JP2015514772A5 - - Google Patents
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- Publication number
- JP2015514772A5 JP2015514772A5 JP2015507145A JP2015507145A JP2015514772A5 JP 2015514772 A5 JP2015514772 A5 JP 2015514772A5 JP 2015507145 A JP2015507145 A JP 2015507145A JP 2015507145 A JP2015507145 A JP 2015507145A JP 2015514772 A5 JP2015514772 A5 JP 2015514772A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- group
- alkyl
- amino
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 25
- 241000700605 Viruses Species 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- -1 aminothionyl Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 5
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 241001115402 Ebolavirus Species 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 2
- 241000713196 Influenza B virus Species 0.000 claims 2
- 241001115401 Marburgvirus Species 0.000 claims 2
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims 2
- 241000710772 Yellow fever virus Species 0.000 claims 2
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229940051021 yellow-fever virus Drugs 0.000 claims 2
- 241000712892 Arenaviridae Species 0.000 claims 1
- 241001493160 California encephalitis virus Species 0.000 claims 1
- 241000711573 Coronaviridae Species 0.000 claims 1
- 241000709687 Coxsackievirus Species 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 241000710945 Eastern equine encephalitis virus Species 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241000711950 Filoviridae Species 0.000 claims 1
- 241000710781 Flaviviridae Species 0.000 claims 1
- 241000190708 Guanarito mammarenavirus Species 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- 241000710842 Japanese encephalitis virus Species 0.000 claims 1
- 241000712890 Junin mammarenavirus Species 0.000 claims 1
- 206010023927 Lassa fever Diseases 0.000 claims 1
- 241000712899 Lymphocytic choriomeningitis mammarenavirus Species 0.000 claims 1
- 241000712898 Machupo mammarenavirus Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 241000150452 Orthohantavirus Species 0.000 claims 1
- 241000712464 Orthomyxoviridae Species 0.000 claims 1
- 241000711504 Paramyxoviridae Species 0.000 claims 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 1
- 241000150350 Peribunyaviridae Species 0.000 claims 1
- 241000709664 Picornaviridae Species 0.000 claims 1
- 241000713126 Punta Toro virus Species 0.000 claims 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 1
- 241000713124 Rift Valley fever virus Species 0.000 claims 1
- 241000712908 Tacaribe mammarenavirus Species 0.000 claims 1
- 241000710924 Togaviridae Species 0.000 claims 1
- 241000700647 Variola virus Species 0.000 claims 1
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 241000710951 Western equine encephalitis virus Species 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 241001493065 dsRNA viruses Species 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- YXMMTUJDQTVJEN-UHFFFAOYSA-N methyl 2-amino-3-methylpentanoate Chemical compound CCC(C)C(N)C(=O)OC YXMMTUJDQTVJEN-UHFFFAOYSA-N 0.000 claims 1
- QVDXUKJJGUSGLS-UHFFFAOYSA-N methyl 2-amino-4-methylpentanoate Chemical compound COC(=O)C(N)CC(C)C QVDXUKJJGUSGLS-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 230000029812 viral genome replication Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261625994P | 2012-04-18 | 2012-04-18 | |
| US61/625,994 | 2012-04-18 | ||
| PCT/US2013/036945 WO2013158746A1 (en) | 2012-04-18 | 2013-04-17 | Compositions and methods for inhibiting viral polymerase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018007131A Division JP6559266B2 (ja) | 2012-04-18 | 2018-01-19 | ウイルスポリメラーゼを阻害するための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015514772A JP2015514772A (ja) | 2015-05-21 |
