JP2015529687A5 - - Google Patents
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- JP2015529687A5 JP2015529687A5 JP2015532150A JP2015532150A JP2015529687A5 JP 2015529687 A5 JP2015529687 A5 JP 2015529687A5 JP 2015532150 A JP2015532150 A JP 2015532150A JP 2015532150 A JP2015532150 A JP 2015532150A JP 2015529687 A5 JP2015529687 A5 JP 2015529687A5
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- 239000000203 mixture Substances 0.000 claims description 124
- 210000004027 cell Anatomy 0.000 claims description 90
- 210000001519 tissue Anatomy 0.000 claims description 76
- 238000000034 method Methods 0.000 claims description 39
- 230000002491 angiogenic effect Effects 0.000 claims description 22
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 22
- 241000124008 Mammalia Species 0.000 claims description 16
- 208000027418 Wounds and injury Diseases 0.000 claims description 14
- 230000006378 damage Effects 0.000 claims description 14
- 208000014674 injury Diseases 0.000 claims description 14
- 108091005804 Peptidases Proteins 0.000 claims description 11
- 102000035195 Peptidases Human genes 0.000 claims description 11
- 239000004365 Protease Substances 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 11
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 241000700605 Viruses Species 0.000 claims description 8
- 210000000988 bone and bone Anatomy 0.000 claims description 8
- 239000011159 matrix material Substances 0.000 claims description 8
- 210000000130 stem cell Anatomy 0.000 claims description 8
- 108060005980 Collagenase Proteins 0.000 claims description 7
- 102000029816 Collagenase Human genes 0.000 claims description 7
- 238000013019 agitation Methods 0.000 claims description 7
- 210000000170 cell membrane Anatomy 0.000 claims description 7
- 238000005119 centrifugation Methods 0.000 claims description 7
- 229960002424 collagenase Drugs 0.000 claims description 7
- 238000010494 dissociation reaction Methods 0.000 claims description 7
- 230000005593 dissociations Effects 0.000 claims description 7
- 108090001109 Thermolysin Proteins 0.000 claims description 6
- 108010007093 dispase Proteins 0.000 claims description 6
- 210000001789 adipocyte Anatomy 0.000 claims description 5
- 238000001990 intravenous administration Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 230000000415 inactivating effect Effects 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 210000003491 skin Anatomy 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 210000002435 tendon Anatomy 0.000 claims description 4
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims description 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 3
- 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 claims description 3
- 101001011906 Homo sapiens Matrix metalloproteinase-14 Proteins 0.000 claims description 3
- 102100030216 Matrix metalloproteinase-14 Human genes 0.000 claims description 3
- 210000002744 extracellular matrix Anatomy 0.000 claims description 3
- 230000002792 vascular Effects 0.000 claims description 3
- 206010073306 Exposure to radiation Diseases 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- 206010063837 Reperfusion injury Diseases 0.000 claims description 2
- 208000026137 Soft tissue injury Diseases 0.000 claims description 2
- 210000004381 amniotic fluid Anatomy 0.000 claims description 2
- 206010003246 arthritis Diseases 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 210000000845 cartilage Anatomy 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 208000037906 ischaemic injury Diseases 0.000 claims description 2
- 210000003041 ligament Anatomy 0.000 claims description 2
- 210000003205 muscle Anatomy 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 230000017423 tissue regeneration Effects 0.000 claims description 2
- 210000003954 umbilical cord Anatomy 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000000735 allogeneic effect Effects 0.000 description 6
- 239000011176 biofiber Substances 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 206010007710 Cartilage injury Diseases 0.000 description 1
- 206010061223 Ligament injury Diseases 0.000 description 1
- 206010061363 Skeletal injury Diseases 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 208000021945 Tendon injury Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703203P | 2012-09-19 | 2012-09-19 | |
| US61/703,203 | 2012-09-19 | ||
