JP2015515633A5 - - Google Patents
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- Publication number
- JP2015515633A5 JP2015515633A5 JP2015508919A JP2015508919A JP2015515633A5 JP 2015515633 A5 JP2015515633 A5 JP 2015515633A5 JP 2015508919 A JP2015508919 A JP 2015508919A JP 2015508919 A JP2015508919 A JP 2015508919A JP 2015515633 A5 JP2015515633 A5 JP 2015515633A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- solid support
- separation matrix
- sulfonic acid
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011159 matrix material Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 239000000178 monomer Substances 0.000 claims 9
- 238000000926 separation method Methods 0.000 claims 7
- 239000007787 solid Substances 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 3
- JWYVGKFDLWWQJX-UHFFFAOYSA-N 1-ethenylazepan-2-one Chemical compound C=CN1CCCCCC1=O JWYVGKFDLWWQJX-UHFFFAOYSA-N 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 150000005215 alkyl ethers Chemical group 0.000 claims 2
- 125000005189 alkyl hydroxy group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical class NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 238000005342 ion exchange Methods 0.000 claims 2
- RQAKESSLMFZVMC-UHFFFAOYSA-N n-ethenylacetamide Chemical compound CC(=O)NC=C RQAKESSLMFZVMC-UHFFFAOYSA-N 0.000 claims 2
- ZQXSMRAEXCEDJD-UHFFFAOYSA-N n-ethenylformamide Chemical compound C=CNC=O ZQXSMRAEXCEDJD-UHFFFAOYSA-N 0.000 claims 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 2
- 125000000542 sulfonic acid group Chemical group 0.000 claims 2
- ZTWTYVWXUKTLCP-UHFFFAOYSA-N vinylphosphonic acid Chemical compound OP(O)(=O)C=C ZTWTYVWXUKTLCP-UHFFFAOYSA-N 0.000 claims 2
- NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical group OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 claims 2
- ATVJXMYDOSMEPO-UHFFFAOYSA-N 3-prop-2-enoxyprop-1-ene Chemical group C=CCOCC=C ATVJXMYDOSMEPO-UHFFFAOYSA-N 0.000 claims 1
- 238000011210 chromatographic step Methods 0.000 claims 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical group OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000010526 radical polymerization reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1250413 | 2012-04-25 | ||
| SE1250413-0 | 2012-04-25 | ||
| PCT/SE2013/050427 WO2013162449A1 (en) | 2012-04-25 | 2013-04-22 | Separation method and separation matrix |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015515633A JP2015515633A (ja) | 2015-05-28 |
| JP2015515633A5 true JP2015515633A5 (cg-RX-API-DMAC7.html) | 2016-06-09 |
| JP6266597B2 JP6266597B2 (ja) | 2018-01-24 |
Family
ID=49483584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015508919A Active JP6266597B2 (ja) | 2012-04-25 | 2013-04-22 | 分離方法及び分離マトリックス |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9573973B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2841177B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6266597B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN104245078B (cg-RX-API-DMAC7.html) |
| IN (1) | IN2014DN08671A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013162449A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9573973B2 (en) * | 2012-04-25 | 2017-02-21 | Ge Healthcare Bioprocess R&D Ab | Separation method and separation matrix |
| JP6056230B2 (ja) * | 2012-07-13 | 2017-01-11 | 東ソー株式会社 | 液体クロマトグラフィー用カチオン交換体 |
| JP6469574B2 (ja) | 2012-09-17 | 2019-02-13 | ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ | 官能化粒状保持体ならびにその製造法及び使用法 |
| EP3052556B1 (en) | 2013-10-03 | 2021-01-20 | 3M Innovative Properties Company | Ligand-functionalized substrates with enhanced binding capacity |
| CN105744996B (zh) * | 2013-11-28 | 2018-10-19 | 通用电气医疗集团生物工艺研发股份公司 | 发酵饮料的稳定 |
| EP3094390B1 (en) | 2014-01-16 | 2021-07-07 | W.R. Grace & CO. - CONN. | Affinity chromatography media and chromatography devices |
| PL3137209T3 (pl) * | 2014-05-02 | 2023-01-02 | W.R. Grace & Co. - Conn. | Funkcjonalizowany materiał nośnikowy i sposoby wytwarzania oraz stosowania funkcjonalizowanego materiału nośnikowego |
| US9718924B2 (en) | 2014-06-30 | 2017-08-01 | Pall Corporation | Hydrophilic block copolymers and membranes prepared therefrom (II) |
| US9309367B2 (en) | 2014-06-30 | 2016-04-12 | Pall Corporation | Membranes comprising cellulosic material and hydrophilic block copolymer (V) |
