JP2015531387A5 - - Google Patents
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- Publication number
- JP2015531387A5 JP2015531387A5 JP2015535011A JP2015535011A JP2015531387A5 JP 2015531387 A5 JP2015531387 A5 JP 2015531387A5 JP 2015535011 A JP2015535011 A JP 2015535011A JP 2015535011 A JP2015535011 A JP 2015535011A JP 2015531387 A5 JP2015531387 A5 JP 2015531387A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- poxvirus
- group
- phosphate
- polyvinylpyrrolidone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 32
- 238000009472 formulation Methods 0.000 claims 25
- 238000002360 preparation method Methods 0.000 claims 14
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 claims 7
- 241000700618 Vaccinia virus Species 0.000 claims 7
- 239000004475 Arginine Substances 0.000 claims 6
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 6
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 229930006000 Sucrose Natural products 0.000 claims 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 6
- 229960003121 arginine Drugs 0.000 claims 6
- 235000009697 arginine Nutrition 0.000 claims 6
- 229930195712 glutamate Natural products 0.000 claims 6
- 229940049906 glutamate Drugs 0.000 claims 6
- 239000005720 sucrose Substances 0.000 claims 6
- 229910019142 PO4 Inorganic materials 0.000 claims 5
- 239000000463 material Substances 0.000 claims 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 5
- 239000010452 phosphate Substances 0.000 claims 5
- 102000006601 Thymidine Kinase Human genes 0.000 claims 4
- 108020004440 Thymidine kinase Proteins 0.000 claims 4
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 4
- 229910000397 disodium phosphate Inorganic materials 0.000 claims 4
- 235000019800 disodium phosphate Nutrition 0.000 claims 4
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims 4
- 235000019796 monopotassium phosphate Nutrition 0.000 claims 4
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 4
- 239000001488 sodium phosphate Substances 0.000 claims 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
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- 239000002245 particle Substances 0.000 claims 2
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- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
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- FDKWRPBBCBCIGA-REOHCLBHSA-N (2r)-2-azaniumyl-3-$l^{1}-selanylpropanoate Chemical compound [Se]C[C@H](N)C(O)=O FDKWRPBBCBCIGA-REOHCLBHSA-N 0.000 claims 1
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- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 1
- AJTVSSFTXWNIRG-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanesulfonic acid Chemical compound OCC[NH+](CCO)CCS([O-])(=O)=O AJTVSSFTXWNIRG-UHFFFAOYSA-N 0.000 claims 1
- LVQFQZZGTZFUNF-UHFFFAOYSA-N 2-hydroxy-3-[4-(2-hydroxy-3-sulfonatopropyl)piperazine-1,4-diium-1-yl]propane-1-sulfonate Chemical compound OS(=O)(=O)CC(O)CN1CCN(CC(O)CS(O)(=O)=O)CC1 LVQFQZZGTZFUNF-UHFFFAOYSA-N 0.000 claims 1
- DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 claims 1
- RZQXOGQSPBYUKH-UHFFFAOYSA-N 3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound OCC(CO)(CO)NCC(O)CS(O)(=O)=O RZQXOGQSPBYUKH-UHFFFAOYSA-N 0.000 claims 1
- XCBLFURAFHFFJF-UHFFFAOYSA-N 3-[bis(2-hydroxyethyl)azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound OCCN(CCO)CC(O)CS(O)(=O)=O XCBLFURAFHFFJF-UHFFFAOYSA-N 0.000 claims 1
- VTOWJTPBPWTSMK-UHFFFAOYSA-N 4-morpholin-4-ylbutane-1-sulfonic acid Chemical compound OS(=O)(=O)CCCCN1CCOCC1 VTOWJTPBPWTSMK-UHFFFAOYSA-N 0.000 claims 1
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- 239000004135 Bone phosphate Substances 0.000 claims 1
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- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306198 | 2012-10-02 | ||
| EP12306198.8 | 2012-10-02 | ||
| PCT/EP2013/070590 WO2014053571A1 (en) | 2012-10-02 | 2013-10-02 | Virus-containing formulation and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531387A JP2015531387A (ja) | 2015-11-02 |
| JP2015531387A5 true JP2015531387A5 (https=) | 2016-11-17 |
| JP6466332B2 JP6466332B2 (ja) | 2019-02-06 |
Family
ID=47018930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015535011A Active JP6466332B2 (ja) | 2012-10-02 | 2013-10-02 | ウイルス含有製剤およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10111947B2 (https=) |
| EP (1) | EP2903600B1 (https=) |
| JP (1) | JP6466332B2 (https=) |
| KR (1) | KR102181658B1 (https=) |
| CN (1) | CN104797242B (https=) |
| AU (1) | AU2013326548B2 (https=) |
| BR (1) | BR112015007314B1 (https=) |
| CA (1) | CA2887156C (https=) |
| DK (1) | DK2903600T3 (https=) |
| ES (1) | ES2928670T3 (https=) |
| IL (1) | IL238064B (https=) |
| MX (1) | MX374287B (https=) |
| NZ (1) | NZ707328A (https=) |
| RU (1) | RU2686108C2 (https=) |
| SG (1) | SG11201502621XA (https=) |
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