JP2015513312A5 - - Google Patents
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- Publication number
- JP2015513312A5 JP2015513312A5 JP2014547503A JP2014547503A JP2015513312A5 JP 2015513312 A5 JP2015513312 A5 JP 2015513312A5 JP 2014547503 A JP2014547503 A JP 2014547503A JP 2014547503 A JP2014547503 A JP 2014547503A JP 2015513312 A5 JP2015513312 A5 JP 2015513312A5
- Authority
- JP
- Japan
- Prior art keywords
- pth
- binding polypeptide
- seq
- collagen
- polypeptide segment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 38
- 229920001184 polypeptide Polymers 0.000 claims 36
- 102000004196 processed proteins & peptides Human genes 0.000 claims 36
- 102000008186 Collagen Human genes 0.000 claims 29
- 108010035532 Collagen Proteins 0.000 claims 29
- 229920001436 collagen Polymers 0.000 claims 29
- 108090000445 Parathyroid hormone Proteins 0.000 claims 22
- 239000003814 drug Substances 0.000 claims 20
- 102000006461 Parathyroid Hormone Receptors Human genes 0.000 claims 19
- 108010058828 Parathyroid Hormone Receptors Proteins 0.000 claims 19
- 230000001580 bacterial effect Effects 0.000 claims 18
- 239000000018 receptor agonist Substances 0.000 claims 16
- 229940044601 receptor agonist Drugs 0.000 claims 16
- 229940124597 therapeutic agent Drugs 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 13
- 230000003779 hair growth Effects 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 6
- 208000025645 collagenopathy Diseases 0.000 claims 5
- 239000002464 receptor antagonist Substances 0.000 claims 5
- 229940044551 receptor antagonist Drugs 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 201000002980 Hyperparathyroidism Diseases 0.000 claims 3
- 201000004384 Alopecia Diseases 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 2
- 241000193403 Clostridium Species 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 241000607598 Vibrio Species 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 208000022605 chemotherapy-induced alopecia Diseases 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 235000019833 protease Nutrition 0.000 claims 2
- 208000024985 Alport syndrome Diseases 0.000 claims 1
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
- 108010049951 Bone Morphogenetic Protein 3 Proteins 0.000 claims 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
- 102100024504 Bone morphogenetic protein 3 Human genes 0.000 claims 1
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 102000015225 Connective Tissue Growth Factor Human genes 0.000 claims 1
- 108010039419 Connective Tissue Growth Factor Proteins 0.000 claims 1
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 108090001047 Fibroblast growth factor 10 Proteins 0.000 claims 1
- 102100028412 Fibroblast growth factor 10 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000381 Fibroblast growth factor 4 Proteins 0.000 claims 1
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims 1
- 102000016355 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Human genes 0.000 claims 1
- 108010092372 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Proteins 0.000 claims 1
- 102000018997 Growth Hormone Human genes 0.000 claims 1
- 108010051696 Growth Hormone Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims 1
- 102000003982 Parathyroid hormone Human genes 0.000 claims 1
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 claims 1
- 108010076289 Platelet-Derived Growth Factor Receptors Proteins 0.000 claims 1
- 208000027077 Stickler syndrome Diseases 0.000 claims 1
- -1 TGF-b Proteins 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 208000004631 alopecia areata Diseases 0.000 claims 1
