JP2015512508A - 生物学的反応システムのための被覆されている基材 - Google Patents

生物学的反応システムのための被覆されている基材 Download PDF

Info

Publication number
JP2015512508A
JP2015512508A JP2015500660A JP2015500660A JP2015512508A JP 2015512508 A JP2015512508 A JP 2015512508A JP 2015500660 A JP2015500660 A JP 2015500660A JP 2015500660 A JP2015500660 A JP 2015500660A JP 2015512508 A JP2015512508 A JP 2015512508A
Authority
JP
Japan
Prior art keywords
reaction
substrate
contact angle
reaction site
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015500660A
Other languages
English (en)
Japanese (ja)
Inventor
エリオドア ゲンシュー，
エリオドア ゲンシュー，
エバン フォスター，
エバン フォスター，
セオドア ストラウブ，
セオドア ストラウブ，
マイケル シー． パラス，
マイケル シー． パラス，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Technologies Corp
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Publication of JP2015512508A publication Critical patent/JP2015512508A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5088—Rigid containers without fluid transport within confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/0038—Drawing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0896—Nanoscaled
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Sampling And Sample Adjustment (AREA)
JP2015500660A 2012-03-16 2013-03-15 生物学的反応システムのための被覆されている基材 Pending JP2015512508A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201261612005P 2012-03-16 2012-03-16
US201261612008P 2012-03-16 2012-03-16
US201261612087P 2012-03-16 2012-03-16
US61/612,087 2012-03-16
US61/612,008 2012-03-16
US61/612,005 2012-03-16
US201261723759P 2012-11-07 2012-11-07
US201261723658P 2012-11-07 2012-11-07
US201261723738P 2012-11-07 2012-11-07
US61/723,759 2012-11-07
US61/723,658 2012-11-07
US61/723,738 2012-11-07
PCT/US2013/032242 WO2013138746A1 (en) 2012-03-16 2013-03-15 Coated substrate for biological reaction systems

Publications (1)

Publication Number Publication Date
JP2015512508A true JP2015512508A (ja) 2015-04-27

Family

ID=48014373

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015500660A Pending JP2015512508A (ja) 2012-03-16 2013-03-15 生物学的反応システムのための被覆されている基材
JP2015500654A Pending JP2015511016A (ja) 2012-03-16 2013-03-15 液体試料を充填するためのシステムおよび方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015500654A Pending JP2015511016A (ja) 2012-03-16 2013-03-15 液体試料を充填するためのシステムおよび方法

Country Status (10)

Country Link
US (4) US10627420B2 (show.php)
EP (2) EP2825311B1 (show.php)
JP (2) JP2015512508A (show.php)
KR (2) KR20150022751A (show.php)
CN (2) CN104334275B (show.php)
AU (2) AU2013231955A1 (show.php)
IN (2) IN2014DN08136A (show.php)
RU (2) RU2014141634A (show.php)
SG (2) SG11201405788UA (show.php)
WO (2) WO2013138724A2 (show.php)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015511015A (ja) * 2012-03-16 2015-04-13 ライフ テクノロジーズ コーポレーション 生体試料を収容するためのシステム及び方法
CA2915475A1 (en) 2013-05-24 2014-11-27 Life Technologies Corporation Case and case holder for biological samples and corresponding method of use
CN106061611A (zh) * 2013-11-18 2016-10-26 生命技术公司 用于装载液体样品的系统和方法
JP6560054B2 (ja) * 2015-08-05 2019-08-14 株式会社古河電工アドバンストエンジニアリング 検体導入部材、ウェルへの検体導入方法
WO2017038682A1 (ja) * 2015-08-28 2017-03-09 国立研究開発法人理化学研究所 鋳型核酸の分析方法、標的物質の分析方法、鋳型核酸または標的物質の分析用キット、および鋳型核酸または標的物質の分析用装置
CN105543064B (zh) * 2015-12-29 2018-04-17 西安交通大学 一种数字pcr芯片及其使用方法
WO2017123626A1 (en) * 2016-01-11 2017-07-20 Advandx, Inc. Device for capillary force sample loading and improved assay performance
CN106111220A (zh) * 2016-06-20 2016-11-16 北京领宇科技有限公司 一种用于生物/化学反应体系的反应装置及其制备方法和应用
EP3551745A4 (en) 2016-12-12 2020-07-15 Xcella Biosciences, Inc. SCREENING METHODS AND SYSTEMS USING MICROCAPILLARY NETWORKS
US11085039B2 (en) 2016-12-12 2021-08-10 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
CN110382439B (zh) 2016-12-30 2026-07-21 埃克切拉生物科学公司 多级样品回收系统
CN108660068B (zh) * 2018-02-13 2022-04-05 臻准生物工程(山西)有限公司 生物反应芯片及其制备方法
DK3890876T3 (da) 2018-12-06 2024-07-22 Xcella Biosciences Inc Lateral påfyldning af mikrokapillære arrays
CA3156776A1 (en) 2019-11-08 2021-05-14 xCella Biosciences, Inc. Apparatus and methods for laser-based single cell recovery from microcapillary arrays
DE102019220017A1 (de) * 2019-12-18 2021-06-24 Robert Bosch Gesellschaft mit beschränkter Haftung Aufnahmeeinheit zum Aufnehmen eines Fluids, Verfahren und Vorrichtung zum Herstellen einer Aufnahmeeinheit, Verfahren und Vorrichtung zum Betreiben einer Aufnahmeeinheit und Aufnahmeeinrichtung
US20230347349A1 (en) * 2020-09-10 2023-11-02 Nuclera Nucleics Ltd Composite top plate for magnetic and temperature control in a digital microfluidic device
CN114985023B (zh) * 2021-10-27 2024-01-05 北京擎科生物科技股份有限公司 微阵列芯片和包括其的寡核苷酸合成装置
EP4433796A4 (en) * 2021-11-19 2025-10-22 Univ Cornell OMNIPHOBIC TILES (DOTS) WITH SURFACE PATTERNS, ASSOCIATED MANUFACTURE, LOADING AND USE
CN114414811B (zh) * 2021-12-15 2024-12-31 中核同辐（长春）辐射技术有限公司 一种羟基改性蛋白质芯片的制备方法
KR20230138571A (ko) 2022-03-23 2023-10-05 삼성전자주식회사 바이오 입자 검출 장치 및 방법