| JP2015514772A5 true JP2015514772A5 (enExample) | 2016-06-16 |
Family
ID=49384030
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015507145A Pending JP2015514772A (ja) | 2012-04-18 | 2013-04-17 | ウイルスポリメラーゼを阻害するための組成物および方法 |
| JP2018007131A Active JP6559266B2 (ja) | 2012-04-18 | 2018-01-19 | ウイルスポリメラーゼを阻害するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018007131A Active JP6559266B2 (ja) | 2012-04-18 | 2018-01-19 | ウイルスポリメラーゼを阻害するための組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9580428B2 (enExample) |
| EP (1) | EP2838535B1 (enExample) |
| JP (2) | JP2015514772A (enExample) |
| KR (3) | KR102156819B1 (enExample) |
| CN (1) | CN104379146B (enExample) |
| AR (1) | AR090699A1 (enExample) |
| AU (1) | AU2013249344B2 (enExample) |
| BR (1) | BR112014025909B1 (enExample) |
| CA (1) | CA2870722C (enExample) |
| IL (1) | IL235123A (enExample) |
| MX (1) | MX363270B (enExample) |
| RU (1) | RU2654482C2 (enExample) |
| TW (1) | TWI664180B (enExample) |
| WO (1) | WO2013158746A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2898885B1 (en) | 2010-10-15 | 2017-11-22 | Biocryst Pharmaceuticals, Inc. | Pyrrolopyrimidine derivatives for use in the treatment of viral infections |
| AU2013344422A1 (en) * | 2012-11-16 | 2015-07-02 | Biocryst Pharmaceuticals, Inc. | Antiviral azasugar-containing nucleosides |
| CN103864791B (zh) * | 2014-03-18 | 2016-01-27 | 福建天泉药业股份有限公司 | 一种恩替卡韦衍生物及其制备方法 |
| CN104513249B (zh) * | 2014-12-26 | 2016-08-31 | 苏州明锐医药科技有限公司 | 抗埃博拉病毒药物bcx4430的制备方法 |
| WO2016110527A1 (en) * | 2015-01-07 | 2016-07-14 | Euro-Celtique S.A. | Process for manufacture of forodesine |
| TWI874791B (zh) * | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| WO2021207386A1 (en) * | 2020-04-07 | 2021-10-14 | Biocryst Pharmaceuticals, Inc. | Methods, compositions, and dosing regimens for treatment of sars-cov-2 infections |
| WO2021211757A1 (en) * | 2020-04-14 | 2021-10-21 | Oyagen, Inc. | Method for treating arenaviridae infections |
| CN111704619B (zh) * | 2020-07-30 | 2021-10-19 | 四川大学 | 一种Forodesine的制备方法 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| CA3098164A1 (en) * | 2020-11-05 | 2022-05-05 | Eurofins Cdmo Alphora Inc. | Process for preparation of advanced intermediate for eribulin synthesys |
| IL310854A (en) | 2021-08-20 | 2024-04-01 | Shionogi & Co | Nucleoside compounds and their drug derivatives possessing viral growth inhibitory activity |
| CN113666941B (zh) * | 2021-09-01 | 2023-03-10 | 浙江珲达生物科技有限公司 | 一种2,3-O-异亚丙基-D-核糖酸-γ-内酯的重结晶方法 |
| US12552827B2 (en) | 2022-01-21 | 2026-02-17 | Biocryst Pharmaceuticals, Inc. | Synthesis of an antiviral azasugar triphosphate |
| CN116693541A (zh) * | 2023-06-15 | 2023-09-05 | 安徽大学 | 一种4-氯-5h-吡咯并[3,2-d]嘧啶的合成方法 |
| CN118359623B (zh) * | 2024-04-16 | 2025-06-27 | 上海陶术生物科技股份有限公司 | 一种呋咯地辛的合成方法、中间体及应用 |
| CN118359622B (zh) * | 2024-04-16 | 2025-08-26 | 上海陶术生物科技股份有限公司 | 加利司伟中间体的制备方法 |
| CN118359621B (zh) * | 2024-04-16 | 2025-05-16 | 上海陶术生物科技股份有限公司 | 加利司伟及加利司伟中间体的制备方法和相应的加利司伟中间体 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985848A (en) * | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
| SI2077268T1 (sl) * | 1999-04-08 | 2017-07-31 | Victoria Link Limited | Postopek za pripravo inhibitorjev nukleozidnega metabolizma |
| MY141594A (en) * | 2000-06-15 | 2010-05-14 | Novirio Pharmaceuticals Ltd | 3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES |
| US7109331B2 (en) * | 2000-08-29 | 2006-09-19 | Industrial Research Limited | 5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors |
| WO2002069903A2 (en) | 2001-03-06 | 2002-09-12 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
| US7388002B2 (en) | 2001-11-14 | 2008-06-17 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| US7098334B2 (en) * | 2002-03-25 | 2006-08-29 | Industrial Research Limited | 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
