JP2015515633A5 - - Google Patents
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- Publication number
- JP2015515633A5 JP2015515633A5 JP2015508919A JP2015508919A JP2015515633A5 JP 2015515633 A5 JP2015515633 A5 JP 2015515633A5 JP 2015508919 A JP2015508919 A JP 2015508919A JP 2015508919 A JP2015508919 A JP 2015508919A JP 2015515633 A5 JP2015515633 A5 JP 2015515633A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- solid support
- separation matrix
- sulfonic acid
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011159 matrix material Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 239000000178 monomer Substances 0.000 claims 9
- 238000000926 separation method Methods 0.000 claims 7
- 239000007787 solid Substances 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 3
- JWYVGKFDLWWQJX-UHFFFAOYSA-N 1-ethenylazepan-2-one Chemical compound C=CN1CCCCCC1=O JWYVGKFDLWWQJX-UHFFFAOYSA-N 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 150000005215 alkyl ethers Chemical group 0.000 claims 2
- 125000005189 alkyl hydroxy group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical class NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 238000005342 ion exchange Methods 0.000 claims 2
- RQAKESSLMFZVMC-UHFFFAOYSA-N n-ethenylacetamide Chemical compound CC(=O)NC=C RQAKESSLMFZVMC-UHFFFAOYSA-N 0.000 claims 2
- ZQXSMRAEXCEDJD-UHFFFAOYSA-N n-ethenylformamide Chemical compound C=CNC=O ZQXSMRAEXCEDJD-UHFFFAOYSA-N 0.000 claims 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 2
- 125000000542 sulfonic acid group Chemical group 0.000 claims 2
- ZTWTYVWXUKTLCP-UHFFFAOYSA-N vinylphosphonic acid Chemical compound OP(O)(=O)C=C ZTWTYVWXUKTLCP-UHFFFAOYSA-N 0.000 claims 2
- NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical group OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 claims 2
- ATVJXMYDOSMEPO-UHFFFAOYSA-N 3-prop-2-enoxyprop-1-ene Chemical group C=CCOCC=C ATVJXMYDOSMEPO-UHFFFAOYSA-N 0.000 claims 1
- 238000011210 chromatographic step Methods 0.000 claims 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical group OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000010526 radical polymerization reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1250413-0 | 2012-04-25 | ||
| SE1250413 | 2012-04-25 | ||
| PCT/SE2013/050427 WO2013162449A1 (en) | 2012-04-25 | 2013-04-22 | Separation method and separation matrix |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015515633A JP2015515633A (ja) | 2015-05-28 |
| JP2015515633A5 true JP2015515633A5 (enExample) | 2016-06-09 |
| JP6266597B2 JP6266597B2 (ja) | 2018-01-24 |
Family
ID=49483584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015508919A Active JP6266597B2 (ja) | 2012-04-25 | 2013-04-22 | 分離方法及び分離マトリックス |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9573973B2 (enExample) |
| EP (1) | EP2841177B1 (enExample) |
| JP (1) | JP6266597B2 (enExample) |
| CN (1) | CN104245078B (enExample) |
| IN (1) | IN2014DN08671A (enExample) |
| WO (1) | WO2013162449A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104245078B (zh) * | 2012-04-25 | 2016-07-06 | 通用电气健康护理生物科学股份公司 | 分离方法和分离基质 |
| JP6056230B2 (ja) * | 2012-07-13 | 2017-01-11 | 東ソー株式会社 | 液体クロマトグラフィー用カチオン交換体 |
| MY195756A (en) | 2012-09-17 | 2023-02-09 | Grace W R & Co | Functionalized Particulate Support Material and Methods of Making and Using the Same |
| CN105593276B (zh) | 2013-10-03 | 2020-03-27 | 3M创新有限公司 | 具有增强的结合容量的配体官能化基材 |
| WO2015080657A1 (en) * | 2013-11-28 | 2015-06-04 | Ge Healthcare Bio-Sciences Ab | Stabilization of fermented beverages |
| JP6853670B2 (ja) | 2014-01-16 | 2021-04-07 | ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ | 親和性クロマトグラフィー媒体及びクロマトグラフィーデバイス |
| JP6914189B2 (ja) * | 2014-05-02 | 2021-08-04 | ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ | 官能化担体材料並びに官能化担体材料を作製及び使用する方法 |
| US9394407B2 (en) | 2014-06-30 | 2016-07-19 | Pall Corporation | Hydrophilic block copolymers and membranes prepared therefrom (I) |
| US9718924B2 (en) | 2014-06-30 | 2017-08-01 | Pall Corporation | Hydrophilic block copolymers and membranes prepared therefrom (II) |
| US9309367B2 (en) | 2014-06-30 | 2016-04-12 | Pall Corporation | Membranes comprising cellulosic material and hydrophilic block copolymer (V) |
