JP2020508984A5 - - Google Patents
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- Publication number
- JP2020508984A5 JP2020508984A5 JP2019543282A JP2019543282A JP2020508984A5 JP 2020508984 A5 JP2020508984 A5 JP 2020508984A5 JP 2019543282 A JP2019543282 A JP 2019543282A JP 2019543282 A JP2019543282 A JP 2019543282A JP 2020508984 A5 JP2020508984 A5 JP 2020508984A5
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- seq
- binding
- polypeptide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000008186 Collagen Human genes 0.000 claims description 54
- 229920001436 collagen Polymers 0.000 claims description 54
- 108010035532 Collagen Proteins 0.000 claims description 53
- 229920001184 polypeptide Polymers 0.000 claims description 39
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 39
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 39
- 239000011230 binding agent Substances 0.000 claims description 31
- 239000003814 drug Substances 0.000 claims description 26
- 229940124597 therapeutic agent Drugs 0.000 claims description 22
- 102000003982 Parathyroid hormone Human genes 0.000 claims description 16
- 108090000445 Parathyroid hormone Proteins 0.000 claims description 16
- 239000000199 parathyroid hormone Substances 0.000 claims description 16
- 229960001319 parathyroid hormone Drugs 0.000 claims description 16
- 150000001413 amino acids Chemical group 0.000 claims description 12
- 239000012634 fragment Substances 0.000 claims description 9
- 102000006461 Parathyroid Hormone Receptors Human genes 0.000 claims description 8
- 108010058828 Parathyroid Hormone Receptors Proteins 0.000 claims description 8
- 239000003102 growth factor Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000000018 receptor agonist Substances 0.000 claims description 4
- 229940044601 receptor agonist Drugs 0.000 claims description 4
- 239000002464 receptor antagonist Substances 0.000 claims description 4
- 229940044551 receptor antagonist Drugs 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- 208000027932 Collagen disease Diseases 0.000 claims description 3
- 201000004384 Alopecia Diseases 0.000 claims description 2
- 208000024985 Alport syndrome Diseases 0.000 claims description 2
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 2
- 108010049951 Bone Morphogenetic Protein 3 Proteins 0.000 claims description 2
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims description 2
- 102100024504 Bone morphogenetic protein 3 Human genes 0.000 claims description 2
- 206010007710 Cartilage injury Diseases 0.000 claims description 2
- 108060005980 Collagenase Proteins 0.000 claims description 2
- 102000029816 Collagenase Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 102100028071 Fibroblast growth factor 7 Human genes 0.000 claims description 2
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims description 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims description 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 2
- 102000018997 Growth Hormone Human genes 0.000 claims description 2
- 108010051696 Growth Hormone Proteins 0.000 claims description 2
- 201000002980 Hyperparathyroidism Diseases 0.000 claims description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims description 2
- 208000033463 Ischaemic neuropathy Diseases 0.000 claims description 2
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims description 2
- 208000027077 Stickler syndrome Diseases 0.000 claims description 2
- 108091005735 TGF-beta receptors Proteins 0.000 claims description 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 2
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 claims description 2
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims description 2
- 101800004564 Transforming growth factor alpha Proteins 0.000 claims description 2
- 102400001320 Transforming growth factor alpha Human genes 0.000 claims description 2
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 210000004899 c-terminal region Anatomy 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
- 229960002424 collagenase Drugs 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 239000000122 growth hormone Substances 0.000 claims description 2
- 230000003779 hair growth Effects 0.000 claims description 2
- 208000024963 hair loss Diseases 0.000 claims description 2
- 230000003676 hair loss Effects 0.000 claims description 2
