JP2015532642A5 - - Google Patents
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- JP2015532642A5 JP2015532642A5 JP2015527533A JP2015527533A JP2015532642A5 JP 2015532642 A5 JP2015532642 A5 JP 2015532642A5 JP 2015527533 A JP2015527533 A JP 2015527533A JP 2015527533 A JP2015527533 A JP 2015527533A JP 2015532642 A5 JP2015532642 A5 JP 2015532642A5
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- alkyl
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- het
- Prior art date
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- 125000000217 alkyl group Chemical group 0.000 claims 85
- 125000000753 cycloalkyl group Chemical group 0.000 claims 33
- 125000003342 alkenyl group Chemical group 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 125000000304 alkynyl group Chemical group 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 102000004311 liver X receptors Human genes 0.000 claims 11
- 108090000865 liver X receptors Proteins 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 239000000556 agonist Substances 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 6
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 230000001028 anti-proliverative effect Effects 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 2
- 102000013918 Apolipoproteins E Human genes 0.000 claims 2
- 108010025628 Apolipoproteins E Proteins 0.000 claims 2
- 229940125431 BRAF inhibitor Drugs 0.000 claims 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 2
- 239000012275 CTLA-4 inhibitor Substances 0.000 claims 2
- 239000012824 ERK inhibitor Substances 0.000 claims 2
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 2
- 229940124647 MEK inhibitor Drugs 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 239000012270 PD-1 inhibitor Substances 0.000 claims 2
- 239000012668 PD-1-inhibitor Substances 0.000 claims 2
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 2
- 125000005157 alkyl carboxy group Chemical group 0.000 claims 2
- 238000011319 anticancer therapy Methods 0.000 claims 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 claims 2
- 229960002465 dabrafenib Drugs 0.000 claims 2
- 229960003901 dacarbazine Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229950009791 durvalumab Drugs 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960005386 ipilimumab Drugs 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 208000037819 metastatic cancer Diseases 0.000 claims 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108091025686 miR-199a stem-loop Proteins 0.000 claims 2
- 108091083769 miR-199a-1 stem-loop Proteins 0.000 claims 2
- 108091047470 miR-199a-2 stem-loop Proteins 0.000 claims 2
- 108091048350 miR-199a-3 stem-loop Proteins 0.000 claims 2
- 108091056793 miR-199a-4 stem-loop Proteins 0.000 claims 2
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims 2
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 claims 2
- 229960004066 trametinib Drugs 0.000 claims 2
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims 2
- 229960003862 vemurafenib Drugs 0.000 claims 2
- ASGMFNBUXDJWJJ-JLCFBVMHSA-N (1R,3R)-3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethylcyclopentane-1-carboxamide Chemical compound BrC1=NN(C2=NC(=NC=C21)N[C@H]1C[C@@](CC1)(C(=O)NC)C)C1=CC=C(C=C1)C=1SC(=NN=1)C ASGMFNBUXDJWJJ-JLCFBVMHSA-N 0.000 claims 1
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- QBWKPGNFQQJGFY-QLFBSQMISA-N 3-[(1r)-1-[(2r,6s)-2,6-dimethylmorpholin-4-yl]ethyl]-n-[6-methyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Chemical compound N1([C@H](C)C2=NSC(NC=3C4=NC=C(N4C=C(C)N=3)C3=CNN=C3)=C2)C[C@H](C)O[C@H](C)C1 QBWKPGNFQQJGFY-QLFBSQMISA-N 0.000 claims 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100031168 CCN family member 2 Human genes 0.000 claims 1
- 101100463133 Caenorhabditis elegans pdl-1 gene Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229940127007 Compound 39 Drugs 0.000 claims 1
