JP2015532642A5 - - Google Patents
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- JP2015532642A5 JP2015532642A5 JP2015527533A JP2015527533A JP2015532642A5 JP 2015532642 A5 JP2015532642 A5 JP 2015532642A5 JP 2015527533 A JP2015527533 A JP 2015527533A JP 2015527533 A JP2015527533 A JP 2015527533A JP 2015532642 A5 JP2015532642 A5 JP 2015532642A5
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- 125000000217 alkyl group Chemical group 0.000 claims 85
- 125000000753 cycloalkyl group Chemical group 0.000 claims 33
- 125000003342 alkenyl group Chemical group 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 125000000304 alkynyl group Chemical group 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 102000004311 liver X receptors Human genes 0.000 claims 11
- 108090000865 liver X receptors Proteins 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 239000000556 agonist Substances 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 6
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 230000001028 anti-proliverative effect Effects 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 2
- 102000013918 Apolipoproteins E Human genes 0.000 claims 2
- 108010025628 Apolipoproteins E Proteins 0.000 claims 2
- 229940125431 BRAF inhibitor Drugs 0.000 claims 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 2
- 239000012275 CTLA-4 inhibitor Substances 0.000 claims 2
- 239000012824 ERK inhibitor Substances 0.000 claims 2
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 2
- 229940124647 MEK inhibitor Drugs 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 239000012270 PD-1 inhibitor Substances 0.000 claims 2
- 239000012668 PD-1-inhibitor Substances 0.000 claims 2
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 2
- 125000005157 alkyl carboxy group Chemical group 0.000 claims 2
- 238000011319 anticancer therapy Methods 0.000 claims 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 claims 2
- 229960002465 dabrafenib Drugs 0.000 claims 2
- 229960003901 dacarbazine Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229950009791 durvalumab Drugs 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960005386 ipilimumab Drugs 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 208000037819 metastatic cancer Diseases 0.000 claims 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108091025686 miR-199a stem-loop Proteins 0.000 claims 2
- 108091083769 miR-199a-1 stem-loop Proteins 0.000 claims 2
- 108091047470 miR-199a-2 stem-loop Proteins 0.000 claims 2
- 108091048350 miR-199a-3 stem-loop Proteins 0.000 claims 2
- 108091056793 miR-199a-4 stem-loop Proteins 0.000 claims 2
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims 2
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 claims 2
- 229960004066 trametinib Drugs 0.000 claims 2
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims 2
- 229960003862 vemurafenib Drugs 0.000 claims 2
- ASGMFNBUXDJWJJ-JLCFBVMHSA-N (1R,3R)-3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethylcyclopentane-1-carboxamide Chemical compound BrC1=NN(C2=NC(=NC=C21)N[C@H]1C[C@@](CC1)(C(=O)NC)C)C1=CC=C(C=C1)C=1SC(=NN=1)C ASGMFNBUXDJWJJ-JLCFBVMHSA-N 0.000 claims 1
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- QBWKPGNFQQJGFY-QLFBSQMISA-N 3-[(1r)-1-[(2r,6s)-2,6-dimethylmorpholin-4-yl]ethyl]-n-[6-methyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Chemical compound N1([C@H](C)C2=NSC(NC=3C4=NC=C(N4C=C(C)N=3)C3=CNN=C3)=C2)C[C@H](C)O[C@H](C)C1 QBWKPGNFQQJGFY-QLFBSQMISA-N 0.000 claims 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100031168 CCN family member 2 Human genes 0.000 claims 1
- 101100463133 Caenorhabditis elegans pdl-1 gene Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229940127007 Compound 39 Drugs 0.000 claims 1
- 102100029715 DnaJ homolog subfamily A member 4 Human genes 0.000 claims 1
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 claims 1