- 208000003215 hereditary nephritis Diseases 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 208000031225 myocardial ischemia Diseases 0.000 claims description 2
- 102000040430 polynucleotide Human genes 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims description 2
- 239000002157 polynucleotide Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 150000003384 small molecules Chemical class 0.000 claims description 2
- 208000020431 spinal cord injury Diseases 0.000 claims description 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 2
- 230000008467 tissue growth Effects 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims 2
- 108010059616 Activins Proteins 0.000 claims 1
- 208000002197 Ehlers-Danlos syndrome Diseases 0.000 claims 1
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 1
- 239000000488 activin Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 6
- 241000124008 Mammalia Species 0.000 description 2
- 230000008468 bone growth Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023044982A JP7682503B2 (ja) | 2017-02-10 | 2023-03-22 | コラーゲン結合薬剤組成物およびその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762457410P | 2017-02-10 | 2017-02-10 | |
| US62/457,410 | 2017-02-10 | ||
| PCT/US2018/017665 WO2018148573A1 (en) | 2017-02-10 | 2018-02-09 | Collagen-binding agent compositions and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023044982A Division JP7682503B2 (ja) | 2017-02-10 | 2023-03-22 | コラーゲン結合薬剤組成物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508984A JP2020508984A (ja) | 2020-03-26 |
| JP2020508984A5 true JP2020508984A5 (enExample) | 2021-03-25 |
| JP7397440B2 JP7397440B2 (ja) | 2023-12-13 |
Family
ID=63107889
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019543282A Active JP7397440B2 (ja) | 2017-02-10 | 2018-02-09 | コラーゲン結合薬剤組成物およびその使用方法 |
| JP2023044982A Active JP7682503B2 (ja) | 2017-02-10 | 2023-03-22 | コラーゲン結合薬剤組成物およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023044982A Active JP7682503B2 (ja) | 2017-02-10 | 2023-03-22 | コラーゲン結合薬剤組成物およびその使用方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US11624060B2 (enExample) |
| JP (2) | JP7397440B2 (enExample) |
| WO (1) | WO2018148573A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2816009T3 (es) * | 2011-12-14 | 2021-03-31 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| WO2018148573A1 (en) * | 2017-02-10 | 2018-08-16 | The Board Of Trustees Of The University Of Arkansas | Collagen-binding agent compositions and methods of using the same |
| US12403179B2 (en) * | 2021-02-18 | 2025-09-02 | The Board Of Trustees Of The University Of Arkansas | Release of growth factors at wound healing stages |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8516421D0 (en) | 1985-06-28 | 1985-07-31 | Biotechnology Interface Ltd | Fibronectins |
| WO1994022468A1 (en) | 1993-04-02 | 1994-10-13 | Anticancer, Inc. | Method for delivering beneficial compositions to hair follicles |
| WO1998004591A1 (en) | 1996-07-31 | 1998-02-05 | The General Hospital Corporation | Novel parathyroid hormone-related peptide analogs |
| US20100267012A1 (en) | 1997-11-04 | 2010-10-21 | Bergeron Michel G | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| US6387663B1 (en) | 1998-07-31 | 2002-05-14 | University Of Southern California | Targeting pharmaceutical agents to injured tissues |
| US7601685B2 (en) | 1998-08-27 | 2009-10-13 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
| US20020102709A1 (en) | 1999-02-19 | 2002-08-01 | Tetsuya Ishikawa | Collagen-binding physiologically active polypeptide |
| EP1151116A1 (en) | 1999-02-19 | 2001-11-07 | Terumo Kabushiki Kaisha | Collagen-binding physiologically active polypeptide |
| US6908994B1 (en) | 1999-05-10 | 2005-06-21 | The Texas A&M University System | Collagen-binding proteins from enterococcal bacteria |
| US7396664B2 (en) | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| US20050124537A1 (en) | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| US20040053368A1 (en) | 2000-08-15 | 2004-03-18 | Tetsuya Ishikawa | Collagen-binding hybrid polypeptide |
| JP2002058485A (ja) | 2000-08-16 | 2002-02-26 | Terumo Corp | コラーゲン結合性を有する骨形成促進融合蛋白質 |
| JP4560291B2 (ja) | 2001-12-18 | 2010-10-13 | イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ | 組織操作のための成長因子改変タンパク質マトリクス |
| JP2003284553A (ja) * | 2002-03-28 | 2003-10-07 | Seikagaku Kogyo Co Ltd | 生理活性タンパク質 |