| US9254466B2 (en) * | 2014-06-30 | 2016-02-09 | Pall Corporation | Crosslinked cellulosic membranes |
| US9962662B2 (en) | 2014-06-30 | 2018-05-08 | Pall Corporation | Fluorinated polymer and use thereof in the preparation of hydrophilic membranes (vi) |
| JP6845139B2 (ja) * | 2014-12-15 | 2021-03-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 粗製溶液からの標的分子捕捉 |
| JP6810039B2 (ja) * | 2015-07-31 | 2021-01-06 | 株式会社ダイセル | 超臨界流体クロマトグラフィー用の固定相 |
| JP6922892B2 (ja) * | 2016-03-11 | 2021-08-18 | 昭和電工マテリアルズ株式会社 | 分離材、該分離材を備えるカラム、及び分離材の製造方法 |
| JP6648565B2 (ja) * | 2016-03-11 | 2020-02-14 | 日立化成株式会社 | 分離材 |
| ES2986551T3 (es) | 2016-04-06 | 2024-11-11 | Cytiva Bioprocess R & D Ab | Matriz de cromatografía |
| WO2018048696A1 (en) | 2016-09-09 | 2018-03-15 | 3M Innovative Properties Company | Functionalized copolymers and use thereof |
| US20190217285A1 (en) * | 2016-09-09 | 2019-07-18 | Asahi Kasei Medical Co., Ltd. | Strong cation exchange chromatographic matrix and method for using same |
| GB201810690D0 (en) | 2018-06-29 | 2018-08-15 | Ge Healthcare Bioprocess R&D Ab | Chromatography beads, production and use thereof |
| GB201902743D0 (en) * | 2019-02-28 | 2019-04-17 | Ge Healthcare Bio Sciences Ab | Improvements in and relating to optimizing the operation of a chromatography system |
| JP7365631B2 (ja) * | 2019-09-02 | 2023-10-20 | 国立大学法人福井大学 | ホスホン酸又はホスホン酸エステル構造を有するコア－シェル型高分子微粒子、粒子分散液、成形体及び前記微粒子の製造方法 |
| GB202006231D0 (en) * | 2020-04-28 | 2020-06-10 | Puridify Ltd | Seperation matrix and metod for seperation |
| CN119730955A (zh) * | 2022-09-02 | 2025-03-28 | 菲诺米耐斯公司 | 层析吸附剂的组合物和用于分析抗体药物缀合物的方法 |
| US12434218B2 (en) | 2023-11-28 | 2025-10-07 | Phenomenex, Inc. | Pore structure for separation of adeno-associated viruses (AAVS) from their aggregates |
| WO2025118020A1 (en) * | 2023-12-07 | 2025-06-12 | The University Of Queensland | A polymer for improved purification of extracellular vesicles |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01500836A (ja) * | 1987-04-21 | 1989-03-23 | ミュラー‐シュルテ，デトレフ | 固体担体およびそれに結合した特定のリガンドによる、水溶液から酵素を分離するアフィニティークロマトグラフ法 |
| DE3811042A1 (de) * | 1988-03-31 | 1989-10-19 | Merck Patent Gmbh | Ionenaustauscher |
| US20020104801A1 (en) | 1998-04-06 | 2002-08-08 | Nicolas Voute | Small dense microporous solid support materials, their preparation,and use for purification of large macromolecules and bioparticles |
| DE69936920T2 (de) | 1998-06-12 | 2008-05-15 | Waters Investments Ltd., New Castle | Neue poröse ionenaustauschharze für die festphasenextraktion und chromatographie |
| SE0302509D0 (sv) | 2003-09-19 | 2003-09-19 | Amersham Biosciences Ab | Matrix for separation of polyethers and method of separation |
| US7691263B1 (en) * | 2005-05-20 | 2010-04-06 | Brigham Young University | Monolithic column technology for liquid chromatography |
| CN101678318B (zh) | 2007-05-25 | 2013-09-25 | 默克专利股份公司 | 用于阳离子交换色谱法的接枝共聚物 |
| CN101249425B (zh) * | 2007-11-26 | 2011-04-27 | 福州大学 | 一种兼具亲水离子交换和反相离子交换两种分离模式色谱柱的原料配方和制备方法 |
| CN101249427B (zh) * | 2007-11-26 | 2011-05-11 | 福州大学 | 一种极性离子交换电色谱柱的原料配方及制备方法 |
| CA2780095C (en) | 2009-11-13 | 2018-12-11 | Merck Millipore Ltd. | Hydrophobic interaction chromatography membranes, and methods of use thereof |
| JP5474881B2 (ja) | 2010-07-28 | 2014-04-16 | ローム アンド ハース カンパニー | 向上したクロマトグラフィー媒体の製造方法および使用方法 |
| JP5460651B2 (ja) | 2010-07-28 | 2014-04-02 | ローム アンド ハース カンパニー | クロマトグラフィー媒体性能を向上させるグラフト化方法 |
| JP2013532829A (ja) | 2010-07-29 | 2013-08-19 | イー・エム・デイー・ミリポア・コーポレイシヨン | クロマトグラフィーの媒介性能を改善するためのグラフト法 |
| CN104245078B (zh) * | 2012-04-25 | 2016-07-06 | 通用电气健康护理生物科学股份公司 | 分离方法和分离基质 |
-
2013
- 2013-04-22 CN CN201380021764.2A patent/CN104245078B/zh active Active
- 2013-04-22 IN IN8671DEN2014 patent/IN2014DN08671A/en unknown
- 2013-04-22 WO PCT/SE2013/050427 patent/WO2013162449A1/en not_active Ceased
- 2013-04-22 JP JP2015508919A patent/JP6266597B2/ja active Active
- 2013-04-22 US US14/396,207 patent/US9573973B2/en active Active
- 2013-04-22 EP EP13781240.0A patent/EP2841177B1/en active Active
-
2017
- 2017-01-16 US US15/407,240 patent/US10124328B2/en active Active
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