| US9394407B2 (en) | 2014-06-30 | 2016-07-19 | Pall Corporation | Hydrophilic block copolymers and membranes prepared therefrom (I) |
| US9254466B2 (en) * | 2014-06-30 | 2016-02-09 | Pall Corporation | Crosslinked cellulosic membranes |
| US9962662B2 (en) | 2014-06-30 | 2018-05-08 | Pall Corporation | Fluorinated polymer and use thereof in the preparation of hydrophilic membranes (vi) |
| US10617975B2 (en) | 2014-12-15 | 2020-04-14 | Merck Patent Gmbh | Target molecule capture from crude solutions |
| US11014019B2 (en) | 2015-07-31 | 2021-05-25 | Daicel Corporation | Stationary phase for supercritical fluid chromatography |
| JP6922892B2 (ja) * | 2016-03-11 | 2021-08-18 | 昭和電工マテリアルズ株式会社 | 分離材、該分離材を備えるカラム、及び分離材の製造方法 |
| JP6648565B2 (ja) * | 2016-03-11 | 2020-02-14 | 日立化成株式会社 | 分離材 |
| US10864512B2 (en) | 2016-04-06 | 2020-12-15 | Cytiva Bioprocess R&D Ab | Chromatography matrix |
| US20190217285A1 (en) * | 2016-09-09 | 2019-07-18 | Asahi Kasei Medical Co., Ltd. | Strong cation exchange chromatographic matrix and method for using same |
| WO2018048696A1 (en) | 2016-09-09 | 2018-03-15 | 3M Innovative Properties Company | Functionalized copolymers and use thereof |
| GB201810690D0 (en) | 2018-06-29 | 2018-08-15 | Ge Healthcare Bioprocess R&D Ab | Chromatography beads, production and use thereof |
| GB201902743D0 (en) * | 2019-02-28 | 2019-04-17 | Ge Healthcare Bio Sciences Ab | Improvements in and relating to optimizing the operation of a chromatography system |
| JP7365631B2 (ja) * | 2019-09-02 | 2023-10-20 | 国立大学法人福井大学 | ホスホン酸又はホスホン酸エステル構造を有するコア－シェル型高分子微粒子、粒子分散液、成形体及び前記微粒子の製造方法 |
| GB202006231D0 (en) * | 2020-04-28 | 2020-06-10 | Puridify Ltd | Seperation matrix and metod for seperation |
| EP4580804A1 (en) * | 2022-09-02 | 2025-07-09 | Phenomenex, Inc. | Composition of chromatographic sorbents and methods for analysis of antibody drug conjugates |
| US12434218B2 (en) | 2023-11-28 | 2025-10-07 | Phenomenex, Inc. | Pore structure for separation of adeno-associated viruses (AAVS) from their aggregates |
| WO2025118020A1 (en) * | 2023-12-07 | 2025-06-12 | The University Of Queensland | A polymer for improved purification of extracellular vesicles |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01500836A (ja) * | 1987-04-21 | 1989-03-23 | ミュラー‐シュルテ，デトレフ | 固体担体およびそれに結合した特定のリガンドによる、水溶液から酵素を分離するアフィニティークロマトグラフ法 |
| DE3811042A1 (de) | 1988-03-31 | 1989-10-19 | Merck Patent Gmbh | Ionenaustauscher |
| US20020104801A1 (en) * | 1998-04-06 | 2002-08-08 | Nicolas Voute | Small dense microporous solid support materials, their preparation,and use for purification of large macromolecules and bioparticles |
| DE69936920T2 (de) | 1998-06-12 | 2008-05-15 | Waters Investments Ltd., New Castle | Neue poröse ionenaustauschharze für die festphasenextraktion und chromatographie |
| SE0302509D0 (sv) | 2003-09-19 | 2003-09-19 | Amersham Biosciences Ab | Matrix for separation of polyethers and method of separation |
| US7691263B1 (en) * | 2005-05-20 | 2010-04-06 | Brigham Young University | Monolithic column technology for liquid chromatography |
| EP2152405B2 (de) | 2007-05-25 | 2017-04-05 | Merck Patent GmbH | Mischpfropfpolymere für die kationenaustauschchromatographie |
| CN101249425B (zh) * | 2007-11-26 | 2011-04-27 | 福州大学 | 一种兼具亲水离子交换和反相离子交换两种分离模式色谱柱的原料配方和制备方法 |
| CN101249427B (zh) * | 2007-11-26 | 2011-05-11 | 福州大学 | 一种极性离子交换电色谱柱的原料配方及制备方法 |
| KR20170104656A (ko) | 2009-11-13 | 2017-09-15 | 나트릭스 세퍼레이션즈, 인코포레이티드 | 소수성 상호반응 크로마토그래피용 막 및 그의 사용방법 |
| JP5460651B2 (ja) | 2010-07-28 | 2014-04-02 | ローム アンド ハース カンパニー | クロマトグラフィー媒体性能を向上させるグラフト化方法 |
| JP5474881B2 (ja) | 2010-07-28 | 2014-04-16 | ローム アンド ハース カンパニー | 向上したクロマトグラフィー媒体の製造方法および使用方法 |
| KR20130028939A (ko) | 2010-07-29 | 2013-03-20 | 이엠디 밀리포어 코포레이션 | 크로마토그래피 매질 성능을 개선하기 위한 그라프팅 방법 |
| US9573973B2 (en) * | 2012-04-25 | 2017-02-21 | Ge Healthcare Bioprocess R&D Ab | Separation method and separation matrix |
-
2013
- 2013-04-22 US US14/396,207 patent/US9573973B2/en active Active
- 2013-04-22 CN CN201380021764.2A patent/CN104245078B/zh active Active
- 2013-04-22 IN IN8671DEN2014 patent/IN2014DN08671A/en unknown
- 2013-04-22 EP EP13781240.0A patent/EP2841177B1/en active Active
- 2013-04-22 WO PCT/SE2013/050427 patent/WO2013162449A1/en not_active Ceased
- 2013-04-22 JP JP2015508919A patent/JP6266597B2/ja active Active
-
2017
- 2017-01-16 US US15/407,240 patent/US10124328B2/en active Active
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