JP2015524420A5 - - Google Patents
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- Publication number
- JP2015524420A5 JP2015524420A5 JP2015523536A JP2015523536A JP2015524420A5 JP 2015524420 A5 JP2015524420 A5 JP 2015524420A5 JP 2015523536 A JP2015523536 A JP 2015523536A JP 2015523536 A JP2015523536 A JP 2015523536A JP 2015524420 A5 JP2015524420 A5 JP 2015524420A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- hpv type
- seq
- terminal
- hpv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims 60
- 108090000623 proteins and genes Proteins 0.000 claims 60
- 102000037865 fusion proteins Human genes 0.000 claims 35
- 108020001507 fusion proteins Proteins 0.000 claims 35
- 108090000765 processed proteins & peptides Proteins 0.000 claims 32
- 210000004899 c-terminal region Anatomy 0.000 claims 29
- 229920001184 polypeptide Polymers 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 29
- 239000012634 fragment Substances 0.000 claims 26
- 239000000427 antigen Substances 0.000 claims 19
- 102000036639 antigens Human genes 0.000 claims 19
- 108091007433 antigens Proteins 0.000 claims 19
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 14
- 230000028993 immune response Effects 0.000 claims 12
- 230000001575 pathological effect Effects 0.000 claims 12
- 230000002265 prevention Effects 0.000 claims 11
- 241000341655 Human papillomavirus type 16 Species 0.000 claims 9
- 238000011282 treatment Methods 0.000 claims 9
- 210000001744 T-lymphocyte Anatomy 0.000 claims 8
- 230000001939 inductive effect Effects 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 5
- 244000052769 pathogen Species 0.000 claims 5
- 230000001717 pathogenic effect Effects 0.000 claims 5
- 231100000588 tumorigenic Toxicity 0.000 claims 5
- 230000000381 tumorigenic effect Effects 0.000 claims 5
- 230000001024 immunotherapeutic effect Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 241000588832 Bordetella pertussis Species 0.000 claims 2
- 241000588807 Bordetella Species 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 101150096136 cyaC gene Proteins 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305898.4A EP2689786A1 (en) | 2012-07-23 | 2012-07-23 | HPV/CYAA-based chimeric proteins and their uses in the induction of immune responses against HPV infection and HPV-induced disorders |
| EP12305898.4 | 2012-07-23 | ||
| PCT/EP2013/065549 WO2014016312A1 (en) | 2012-07-23 | 2013-07-23 | Hpv/cyaa-based chimeric proteins and their uses in the induction of immune responses against hpv infection and hpv-induced disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524420A JP2015524420A (ja) | 2015-08-24 |
| JP2015524420A5 true JP2015524420A5 (enExample) | 2016-08-18 |
| JP6466328B2 JP6466328B2 (ja) | 2019-02-13 |
Family
ID=48832935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015523536A Expired - Fee Related JP6466328B2 (ja) | 2012-07-23 | 2013-07-23 | ＨＰＶ／ＣｙａＡベースのキメラタンパク質並びにＨＰＶ感染及びＨＰＶ誘導性障害に対する免疫応答の誘導におけるその使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9827302B2 (enExample) |
| EP (2) | EP2689786A1 (enExample) |
| JP (1) | JP6466328B2 (enExample) |
| KR (1) | KR20150031487A (enExample) |
| CN (1) | CN104736173B (enExample) |
| AU (1) | AU2013295047B2 (enExample) |
| CA (1) | CA2879999A1 (enExample) |
| DK (1) | DK2874657T3 (enExample) |
| ES (1) | ES2712647T3 (enExample) |
| HR (1) | HRP20190108T1 (enExample) |
| HU (1) | HUE042808T2 (enExample) |