- 101000866014 Homo sapiens DnaJ homolog subfamily A member 4 Proteins 0.000 claims 1
- 101001039207 Homo sapiens Low-density lipoprotein receptor-related protein 8 Proteins 0.000 claims 1
- 101000896414 Homo sapiens Nuclear nucleic acid-binding protein C1D Proteins 0.000 claims 1
- 101001043564 Homo sapiens Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 claims 1
- 102100040705 Low-density lipoprotein receptor-related protein 8 Human genes 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 102100021923 Prolow-density lipoprotein receptor-related protein 1 Human genes 0.000 claims 1
- 125000004171 alkoxy aryl group Chemical group 0.000 claims 1
- 239000002257 antimetastatic agent Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 229940125797 compound 12 Drugs 0.000 claims 1
- 229940125782 compound 2 Drugs 0.000 claims 1
- 229940125846 compound 25 Drugs 0.000 claims 1
- 229940127573 compound 38 Drugs 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000004445 cyclohaloalkyl Chemical group 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- -1 ipilimumab Chemical compound 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 108091083606 miR-1908 stem-loop Proteins 0.000 claims 1
- 108091023818 miR-7 stem-loop Proteins 0.000 claims 1
- DYMRYCZRMAHYKE-UHFFFAOYSA-N n-diazonitramide Chemical compound [O-][N+](=O)N=[N+]=[N-] DYMRYCZRMAHYKE-UHFFFAOYSA-N 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- PIDFDZJZLOTZTM-KHVQSSSXSA-N ombitasvir Chemical compound COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NC1=CC=C([C@H]2N([C@@H](CC2)C=2C=CC(NC(=O)[C@H]3N(CCC3)C(=O)[C@@H](NC(=O)OC)C(C)C)=CC=2)C=2C=CC(=CC=2)C(C)(C)C)C=C1 PIDFDZJZLOTZTM-KHVQSSSXSA-N 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261682339P | 2012-08-13 | 2012-08-13 | |
| US61/682,339 | 2012-08-13 | ||
| US201361784057P | 2013-03-14 | 2013-03-14 | |
| US61/784,057 | 2013-03-14 | ||
| PCT/US2013/054690 WO2014028461A2 (en) | 2012-08-13 | 2013-08-13 | Treatment and diagnosis of melanoma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018023820A Division JP6523502B2 (ja) | 2012-08-13 | 2018-02-14 | メラノーマの処置および診断 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015532642A JP2015532642A (ja) | 2015-11-12 |
| JP2015532642A5 true JP2015532642A5 (https=) | 2016-09-29 |
| JP6320382B2 JP6320382B2 (ja) | 2018-05-09 |
Family
ID=50101591
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527533A Active JP6320382B2 (ja) | 2012-08-13 | 2013-08-13 | メラノーマの処置および診断 |
| JP2018023820A Active JP6523502B2 (ja) | 2012-08-13 | 2018-02-14 | メラノーマの処置および診断 |
| JP2019083874A Active JP7005551B2 (ja) | 2012-08-13 | 2019-04-25 | メラノーマの処置および診断 |
| JP2021105207A Active JP7472080B2 (ja) | 2012-08-13 | 2021-06-24 | メラノーマの処置および診断 |
| JP2023223727A Pending JP2024041827A (ja) | 2012-08-13 | 2023-12-28 | メラノーマの処置および診断 |
| JP2026001136A Pending JP2026062949A (ja) | 2012-08-13 | 2026-01-06 | メラノーマの処置および診断 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018023820A Active JP6523502B2 (ja) | 2012-08-13 | 2018-02-14 | メラノーマの処置および診断 |
| JP2019083874A Active JP7005551B2 (ja) | 2012-08-13 | 2019-04-25 | メラノーマの処置および診断 |
| JP2021105207A Active JP7472080B2 (ja) | 2012-08-13 | 2021-06-24 | メラノーマの処置および診断 |
| JP2023223727A Pending JP2024041827A (ja) | 2012-08-13 | 2023-12-28 | メラノーマの処置および診断 |
| JP2026001136A Pending JP2026062949A (ja) | 2012-08-13 | 2026-01-06 | メラノーマの処置および診断 |
Country Status (10)
| Country | Link |
|---|---|
| US (8) | US9399028B2 (https=) |
| EP (3) | EP3626309B1 (https=) |
| JP (6) | JP6320382B2 (https=) |
| CN (3) | CN116271053A (https=) |
| AU (4) | AU2013302861A1 (https=) |
| CA (2) | CA3211094A1 (https=) |
| DK (1) | DK2882496T3 (https=) |
| ES (2) | ES2941477T3 (https=) |
| HU (1) | HUE046292T2 (https=) |
| WO (1) | WO2014028461A2 (https=) |
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| BRPI0913578A2 (pt) | 2008-05-14 | 2017-06-06 | Dermtech Int | diagnose de melanoma e lentigo solar por análise de ácido nucléico |
