|
US7973169B2
(en)
|
2003-09-06 |
2011-07-05 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette transporters
|
|
US7977322B2
(en)
|
2004-08-20 |
2011-07-12 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters
|
|
CA2881078C
(en)
|
2004-06-24 |
2018-10-02 |
Vertex Pharmaceuticals Incorporated |
Modulators of atp-binding cassette transporters
|
|
RU2008109031A
(ru)
|
2005-08-11 |
2009-09-20 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Модуляторы муковисцидозного трансмембранного регулятора проводимости
|
|
PT2404919E
(pt)
|
2005-11-08 |
2013-10-22 |
Vertex Pharma |
Composto heterocíclico útil como um modulador de transportadores de cassete de ligação a atp
|
|
LT1993360T
(lt)
|
2005-12-28 |
2017-06-12 |
Vertex Pharmaceuticals Incorporated |
N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
|
|
JP5420395B2
(ja)
|
2006-04-07 |
2014-02-19 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atp結合カセット輸送体の調節剤
|
|
US7645789B2
(en)
|
2006-04-07 |
2010-01-12 |
Vertex Pharmaceuticals Incorporated |
Indole derivatives as CFTR modulators
|
|
US10022352B2
(en)
|
2006-04-07 |
2018-07-17 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters
|
|
USRE50453E1
(en)
|
2006-04-07 |
2025-06-10 |
Vertex Pharmaceuticals Incorporated |
Indole derivatives as CFTR modulators
|
|
US8563573B2
(en)
|
2007-11-02 |
2013-10-22 |
Vertex Pharmaceuticals Incorporated |
Azaindole derivatives as CFTR modulators
|
|
EP2164840A2
(en)
|
2007-05-09 |
2010-03-24 |
Vertex Pharmaceuticals Incorporated |
Modulators of cftr
|
|
CA2696298C
(en)
|
2007-08-24 |
2016-09-06 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
CN102743385B
(zh)
|
2007-11-16 |
2014-09-17 |
沃泰克斯药物股份有限公司 |
Atp结合盒转运蛋白的异喹啉调节剂
|
|
CA2989620C
(en)
|
2007-12-07 |
2022-05-03 |
Vertex Pharmaceuticals Incorporated |
Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
|
|
HUE049642T2
(hu)
|
2007-12-07 |
2020-09-28 |
Vertex Pharma |
3-(6-(1-(2,2-Difluorbenzo[d][1,3]dioxol-5-il)-ciklopropánkarboxamido)-3-metilpiridin-2-il)-benzoesav szilárd formái
|
|
US20100036130A1
(en)
|
2007-12-07 |
2010-02-11 |
Vertex Pharmaceuticals Incorporated |
Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
|
|
CA2716109C
(en)
|
2008-02-28 |
2016-07-19 |
Vertex Pharmaceuticals Incorporated |
Heteroaryl derivatives as cftr modulators
|
|
US20100074949A1
(en)
|
2008-08-13 |
2010-03-25 |
William Rowe |
Pharmaceutical composition and administration thereof
|
|
US12458635B2
(en)
|
2008-08-13 |
2025-11-04 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical composition and administrations thereof
|
|
SI3330255T1
(sl)
|
2009-03-20 |
2021-03-31 |
Vertex Pharmaceuticals Incorporated |
Postopek izdelave regulatorja transmembranske prevodnosti pri cistični fibrozi
|
|
US8802868B2
(en)
|
2010-03-25 |
2014-08-12 |
Vertex Pharmaceuticals Incorporated |
Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
|
|
TWI549950B
(zh)
|
2010-04-07 |
2016-09-21 |
維泰克斯製藥公司 |
3-(6-(1-(2,2-二氟苯并[d][1,3]二氧雜環戊烯-5-基)環丙烷甲醯胺基)-3-甲基吡啶-2-基)苯甲酸之固體形式
|
|
ES2900353T3
(es)
|
2010-04-07 |
2022-03-16 |
Vertex Pharma |
Composiciones farmacéuticas de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiriidin-2-il)benzoico y administración de las mismas
|
|
RU2569678C2
(ru)
|
2010-04-22 |
2015-11-27 |
Вертекс Фармасьютикалз Инкорпорейтед |
Способ получения циклоалкилкарбоксамидо-индольных соединений
|
|
HUE047354T2
(hu)
|
2011-05-18 |
2020-04-28 |
Vertex Pharmaceuticals Europe Ltd |
Ivacaftor deuterizált származékai
|
|
CA2852991C
(en)
|
