JP2015524082A5 - - Google Patents
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- JP2015524082A5 JP2015524082A5 JP2015514217A JP2015514217A JP2015524082A5 JP 2015524082 A5 JP2015524082 A5 JP 2015524082A5 JP 2015514217 A JP2015514217 A JP 2015514217A JP 2015514217 A JP2015514217 A JP 2015514217A JP 2015524082 A5 JP2015524082 A5 JP 2015524082A5
- Authority
- JP
- Japan
- Prior art keywords
- copolymer
- group
- polymer
- ophthalmic device
- meth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001577 copolymer Polymers 0.000 claims description 46
- 229920000642 polymer Polymers 0.000 claims description 42
- 238000006116 polymerization reaction Methods 0.000 claims description 11
- 150000002632 lipids Chemical class 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 229920001296 polysiloxane Polymers 0.000 claims description 7
- 239000003431 cross linking reagent Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 description 41
- 238000000034 method Methods 0.000 description 20
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 17
- 239000000178 monomer Substances 0.000 description 13
- -1 cyano, silyl Chemical group 0.000 description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 8
- 239000003889 eye drop Substances 0.000 description 8
- 229920001515 polyalkylene glycol Polymers 0.000 description 6
- 239000004971 Cross linker Substances 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 125000000129 anionic group Chemical group 0.000 description 4
- 229920006037 cross link polymer Polymers 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 3
- 125000002947 alkylene group Chemical group 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 229920000831 ionic polymer Polymers 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- HMYBDZFSXBJDGL-UHFFFAOYSA-N 1,3-bis(ethenyl)imidazolidin-2-one Chemical compound C=CN1CCN(C=C)C1=O HMYBDZFSXBJDGL-UHFFFAOYSA-N 0.000 description 2
- BJELTSYBAHKXRW-UHFFFAOYSA-N 2,4,6-triallyloxy-1,3,5-triazine Chemical compound C=CCOC1=NC(OCC=C)=NC(OCC=C)=N1 BJELTSYBAHKXRW-UHFFFAOYSA-N 0.000 description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- XRUKRHLZDVJJSX-UHFFFAOYSA-N 4-cyanopentanoic acid Chemical class N#CC(C)CCC(O)=O XRUKRHLZDVJJSX-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical class C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 125000004423 acyloxy group Chemical group 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 125000004663 dialkyl amino group Chemical group 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229920001480 hydrophilic copolymer Polymers 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- WFKAJVHLWXSISD-UHFFFAOYSA-N isobutyramide Chemical compound CC(C)C(N)=O WFKAJVHLWXSISD-UHFFFAOYSA-N 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000004929 pyrrolidonyl group Chemical group N1(C(CCC1)=O)* 0.000 description 2
- 229920000208 temperature-responsive polymer Polymers 0.000 description 2
- HXKKHQJGJAFBHI-UHFFFAOYSA-N 1-aminopropan-2-ol Chemical compound CC(O)CN HXKKHQJGJAFBHI-UHFFFAOYSA-N 0.000 description 1
- ABYZXVFUYMAIGL-UHFFFAOYSA-N 3-(2-methylbutyl)aziridin-2-one Chemical compound CCC(C)CC1NC1=O ABYZXVFUYMAIGL-UHFFFAOYSA-N 0.000 description 1
- PWXIKGAMKWRXHD-UHFFFAOYSA-N 3-butylaziridin-2-one Chemical group CCCCC1NC1=O PWXIKGAMKWRXHD-UHFFFAOYSA-N 0.000 description 1
- JRDBJIDIYUPWNR-UHFFFAOYSA-N 3-pentan-2-ylaziridin-2-one Chemical group CCCC(C)C1NC1=O JRDBJIDIYUPWNR-UHFFFAOYSA-N 0.000 description 1
- 101710141544 Allatotropin-related peptide Proteins 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- CVCDIGOEHQSPNM-UHFFFAOYSA-N CNC(C)=O.C(CC)S(=O)(=O)O Chemical compound CNC(C)=O.C(CC)S(=O)(=O)O CVCDIGOEHQSPNM-UHFFFAOYSA-N 0.000 description 1