| DK2820013T3 (en) | 2012-03-02 | 2018-10-29 | Ralexar Therapeutics Inc | Liver X Receptor (LXR) modulators for the treatment of dermal diseases, disorders and conditions |
| EP3626309B1 (en) | 2012-08-13 | 2023-03-08 | The Rockefeller University | Lxrbeta agonist for the treatment of cancer |
| PT3041835T (pt) | 2013-09-04 | 2020-07-13 | Ellora Therapeutics Inc | Moduladores de recetor de fígado x (lxr) |
| JP2016532713A (ja) | 2013-09-04 | 2016-10-20 | アレクサー セラピューティクス， インク． | 肝臓ｘ受容体（ｌｘｒ）調節因子 |
| US10669296B2 (en) | 2014-01-10 | 2020-06-02 | Rgenix, Inc. | LXR agonists and uses thereof |
| WO2019161126A1 (en) | 2018-02-14 | 2019-08-22 | Dermtech, Inc. | Novel gene classifiers and uses thereof in non-melanoma skin cancers |
| WO2016100619A2 (en) * | 2014-12-17 | 2016-06-23 | Rgenix, Inc. | Treatment and diagnosis of cancer |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| US10709428B2 (en) | 2015-05-01 | 2020-07-14 | Dermtech, Inc. | Non-invasive skin collection system |
| US11802305B2 (en) * | 2015-06-24 | 2023-10-31 | Oxford BioDynamics PLC | Detection processes using sites of chromosome interaction |
| US20200046671A1 (en) * | 2015-06-29 | 2020-02-13 | Regents Of The University Of Minnesota | Apobec3b mutagenesis and immunotherapy |
| JP2018527895A (ja) | 2015-06-29 | 2018-09-27 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 抗−ａｐｏｂｅｃ３抗体並びにその製造及び使用方法 |
| CA3010883A1 (en) * | 2016-01-11 | 2017-07-20 | The Rockefeller University | Methods for the treatment of myeloid derived suppressor cells related disorders |
| WO2017142988A1 (en) | 2016-02-18 | 2017-08-24 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for treating melanoma |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI755395B (zh) * | 2016-05-13 | 2022-02-21 | 美商再生元醫藥公司 | 抗-pd-1抗體與輻射治療癌症之組合 |
| WO2018013534A1 (en) * | 2016-07-11 | 2018-01-18 | Dana-Farber Cancer Institute, Inc. | Methods for treating pten deficient epithelial cancers using a combination of anti-pi3kbeta and anti-immune checkpoint agents |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
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| CN106890315B (zh) * | 2017-03-16 | 2019-09-06 | 北京热休生物技术有限公司 | Apo-e蛋白及其多肽在治疗与预防癌症中的应用 |
| AU2018269982B2 (en) * | 2017-05-16 | 2024-06-13 | Biomed Valley Discoveries, Inc. | Compositions and methods for treating cancer with atypical BRAF mutations |
| EP3713575A4 (en) | 2017-11-21 | 2021-08-25 | Rgenix, Inc. | POLYMORPHS AND THEIR USES |
| JP7616995B2 (ja) * | 2018-11-28 | 2025-01-17 | プリベイル セラピューティクス，インコーポレーテッド | 神経変性疾患のための遺伝子治療 |
| AU2020228660A1 (en) * | 2019-02-28 | 2021-08-26 | Inspirna, Inc. | APOE genotyping in cancer prognostics and treatment |
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| WO2020222858A1 (en) * | 2019-04-27 | 2020-11-05 | Ocugen, Inc. | Adeno-associated virus vector mediated gene therapy for ophthalmic diseases |
| CN110218235B (zh) * | 2019-05-09 | 2020-09-25 | 中山大学 | 一种化合物及其制备方法和作为荧光偏振探针在LXRβ配体筛选中的应用 |
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| WO2021062157A1 (en) * | 2019-09-27 | 2021-04-01 | The Rockefeller University | Compositions and methods for treating metastatic gastrointestinal cancer |
| RU2716811C1 (ru) * | 2019-11-14 | 2020-03-16 | федеральное государственное бюджетное образовательное учреждение высшего образования "Новгородский государственный университет имени Ярослава Мудрого" | Способ ранней диагностики поверхностно распространяющихся меланом |
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| EP4081302A4 (en) | 2019-12-23 | 2025-01-29 | University Of Massachusetts | OLIGONUCLEOTIDES FOR TISSUE-SPECIFIC GENE EXPRESSION MODULATION |
| US20240101640A1 (en) * | 2020-08-21 | 2024-03-28 | Csl Behring Ag | Cd91 polypeptide for use in detecting hemopexin:heme complex |
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