2011-11-08 |
2019-12-31 |
Vertex Pharmaceuticals Incorporated |
Modulators of atp-binding cassette transporters
|
|
NZ627750A
(en)
|
2012-01-06 |
2016-11-25 |
Abide Therapeutics Inc |
Carbamate compounds and of making and using same
|
|
NZ727015A
(en)
|
2012-01-25 |
2017-12-22 |
Vertex Pharma |
Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
|
|
EP2819670B1
(en)
|
2012-02-27 |
2026-05-20 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical Composition and Their Administration
|
|
AU2013290444B2
(en)
|
2012-07-16 |
2018-04-26 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
|
|
KR102396897B1
(ko)
*
|
2012-11-02 |
2022-05-13 |
버텍스 파마슈티칼스 인코포레이티드 |
Cftr 매개된 질환의 치료를 위한 약제학적 조성물
|
|
US9303918B2
(en)
*
|
2013-03-15 |
2016-04-05 |
Monosol Rx, Llc |
Process for drying a wet film with control of loss on drying
|
|
WO2014176553A1
(en)
*
|
2013-04-26 |
2014-10-30 |
Vertex Pharmaceuticals Incorporated |
Correctors acting through msd1 of cftr protein
|
|
CA2930199C
(en)
|
2013-11-12 |
2022-10-25 |
Vertex Pharmaceuticals Incorporated |
Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases
|
|
PL3925607T5
(pl)
|
2014-04-15 |
2026-06-01 |
Vertex Pharmaceuticals Incorporated |
Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
|
|
TW202140422A
(zh)
|
2014-10-06 |
2021-11-01 |
美商維泰克斯製藥公司 |
囊腫纖維化症跨膜傳導調節蛋白之調節劑
|
|
CA2963945C
(en)
|
2014-10-07 |
2023-01-10 |
Vertex Pharmaceuticals Incorporated |
Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
|
|
HUE055423T2
(hu)
|
2014-11-18 |
2021-11-29 |
Vertex Pharma |
Eljárás nagy áteresztõképességû tesztelõ nagy teljesítményû folyadék-kromatográfia elvégzésére
|
|
US10450302B2
(en)
|
2015-05-11 |
2019-10-22 |
Lundbeck La Jolla Research Center, Inc. |
Methods of treating inflammation or neuropathic pain
|
|
HK1258473A1
(zh)
|
2015-09-25 |
2019-11-15 |
Vertex Pharmaceuticals (Europe) Limited |
氘代cftr增效剂
|
|
WO2017151725A1
(en)
*
|
2016-03-03 |
2017-09-08 |
Nivalis Therapeutics, Inc. |
Formulations of an s-nitrosoglutathione reductase inhibitor
|
|
ES2946970T3
(es)
|
2016-03-31 |
2023-07-28 |
Vertex Pharma |
Regulador de conductancia transmembrana de moduladores de fibrosis quística
|
|
US10376501B2
(en)
|
2016-04-25 |
2019-08-13 |
Druggability Technologies Ip Holdco Limited |
Complexes of lumacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
|
|
HUP1600269A2
(hu)
|
2016-04-25 |
2017-10-30 |
Druggability Tech Ip Holdco Ltd |
Lumacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyászati készítményei
|
|
US10206915B2
(en)
|
2016-04-25 |
2019-02-19 |
Druggability Technologies Ip Holdco Limited |
Complexes of Ivacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
|
|
HUP1600271A2
(hu)
*
|
2016-04-25 |
2017-10-30 |
Druggability Tech Ip Holdco Ltd |
Ivacaftor és Lumacaftor sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadható készítményei
|
|
US10383865B2
(en)
|
2016-04-25 |
2019-08-20 |
Druggability Technologies Ip Holdco Limited |
Pharmaceutical combination composition comprising complex formulations of Ivacaftor and Lumacaftor and their salts and derivatives, process for their preparation thereof and pharmaceutical compositions containing them
|
|
HUP1600270A2
(hu)
|
2016-04-25 |
2017-10-30 |
Druggability Tech Ip Holdco Ltd |
Ivacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadott készítményei
|
|
GEP20217329B
(en)
|
2016-09-30 |
2021-12-10 |
Vertex Pharma |
Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
|
|
CA3043609A1
(en)
|
2016-11-16 |
2018-05-24 |