| JP4750416B2 (ja) | 2002-07-25 | 2011-08-17 | ザ ジェネラル ホスピタル コーポレイション | 副甲状腺ホルモン受容体の活性化と造血前駆細胞の増殖 |
| ES2269973T3 (es) | 2003-02-13 | 2007-04-01 | Synthes Ag Chur | Mezcla inyectable para sustituir un tejido oseo. |
| US20040220094A1 (en) | 2003-05-01 | 2004-11-04 | Skinner Keith K. | Inverse agonist and agonist peptides that stimulate/inhibit hair growth |
| WO2005046798A1 (en) | 2003-11-12 | 2005-05-26 | Nps Allelix Corp. | Treatment of bone loss utilizing full length parathyroid hormone |
| EP1557176A1 (en) | 2004-01-26 | 2005-07-27 | Ferring B.V. | Treatment of bone metastases by means of PTH receptor agonists |
| WO2005078085A1 (ja) | 2004-02-16 | 2005-08-25 | Techno Network Shikoku Co., Ltd. | コラーゲン様構造を有するポリペプチド |
| HUE055861T2 (hu) | 2004-04-21 | 2021-12-28 | Alexion Pharma Inc | Csontbejuttató konjugátumok és azok alkalmazási módszere fehérjék csonthoz kötéséhez |
| WO2006073711A2 (en) | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
| ATE514712T1 (de) | 2005-12-26 | 2011-07-15 | Yantai Zhenghai Bio Technology Co Ltd | Aktivierte collagen-gerüstmaterialien und ihre speziellen kondensierten aktiven restorationsfaktoren |
| CA2669914C (en) | 2006-11-16 | 2017-11-07 | Kai Pharmaceuticals, Inc. | Polycationic calcium modulator peptides for the treatment of hyperparathyroidism and hypercalcemic disorders |
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| DK2155874T3 (en) | 2007-04-09 | 2016-08-01 | Univ Arkansas | FUSION PROTEIN OF COLLAGE BINDING DOMAIN AND parathyroid hormone |
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| WO2011060431A2 (en) | 2009-11-16 | 2011-05-19 | University Of Maryland Baltimore | Multivalent live vector vaccine against clostridium difficile-associated disease |
| JPWO2011142425A1 (ja) | 2010-05-12 | 2013-07-22 | 国立大学法人 香川大学 | 上皮層含有組織の再生材および再生評価方法 |
| ES2385239B1 (es) | 2010-09-30 | 2013-06-19 | Proteos Biotech S.L.U. | Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno. |
| AU2012227790C1 (en) | 2011-03-16 | 2016-06-30 | Meiji Seika Pharma Co., Ltd. | Probe for analyzing biological tissue and method for utilizing same |
| JP5512887B2 (ja) | 2011-05-13 | 2014-06-04 | 学校法人北里研究所 | 成長因子アンカーリング型骨移植材料および成長因子アンカーリング型骨移植材料製造用キット |
| ES2816009T3 (es) | 2011-12-14 | 2021-03-31 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| EP4015627B1 (en) | 2012-01-12 | 2023-09-27 | Endo Global Ventures | Clostridium histolyticum enzyme |
| WO2013120030A1 (en) | 2012-02-08 | 2013-08-15 | Shining Golden Yida Welding & Cutting Machinery Manufacture Ltd. | Rotary vane air motor with improved vanes and other improvements |
| US9526765B2 (en) | 2012-02-09 | 2016-12-27 | The Kitasato Institute | Delivery of therapeutic agents by a collagen binding protein |
| EP2937088B1 (en) | 2012-12-21 | 2020-11-18 | Tokushima University | Composition having tissue repairing activity and utilization thereof |
| WO2015048334A2 (en) | 2013-09-25 | 2015-04-02 | Pronutria, Inc. | Edible species nutritive polypeptides and methods of production and use thereof |
| US9539363B2 (en) | 2014-04-24 | 2017-01-10 | Warsaw Orthopedic, Inc. | Collagen matrix |
| WO2016060252A1 (ja) | 2014-10-16 | 2016-04-21 | 学校法人北里研究所 | 神経再生用移植材料、神経再生用移植材料の製造方法、及び神経再生用移植材料製造用キット |
| EP3112474A1 (en) | 2015-06-29 | 2017-01-04 | Evonik Degussa GmbH | Method of detecting avian necrotic enteritis |
| CN109789189B (zh) | 2016-09-29 | 2024-01-23 | 阿森迪斯药物骨疾病股份有限公司 | 控释pth化合物的剂量方案 |
| WO2018148573A1 (en) | 2017-02-10 | 2018-08-16 | The Board Of Trustees Of The University Of Arkansas | Collagen-binding agent compositions and methods of using the same |
| WO2019113123A1 (en) | 2017-12-04 | 2019-06-13 | Precithera, Inc. | TGF-ß RECEPTOR FUSION PROTEINS AND OTHER TGF-ß ANTAGONISTS FOR REDUCING TGF-ß SIGNALING |
| US10519236B2 (en) | 2018-01-23 | 2019-12-31 | New York University | Antibodies specific to delta 1 chain of T cell receptor |
| WO2019173829A1 (en) | 2018-03-09 | 2019-09-12 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Delivering biological drugs to tissues |
-
2018
- 2018-02-09 WO PCT/US2018/017665 patent/WO2018148573A1/en not_active Ceased
- 2018-02-09 US US16/485,290 patent/US11624060B2/en active Active
- 2018-02-09 JP JP2019543282A patent/JP7397440B2/ja active Active
-
2023
- 2023-03-22 JP JP2023044982A patent/JP7682503B2/ja active Active
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