JP2016006125A5 - - Google Patents
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- Publication number
- JP2016006125A5 JP2016006125A5 JP2015196105A JP2015196105A JP2016006125A5 JP 2016006125 A5 JP2016006125 A5 JP 2016006125A5 JP 2015196105 A JP2015196105 A JP 2015196105A JP 2015196105 A JP2015196105 A JP 2015196105A JP 2016006125 A5 JP2016006125 A5 JP 2016006125A5
- Authority
- JP
- Japan
- Prior art keywords
- glp
- ala
- analog
- intestinal
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67806605P | 2005-05-04 | 2005-05-04 | |
| US60/678,066 | 2005-05-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013077830A Division JP5876434B2 (ja) | 2005-05-04 | 2013-04-03 | グルカゴン様ペプチド−２（ｇｌｐ−２）アナログ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016006125A JP2016006125A (ja) | 2016-01-14 |
| JP2016006125A5 true JP2016006125A5 (https=) | 2016-03-10 |
| JP6272284B2 JP6272284B2 (ja) | 2018-01-31 |
Family
ID=36649773
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008509505A Expired - Lifetime JP5405105B2 (ja) | 2005-05-04 | 2006-05-04 | グルカゴン様ペプチド−２（ｇｌｐ−２）アナログ |
| JP2013077830A Expired - Fee Related JP5876434B2 (ja) | 2005-05-04 | 2013-04-03 | グルカゴン様ペプチド−２（ｇｌｐ−２）アナログ |
| JP2015196105A Expired - Lifetime JP6272284B2 (ja) | 2005-05-04 | 2015-10-01 | グルカゴン様ペプチド−２（ｇｌｐ−２）アナログ |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008509505A Expired - Lifetime JP5405105B2 (ja) | 2005-05-04 | 2006-05-04 | グルカゴン様ペプチド−２（ｇｌｐ−２）アナログ |
| JP2013077830A Expired - Fee Related JP5876434B2 (ja) | 2005-05-04 | 2013-04-03 | グルカゴン様ペプチド−２（ｇｌｐ−２）アナログ |
Country Status (24)
| Country | Link |
|---|---|
| US (7) | US7563770B2 (https=) |
| EP (4) | EP1877435B2 (https=) |
| JP (3) | JP5405105B2 (https=) |
| KR (3) | KR101242951B1 (https=) |
| CN (2) | CN101171262B (https=) |
| AT (1) | ATE498631T1 (https=) |
| AU (1) | AU2006242998B2 (https=) |
| BR (1) | BRPI0610091B1 (https=) |
| CA (1) | CA2607150C (https=) |
| CY (1) | CY1111411T1 (https=) |
| DE (1) | DE602006020123D1 (https=) |
| DK (1) | DK1877435T4 (https=) |
| EA (1) | EA014184B1 (https=) |
| ES (1) | ES2361095T5 (https=) |
| IL (3) | IL186746A (https=) |
| MX (1) | MX2007013431A (https=) |
| NO (1) | NO345236B1 (https=) |
| NZ (4) | NZ593050A (https=) |
| PL (1) | PL1877435T5 (https=) |
| PT (1) | PT1877435E (https=) |
| SI (1) | SI1877435T2 (https=) |
| UA (1) | UA95235C2 (https=) |
| WO (1) | WO2006117565A2 (https=) |
| ZA (2) | ZA200709384B (https=) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| ES2348230T3 (es) | 2002-06-07 | 2010-12-01 | Dyax Corp. | Prevención y reducción de la isquemia. |
| EP2386310B1 (en) | 2002-08-28 | 2018-11-07 | Dyax Corp. | Methods for preserving organs and tissues |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| UA95235C2 (en) * | 2005-05-04 | 2011-07-25 | Зииланд Фарма А/С | Glucagon-like-peptide-2 (glp-2) analogues |
| EP2001500A4 (en) * | 2006-03-10 | 2010-07-28 | Dyax Corp | FORMULATIONS FOR ECALLANTIDE |
| ES2401299T5 (es) † | 2006-07-26 | 2016-04-06 | Sandoz Ag | Formulaciones de caspofungina |
| MX2009002756A (es) * | 2006-09-12 | 2009-05-25 | Cosmo Technologies Ltd | Composiciones farmaceuticas para la administracion oral o rectal de sustancias proteinicas. |
| CN101573376B (zh) | 2006-11-08 | 2013-11-06 | 西兰制药公司 | 选择性胰高血糖素样肽-2（glp-2）类似物 |
| US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
| KR20090035279A (ko) * | 2007-10-05 | 2009-04-09 | 경희대학교 산학협력단 | 위장관 손상 예방 및 치료용 조성물 |
