1−3エステル基であり、
R4が、−Hや−OH或いは−O−グリコシル基(単糖や二糖或いは多糖類である)やC1−3エステル基であり、
R5が、C1−3カルボキシ基やC1−3エステル基である。
R1が、−Hや−OH或いは−O−グリコシル基(単糖や二糖或いは多糖類である)やC1−3エステル基であり、
R2が、−OHや−O−グリコシル基(単糖や二糖或いは多糖類である)やC1−3エステル基であり、
R3が、C1−3カルボキシ基やC1−3エステル基である。
R2が、C1−3カルボキシ基やC1−3エステル基である。
R1が、−OHや=O或いは−O−グリコシル基(単糖や二糖或いは多糖類である)やC1−3エステル基であり、
R2が、−Hや−OH、=O或いは−O−グリコシル基(単糖や二糖或いは多糖類である)やC1−3エステル基であり、
R3が、−Hや−OH或いは−O−グリコシル基(単糖や二糖或いは多糖類である)やC1−3エステル基であり、
R4が、−Hやメチル基であり、
R5が、−Hや−OH、メチル基或いは−O−グリコシル基(単糖や二糖或いは多糖類である)やC1−3エステル基であり、R6が、−Hやメチル基である。
1、正常組(コード名:Normal組):正常マウスで、通常生理食塩溶液を供与し、
2、腫瘤組(コード名:Cancer組):癌細胞が接種されたマウスで、通常生理食塩溶液を供与し、
3、腫瘤+化療薬品組(コード名:CGC組):癌細胞が接種されたマウスで、シスプラチンやゲムシタビンの臨床化療薬品が注射され、
4、腫瘤+ベニクスノキタケ子実体抽出物+化療薬品組(コード名:CGCA組):癌細胞が接種されたマウスで、シスプラチンやゲムシタビンの臨床化療薬品が注射され、それとともに、ベニクスノキタケ子実体抽出物を、300mg/kg/dayで、供与し、及び
5、腫瘤+ベニクスノキタケ子実体抽出物(コード名:CA組):ベニクスノキタケ子実体抽出物を、300mg/kg/dayで、供与する。
1、腫瘤組(コード名:Cancer組):癌細胞が接種され、
2、腫瘤+化療薬品組(コード名:CGC組):癌細胞が接種されて、シスプラチンやゲムシタビンの臨床化療薬品を注射し、
3、腫瘤+ベニクスノキタケ子実体抽出物+化療薬品組(コード名:CGCA300組):癌細胞が接種されて、シスプラチンやゲムシタビンの臨床化療薬品を注射し、それに合わせて、300mg/kg/dayのベニクスノキタケ子実体抽出物を供与し、
4、腫瘤+ベニクスノキタケ子実体抽出物+化療薬品組(コード名:CGCA150組):癌細胞が接種されて、シスプラチンやゲムシタビンの臨床化療薬品を注射し、それに合わせて、150mg/kg/dayのベニクスノキタケ子実体抽出物を供与し、
5、腫瘤+ベニクスノキタケ子実体抽出物+化療薬品組(コード名:CGCA75組):癌細胞が接種されて、シスプラチンやゲムシタビンの臨床化療薬品を注射し、それに合わせて、75mg/kg/dayのベニクスノキタケ子実体抽出物を供与する。
Claims (22)
- 有効薬用量のベニクスノキタケ子実体抽出物と、
薬学的に許容しうる担体と、が含有され、
上記ベニクスノキタケ子実体抽出物が、化療薬品を補助して、癌症を治療し、癌症副作用を改善し、上記化療薬品が、シスプラチン(cisplatin)やゲムシタビン(gemcitabine)である、
ことを特徴とする補助化療薬品とされる医薬組成物。 - 上記ベニクスノキタケ子実体抽出物の成分には、アントシンK(antcin K)やアントシンC(antcin C)、アントシンH(antcin H)及びその化学誘導体が含まれる、ことを特徴とする補助化療薬品とされる請求項1に記載の医薬組成物。
- 上記ベニクスノキタケ子実体抽出物の成分には、デヒドロスルフレン酸(dehydrosulphurenic acid)やデヒドロエブリコ酸(Dehydroeburicoic acid)及びその化学誘導体が含まれる、ことを特徴とする補助化療薬品とされる請求項1に記載の医薬組成物。
- 上記ベニクスノキタケ子実体抽出物の成分には、アントシンB(antcin B)やアントシンA(antcin A)及びその化学誘導体が含まれる、ことを特徴とする補助化療薬品とされる請求項1に記載の医薬組成物。