- VKTUOEHEJNQDBY-UHFFFAOYSA-N C[N+](C)(C)CC(O)=P(CCC([O-])=O)=O Chemical compound C[N+](C)(C)CC(O)=P(CCC([O-])=O)=O VKTUOEHEJNQDBY-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- MGJKQDOBUOMPEZ-UHFFFAOYSA-N N,N'-dimethylurea Chemical compound CNC(=O)NC MGJKQDOBUOMPEZ-UHFFFAOYSA-N 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical class CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 125000002015 acyclic group Chemical group 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 125000005333 aroyloxy group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 238000010560 atom transfer radical polymerization reaction Methods 0.000 description 1
- 125000000656 azaniumyl group Chemical group [H][N+]([H])([H])[*] 0.000 description 1
- 125000005620 boronic acid group Chemical group 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical compound NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical class CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- IXHFNEAFAWRVCF-UHFFFAOYSA-N n,2-dimethylpropanamide Chemical compound CNC(=O)C(C)C IXHFNEAFAWRVCF-UHFFFAOYSA-N 0.000 description 1
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 description 1
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 1
- ZTUGCJNAJJDKDC-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(=C)C(=O)NCCCO ZTUGCJNAJJDKDC-UHFFFAOYSA-N 0.000 description 1
- RKISUIUJZGSLEV-UHFFFAOYSA-N n-[2-(octadecanoylamino)ethyl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCCNC(=O)CCCCCCCCCCCCCCCCC RKISUIUJZGSLEV-UHFFFAOYSA-N 0.000 description 1
- LFKORVQXDHAIFK-UHFFFAOYSA-N n-[2-[2-(prop-2-enoylamino)ethoxy]ethyl]prop-2-enamide Chemical compound C=CC(=O)NCCOCCNC(=O)C=C LFKORVQXDHAIFK-UHFFFAOYSA-N 0.000 description 1
- QJQAMHYHNCADNR-UHFFFAOYSA-N n-methylpropanamide Chemical compound CCC(=O)NC QJQAMHYHNCADNR-UHFFFAOYSA-N 0.000 description 1
- CHDKQNHKDMEASZ-UHFFFAOYSA-N n-prop-2-enoylprop-2-enamide Chemical compound C=CC(=O)NC(=O)C=C CHDKQNHKDMEASZ-UHFFFAOYSA-N 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- 150000004714 phosphonium salts Chemical class 0.000 description 1
- 125000004928 piperidonyl group Chemical group 0.000 description 1
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 description 1
- 239000012985 polymerization agent Substances 0.000 description 1
- XUWVIABDWDTJRZ-UHFFFAOYSA-N propan-2-ylazanide Chemical compound CC(C)[NH-] XUWVIABDWDTJRZ-UHFFFAOYSA-N 0.000 description 1
- KCXFHTAICRTXLI-UHFFFAOYSA-M propane-1-sulfonate Chemical compound CCCS([O-])(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-M 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000005415 substituted alkoxy group Chemical group 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261651767P | 2012-05-25 | 2012-05-25 | |
| US61/651,767 | 2012-05-25 | ||
| US201361771959P | 2013-03-04 | 2013-03-04 | |
| US201361771961P | 2013-03-04 | 2013-03-04 | |
| US61/771,959 | 2013-03-04 | ||
| US61/771,961 | 2013-03-04 | ||
| US13/840,919 | 2013-03-15 | ||
| US13/840,919 US10073192B2 (en) | 2012-05-25 | 2013-03-15 | Polymers and nanogel materials and methods for making and using the same |
| US13/899,694 US9244196B2 (en) | 2012-05-25 | 2013-05-22 | Polymers and nanogel materials and methods for making and using the same |
| US13/899,694 | 2013-05-22 | ||
| US13/899,676 | 2013-05-22 | ||
| US13/899,676 US9297929B2 (en) | 2012-05-25 | 2013-05-22 | Contact lenses comprising water soluble N-(2 hydroxyalkyl) (meth)acrylamide polymers or copolymers |
| PCT/US2013/042628 WO2013177506A2 (en) | 2012-05-25 | 2013-05-24 | Polymers and nanogel materials and methods for making and using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018014560A Division JP2018092178A (ja) | 2012-05-25 | 2018-01-31 | ポリマー及びナノゲル材料並びにその製造方法及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524082A JP2015524082A (ja) | 2015-08-20 |