| US20090110713A1 (en) * | 2007-10-31 | 2009-04-30 | Florencia Lim | Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices |
| US8637454B2 (en) | 2009-01-06 | 2014-01-28 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| CN101824087A (zh) * | 2009-03-05 | 2010-09-08 | 连云港恒邦医药科技有限公司 | 胰高血糖素样肽-2类似物及其制备方法和用途 |
| EP2314616A1 (en) * | 2009-10-23 | 2011-04-27 | Ferring B.V. | Peptidic GLP-2 agonists |
| SMT201800552T1 (it) | 2010-01-06 | 2018-11-09 | Dyax Corp | Proteine che legano la callicreina plasmatica |
| JP5908478B2 (ja) | 2010-08-30 | 2016-04-26 | エヌピーエス ファーマシューティカルズ インコーポレイテッドＮｐｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ｈ「Ｇｌｙ２」ＧＬＰ−２の固相合成 |
| KR102320178B1 (ko) | 2011-01-06 | 2021-11-02 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 |
| CN102212127B (zh) * | 2011-05-17 | 2015-02-04 | 上海景泽生物技术有限公司 | 胰高血糖素样肽-2聚乙二醇结合物及其制备方法和用途 |
| CN102924589B (zh) * | 2011-08-11 | 2016-08-24 | 中肽生化有限公司 | 胰高血糖素样肽-2(glp-2)的类似物及其制备方法和用途 |
| JP6206972B2 (ja) | 2011-09-12 | 2017-10-04 | アムニクス オペレーティング インコーポレイテッド | グルカゴン様ペプチド−２組成物およびその作製法および使用法 |
| KR101895047B1 (ko) | 2011-12-30 | 2018-09-06 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 위치 특이적 글루카곤 유사 펩타이드-2 약물 결합체 |
| JP6355563B2 (ja) | 2012-02-27 | 2018-07-11 | アムニクス オペレーティング インコーポレイテッド | Ｘｔｅｎ共役組成物およびそれを製造する方法 |
| CN104540850B (zh) | 2012-05-03 | 2018-05-18 | 西兰制药公司 | 胰高血糖素样肽2(glp-2)类似物 |
| US20150038674A1 (en) * | 2013-08-05 | 2015-02-05 | Bayrak Bertan Boran | Use of glp-2 analogues in pulmonary diseases for therapeutic purpose |
| US10428158B2 (en) | 2014-03-27 | 2019-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
| US20160067311A1 (en) * | 2014-09-10 | 2016-03-10 | Helsinn Healthcare Sa | Use of elsiglutide to treat gastrointestinal mucositis including chemotherapy-induced diarrhea |
| US20170087216A1 (en) * | 2015-09-17 | 2017-03-30 | Helsinn Healthcare Sa | Therapeutic Uses of Elsiglutide |
| EP3387018A1 (en) | 2015-12-11 | 2018-10-17 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| CN107987170B (zh) * | 2016-10-27 | 2018-12-18 | 浙江道尔生物科技有限公司 | 一种用于治疗肠道疾病的融合蛋白 |
| CA3044915A1 (en) * | 2016-12-09 | 2018-06-14 | Zealand Pharma A/S | Glp-1/glp-2 dual agonists |
| WO2018104558A1 (en) * | 2016-12-09 | 2018-06-14 | Zealand Pharma A/S | Acylated glp-1/glp-2 dual agonists |
| EP3551651B1 (en) * | 2016-12-09 | 2024-03-06 | Zealand Pharma A/S | Acylated glp-1/glp-2 dual agonists |
| WO2018104559A1 (en) * | 2016-12-09 | 2018-06-14 | Zealand Pharma A/S | Glp-1/glp-2 dual agonists |
| WO2018142363A1 (en) * | 2017-02-06 | 2018-08-09 | Orbicular Pharmaceutical Technologies Private Limited | Ready to use compositions of glp-2 analogues through self-administrable devices |
| IL299864B2 (en) * | 2017-06-16 | 2024-06-01 | Zealand Pharma As | Dosage regimes for the administration of glucagon-like-peptide-2 (glp-2) analogues |
| EA202090571A1 (ru) * | 2017-09-28 | 2020-07-30 | Ханми Фарм. Ко., Лтд. | Конъюгаты производных glp-2 пролонгированного действия |
| WO2019086559A1 (fr) | 2017-10-31 | 2019-05-09 | Adocia | Composition comprenant un agoniste du recepteur du glp-2 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| WO2020020904A1 (en) | 2018-07-23 | 2020-01-30 | Zealand Pharma A/S | Therapeutic uses of glp-2 agonists |
| EP3628683A1 (en) * | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulations of glucagon-like-peptide-2 (glp-2) analogues |