- 230000008468 bone growth Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 208000003215 hereditary nephritis Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000199 parathyroid hormone Substances 0.000 claims 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161570620P | 2011-12-14 | 2011-12-14 | |
| US61/570,620 | 2011-12-14 | ||
| US201261596869P | 2012-02-09 | 2012-02-09 | |
| US61/596,869 | 2012-02-09 | ||
| PCT/US2012/069831 WO2013090770A2 (en) | 2011-12-14 | 2012-12-14 | Delivery of therapeutic agents by a collagen binding protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018038513A Division JP6697019B2 (ja) | 2011-12-14 | 2018-03-05 | コラーゲン結合タンパク質による治療剤の送達 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015513312A JP2015513312A (ja) | 2015-05-07 |
| JP2015513312A5 true JP2015513312A5 (enExample) | 2016-02-04 |
| JP6366507B2 JP6366507B2 (ja) | 2018-08-01 |
Family
ID=48613370
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547503A Active JP6366507B2 (ja) | 2011-12-14 | 2012-12-14 | コラーゲン結合タンパク質による治療剤の送達 |
| JP2018038513A Active JP6697019B2 (ja) | 2011-12-14 | 2018-03-05 | コラーゲン結合タンパク質による治療剤の送達 |
| JP2020000376A Pending JP2020073554A (ja) | 2011-12-14 | 2020-01-06 | コラーゲン結合タンパク質による治療剤の送達 |
| JP2021172953A Active JP7327765B2 (ja) | 2011-12-14 | 2021-10-22 | コラーゲン結合タンパク質による治療剤の送達 |
| JP2023121669A Pending JP2023153154A (ja) | 2011-12-14 | 2023-07-26 | コラーゲン結合タンパク質による治療剤の送達 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018038513A Active JP6697019B2 (ja) | 2011-12-14 | 2018-03-05 | コラーゲン結合タンパク質による治療剤の送達 |
| JP2020000376A Pending JP2020073554A (ja) | 2011-12-14 | 2020-01-06 | コラーゲン結合タンパク質による治療剤の送達 |
| JP2021172953A Active JP7327765B2 (ja) | 2011-12-14 | 2021-10-22 | コラーゲン結合タンパク質による治療剤の送達 |
| JP2023121669A Pending JP2023153154A (ja) | 2011-12-14 | 2023-07-26 | コラーゲン結合タンパク質による治療剤の送達 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9579273B2 (enExample) |
| EP (4) | EP4397755A3 (enExample) |
| JP (5) | JP6366507B2 (enExample) |
| CA (2) | CA2859412C (enExample) |
| DK (2) | DK2790717T3 (enExample) |
| ES (3) | ES2816009T3 (enExample) |
| WO (1) | WO2013090770A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2155874T3 (en) | 2007-04-09 | 2016-08-01 | Univ Arkansas | FUSION PROTEIN OF COLLAGE BINDING DOMAIN AND parathyroid hormone |
| ES2816009T3 (es) * | 2011-12-14 | 2021-03-31 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| US9526765B2 (en) | 2012-02-09 | 2016-12-27 | The Kitasato Institute | Delivery of therapeutic agents by a collagen binding protein |
| WO2018148573A1 (en) * | 2017-02-10 | 2018-08-16 | The Board Of Trustees Of The University Of Arkansas | Collagen-binding agent compositions and methods of using the same |
| GB201706781D0 (en) | 2017-04-28 | 2017-06-14 | Univ Sheffield | Parathyroid hormone fusion polypeptide |
| KR101964376B1 (ko) * | 2017-09-29 | 2019-04-01 | 주식회사 나이벡 | 부갑상선호르몬(parathyroid hormone, PTH)에 골조직 선택성 펩타이드가 결합되어 있는 융합 펩타이드를 포함하는 약학 조성물 및 생체재료 |
| JP7045166B2 (ja) * | 2017-11-07 | 2022-03-31 | 株式会社ニッピ | コラーゲン結合材、その製造方法、ドラッグデリバリーシステム、および担持体 |
| WO2019173829A1 (en) | 2018-03-09 | 2019-09-12 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Delivering biological drugs to tissues |
| US20220363778A1 (en) * | 2019-08-28 | 2022-11-17 | The Research Foundation For The State University Of New York | Targeted delivery of tumor matrix modifying enzymes |
| JP7774276B2 (ja) * | 2020-09-02 | 2025-11-21 | コラジェン・ファーマ株式会社 | ペプチドを含む組成物及びその用途 |
| US12403179B2 (en) | 2021-02-18 | 2025-09-02 | The Board Of Trustees Of The University Of Arkansas | Release of growth factors at wound healing stages |
| AU2023298113A1 (en) * | 2022-06-27 | 2025-01-16 | Sustain Holdings, Llc | Collagen peptide-based medicament compositions and uses thereof |
