CN104736173B - 基于hpv/cyaa的嵌合蛋白及它们在诱导针对hpv感染和hpv诱导的疾病的免疫应答中的应用 - Google Patents
基于hpv/cyaa的嵌合蛋白及它们在诱导针对hpv感染和hpv诱导的疾病的免疫应答中的应用 Download PDFInfo
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
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- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00011—Details
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- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Biotechnology (AREA)
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- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Mycology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305898.4A EP2689786A1 (en) | 2012-07-23 | 2012-07-23 | HPV/CYAA-based chimeric proteins and their uses in the induction of immune responses against HPV infection and HPV-induced disorders |
| EP12305898.4 | 2012-07-23 | ||
| PCT/EP2013/065549 WO2014016312A1 (en) | 2012-07-23 | 2013-07-23 | Hpv/cyaa-based chimeric proteins and their uses in the induction of immune responses against hpv infection and hpv-induced disorders |
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| Publication Number | Publication Date |
|---|---|
| CN104736173A CN104736173A (zh) | 2015-06-24 |
| CN104736173B true CN104736173B (zh) | 2019-02-05 |
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| EP (2) | EP2689786A1 (enExample) |
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| EP2690172A1 (en) * | 2012-07-23 | 2014-01-29 | Genticel | CYAA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses |
| EP3037103A1 (en) | 2014-12-23 | 2016-06-29 | Genticel | Immunotherapeutic vaccine comprising E7 proteins of HPV16 and HPV18 fused with CyaA, for use in subjects infected with HPV |
| EP3323424A1 (en) * | 2016-11-17 | 2018-05-23 | Cyanimal IP | Cyaa polypeptides as immune enhancer |
| WO2020039033A1 (en) * | 2018-08-23 | 2020-02-27 | Glaxosmithkline Biologicals Sa | Immunogenic proteins and compositions |
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| JPH01209817A (ja) | 1988-02-17 | 1989-08-23 | Yamaha Corp | 浮動少数点形ディジタル・アナログ変換器 |
| PT1188446E (pt) | 2000-09-15 | 2009-11-10 | Pasteur Institut | Vectores proteinácios para a distribuição da molécula a células que expressam cd11b |
| EP1489092A1 (en) | 2003-06-18 | 2004-12-22 | Institut Pasteur | Modified Bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof |
| SI1576967T1 (sl) | 2004-03-18 | 2008-02-29 | Pasteur Institut | Rekombinantni protein, ki nosi epitope humanega papilomavirusa, vstavljene v adenilat ciklazni protein ali njegov fragment, in njegove terapevtske uporabe |
| US8183007B2 (en) | 2008-07-22 | 2012-05-22 | Promega Corporation | ADP detection based methods using adenylate cyclase and bioluminescence |
| EP2478915A1 (en) * | 2011-01-24 | 2012-07-25 | Genticel | CyaA-carried polypeptide(s) and use to induce both therapeutic and prophylactic immune responses |
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2013
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Non-Patent Citations (1)
| Title |
|---|
| Technology evaluation:HPV caccine (quadrivalent),Aventis Pasteur MSD/CSL;Reinis M;《CURRENT OPINION MOLECULAR THERAPEUTICS》;20041231;第6卷(第2期);第206-211页 |
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| ES2712647T3 (es) | 2019-05-14 |
| HRP20190108T1 (hr) | 2019-03-22 |
| PT2874657T (pt) | 2019-02-18 |
| JP2015524420A (ja) | 2015-08-24 |
| HK1208822A1 (en) | 2016-03-18 |
| KR20150031487A (ko) | 2015-03-24 |
| TR201900695T4 (en) | 2019-03-21 |
| US9827302B2 (en) | 2017-11-28 |
| HUE042808T2 (hu) | 2019-07-29 |
| SI2874657T1 (sl) | 2019-03-29 |
| CN104736173A (zh) | 2015-06-24 |
| LT2874657T (lt) | 2019-02-25 |
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| RU2015100212A (ru) | 2016-09-10 |
| AU2013295047A1 (en) | 2015-02-05 |
| RS58313B1 (sr) | 2019-03-29 |
| JP6466328B2 (ja) | 2019-02-13 |
| SMT201900057T1 (it) | 2019-02-28 |
| EP2874657A1 (en) | 2015-05-27 |
| DK2874657T3 (en) | 2019-02-11 |
| US20150250867A1 (en) | 2015-09-10 |
| PL2874657T3 (pl) | 2019-05-31 |
| CA2879999A1 (en) | 2014-01-30 |
| EP2874657B1 (en) | 2018-10-17 |
| MX2015001021A (es) | 2015-08-05 |
| EP2689786A1 (en) | 2014-01-29 |
| AU2013295047B2 (en) | 2018-02-22 |
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