Abide Therapeutics, Inc. |
Pharmaceutical formulations
|
|
PL3541807T3
(pl)
|
2016-11-16 |
2022-01-17 |
H. Lundbeck A/S |
Krystaliczna postać inhibitora magl
|
|
EA202192783A1
(ru)
|
2016-12-09 |
2022-02-24 |
Вертекс Фармасьютикалз Инкорпорейтед |
Модулятор регулятора трансмембранной проводимости при муковисцидозе, фармацевтические композиции, способы лечения и способ получения указанного модулятора
|
|
MA54105A
(fr)
|
2017-06-08 |
2021-09-15 |
Vertex Pharma |
Méthodes de traitement de la fibrose kystique
|
|
IL272032B2
(en)
|
2017-07-17 |
2026-04-01 |
Vertex Pharma |
Combination therapy for the treatment of cystic fibrosis including N-(1,3-DIMETHYLPYRAZOL-4-YL)SULFONYL-6-[3-(3,3,3-TRIFLUORO-2,2- DIMETHYL-PROPOXY)PYRAZOL-1-YL]-2-[(4S)-2,2,4- TRIMETHYLPYRROLIDIN-1-YL]PYRIDINE-3-CARBOXAMIDE and
|
|
MA49752A
(fr)
|
2017-08-02 |
2021-04-21 |
Vertex Pharma |
Procédés de préparation de composés de pyrrolidine
|
|
CA3078893A1
(en)
|
2017-10-19 |
2019-04-25 |
Vertex Pharmaceuticals Incorporated |
Crystalline forms and compositions of cftr modulators
|
|
WO2019109021A1
(en)
|
2017-12-01 |
2019-06-06 |
Vertex Pharmaceuticals Incorporated |
Processes for making modulators of cystic fibrosis transmembrane conductance regulator
|
|
KR102716244B1
(ko)
|
2017-12-08 |
2024-10-14 |
버텍스 파마슈티칼스 인코포레이티드 |
낭포성 섬유증 막횡단 전도 조절자의 조정제의 제조 방법
|
|
TWI810243B
(zh)
|
2018-02-05 |
2023-08-01 |
美商維泰克斯製藥公司 |
用於治療囊腫纖化症之醫藥組合物
|
|
RS64018B1
(sr)
|
2018-02-15 |
2023-03-31 |
Vertex Pharma |
Makrocikli kao modulatori transmembranskog regulatora provodnosti cistične fibroze, njihove farmaceutske kompozicije, njihova upotreba u lečenju cistične fibroze i proces njihove izrade
|
|
WO2019195739A1
(en)
|
2018-04-05 |
2019-10-10 |
Alexander Russell Abela |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
WO2019200246A1
(en)
|
2018-04-13 |
2019-10-17 |
Alexander Russell Abela |
Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
|
|
MA54227B1
(fr)
|
2018-11-14 |
2023-03-31 |
Vertex Pharma |
Méthodes de traitement de la fibrose kystique
|
|
TWI848092B
(zh)
|
2019-04-03 |
2024-07-11 |
美商維泰克斯製藥公司 |
囊腫纖維化跨膜傳導調節蛋白調節劑
|
|
WO2020214921A1
(en)
|
2019-04-17 |
2020-10-22 |
Vertex Pharmaceuticals Incorporated |
Solid forms of modulators of cftr
|
|
WO2020263989A1
(en)
|
2019-06-24 |
2020-12-30 |
University Of Iowa Research Foundation |
Jnk inhibitors as anticancer agents
|
|
US11873300B2
(en)
|
2019-08-14 |
2024-01-16 |
Vertex Pharmaceuticals Incorporated |
Crystalline forms of CFTR modulators
|
|
TWI867024B
(zh)
|
2019-08-14 |
2024-12-21 |
美商維泰克斯製藥公司 |
囊腫纖維化跨膜傳導調節蛋白之調節劑
|
|
TWI899097B
(zh)
|
2019-08-14 |
2025-10-01 |
美商維泰克斯製藥公司 |
製備cftr調節劑之方法
|
|
WO2021030556A1
(en)
|
2019-08-14 |
2021-02-18 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
US11904006B2
(en)
|
2019-12-11 |
2024-02-20 |
University Of Iowa Research Foundation |
Poly(diaminosulfide) particle-based vaccine
|
|
WO2021214550A1
(en)
|
2020-04-21 |
2021-10-28 |
H. Lundbeck A/S |
Synthesis of a monoacylglycerol lipase inhibitor
|
|
WO2022194399A1
(en)
|
2020-07-13 |
2022-09-22 |
Idorsia Pharmaceuticals Ltd |
Macrocycles as cftr modulators
|
|
CR20230120A
(es)
|
2020-08-07 |
2023-09-01 |
Vertex Pharma |
Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
|
|
WO2022036060A1
(en)
|
2020-08-13 |
2022-02-17 |
Vertex Pharmaceuticals Incorporated |
Crystalline forms of cftr modulators
|
|
MX2023004072A
(es)
|
2020-10-07 |
2023-07-05 |
Vertex Pharma |
Moduladores del regulador de la conductancia transmembrana de la fibrosis quistica.
