JP2016028035A5 - - Google Patents
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- Publication number
- JP2016028035A5 JP2016028035A5 JP2015159434A JP2015159434A JP2016028035A5 JP 2016028035 A5 JP2016028035 A5 JP 2016028035A5 JP 2015159434 A JP2015159434 A JP 2015159434A JP 2015159434 A JP2015159434 A JP 2015159434A JP 2016028035 A5 JP2016028035 A5 JP 2016028035A5
- Authority
- JP
- Japan
- Prior art keywords
- expression
- cells
- deletion
- virus
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004881 tumor cell Anatomy 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- 230000014509 gene expression Effects 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 238000012217 deletion Methods 0.000 description 4
- 230000037430 deletion Effects 0.000 description 4
- 244000309459 oncolytic virus Species 0.000 description 4
- 101100012019 Mus musculus Etv4 gene Proteins 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 206010001258 Adenoviral infections Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 210000000633 nuclear envelope Anatomy 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 230000006648 viral gene expression Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15682209P | 2009-03-02 | 2009-03-02 | |
| US61/156,822 | 2009-03-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011553041A Division JP6072414B2 (ja) | 2009-03-02 | 2010-03-02 | 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018035231A Division JP6817979B2 (ja) | 2009-03-02 | 2018-02-28 | 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016028035A JP2016028035A (ja) | 2016-02-25 |
| JP2016028035A5 true JP2016028035A5 (enExample) | 2017-02-16 |
| JP6375273B2 JP6375273B2 (ja) | 2018-08-15 |
Family
ID=42710189
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011553041A Active JP6072414B2 (ja) | 2009-03-02 | 2010-03-02 | 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体 |
| JP2015159434A Active JP6375273B2 (ja) | 2009-03-02 | 2015-08-12 | 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体 |
| JP2018035231A Active JP6817979B2 (ja) | 2009-03-02 | 2018-02-28 | 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体 |
| JP2020019294A Pending JP2020078326A (ja) | 2009-03-02 | 2020-02-07 | 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体 |
| JP2021158698A Active JP7326396B2 (ja) | 2009-03-02 | 2021-09-29 | 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011553041A Active JP6072414B2 (ja) | 2009-03-02 | 2010-03-02 | 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018035231A Active JP6817979B2 (ja) | 2009-03-02 | 2018-02-28 | 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体 |
| JP2020019294A Pending JP2020078326A (ja) | 2009-03-02 | 2020-02-07 | 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体 |
| JP2021158698A Active JP7326396B2 (ja) | 2009-03-02 | 2021-09-29 | 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体 |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US9073980B2 (enExample) |
| EP (4) | EP4123030A1 (enExample) |
| JP (5) | JP6072414B2 (enExample) |
| KR (4) | KR102020018B1 (enExample) |
| CY (1) | CY1122385T1 (enExample) |
| DK (2) | DK3029144T3 (enExample) |
| ES (2) | ES2557812T3 (enExample) |
| HR (2) | HRP20151396T1 (enExample) |
| HU (2) | HUE046565T2 (enExample) |
| LT (1) | LT3029144T (enExample) |
| PL (2) | PL2403951T3 (enExample) |
| PT (2) | PT2403951E (enExample) |
| SI (2) | SI3029144T1 (enExample) |
| SM (2) | SMT201900565T1 (enExample) |
| WO (1) | WO2010101921A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE046565T2 (hu) | 2009-03-02 | 2020-03-30 | Univ California | Tumorszelektív adenovírus E1A és E1B mutánsok |
| SG11201507393TA (en) | 2013-03-14 | 2015-10-29 | Salk Inst For Biological Studi | Oncolytic adenovirus compositions |
| EP3022320B2 (en) | 2013-07-19 | 2024-09-25 | Ludwig Institute for Cancer Research Ltd | Whole-genome and targeted haplotype reconstruction |