| JP2015524082A5 true JP2015524082A5 (enExample) | 2016-07-14 |
| JP6290189B2 JP6290189B2 (ja) | 2018-03-07 |
Family
ID=49624375
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514217A Expired - Fee Related JP6290189B2 (ja) | 2012-05-25 | 2013-05-24 | ポリマー及びナノゲル材料並びにその製造方法及び使用方法 |
| JP2015514219A Pending JP2015526745A (ja) | 2012-05-25 | 2013-05-24 | 水溶性ｎ−（２ヒドロキシアルキル）（メタ）アクリルアミドポリマー又はコポリマーを含むコンタクトレンズ |
| JP2017218977A Active JP6526768B2 (ja) | 2012-05-25 | 2017-11-14 | 水溶性ｎ−（２ヒドロキシアルキル）（メタ）アクリルアミドポリマー又はコポリマーを含むコンタクトレンズ |
| JP2018014560A Pending JP2018092178A (ja) | 2012-05-25 | 2018-01-31 | ポリマー及びナノゲル材料並びにその製造方法及び使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514219A Pending JP2015526745A (ja) | 2012-05-25 | 2013-05-24 | 水溶性ｎ−（２ヒドロキシアルキル）（メタ）アクリルアミドポリマー又はコポリマーを含むコンタクトレンズ |
| JP2017218977A Active JP6526768B2 (ja) | 2012-05-25 | 2017-11-14 | 水溶性ｎ−（２ヒドロキシアルキル）（メタ）アクリルアミドポリマー又はコポリマーを含むコンタクトレンズ |
| JP2018014560A Pending JP2018092178A (ja) | 2012-05-25 | 2018-01-31 | ポリマー及びナノゲル材料並びにその製造方法及び使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| EP (6) | EP2855547A2 (enExample) |
| JP (4) | JP6290189B2 (enExample) |
| KR (2) | KR20150023485A (enExample) |
| CN (3) | CN104321356B (enExample) |
| AU (1) | AU2013266146A1 (enExample) |
| BR (2) | BR112014029270A2 (enExample) |
| CA (2) | CA2874664A1 (enExample) |
| HK (4) | HK1204794A1 (enExample) |
| IN (1) | IN2014DN09503A (enExample) |
| RU (2) | RU2014152715A (enExample) |
| SG (2) | SG11201407394TA (enExample) |
| TW (2) | TWI582118B (enExample) |
| WO (3) | WO2013177506A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI582118B (zh) * | 2012-05-25 | 2017-05-11 | 壯生和壯生視覺關懷公司 | 含水溶性ｎ－（２羥烷基）（甲基）丙烯醯胺聚合物或共聚物之隱形眼鏡 |
| CN103724573B (zh) * | 2013-12-31 | 2016-01-20 | 东华大学 | 一种两亲性共聚网络的制备方法 |
| CN103865067B (zh) * | 2014-03-21 | 2016-01-06 | 东华大学 | 一种两亲性共聚网络的制备方法 |
| WO2015161199A1 (en) * | 2014-04-18 | 2015-10-22 | Benz Research And Development Corp. | (meth)acrylamide polymers for contact lens and intraocular lens |
| CN104961850B (zh) * | 2015-06-30 | 2017-02-22 | 北京化工大学 | Atrp法构建高转染类脂质体阳离子基因载体 |
| TWI586543B (zh) * | 2015-09-03 | 2017-06-11 | 明基材料股份有限公司 | 著色隱形眼鏡 |
| TWI551616B (zh) * | 2016-01-05 | 2016-10-01 | 望隼科技股份有限公司 | 一種應用於眼科物件之矽水凝膠的製造方法 |
| US11021558B2 (en) | 2016-08-05 | 2021-06-01 | Johnson & Johnson Vision Care, Inc. | Polymer compositions containing grafted polymeric networks and processes for their preparation and use |
| US20190218323A1 (en) * | 2016-08-08 | 2019-07-18 | The University Of Liverpool | Branched polymers |
| US10676575B2 (en) * | 2016-10-06 | 2020-06-09 | Johnson & Johnson Vision Care, Inc. | Tri-block prepolymers and their use in silicone hydrogels |
| US20180169905A1 (en) * | 2016-12-16 | 2018-06-21 | Coopervision International Holding Company, Lp | Contact Lenses With Incorporated Components |
| CN106674545B (zh) * | 2016-12-30 | 2019-04-12 | 合众（佛山）化工有限公司 | 一种基于水性raft聚合法的复合型水凝胶 |
| ES2678773B1 (es) * | 2017-01-16 | 2019-06-12 | Consejo Superior Investigacion | Recubrimientos tipo hidrogel en base vinil-lactamas |
| BR112020001516A2 (pt) * | 2017-07-27 | 2020-07-21 | University Health Network | polímero condutivo à base de ácido benzoico que contém biomaterial para melhoria da condução de tecidos in vitro e in vivo |
| CN109666160B (zh) * | 2017-10-17 | 2023-07-14 | 厦门天策材料科技有限公司 | 一种具有杂化交联网络的动态聚合物 |
| TWI663197B (zh) * | 2018-01-22 | 2019-06-21 | 亨泰光學股份有限公司 | 應用電漿誘導聚合接枝製備具薄膜之隱形眼鏡加工方法 |
| CN111566517B (zh) * | 2018-01-30 | 2023-11-10 | 爱尔康公司 | 在其上具有润滑涂层的隐形眼镜 |
| US11034789B2 (en) | 2018-01-30 | 2021-06-15 | Johnson & Johnson Vision Care, Inc. | Ophthalmic devices containing localized grafted networks and processes for their preparation and use |