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| WO1998004591A1 (en) | 1996-07-31 | 1998-02-05 | The General Hospital Corporation | Novel parathyroid hormone-related peptide analogs |
| US20100267012A1 (en) * | 1997-11-04 | 2010-10-21 | Bergeron Michel G | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| US6387663B1 (en) | 1998-07-31 | 2002-05-14 | University Of Southern California | Targeting pharmaceutical agents to injured tissues |
| US7601685B2 (en) | 1998-08-27 | 2009-10-13 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
| EP1151116A1 (en) | 1999-02-19 | 2001-11-07 | Terumo Kabushiki Kaisha | Collagen-binding physiologically active polypeptide |
| US20020102709A1 (en) | 1999-02-19 | 2002-08-01 | Tetsuya Ishikawa | Collagen-binding physiologically active polypeptide |
| US6908994B1 (en) | 1999-05-10 | 2005-06-21 | The Texas A&M University System | Collagen-binding proteins from enterococcal bacteria |
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| JP4750416B2 (ja) | 2002-07-25 | 2011-08-17 | ザ ジェネラル ホスピタル コーポレイション | 副甲状腺ホルモン受容体の活性化と造血前駆細胞の増殖 |
| ES2269973T3 (es) | 2003-02-13 | 2007-04-01 | Synthes Ag Chur | Mezcla inyectable para sustituir un tejido oseo. |
| US20040220094A1 (en) | 2003-05-01 | 2004-11-04 | Skinner Keith K. | Inverse agonist and agonist peptides that stimulate/inhibit hair growth |
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| US20090005298A1 (en) | 2004-02-27 | 2009-01-01 | The University Of Western Ontario | Bone Sialoprotein Collagen-Binding Peptides |
| HUE055861T2 (hu) | 2004-04-21 | 2021-12-28 | Alexion Pharma Inc | Csontbejuttató konjugátumok és azok alkalmazási módszere fehérjék csonthoz kötéséhez |
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| ES2816009T3 (es) * | 2011-12-14 | 2021-03-31 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
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| WO2018148573A1 (en) * | 2017-02-10 | 2018-08-16 | The Board Of Trustees Of The University Of Arkansas | Collagen-binding agent compositions and methods of using the same |
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| WO2019173829A1 (en) * | 2018-03-09 | 2019-09-12 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Delivering biological drugs to tissues |
| CN112996506A (zh) * | 2018-08-14 | 2021-06-18 | 奥斯特克有限公司 | 吡咯并二吡啶化合物 |
-
2012
- 2012-12-14 ES ES18173596T patent/ES2816009T3/es active Active
- 2012-12-14 US US14/365,226 patent/US9579273B2/en active Active
- 2012-12-14 DK DK12857691.5T patent/DK2790717T3/da active
- 2012-12-14 EP EP24153256.3A patent/EP4397755A3/en active Pending
- 2012-12-14 ES ES12857691T patent/ES2695161T3/es active Active
- 2012-12-14 JP JP2014547503A patent/JP6366507B2/ja active Active
- 2012-12-14 CA CA2859412A patent/CA2859412C/en active Active
- 2012-12-14 WO PCT/US2012/069831 patent/WO2013090770A2/en not_active Ceased
- 2012-12-14 CA CA3113972A patent/CA3113972C/en active Active
- 2012-12-14 EP EP12857691.5A patent/EP2790717B1/en active Active
- 2012-12-14 EP EP20184066.7A patent/EP3808365B1/en active Active
- 2012-12-14 DK DK18173596.0T patent/DK3391899T3/da active
- 2012-12-14 EP EP18173596.0A patent/EP3391899B1/en active Active
- 2012-12-14 ES ES20184066T patent/ES2975215T3/es active Active
-
2017
- 2017-01-17 US US15/407,589 patent/US11001820B2/en active Active
-
2018
- 2018-03-05 JP JP2018038513A patent/JP6697019B2/ja active Active
-
2019
- 2019-02-22 US US16/283,468 patent/US11279922B2/en active Active
-
2020
- 2020-01-06 JP JP2020000376A patent/JP2020073554A/ja active Pending
-
2021
- 2021-10-22 JP JP2021172953A patent/JP7327765B2/ja active Active
-
2023
- 2023-07-26 JP JP2023121669A patent/JP2023153154A/ja active Pending
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