| EP3628682A1 (en) | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulations of glucagon-like-peptide-2 (glp-2) analogues |
| CA3129576A1 (en) * | 2019-02-11 | 2020-08-20 | Opko Biologics Ltd. | Long-acting glp-2 analogs |
| SG11202111311WA (en) | 2019-06-14 | 2021-12-30 | Zealand Pharma As | Pharmaceutical parenteral composition of dual glp1/2 agonist |
| CN110305223B (zh) | 2019-06-26 | 2022-05-13 | 重庆派金生物科技有限公司 | 重组串联融合蛋白制备目标多肽的方法 |
| KR20220150270A (ko) | 2019-10-07 | 2022-11-10 | 칼리오페, 인크. | Gpr119 효능제 |
| MX2022006861A (es) | 2019-12-04 | 2022-07-11 | Scripps Research Inst | Agonistas del receptor glp2 y metodos de uso. |
| EP4090427A1 (en) | 2020-01-13 | 2022-11-23 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
| TW202140440A (zh) | 2020-02-28 | 2021-11-01 | 美商克力歐普股份有限公司 | Gpr40激動劑 |
| EP4126004A1 (en) | 2020-03-30 | 2023-02-08 | Zealand Pharma A/S | Agonist combination |
| WO2021201654A1 (ko) * | 2020-04-03 | 2021-10-07 | 한미약품 주식회사 | Glp-2 유도체 또는 이의 지속형 결합체를 포함하는 방사선요법, 화학요법, 또는 이들의 조합으로 유발된 점막염의 예방 또는 치료용 약학적 조성물 |
| WO2021236617A1 (en) | 2020-05-19 | 2021-11-25 | Kallyope, Inc. | Ampk activators |
| CN111560061A (zh) * | 2020-05-26 | 2020-08-21 | 成都圣诺生物制药有限公司 | 一种Gelpaglutide的制备方法 |
| CN111560062A (zh) * | 2020-05-26 | 2020-08-21 | 成都圣诺生物制药有限公司 | 一种Elisiglutide的制备方法 |
| BR112022025141A2 (pt) | 2020-06-09 | 2023-04-25 | Vectivbio Ag | Fabricação, formulação e dosagem de apraglutida |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
| MX2023006280A (es) * | 2020-12-16 | 2023-06-13 | Zealand Pharma As | Composicion farmaceutica de agonistas duales de glp-1/glp-2. |
| MX2023006901A (es) | 2020-12-16 | 2023-06-26 | Zealand Pharma As | Uso de analogos de glp-2 en pacientes con insuficiencia renal. |
| KR20240032010A (ko) | 2021-06-09 | 2024-03-08 | 더 스크립스 리서치 인스티튜트 | 장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법 |
| CN115636876A (zh) * | 2021-07-20 | 2023-01-24 | 重庆派金生物科技有限公司 | 胰高血糖素样肽-2突变体的定向化学偶联物及其应用 |
| RS67423B1 (sr) | 2021-09-10 | 2025-12-31 | Zealand Pharma As | Postupak za formulisanje sastava koji sadrže analoge glukagonu sličnog peptida-2 (glp-2) |
| IL313732A (en) | 2021-12-23 | 2024-08-01 | Zealand Pharma As | Processes for synthesizing glucagon-like-peptide 2 (glp-2) analogues |
| KR20250075601A (ko) | 2022-09-30 | 2025-05-28 | 질랜드 파마 에이/에스 | 글루카곤-유사-펩타이드-2(glp-2) 유사체 및 단장 증후군(sbs) 치료를 위한 이의 의학적 용도 |
| IL322328A (en) | 2023-01-27 | 2025-09-01 | Zealand Pharma As | Glucagon-like peptide-2 (GLP-2) analogs and their medical uses for the treatment of short bowel syndrome (SBS) |
| CN116478269A (zh) * | 2023-04-28 | 2023-07-25 | 成都奥达生物科技有限公司 | 一种长效替度鲁肽化合物 |
| CN118005766B (zh) * | 2023-06-21 | 2024-09-27 | 杭州信海医药科技有限公司 | 一种Glepaglutide的固相合成方法 |
| TW202535919A (zh) | 2023-12-28 | 2025-09-16 | 丹麥商西蘭製藥公司 | 類升糖素肽2(glp-2)類似物之調配物及其用途 |
| WO2025162422A1 (zh) * | 2024-01-31 | 2025-08-07 | 杭州先为达生物科技股份有限公司 | 胰高血糖素样肽2衍生物及其应用 |
| WO2025181330A1 (en) | 2024-02-29 | 2025-09-04 | Vectivbio Ag | Dosage regimens for glucagon-like peptide 2 (glp-2) analogs |
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| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| JP2961045B2 (ja) | 1993-02-24 | 1999-10-12 | 日清製粉株式会社 | 腸管粘膜増強促進剤 |
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| UA95235C2 (en) | 2005-05-04 | 2011-07-25 | Зииланд Фарма А/С | Glucagon-like-peptide-2 (glp-2) analogues |
| CN101573376B (zh) * | 2006-11-08 | 2013-11-06 | 西兰制药公司 | 选择性胰高血糖素样肽-2（glp-2）类似物 |