- 上記ベニクスノキタケ子実体抽出物の成分には、4,7−ジメトキシ−5− メチル−1,3−ベンゾジオキソール(4,7−dimethoxy−5−methyl− 1,3−benzodioxole、DMB)やその化学誘導体が含まれる、ことを特徴とする補助化療薬品とされる請求項1に記載の医薬組成物。
- カプレやカプセル、滴丸、乳剤、沖劑、水性分散液或いはディスパージョンの経口投与剤である、ことを特徴とする補助化療薬品とされる請求項1に記載の医薬組成物。
- 上記ベニクスノキタケ子実体抽出物は、マウス動物モードにおいて、有効薬用量が、56〜225ミリグラム/キログラム(mg/kg)である、ことを特徴とする補助化療薬品とされる請求項1に記載の医薬組成物。
- 上記ベニクスノキタケ子実体抽出物は、ベニクスノキタケ子実体を、80〜100℃の熱い水に、1〜3時間浸入し、保管液を分離した後、低い極性溶剤で抽出すること、の手順により、上記ベニクスノキタケ子実体抽出物が得られる、ことを特徴とする補助化療薬品とされる請求項1に記載の医薬組成物。
- 上記低い極性の溶剤は、ベンジンやn‐ヘキサン、酢酸エチル、アセトン、エタノール及びその組合せからなるグルップから選ばれる、ことを特徴とする補助化療薬品とされる請求項8に記載の医薬組成物。
- 上記癌症は、肺癌である、ことを特徴とする補助化療薬品とされる請求項1に記載の医薬組成物。
- 上記癌症の副作用は、上記化療薬品で、癌症を治療する過程において、発生する抜け毛症状や筋肉の融解と萎縮、腸胃道の障害或いは腎臓炎症の障害が含まれる、ことを特徴とする補助化療薬品とされる請求項1に記載の医薬組成物。
- 医薬組成物に、有効薬用量のベニクスノキタケ子実体抽出物と、薬学的に許容しうる担体と、が含有されて、化療薬品を補助して、癌症を治療し、癌症副作用を改善し、上記化療薬品が、シスプラチン(cisplatin)やゲムシタビン(gemcitabine)である、
ことを特徴とする医薬組成物の用途。 - 上記癌症は、肺癌である、ことを特徴とする請求項12に記載の医薬組成物の用途。
- 上記癌症の副作用は、上記化療薬品で、癌症を治療する過程において、発生する抜け毛症状や筋肉の融解と萎縮、腸胃道の障害或いは腎臓炎症の障害が含まれる、ことを特徴とする請求項12に記載の医薬組成物の用途。
- 上記ベニクスノキタケ子実体抽出物は、マウス動物モードにおいて、有効薬用量が、56〜225ミリグラム/キログラム(mg/kg)である、ことを特徴とする請求項12に記載の医薬組成物の用途。
- 上記ベニクスノキタケ子実体抽出物の成分には、アントシンK(antcin K)やアントシンC(antcin C)、アントシンH(antcin H)及びその化学誘導体が含まれる、ことを特徴とする請求項12に記載の医薬組成物の用途。
- 上記ベニクスノキタケ子実体抽出物の成分には、デヒドロスルフレン酸(dehydrosulphurenic acid)やデヒドロエブリコ酸(Dehydroeburicoic acid)及びその化学誘導体が含まれる、ことを特徴とする請求項12に記載の医薬組成物の用途。
- 上記ベニクスノキタケ子実体抽出物の成分には、アントシンB(antcin B)やアントシンA(antcin A)及びその化学誘導体が含まれる、ことを特徴とする請求項12に記載の医薬組成物の用途。
- 上記ベニクスノキタケ子実体抽出物の成分には、4,7−ジメトキシ−5− メチル−1,3−ベンゾジオキソール(4,7−dimethoxy−5−methyl− 1,3−benzodioxole、DMB)やその化学誘導体が含まれる、ことを特徴とする請求項12に記載の医薬組成物の用途。
- 上記医薬組成物は、カプレやカプセル、滴丸、乳剤、沖劑、水性分散液或いはディスパージョンの経口投与剤である、ことを特徴とする請求項12に記載の医薬組成物の用途。
- 上記ベニクスノキタケ子実体抽出物は、ベニクスノキタケ子実体を、80〜100℃の熱い水に、1〜3時間浸入し、保管液を分離した後、低い極性溶剤で抽出すること、の手順により、上記ベニクスノキタケ子実体抽出物が得られる、ことを特徴とする請求項12に記載の医薬組成物の用途。
