JP2015531392A5 - - Google Patents
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- Publication number
- JP2015531392A5 JP2015531392A5 JP2015535066A JP2015535066A JP2015531392A5 JP 2015531392 A5 JP2015531392 A5 JP 2015531392A5 JP 2015535066 A JP2015535066 A JP 2015535066A JP 2015535066 A JP2015535066 A JP 2015535066A JP 2015531392 A5 JP2015531392 A5 JP 2015531392A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- morpholin
- methanone
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12188940.6 | 2012-10-18 | ||
| EP12188940 | 2012-10-18 | ||
| PCT/EP2013/071500 WO2014060398A1 (en) | 2012-10-18 | 2013-10-15 | Ethynyl derivatives as modulators of mglur5 receptor activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531392A JP2015531392A (ja) | 2015-11-02 |
| JP2015531392A5 true JP2015531392A5 (OSRAM) | 2016-07-28 |
| JP5989250B2 JP5989250B2 (ja) | 2016-09-07 |
Family
ID=47049067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015535066A Expired - Fee Related JP5989250B2 (ja) | 2012-10-18 | 2013-10-15 | Ｍｇｌｕｒ５受容体活性のモジュレーターとしてのエチニル誘導体 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9227959B2 (OSRAM) |
| EP (1) | EP2909180B1 (OSRAM) |
| JP (1) | JP5989250B2 (OSRAM) |
| KR (1) | KR101684816B1 (OSRAM) |
| CN (1) | CN104718192B (OSRAM) |
| AR (1) | AR093042A1 (OSRAM) |
| AU (1) | AU2013333988B2 (OSRAM) |
| BR (1) | BR112015006454A8 (OSRAM) |
| CA (1) | CA2882520A1 (OSRAM) |
| CL (1) | CL2015000891A1 (OSRAM) |
| CO (1) | CO7200248A2 (OSRAM) |
| CR (1) | CR20150144A (OSRAM) |
| EA (1) | EA025667B1 (OSRAM) |
| ES (1) | ES2599553T3 (OSRAM) |
| IL (1) | IL237380A (OSRAM) |
| MA (1) | MA38012B1 (OSRAM) |
| MX (1) | MX2015004898A (OSRAM) |
| MY (1) | MY168937A (OSRAM) |
| NZ (1) | NZ705144A (OSRAM) |
| PE (1) | PE20150629A1 (OSRAM) |
| PH (1) | PH12015500398B1 (OSRAM) |
| SG (1) | SG11201501392TA (OSRAM) |
| TW (1) | TWI490208B (OSRAM) |
| UA (1) | UA114529C2 (OSRAM) |
| WO (1) | WO2014060398A1 (OSRAM) |
| ZA (1) | ZA201500856B (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA114008C2 (xx) * | 2012-10-18 | 2017-04-10 | Похідні етинілу як модулятори активності рецептора mglur5 | |
| MX378334B (es) | 2015-06-03 | 2025-03-10 | Hoffmann La Roche | Modulador alostérico negativo de un receptor de glutamato metabotrópico (nam) y el uso del mismo para tratar ansiedad, dolor, depresión, parkinson y reflujo gastroesofágico. |
| CN108271370B (zh) * | 2015-09-25 | 2021-03-19 | (由卫生与公众服务部部长代表的)美利坚合众国 | 作为p2y14受体拮抗剂的三唑衍生物 |
| BR112020008583A2 (pt) | 2017-12-08 | 2020-10-20 | Boehringer Ingelheim International Gmbh | derivados de imidazopiridina e uso dos mesmos como medicamento |
| JP7093469B2 (ja) | 2018-10-17 | 2022-06-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ４－ピリジニルメチル－モルホリン誘導体および医薬としてのその使用 |
| WO2020079040A1 (en) * | 2018-10-17 | 2020-04-23 | Boehringer Ingelheim International Gmbh | 4-pyrimidin-5-ylmethyl-morpholine derivatives and the use thereof as medicament |
| US11166958B2 (en) * | 2018-10-17 | 2021-11-09 | Boehringer Ingelheim International Gmbh | 4-pyrazin-2-ylmethyl-morpholine derivatives and the use thereof as medicament |
| EP3980420B1 (en) | 2019-06-04 | 2023-04-19 | Boehringer Ingelheim International GmbH | Imidazopyrazine derivatives and the use thereof as medicament |
| TW202112378A (zh) | 2019-06-04 | 2021-04-01 | 德商百靈佳殷格翰國際股份有限公司 | 嘌呤衍生物及其作為藥物之用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| CA2689282A1 (en) * | 2007-06-03 | 2008-12-11 | Vanderbilt University | Benzamide mglur5 positive allosteric modulators and methods of making and using same |
| US8853392B2 (en) * | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
| US8389536B2 (en) * | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
| WO2013049255A1 (en) * | 2011-09-26 | 2013-04-04 | Vanderbilt University | Substitued 5-(prop-1-yn-1-yl)picolinamide analogs as allosteric modulators of mglur5 receptors |
-
2013
- 2013-10-15 PE PE2015000396A patent/PE20150629A1/es active IP Right Grant
- 2013-10-15 CA CA2882520A patent/CA2882520A1/en not_active Abandoned
- 2013-10-15 NZ NZ705144A patent/NZ705144A/en not_active IP Right Cessation
- 2013-10-15 MY MYPI2015000470A patent/MY168937A/en unknown
- 2013-10-15 KR KR1020157009544A patent/KR101684816B1/ko not_active Expired - Fee Related
- 2013-10-15 JP JP2015535066A patent/JP5989250B2/ja not_active Expired - Fee Related
- 2013-10-15 BR BR112015006454A patent/BR112015006454A8/pt not_active Application Discontinuation
- 2013-10-15 UA UAA201504680A patent/UA114529C2/uk unknown
- 2013-10-15 MX MX2015004898A patent/MX2015004898A/es unknown
- 2013-10-15 AU AU2013333988A patent/AU2013333988B2/en not_active Ceased
- 2013-10-15 EP EP13783003.0A patent/EP2909180B1/en active Active
- 2013-10-15 ES ES13783003.0T patent/ES2599553T3/es active Active
- 2013-10-15 WO PCT/EP2013/071500 patent/WO2014060398A1/en not_active Ceased
- 2013-10-15 EA EA201590699A patent/EA025667B1/ru not_active IP Right Cessation
- 2013-10-15 CN CN201380053660.XA patent/CN104718192B/zh not_active Expired - Fee Related
- 2013-10-15 SG SG11201501392TA patent/SG11201501392TA/en unknown
- 2013-10-17 TW TW102137560A patent/TWI490208B/zh not_active IP Right Cessation
- 2013-10-17 AR ARP130103764A patent/AR093042A1/es unknown
-
2015
- 2015-02-05 ZA ZA2015/00856A patent/ZA201500856B/en unknown
- 2015-02-16 CO CO15032736A patent/CO7200248A2/es unknown
- 2015-02-23 IL IL237380A patent/IL237380A/en not_active IP Right Cessation
- 2015-02-24 PH PH12015500398A patent/PH12015500398B1/en unknown
- 2015-03-18 CR CR20150144A patent/CR20150144A/es unknown
- 2015-04-09 CL CL2015000891A patent/CL2015000891A1/es unknown
- 2015-04-17 US US14/689,375 patent/US9227959B2/en active Active
- 2015-04-17 MA MA38012A patent/MA38012B1/fr unknown
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