| PCT/US2013/060181 WO2014047067A1 (en) | 2012-09-19 | 2013-09-17 | Compositions and methods for treating and preventing tissue injury and disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018017025A Division JP6755893B2 (ja) | 2012-09-19 | 2018-02-02 | 組織傷害および疾患を処置および予防するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529687A JP2015529687A (ja) | 2015-10-08 |
| JP2015529687A5 true JP2015529687A5 (enExample) | 2016-10-27 |
| JP6456829B2 JP6456829B2 (ja) | 2019-01-23 |
Family
ID=50341889
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532150A Active JP6456829B2 (ja) | 2012-09-19 | 2013-09-17 | 組織傷害および疾患を処置および予防するための組成物および方法 |
| JP2018017025A Active JP6755893B2 (ja) | 2012-09-19 | 2018-02-02 | 組織傷害および疾患を処置および予防するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018017025A Active JP6755893B2 (ja) | 2012-09-19 | 2018-02-02 | 組織傷害および疾患を処置および予防するための組成物および方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9713629B2 (enExample) |
| EP (2) | EP3476410B1 (enExample) |
| JP (2) | JP6456829B2 (enExample) |
| KR (1) | KR102270617B1 (enExample) |
| CN (1) | CN104955464B (enExample) |
| AU (2) | AU2013318243B2 (enExample) |
| BR (1) | BR112015006055A2 (enExample) |
| CA (1) | CA2885419A1 (enExample) |
| DK (1) | DK2898064T3 (enExample) |
| ES (2) | ES2899209T3 (enExample) |
| WO (1) | WO2014047067A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2613547T3 (es) | 2011-03-18 | 2017-05-24 | Microvascular Tissues, Inc. | Tejido microvascular alogénico para tratamientos de tejidos blandos |
| US10596202B2 (en) | 2012-09-19 | 2020-03-24 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US11819522B2 (en) | 2012-09-19 | 2023-11-21 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US9872937B2 (en) | 2012-09-19 | 2018-01-23 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| ES2899209T3 (es) | 2012-09-19 | 2022-03-10 | Microvascular Tissues Inc | Composiciones y métodos para tratar y prevenir lesión y enfermedad tisular |
| WO2016111899A1 (en) * | 2015-01-05 | 2016-07-14 | Petrucci Gary M | Methods and materials for treating lung disorders |
| US12551509B2 (en) | 2015-11-18 | 2026-02-17 | Lucina Patent Holdco, Llc | Acellular regenerative products and methods of their manufacture |
| CN108289915A (zh) * | 2015-11-24 | 2018-07-17 | 日本乐敦制药株式会社 | 包含脂肪组织来源基质细胞的肝病治疗剂及其制造方法 |
| US10993969B2 (en) | 2016-02-05 | 2021-05-04 | Gary M. Petrucci | Methods and materials for treating nerve injuries and neurological disorders |
| CN109072185A (zh) * | 2016-03-02 | 2018-12-21 | 微血管组织有限公司 | 增强型多能细胞和微血管组织以及其使用方法 |
| EP3223181B1 (en) * | 2016-03-24 | 2019-12-18 | Sofradim Production | System and method of generating a model and simulating an effect on a surgical repair site |
| AR104691A1 (es) * | 2016-05-18 | 2017-08-09 | Labyes De Uruguay S A | Composición veterinaria de imidacloprid, moxidectina y praziquantel de administración tópica cutánea (spot on) para tratamiento y prevención de las ecto y endoparasitosis que afectan a los perros |
| EP3474665A4 (en) * | 2016-06-24 | 2020-01-01 | Osiris Therapeutics, Inc. | VIVABLE LYOPHILIZED COMPOSITIONS OBTAINED FROM HUMAN TISSUE AND METHOD FOR THE PRODUCTION THEREOF |
| EP3474869B1 (en) | 2016-06-24 | 2025-04-09 | Osiris Therapeutics, Inc. | Human tissue derived compositions and uses thereof |
| US10478531B2 (en) | 2017-06-22 | 2019-11-19 | Gary M. Petrucci | Methods and materials for treating blood vessels |
| WO2019006328A1 (en) * | 2017-06-30 | 2019-01-03 | Allosource | CELL BONE GRAFTS, AND METHODS OF MAKING AND USING |
| US20190083547A1 (en) * | 2017-09-19 | 2019-03-21 | Gary M. Petrucci | Transdermal delivery of amnion tissue preparations |
| US10251917B1 (en) | 2017-09-19 | 2019-04-09 | Gary M. Petrucci | Methods and materials for treating tumors |
| BR112022000502A2 (pt) * | 2019-08-09 | 2022-03-15 | Axolotl Biologix Inc | Método para preparar uma composição derivada de âmnion humano acelular configurada para uso terapêutico, método para tratar um sujeito sofrendo de doença articular degenerativa, e composição derivada de âmnion humano |
| IL293317A (en) * | 2019-11-29 | 2022-07-01 | Novadip Biosciences | Biomaterials for the prevention and the treatment of tissue disorders |
| CN116195741B (zh) * | 2021-11-30 | 2024-07-09 | 内蒙古伊利实业集团股份有限公司 | 乳双歧杆菌bb-12在保护软骨中的应用 |