- 102100029715 DnaJ homolog subfamily A member 4 Human genes 0.000 claims 1
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 claims 1
- 101000866014 Homo sapiens DnaJ homolog subfamily A member 4 Proteins 0.000 claims 1
- 101001039207 Homo sapiens Low-density lipoprotein receptor-related protein 8 Proteins 0.000 claims 1
- 101000896414 Homo sapiens Nuclear nucleic acid-binding protein C1D Proteins 0.000 claims 1
- 101001043564 Homo sapiens Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 claims 1
- 102100040705 Low-density lipoprotein receptor-related protein 8 Human genes 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 102100021923 Prolow-density lipoprotein receptor-related protein 1 Human genes 0.000 claims 1
- 125000004171 alkoxy aryl group Chemical group 0.000 claims 1
- 239000002257 antimetastatic agent Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 229940125797 compound 12 Drugs 0.000 claims 1
- 229940125782 compound 2 Drugs 0.000 claims 1
- 229940125846 compound 25 Drugs 0.000 claims 1
- 229940127573 compound 38 Drugs 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000004445 cyclohaloalkyl Chemical group 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- -1 ipilimumab Chemical compound 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 108091083606 miR-1908 stem-loop Proteins 0.000 claims 1
- 108091023818 miR-7 stem-loop Proteins 0.000 claims 1
- DYMRYCZRMAHYKE-UHFFFAOYSA-N n-diazonitramide Chemical compound [O-][N+](=O)N=[N+]=[N-] DYMRYCZRMAHYKE-UHFFFAOYSA-N 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- PIDFDZJZLOTZTM-KHVQSSSXSA-N ombitasvir Chemical compound COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NC1=CC=C([C@H]2N([C@@H](CC2)C=2C=CC(NC(=O)[C@H]3N(CCC3)C(=O)[C@@H](NC(=O)OC)C(C)C)=CC=2)C=2C=CC(=CC=2)C(C)(C)C)C=C1 PIDFDZJZLOTZTM-KHVQSSSXSA-N 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261682339P | 2012-08-13 | 2012-08-13 | |
| US61/682,339 | 2012-08-13 | ||
| US201361784057P | 2013-03-14 | 2013-03-14 | |
| US61/784,057 | 2013-03-14 | ||
| PCT/US2013/054690 WO2014028461A2 (en) | 2012-08-13 | 2013-08-13 | Treatment and diagnosis of melanoma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018023820A Division JP6523502B2 (ja) | 2012-08-13 | 2018-02-14 | メラノーマの処置および診断 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015532642A JP2015532642A (ja) | 2015-11-12 |
| JP2015532642A5 true JP2015532642A5 (enExample) | 2016-09-29 |
| JP6320382B2 JP6320382B2 (ja) | 2018-05-09 |
Family
ID=50101591
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527533A Active JP6320382B2 (ja) | 2012-08-13 | 2013-08-13 | メラノーマの処置および診断 |
| JP2018023820A Active JP6523502B2 (ja) | 2012-08-13 | 2018-02-14 | メラノーマの処置および診断 |
| JP2019083874A Active JP7005551B2 (ja) | 2012-08-13 | 2019-04-25 | メラノーマの処置および診断 |
| JP2021105207A Active JP7472080B2 (ja) | 2012-08-13 | 2021-06-24 | メラノーマの処置および診断 |
| JP2023223727A Pending JP2024041827A (ja) | 2012-08-13 | 2023-12-28 | メラノーマの処置および診断 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018023820A Active JP6523502B2 (ja) | 2012-08-13 | 2018-02-14 | メラノーマの処置および診断 |
| JP2019083874A Active JP7005551B2 (ja) | 2012-08-13 | 2019-04-25 | メラノーマの処置および診断 |
| JP2021105207A Active JP7472080B2 (ja) | 2012-08-13 | 2021-06-24 | メラノーマの処置および診断 |
| JP2023223727A Pending JP2024041827A (ja) | 2012-08-13 | 2023-12-28 | メラノーマの処置および診断 |
Country Status (10)
| Country | Link |
|---|---|
| US (8) | US9399028B2 (enExample) |
| EP (3) | EP4218935A1 (enExample) |
| JP (5) | JP6320382B2 (enExample) |
| CN (3) | CN116271053A (enExample) |
| AU (4) | AU2013302861A1 (enExample) |
| CA (2) | CA3211094A1 (enExample) |
| DK (1) | DK2882496T3 (enExample) |
| ES (2) | ES2765573T3 (enExample) |
| HU (1) | HUE046292T2 (enExample) |