| PL3198009T3 (pl) | 2014-09-24 | 2022-01-24 | Salk Institute For Biological Studies | Onkolityczne wirusy nowotworowe i sposoby zastosowania |
| JP7015551B2 (ja) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
| JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
| AU2017336546C1 (en) * | 2016-09-27 | 2025-05-29 | Epicentrx, Inc. | Immunomodulatory fusion proteins |
| WO2018111767A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
| US10232053B2 (en) * | 2016-12-30 | 2019-03-19 | Trieza Therapeutics, Inc. | Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer |
| US20190352616A1 (en) * | 2017-01-30 | 2019-11-21 | Epicentrx, Inc. | Multiple transgene recombinant adenovirus |
| MX2019008922A (es) * | 2017-01-30 | 2020-01-20 | Epicentrx Inc | Mutantes de la caja tata y de la caja caat selectivas de tumor. |
| CA3059605A1 (en) | 2017-04-10 | 2018-10-18 | Epicentrx, Inc. | Method for producing recombinant virus |
| EA201990822A1 (ru) * | 2017-04-12 | 2020-01-09 | Эписентарикс, Инк. | Иммуномодулирующие слитые белки |
| CA3064892A1 (en) * | 2017-05-24 | 2018-11-29 | Epicentrx, Inc. | Anti-angiogenic adenovirus |
| KR102702230B1 (ko) * | 2017-05-26 | 2024-09-03 | 에피센트알엑스, 인코포레이티드 | 트랜스진을 보유하는 재조합 아데노바이러스 |
| KR102757384B1 (ko) | 2017-09-27 | 2025-01-20 | 에피센트알엑스, 인코포레이티드 | 면역조절 융합 단백질 |
| WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
| KR20200135986A (ko) | 2018-03-19 | 2020-12-04 | 멀티비르 인코포레이티드 | 종양 억제인자 유전자 치료 및 cd122/cd132 작용제를 포함하는 암 치료를 위한 방법 및 조성물 |
| US12295976B2 (en) | 2018-03-28 | 2025-05-13 | Epicentrx, Inc. | Personalized cancer vaccines |
| JP7430395B2 (ja) | 2018-04-09 | 2024-02-13 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 複製特質が増強された腫瘍溶解性アデノウイルス組成物 |
| US12233096B2 (en) * | 2018-08-31 | 2025-02-25 | Orca Therapeutics B.V. | Recombinant replication competent viruses comprising a coding region for glycogen synthase kinase-3 (GSK3) and methods of killing aberrant cells |
| JP7640538B2 (ja) | 2019-10-08 | 2025-03-05 | トラスティーズ オブ ボストン カレッジ | 複数の異なる非天然アミノ酸を含有するタンパク質、並びにそのようなタンパク質の製造方法及び使用方法 |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| AU2021357520A1 (en) | 2020-03-05 | 2022-09-29 | Neotx Therapeutics Ltd. | Methods and compositions for treating cancer with immune cells |
| CN114262691A (zh) * | 2020-09-16 | 2022-04-01 | 杭州康万达医药科技有限公司 | 分离的能够用于表达外源基因的溶瘤腺病毒、载体、治疗剂及其用途 |
| WO2024015876A1 (en) | 2022-07-13 | 2024-01-18 | Epicentrx, Inc. | Adenoviral vectors encapsulated in cationic liposomes, and preparation and use thereof |
| CN118931897B (zh) * | 2024-06-27 | 2026-01-16 | 中山大学 | 一种识别肿瘤细胞并诱导其焦亡的基因、重组载体和重组病毒及其应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643567A (en) * | 1990-12-04 | 1997-07-01 | Board Of Regents, The University Of Texas System | Methods for the suppression of neu mediated tumors by adenoviral E1A and SV40 large T antigen |
| US5352775A (en) | 1991-01-16 | 1994-10-04 | The Johns Hopkins Univ. | APC gene and nucleic acid probes derived therefrom |
| EP0659209A1 (en) | 1991-07-26 | 1995-06-28 | The University Of Rochester | Cancer therapy utilizing malignant cells |
| US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| EP0711829A3 (en) * | 1993-09-15 | 1997-07-09 | Viagene Inc | Recombinant alphavirus vector |
| AUPN477695A0 (en) | 1995-08-14 | 1995-09-07 | Commonwealth Scientific And Industrial Research Organisation | Gene therapy |
| US5902925A (en) | 1996-07-01 | 1999-05-11 | Integrated Sensor Solutions | System and method for high accuracy calibration of a sensor for offset and sensitivity variation with temperature |
| GB9626029D0 (en) | 1996-12-14 | 1997-01-29 | Univ Leeds | EVH-1 vectors |
| US20050287120A1 (en) | 1997-03-21 | 2005-12-29 | Fisher Paul B | Cancer - targeted viral vectors |
| US6764674B1 (en) * | 1999-01-28 | 2004-07-20 | Onyx Pharmaceuticals Inc. | Adenovirus E1B shuttle vectors |