| US20040242599A1 (en) | 2003-02-27 | 2004-12-02 | Biocryst Pharmaceuticals, Inc. | Cyclopentene nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| US20040229839A1 (en) | 2003-05-14 | 2004-11-18 | Biocryst Pharmaceuticals, Inc. | Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| US20050187170A1 (en) | 2003-06-16 | 2005-08-25 | Biocryst Pharmaceuticals, Inc. | Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors |
| US20050080053A1 (en) | 2003-08-29 | 2005-04-14 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| ES2342069T4 (es) * | 2003-09-05 | 2011-01-26 | Anadys Pharmaceuticals, Inc. | Ligandos de tlr7 para el tratamiento de la hepatitis c. |
| US20070167353A1 (en) | 2003-10-24 | 2007-07-19 | John Hilfinger | Prodrug composition |
| WO2006002231A1 (en) * | 2004-06-22 | 2006-01-05 | Biocryst Pharmaceuticals, Inc. | Aza nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
| KR20070100237A (ko) | 2004-10-29 | 2007-10-10 | 바이오크리스트 파마수티컬즈, 인코퍼레이티드 | 치료용 푸로피리미딘 및 티에노피리미딘 |
| CA2597683A1 (en) * | 2005-02-28 | 2006-09-08 | Genelabs Technologies, Inc. | Tricyclic-nucleoside prodrugs for treating viral infections |
| CA2602533A1 (en) * | 2005-03-29 | 2006-10-05 | Biocryst Pharmaceuticals, Inc. | Use of c-nucleoside analogs for treatment of hepatitis c related viral infections |
| US7632821B2 (en) | 2005-08-09 | 2009-12-15 | Merck & Co., Inc. | Ribonucleoside cyclic acetal derivatives for the treatment of RNA-dependent RNA viral infection |
| WO2007069924A1 (en) * | 2005-12-15 | 2007-06-21 | Industrial Research Limited | Deazapurine analogs of 4'-aza-l-nucleosides |
| US7759495B2 (en) * | 2006-08-11 | 2010-07-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JP2010502748A (ja) | 2006-09-11 | 2010-01-28 | サザン リサーチ インスティテュート | アゾールヌクレオシド、並びに、ｒｎａ／ｄｎａウイルスポリメラーゼ阻害剤としての使用 |
| SG177974A1 (en) | 2007-01-12 | 2012-02-28 | Biocryst Pharm Inc | Antiviral nucleoside analogs |
| TW200942243A (en) | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
| ES2519568T3 (es) * | 2009-03-24 | 2014-11-07 | Biocryst Pharmaceuticals, Inc. | Sales farmacéuticas útiles de 7-[(3R,4R)-3-hidroxi-4-hidroximetil-pirrolidin-1-ilmetil]-3,5-dihidro-pirrolo[3,2-d]pirimidin-4-ona |
| EP2898885B1 (en) * | 2010-10-15 | 2017-11-22 | Biocryst Pharmaceuticals, Inc. | Pyrrolopyrimidine derivatives for use in the treatment of viral infections |
-
2013
- 2013-04-16 AR ARP130101229A patent/AR090699A1/es active IP Right Grant
- 2013-04-17 CA CA2870722A patent/CA2870722C/en active Active
- 2013-04-17 KR KR1020147032192A patent/KR102156819B1/ko active Active
- 2013-04-17 US US14/395,355 patent/US9580428B2/en active Active
- 2013-04-17 KR KR1020217002466A patent/KR102409853B1/ko active Active
- 2013-04-17 KR KR1020207016520A patent/KR20200070428A/ko not_active Ceased
- 2013-04-17 TW TW102113674A patent/TWI664180B/zh active
- 2013-04-17 EP EP13778292.6A patent/EP2838535B1/en active Active
- 2013-04-17 MX MX2014012525A patent/MX363270B/es unknown
- 2013-04-17 BR BR112014025909-7A patent/BR112014025909B1/pt active IP Right Grant
- 2013-04-17 JP JP2015507145A patent/JP2015514772A/ja active Pending
- 2013-04-17 RU RU2014145857A patent/RU2654482C2/ru active
- 2013-04-17 AU AU2013249344A patent/AU2013249344B2/en active Active
- 2013-04-17 WO PCT/US2013/036945 patent/WO2013158746A1/en not_active Ceased
- 2013-04-17 CN CN201380031507.7A patent/CN104379146B/zh active Active
-
2014
- 2014-10-19 IL IL235123A patent/IL235123A/en active IP Right Grant
-
2017
- 2017-01-20 US US15/411,297 patent/US20170128454A1/en not_active Abandoned
-
2018
- 2018-01-19 JP JP2018007131A patent/JP6559266B2/ja active Active
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