| JP7376897B2 (ja) * | 2022-03-09 | 2023-11-09 | 成浩 小島 | 摘出組織処理装置、および摘出組織処理方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5358931A (en) | 1990-01-17 | 1994-10-25 | The Regents Of The University Of California | Interaction of thermal hysteresis proteins with cells and cell membranes and associated applications |
| DE69534151T2 (de) | 1994-02-22 | 2006-01-12 | Nippon Telegraph And Telephone Corp. | Gefriergetrocknete Blutzellen, Stammzellen und Plättchen und Verfahren zu deren Herstellung |
| JP3183074B2 (ja) | 1994-06-14 | 2001-07-03 | 松下電器産業株式会社 | 音声符号化装置 |
| US5786907A (en) | 1994-12-20 | 1998-07-28 | International Business Machines Corporation | High speed color compensation system |
| WO1997026326A1 (en) | 1996-01-16 | 1997-07-24 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and non-hematopoietic tissues and their use |
| US6200606B1 (en) | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| US5786207A (en) | 1997-05-28 | 1998-07-28 | University Of Pittsburgh | Tissue dissociating system and method |
| US6355699B1 (en) | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
| US6200506B1 (en) | 1999-12-10 | 2001-03-13 | Tachi-Co., Ltd | Method for forming a headrest |
| ATE542123T1 (de) | 2002-06-27 | 2012-02-15 | Core Dynamics Ltd | Verbessertes verfahren zum einfrieren lebensfähiger zellen |
| US20060127873A1 (en) | 2002-07-16 | 2006-06-15 | Caroline Hoemann | Composition for cytocompatible, injectable, self-gelling chitosan solutions for encapsulating and delivering live cells or biologically active factors |
| AR047712A1 (es) | 2002-09-07 | 2006-02-15 | Royal Veterinary College | Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas |
| US7270946B2 (en) | 2002-10-04 | 2007-09-18 | Organ Recovery Systems, Inc. | Method for treatment of cellular materials with sugars prior to preservation |
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| US9301976B2 (en) * | 2010-08-19 | 2016-04-05 | The Regents Of The University Of California | Compositions comprising perivascular stem cells and nell-1 protein |
| AU2011295779B2 (en) * | 2010-09-01 | 2015-08-27 | Miromatrix Medical Inc. | Methods of recellularizing a tissue or organ for improved transplantability |
| WO2012091911A1 (en) * | 2010-12-27 | 2012-07-05 | Intellicell Biosciences, Inc. | Ultrasonic cavitation derived stromal or mesenchymal vascular extracts and cells derived therefrom obtained from adipose tissue and use thereof |
| ES2613547T3 (es) | 2011-03-18 | 2017-05-24 | Microvascular Tissues, Inc. | Tejido microvascular alogénico para tratamientos de tejidos blandos |
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| WO2013142192A1 (en) | 2012-03-19 | 2013-09-26 | Richard Burt | Methods and compositions for regenerating and repairing damaged tissue using nonviable irradiated or lyophilized pluripotent stem cells |
| US10596202B2 (en) | 2012-09-19 | 2020-03-24 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US9872937B2 (en) | 2012-09-19 | 2018-01-23 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| ES2899209T3 (es) | 2012-09-19 | 2022-03-10 | Microvascular Tissues Inc | Composiciones y métodos para tratar y prevenir lesión y enfermedad tisular |
| EP3660140A1 (en) | 2014-01-31 | 2020-06-03 | DSM IP Assets B.V. | Adipose tissue processing centrifuge and methods of use |
-
2013
- 2013-09-17 ES ES18205901T patent/ES2899209T3/es active Active
- 2013-09-17 KR KR1020157008714A patent/KR102270617B1/ko active Active
- 2013-09-17 BR BR112015006055A patent/BR112015006055A2/pt not_active Application Discontinuation
- 2013-09-17 CN CN201380059307.2A patent/CN104955464B/zh not_active Expired - Fee Related
- 2013-09-17 JP JP2015532150A patent/JP6456829B2/ja active Active
- 2013-09-17 EP EP18205901.4A patent/EP3476410B1/en active Active
- 2013-09-17 US US14/429,511 patent/US9713629B2/en active Active
- 2013-09-17 EP EP13839621.3A patent/EP2898064B1/en active Active
- 2013-09-17 DK DK13839621.3T patent/DK2898064T3/en active
- 2013-09-17 CA CA2885419A patent/CA2885419A1/en active Pending
- 2013-09-17 ES ES13839621T patent/ES2710921T3/es active Active
- 2013-09-17 WO PCT/US2013/060181 patent/WO2014047067A1/en not_active Ceased
- 2013-09-17 AU AU2013318243A patent/AU2013318243B2/en active Active
-
2017
- 2017-06-26 US US15/633,311 patent/US10729729B2/en active Active
-
2018
- 2018-02-02 JP JP2018017025A patent/JP6755893B2/ja active Active
-
2019
- 2019-05-21 AU AU2019203555A patent/AU2019203555B2/en active Active
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