| CN102282167B (zh) | 2008-12-15 | 2014-08-13 | 西兰制药公司 | 胰高血糖素类似物 |
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-
2006
- 2006-05-04 UA UAA200713558A patent/UA95235C2/ru unknown
- 2006-05-04 BR BRPI0610091-0A patent/BRPI0610091B1/pt active IP Right Grant
- 2006-05-04 EP EP06727006.6A patent/EP1877435B2/en not_active Expired - Lifetime
- 2006-05-04 NZ NZ593050A patent/NZ593050A/xx unknown
- 2006-05-04 NZ NZ591178A patent/NZ591178A/en not_active IP Right Cessation
- 2006-05-04 DE DE602006020123T patent/DE602006020123D1/de not_active Expired - Lifetime
- 2006-05-04 PT PT06727006T patent/PT1877435E/pt unknown
- 2006-05-04 KR KR1020117015195A patent/KR101242951B1/ko not_active Expired - Fee Related
- 2006-05-04 PL PL06727006T patent/PL1877435T5/pl unknown
- 2006-05-04 AU AU2006242998A patent/AU2006242998B2/en active Active
- 2006-05-04 CN CN2006800152135A patent/CN101171262B/zh not_active Expired - Lifetime
- 2006-05-04 WO PCT/GB2006/001633 patent/WO2006117565A2/en not_active Ceased
- 2006-05-04 ES ES06727006T patent/ES2361095T5/es not_active Expired - Lifetime
- 2006-05-04 KR KR1020117015196A patent/KR101242795B1/ko not_active Expired - Fee Related
- 2006-05-04 KR KR1020077028167A patent/KR101200227B1/ko not_active Expired - Lifetime
- 2006-05-04 CN CN201210124331.7A patent/CN102659938B/zh not_active Expired - Fee Related
- 2006-05-04 JP JP2008509505A patent/JP5405105B2/ja not_active Expired - Lifetime
- 2006-05-04 EP EP10009232A patent/EP2295452A1/en not_active Withdrawn
- 2006-05-04 NZ NZ591179A patent/NZ591179A/en not_active IP Right Cessation
- 2006-05-04 EA EA200702408A patent/EA014184B1/ru unknown
- 2006-05-04 CA CA2607150A patent/CA2607150C/en not_active Expired - Lifetime
- 2006-05-04 NZ NZ562943A patent/NZ562943A/en not_active IP Right Cessation
- 2006-05-04 SI SI200630985T patent/SI1877435T2/sl unknown
- 2006-05-04 AT AT06727006T patent/ATE498631T1/de active
- 2006-05-04 EP EP10009231A patent/EP2295451A1/en not_active Withdrawn
- 2006-05-04 MX MX2007013431A patent/MX2007013431A/es active IP Right Grant
- 2006-05-04 US US11/429,168 patent/US7563770B2/en not_active Expired - Lifetime
- 2006-05-04 DK DK06727006.6T patent/DK1877435T4/da active
- 2006-05-04 EP EP18206332.1A patent/EP3473646A1/en active Pending
- 2006-11-09 US US11/595,496 patent/US7745403B2/en active Active
-
2007
- 2007-10-18 IL IL186746A patent/IL186746A/en active IP Right Grant
- 2007-10-31 ZA ZA2007/09384A patent/ZA200709384B/en unknown
- 2007-11-23 NO NO20076043A patent/NO345236B1/no unknown
-
2009
- 2009-12-21 US US12/643,261 patent/US8163696B2/en not_active Expired - Lifetime
- 2009-12-21 US US12/643,233 patent/US8263552B2/en not_active Expired - Lifetime
-
2011
- 2011-01-16 IL IL210669A patent/IL210669A/en active IP Right Grant
- 2011-01-16 IL IL210668A patent/IL210668A/en active IP Right Grant
- 2011-01-28 ZA ZA2011/00753A patent/ZA201100753B/en unknown
- 2011-05-05 CY CY20111100436T patent/CY1111411T1/el unknown
-
2012
- 2012-06-28 US US13/536,377 patent/US9125882B2/en not_active Expired - Lifetime
-
2013
- 2013-04-03 JP JP2013077830A patent/JP5876434B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-08 US US14/847,938 patent/US9580487B2/en not_active Expired - Lifetime
- 2015-10-01 JP JP2015196105A patent/JP6272284B2/ja not_active Expired - Lifetime
-
2017
- 2017-01-20 US US15/411,649 patent/US20170137487A1/en not_active Abandoned
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