| EP1135514B1 (en) * | 1999-01-28 | 2009-05-13 | Onyx Pharmaceuticals, Inc. | E1b-deleted adenoviral shuttle vectors |
| AU2001257611A1 (en) * | 2000-04-28 | 2001-11-12 | Avigen, Inc. | Polynucleotides for use in recombinant adeno-associated virus virion production |
| AU2001285263A1 (en) * | 2000-08-25 | 2002-03-13 | The General Hospital Corporation | Selective precipitation of viruses |
| CN1183250C (zh) | 2000-12-01 | 2005-01-05 | 卫健生物科技有限公司 | 高效表达肿瘤血管生成抑制因子的肿瘤细胞内特异性增殖的病毒及其构建方法 |
| GB0117198D0 (en) | 2001-07-13 | 2001-09-05 | Btg Int Ltd | Anti-neoplastic viral agents |
| US20040219516A1 (en) * | 2002-07-18 | 2004-11-04 | Invitrogen Corporation | Viral vectors containing recombination sites |
| EP1585964A4 (en) * | 2002-08-28 | 2008-07-16 | Introgen Therapeutics Inc | CHROMATOGRAPHIC METHODS FOR PURIFYING ADENOVIRUSES |
| CA2590257A1 (en) * | 2003-11-14 | 2005-06-09 | Per Sonne Holm | Novel adenoviruses, nucleic acids that code for the same and the use of said viruses |
| WO2006070024A2 (de) * | 2004-12-31 | 2006-07-06 | Per Sonne Holm | E1 -minus adenoviren und deren verwendung |
| CN101663397B (zh) | 2007-04-20 | 2015-04-22 | 宝生物工程株式会社 | 用于基因治疗的载体 |
| HUE046565T2 (hu) | 2009-03-02 | 2020-03-30 | Univ California | Tumorszelektív adenovírus E1A és E1B mutánsok |
-
2010
- 2010-03-02 HU HUE15182086A patent/HUE046565T2/hu unknown
- 2010-03-02 PL PL10749205T patent/PL2403951T3/pl unknown
- 2010-03-02 US US13/254,825 patent/US9073980B2/en active Active
- 2010-03-02 EP EP22178897.9A patent/EP4123030A1/en active Pending
- 2010-03-02 KR KR1020187012031A patent/KR102020018B1/ko active Active
- 2010-03-02 EP EP10749205.0A patent/EP2403951B1/en active Active
- 2010-03-02 EP EP15182086.7A patent/EP3029144B1/en active Active
- 2010-03-02 DK DK15182086.7T patent/DK3029144T3/da active
- 2010-03-02 ES ES10749205.0T patent/ES2557812T3/es active Active
- 2010-03-02 JP JP2011553041A patent/JP6072414B2/ja active Active
- 2010-03-02 KR KR1020197025813A patent/KR102150027B1/ko active Active
- 2010-03-02 SI SI201031944T patent/SI3029144T1/sl unknown
- 2010-03-02 PT PT107492050T patent/PT2403951E/pt unknown
- 2010-03-02 KR KR1020117022884A patent/KR101752910B1/ko active Active
- 2010-03-02 EP EP19171420.3A patent/EP3591059B1/en active Active
- 2010-03-02 SI SI201031077T patent/SI2403951T1/sl unknown
- 2010-03-02 ES ES15182086T patent/ES2750305T3/es active Active
- 2010-03-02 KR KR1020177017391A patent/KR101922539B1/ko active Active
- 2010-03-02 PT PT151820867T patent/PT3029144T/pt unknown
- 2010-03-02 LT LT15182086T patent/LT3029144T/lt unknown
- 2010-03-02 SM SM20190565T patent/SMT201900565T1/it unknown
- 2010-03-02 HU HUE10749205A patent/HUE026386T2/en unknown
- 2010-03-02 WO PCT/US2010/025926 patent/WO2010101921A2/en not_active Ceased
- 2010-03-02 PL PL15182086T patent/PL3029144T3/pl unknown
- 2010-03-02 DK DK10749205.0T patent/DK2403951T3/en active
- 2010-03-02 HR HRP20151396T patent/HRP20151396T1/hr unknown
-
2015
- 2015-05-26 US US14/722,021 patent/US20160017294A1/en not_active Abandoned
- 2015-08-12 JP JP2015159434A patent/JP6375273B2/ja active Active
- 2015-12-31 SM SM201500329T patent/SMT201500329B/it unknown
-
2018
- 2018-02-28 JP JP2018035231A patent/JP6817979B2/ja active Active
- 2018-08-08 US US16/058,886 patent/US10876097B2/en active Active
-
2019
- 2019-10-03 HR HRP20191808TT patent/HRP20191808T1/hr unknown
- 2019-10-10 CY CY20191101067T patent/CY1122385T1/el unknown
-
2020
- 2020-02-07 JP JP2020019294A patent/JP2020078326A/ja active Pending
- 2020-11-20 US US17/100,671 patent/US11618888B2/en active Active
-
2021
- 2021-09-29 JP JP2021158698A patent/JP7326396B2/ja active Active
-
2022
- 2022-11-23 US US17/993,182 patent/US12195766B2/en active Active
-
2024
- 2024-12-05 US US18/969,407 patent/US20250327037A1/en active Pending
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