| US10996491B2 (en) | 2018-03-23 | 2021-05-04 | Johnson & Johnson Vision Care, Inc. | Ink composition for cosmetic contact lenses |
| CN109734845A (zh) * | 2018-12-03 | 2019-05-10 | 华东理工大学 | 一种基于聚电解质为模板的纳米凝胶的制备方法 |
| AU2019399661A1 (en) * | 2018-12-10 | 2021-05-20 | Seed Co., Ltd. | UV absorbing ocular lens |
| CN113613998B (zh) * | 2019-01-29 | 2023-04-11 | 鲍希与洛姆伯股份有限公司 | 用于隐形眼镜的包装溶液 |
| CN110359276A (zh) * | 2019-07-30 | 2019-10-22 | 北京化工大学常州先进材料研究院 | 聚异丙基丙烯酰胺分子刷聚癸二酸甘油酯基纤维膜及其制备方法和应用 |
| US11891526B2 (en) | 2019-09-12 | 2024-02-06 | Johnson & Johnson Vision Care, Inc. | Ink composition for cosmetic contact lenses |
| KR20220034199A (ko) * | 2019-09-18 | 2022-03-17 | 알콘 인코포레이티드 | 습식-패킹 소프트 하이드로겔 안구 삽입물 |
| RU200536U1 (ru) * | 2020-02-05 | 2020-10-28 | Федеральное государственное казенное военное образовательное учреждение высшего образования "Военная академия материально-технического обеспечения имени генерала армии А.В. Хрулёва" | Многослойный защитный визир |
| CN111825874B (zh) * | 2020-07-02 | 2021-08-10 | 华中科技大学 | 一种基于表面引发制备的聚合物电解质、其制备和应用 |
| CN113736100B (zh) * | 2021-08-12 | 2023-04-14 | 湖南工业大学 | 一种纳米金属有机框架增韧的高强度荧光水凝胶及其制备方法 |
| US20240168200A1 (en) * | 2021-11-12 | 2024-05-23 | Pegavision Corporation | Contact lens and manufacturing method thereof |
| TWI849382B (zh) * | 2022-02-21 | 2024-07-21 | 穎利科技股份有限公司 | 基材表面親水處理之方法及具親水改質表面之基材 |
| EP4599224A1 (en) * | 2022-12-27 | 2025-08-13 | Life Technologies Corporation | Rapid gelling aqueous mounting media |
| CN118079034B (zh) * | 2024-04-25 | 2024-08-06 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种可t1和t2信号切换的响应型磁共振成像造影剂及其制备方法和应用 |
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-
2013
- 2013-05-24 TW TW102118348A patent/TWI582118B/zh active
- 2013-05-24 WO PCT/US2013/042628 patent/WO2013177506A2/en not_active Ceased
- 2013-05-24 EP EP13729150.6A patent/EP2855547A2/en not_active Withdrawn
- 2013-05-24 EP EP17198865.2A patent/EP3296334B9/en not_active Revoked
- 2013-05-24 BR BR112014029270A patent/BR112014029270A2/pt not_active Application Discontinuation
- 2013-05-24 HK HK15105318.7A patent/HK1204794A1/xx unknown
- 2013-05-24 EP EP13727758.8A patent/EP2855545B1/en not_active Revoked
- 2013-05-24 HK HK15109726.5A patent/HK1209142A1/xx unknown
- 2013-05-24 EP EP24204932.8A patent/EP4502052A3/en not_active Withdrawn
- 2013-05-24 HK HK15109232.2A patent/HK1208482A1/xx unknown
- 2013-05-24 AU AU2013266146A patent/AU2013266146A1/en not_active Abandoned
- 2013-05-24 CA CA2874664A patent/CA2874664A1/en not_active Abandoned
- 2013-05-24 CN CN201380027517.3A patent/CN104321356B/zh not_active Expired - Fee Related
- 2013-05-24 EP EP18176232.9A patent/EP3401342A1/en not_active Withdrawn
- 2013-05-24 WO PCT/US2013/042658 patent/WO2013177523A2/en not_active Ceased
- 2013-05-24 BR BR112014029253A patent/BR112014029253A2/pt not_active Application Discontinuation
- 2013-05-24 TW TW102118452A patent/TWI598387B/zh not_active IP Right Cessation
- 2013-05-24 SG SG11201407394TA patent/SG11201407394TA/en unknown
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- 2013-05-24 JP JP2015514217A patent/JP6290189B2/ja not_active Expired - Fee Related
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- 2013-05-24 CN CN201710281355.6A patent/CN107254026A/zh active Pending
- 2013-05-24 CA CA2874718A patent/CA2874718A1/en not_active Abandoned
- 2013-05-24 EP EP13728602.7A patent/EP2855546B1/en not_active Revoked
- 2013-05-24 RU RU2014152715A patent/RU2014152715A/ru unknown
- 2013-05-24 KR KR20147036331A patent/KR20150023485A/ko not_active Withdrawn
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- 2013-05-24 RU RU2014152725A patent/RU2640593C2/ru not_active IP Right Cessation
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2017
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