| LT (1) | LT2874657T (enExample) |
| MX (1) | MX2015001021A (enExample) |
| PL (1) | PL2874657T3 (enExample) |
| PT (1) | PT2874657T (enExample) |
| RS (1) | RS58313B1 (enExample) |
| RU (1) | RU2015100212A (enExample) |
| SI (1) | SI2874657T1 (enExample) |
| SM (1) | SMT201900057T1 (enExample) |
| TR (1) | TR201900695T4 (enExample) |
| WO (1) | WO2014016312A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2690172A1 (en) * | 2012-07-23 | 2014-01-29 | Genticel | CYAA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses |
| EP3037103A1 (en) | 2014-12-23 | 2016-06-29 | Genticel | Immunotherapeutic vaccine comprising E7 proteins of HPV16 and HPV18 fused with CyaA, for use in subjects infected with HPV |
| EP3323424A1 (en) * | 2016-11-17 | 2018-05-23 | Cyanimal IP | Cyaa polypeptides as immune enhancer |
| CN112912097A (zh) * | 2018-08-23 | 2021-06-04 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性蛋白和组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01209817A (ja) | 1988-02-17 | 1989-08-23 | Yamaha Corp | 浮動少数点形ディジタル・アナログ変換器 |
| ATE438409T1 (de) | 2000-09-15 | 2009-08-15 | Pasteur Institut | Proteinhaltigen vektoren zur einführung von moleküle in cd11b exprimirende zellen |
| EP1489092A1 (en) | 2003-06-18 | 2004-12-22 | Institut Pasteur | Modified Bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof |
| SI1576967T1 (sl) | 2004-03-18 | 2008-02-29 | Pasteur Institut | Rekombinantni protein, ki nosi epitope humanega papilomavirusa, vstavljene v adenilat ciklazni protein ali njegov fragment, in njegove terapevtske uporabe |
| JP5753083B2 (ja) | 2008-07-22 | 2015-07-22 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | Ａｄｐ検出に基づく発光ホスホトランスフェラーゼまたはａｔｐヒドロラーゼのアッセイ法 |
| EP2478915A1 (en) * | 2011-01-24 | 2012-07-25 | Genticel | CyaA-carried polypeptide(s) and use to induce both therapeutic and prophylactic immune responses |
-
2012
- 2012-07-23 EP EP12305898.4A patent/EP2689786A1/en not_active Withdrawn
-
2013
- 2013-07-23 HR HRP20190108TT patent/HRP20190108T1/hr unknown
- 2013-07-23 EP EP13739725.3A patent/EP2874657B1/en active Active
- 2013-07-23 SI SI201331327T patent/SI2874657T1/sl unknown
- 2013-07-23 CA CA2879999A patent/CA2879999A1/en not_active Abandoned
- 2013-07-23 ES ES13739725T patent/ES2712647T3/es active Active
- 2013-07-23 US US14/416,384 patent/US9827302B2/en not_active Expired - Fee Related
- 2013-07-23 HU HUE13739725A patent/HUE042808T2/hu unknown
- 2013-07-23 DK DK13739725.3T patent/DK2874657T3/en active
- 2013-07-23 LT LTEP13739725.3T patent/LT2874657T/lt unknown
- 2013-07-23 MX MX2015001021A patent/MX2015001021A/es unknown
- 2013-07-23 KR KR20157004540A patent/KR20150031487A/ko not_active Withdrawn
- 2013-07-23 TR TR2019/00695T patent/TR201900695T4/en unknown
- 2013-07-23 RS RS20190082A patent/RS58313B1/sr unknown
- 2013-07-23 WO PCT/EP2013/065549 patent/WO2014016312A1/en not_active Ceased
- 2013-07-23 RU RU2015100212A patent/RU2015100212A/ru not_active Application Discontinuation
- 2013-07-23 AU AU2013295047A patent/AU2013295047B2/en not_active Ceased
- 2013-07-23 CN CN201380049453.7A patent/CN104736173B/zh not_active Expired - Fee Related
- 2013-07-23 JP JP2015523536A patent/JP6466328B2/ja not_active Expired - Fee Related
- 2013-07-23 PT PT13739725T patent/PT2874657T/pt unknown
- 2013-07-23 SM SM20190057T patent/SMT201900057T1/it unknown
- 2013-07-23 PL PL13739725T patent/PL2874657T3/pl unknown
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