- 上記低い極性の溶剤は、ベンジンやn‐ヘキサン、酢酸エチル、アセトン、エタノール及びその組合せからなるグルップから選ばれる、ことを特徴とする請求項21に記載の医薬組成物の用途。
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TWI634901B (zh) * | 2017-12-14 | 2018-09-11 | 郭道明 | 用於降低胰臟癌治療藥物副作用之醫藥組合物、製備方法及其用途 |
CN107510813A (zh) * | 2016-06-15 | 2017-12-26 | 郭道明 | 用于降低癌症治疗药物副作用的医药组合物、制备方法及其用途 |
CN113444135B (zh) * | 2020-03-26 | 2022-09-09 | 北京大学 | 一种牛樟芝四环三萜糖苷及其酶催化制备方法和用途 |
WO2021236808A1 (en) * | 2020-05-19 | 2021-11-25 | Arjil Biotech Holding Company Limited | Use of terpenoids in the treatment or prevention of fibrotic diseases |
CN116348123A (zh) * | 2020-09-29 | 2023-06-27 | 浩峰生物科技股份有限公司 | 樟芝酸h及其衍生物用于治疗中枢神经系统疾病的用途 |
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JP2004091780A (ja) * | 2002-08-30 | 2004-03-25 | Taiso Seibutsu Kagi Kofun Yugenkoshi | Antrodiacamphorata菌体の多糖類 |
US20130089627A1 (en) * | 2011-10-11 | 2013-04-11 | New Bellus Enterprises Co., Ltd. | Method for treating a cancer caused by cancer stem cells |
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JP2004091780A (ja) * | 2002-08-30 | 2004-03-25 | Taiso Seibutsu Kagi Kofun Yugenkoshi | Antrodiacamphorata菌体の多糖類 |
US20130089627A1 (en) * | 2011-10-11 | 2013-04-11 | New Bellus Enterprises Co., Ltd. | Method for treating a cancer caused by cancer stem cells |
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JP2017226641A (ja) * | 2016-06-23 | 2017-12-28 | 台灣利得生物科技股▲ふん▼有限公司 | 牛樟芝活性組成物 |
JP2019147849A (ja) * | 2016-06-23 | 2019-09-05 | 台灣利得生物科技股▲ふん▼有限公司 | 牛樟芝活性組成物の製造方法 |
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TW201618801A (zh) | 2016-06-01 |
DE102015120353A1 (de) | 2016-06-02 |
TWI598104B (zh) | 2017-09-11 |
JP6209579B2 (ja) | 2017-10-04 |
US20160151435A1 (en) | 2016-06-02 |
KR20160064966A (ko) | 2016-06-08 |
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