|
|
US12612416B2
(en)
|
2020-10-07 |
2026-04-28 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
US20230382924A1
(en)
|
2020-10-07 |
2023-11-30 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
WO2022076627A1
(en)
|
2020-10-07 |
2022-04-14 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
BR112023006470A2
(pt)
|
2020-10-07 |
2023-09-26 |
Vertex Pharma |
Moduladores de regulador de condutância transmembrana de fibrose cística
|
|
WO2022076628A1
(en)
|
2020-10-07 |
2022-04-14 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
WO2022076626A1
(en)
|
2020-10-07 |
2022-04-14 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
US20230373974A1
(en)
|
2020-10-07 |
2023-11-23 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
WO2022076620A1
(en)
|
2020-10-07 |
2022-04-14 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
TW202233635A
(zh)
|
2020-10-07 |
2022-09-01 |
美商維泰克斯製藥公司 |
囊腫纖維化跨膜傳導調節蛋白之調節劑
|
|
US12324802B2
(en)
|
2020-11-18 |
2025-06-10 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
MX2023006770A
(es)
|
2020-12-10 |
2023-08-14 |
Vertex Pharma |
Metodos de tratamiento para fibrosis quistica.
|
|
WO2022125963A1
(en)
*
|
2020-12-11 |
2022-06-16 |
University Of Iowa Research Foundation |
Compositions comprising molecules for cystic fibrosis treatment
|
|
EP4304593A4
(en)
*
|
2021-03-09 |
2024-08-07 |
Laurus Labs Limited |
ORAL FILM OF CFTR MODULATOR(S)
|
|
CN119095597A
(zh)
|
2022-02-03 |
2024-12-06 |
弗特克斯药品有限公司 |
治疗囊性纤维化的方法
|
|
CA3251045A1
(en)
|
2022-02-08 |
2023-08-17 |
Vertex Pharmaceuticals Incorporated |
MODULATORS OF THE TRANSMEMBRANE CONDUCTANCE REGULATOR IN CYSTIC FIBROSIS
|
|
PE20250606A1
(es)
|
2022-04-06 |
2025-02-26 |
Vertex Pharma |
Moduladores del regulador de la conductancia transmembrana de la fibrosis quistica
|
|
AU2023273614A1
(en)
|
2022-05-16 |
2024-11-07 |
Vertex Pharmaceuticals Incorporated |
Methods of treatment for cystic fibrosis
|
|
CA3267791A1
(en)
|
2022-09-15 |
2024-03-21 |
Idorsia Pharmaceuticals Ltd |
CRYSTALLINE FORM OF (3S,7S,10R,13R)-13-BENZYL-20-FLUORO-7-ISOBUTYL-N-(2-(3-METHOXY-1,2,4-OXADIAZOL-5-YL)ETHYL)-6,9-DIMETHYL-1,5,8,11-TETRAOXO-10-(2,2,2-TRIFLUOROETHYL)-1,2,3,4,5,6,7,8,9,10,11,12,13,14-TETRADECAHYDRO-[1]OXA[4,7,10,14]TETRAAZACYCLOHEPTADECINO [16,17-F]QUINOLINE-3-CARBOXAMIDE
|
|
WO2024056798A1
(en)
|
2022-09-15 |
2024-03-21 |
Idorsia Pharmaceuticals Ltd |
Macrocyclic cftr modulators
|
|
CN119907667A
(zh)
|
2022-09-15 |
2025-04-29 |
爱杜西亚药品有限公司 |
大环cftr调节剂与cftr校正剂和/或cftr增效剂的组合
|
|
CN122374316A
(zh)
|
2023-10-04 |
2026-07-10 |
弗特克斯药品有限公司 |
囊性纤维化跨膜传导调控因子的调节剂
|
|
WO2025186214A1
(en)
|
2024-03-05 |
2025-09-12 |
Idorsia Pharmaceuticals Ltd |
Macrocyclic cftr modulators
|