| WO (1) | WO2014028461A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2724322C (en) | 2008-05-14 | 2019-07-16 | Dermtech International | Diagnosis of melanoma and solar lentigo by nucleic acid analysis |
| PL2820013T3 (pl) | 2012-03-02 | 2019-01-31 | Ralexar Therapeutics, Inc. | Modulatory receptorów X wątroby (LXR) do leczenia chorób, zaburzeń i stanów skórnych |
| HUE046292T2 (hu) * | 2012-08-13 | 2020-02-28 | Univ Rockefeller | Melanóma kezelése és diagnosztizálása |
| ES2804304T3 (es) | 2013-09-04 | 2021-02-05 | Ellora Therapeutics Inc | Moduladores del receptor X hepático (LXR) |
| SG11201601644RA (en) | 2013-09-04 | 2016-04-28 | Alexar Therapeutics Inc | Liver x receptor (lxr) modulators |
| AU2015204572B2 (en) * | 2014-01-10 | 2020-07-30 | Inspirna, Inc. | LXR agonists and uses thereof |
| WO2016179043A1 (en) | 2015-05-01 | 2016-11-10 | Dermtech, Inc. | Non-invasive skin collection system |
| US20190125745A1 (en) * | 2014-12-17 | 2019-05-02 | Rgenix, Inc. | Treatment and diagnosis of cancer |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| AU2016281776B2 (en) * | 2015-06-24 | 2019-09-05 | Oxford BioDynamics PLC | Detection processes using sites of chromosome interaction |
| US20200046671A1 (en) * | 2015-06-29 | 2020-02-13 | Regents Of The University Of Minnesota | Apobec3b mutagenesis and immunotherapy |
| EP3313993A4 (en) | 2015-06-29 | 2019-06-19 | Regents of the University of Minnesota | ANTI-APOBEC3 ANTIBODIES AND METHOD OF PREPARATION AND USE |
| JP7025022B2 (ja) * | 2016-01-11 | 2022-02-24 | ザ ロックフェラー ユニバーシティー | 骨髄系由来抑制細胞関連障害の治療のための方法 |
| EP3416668A4 (en) | 2016-02-18 | 2020-02-19 | The Wistar Institute Of Anatomy And Biology | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MELANOMA |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI822521B (zh) * | 2016-05-13 | 2023-11-11 | 美商再生元醫藥公司 | 藉由投予pd-1抑制劑治療皮膚癌之方法 |
| CN109689062B (zh) * | 2016-07-11 | 2023-02-17 | 丹娜法伯癌症研究院 | 使用抗PI3Kβ和抗免疫检查点药剂的组合治疗PTEN缺陷型上皮癌的方法 |
| JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
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| CN106890315B (zh) * | 2017-03-16 | 2019-09-06 | 北京热休生物技术有限公司 | Apo-e蛋白及其多肽在治疗与预防癌症中的应用 |
| US20210085663A1 (en) * | 2017-05-16 | 2021-03-25 | Biomed Valley Discoveries, Inc. | Compositions and methods for treating cancer with atypical braf mutations |
| AU2018373028A1 (en) | 2017-11-21 | 2020-04-30 | Inspirna, Inc. | Polymorphs and uses thereof |
| EP3752645A4 (en) | 2018-02-14 | 2022-04-13 | Dermtech, Inc. | Novel gene classifiers and uses thereof in non-melanoma skin cancers |
| MX2021006253A (es) * | 2018-11-28 | 2021-09-21 | Prevail Therapeutics Inc | Terapias génicas para enfermedad neurodegenerativa. |
| US20220127680A1 (en) * | 2019-02-28 | 2022-04-28 | The Rockefeller Universtiy | Apoe genotyping in cancer prognostics and treatment |
| AU2020247911A1 (en) | 2019-03-26 | 2021-11-11 | Dermtech, Llc | Novel gene classifiers and uses thereof in skin cancers |
| JP2022530845A (ja) * | 2019-04-27 | 2022-07-04 | オクジェン アイエヌシー． | 眼疾患に対するａｄｅｎｏ随伴ウイルス連ウイルスベクター媒介遺伝子治療 |
| CN110218235B (zh) * | 2019-05-09 | 2020-09-25 | 中山大学 | 一种化合物及其制备方法和作为荧光偏振探针在LXRβ配体筛选中的应用 |
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| US20220339184A1 (en) * | 2019-09-27 | 2022-10-27 | The Rockefeller University | Compositions and methods to treat metastatic gastrointestinal cancer |
| RU2716811C1 (ru) * | 2019-11-14 | 2020-03-16 | федеральное государственное бюджетное образовательное учреждение высшего образования "Новгородский государственный университет имени Ярослава Мудрого" | Способ ранней диагностики поверхностно распространяющихся меланом |
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| CA3162845A1 (en) * | 2019-12-23 | 2021-07-01 | Anastasia Khvorova | Oligonucleotides for tissue specific gene expression modulation |
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