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04301608A (ja) * 1991-03-29 1992-10-26 Hitachi Cable Ltd 合成樹脂光伝送体の製造方法
JPH05126716A (ja) * 1991-11-06 1993-05-21 Dainippon Printing Co Ltd 前進及び後退接触角測定方法
JP2001519449A (ja) * 1997-10-03 2001-10-23 ミネソタ マイニング アンド マニュファクチャリング カンパニー ポリマーのコロナ処理
JP2002214232A (ja) * 2001-01-12 2002-07-31 Toray Ind Inc 選択結合性物質固定化フィルム及びそれを用いた被検物質の測定方法
JP2002335960A (ja) * 2001-05-15 2002-11-26 Moritex Corp Ｐｃｒ用マイクロプレート及びそれを用いたｐｃｒ法
US20030047688A1 (en) * 2001-08-07 2003-03-13 Faris Gregory W. Optical microfluidic devices and methods
JP2004517175A (ja) * 2000-12-29 2004-06-10 エヌ・ケー・ティー リサーチ アンド イノベーション アクティーゼルスカブ 化合物を固定する基質の調製方法、その基質およびその使用方法
US20040171135A1 (en) * 2001-03-23 2004-09-02 President And Fellows Of Harvard College Selective deposition of materials on countoured surfaces
JP2005536727A (ja) * 2002-08-23 2005-12-02 バイオトローブ・インク 毛管作用移送ピン
JP2007515263A (ja) * 2003-03-31 2007-06-14 アイトゲノシッシュ テヒニッシュ ホーホシューレ チューリッヒ 制御された界面化学勾配
JP2007521458A (ja) * 2003-07-14 2007-08-02 キアゲン サイエンシス インコーポレイテッド 異なる湿潤性を有する試料提示器具
JP2007529015A (ja) * 2004-03-12 2007-10-18 バイオトローブ， インコーポレイテッド ナノリットルのアレイローディング
JP2008509398A (ja) * 2004-08-04 2008-03-27 バイオトローブ， インコーポレイテッド ディスペンサーアレイのロケーションを登録するための方法およびシステム
JP2009509144A (ja) * 2005-09-15 2009-03-05 バイオトローブ， インコーポレイテッド マイクロ流体アレイアッセイのためのサーマルサイクラ
JP2010510777A (ja) * 2006-11-24 2010-04-08 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 液滴中においてサンプルを処理するための装置、およびそれを使用する方法
US20100298163A1 (en) * 2008-01-04 2010-11-25 The Royal Institution For The Advancement Of Learning/Mcgill University Microfluidic microarray system and method for the multiplexed analysis of biomolecules
JP2011203272A (ja) * 2002-12-26 2011-10-13 Meso Scale Technologies Llc アッセイカートリッジ及び同アッセイカートリッジを用いた方法
WO2011157895A1 (en) * 2010-06-15 2011-12-22 Åbo Akademi University Method for manufacturing a sheet-like reaction plate, reaction plate and its use

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110555A (en) * 1989-09-18 1992-05-05 Miles Inc. Capillary flow apparatus for inoculation of a test substrate
WO1997006890A1 (en) 1995-08-11 1997-02-27 Robbins Scientific Corporation Compartmentalized multi-well container
DE19740806C2 (de) * 1997-09-17 1999-10-07 Schott Glas Mikrotiterplatte aus Kunststoff
US6027873A (en) * 1999-03-19 2000-02-22 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
JP2000271525A (ja) * 1999-03-26 2000-10-03 Mitsubishi Paper Mills Ltd 塗布装置
US7332271B2 (en) * 2000-02-18 2008-02-19 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
CA2451201A1 (en) * 2001-06-20 2003-01-03 Cytonome, Inc. Microfabricated two-pin liquid sample dispensing system
NL1019378C2 (nl) * 2001-11-16 2003-05-20 Univ Delft Tech Werkwijze voor het vullen van een putje in een substraat.
US7258839B2 (en) * 2001-12-21 2007-08-21 Cytonome, Inc. Temperature controlled microfabricated two-pin liquid sample dispensing system
WO2003100421A1 (en) * 2002-05-28 2003-12-04 Bio Strand, Inc. Specimen distributing device, coating part manufacturing method, specimen distributing method, and substrate activating device
JP2004109107A (ja) * 2002-07-25 2004-04-08 Nippon Sheet Glass Co Ltd 生化学用容器
JP2004184100A (ja) * 2002-11-29 2004-07-02 I Design:Kk 分析用具、それを用いた分析方法及び、分析用具の製造方法
EP1608952B1 (en) 2002-12-20 2016-08-10 Life Technologies Corporation Assay apparatus and method using microfluidic arrays
US20060233671A1 (en) 2003-09-19 2006-10-19 Beard Nigel P High density plate filler
US8277760B2 (en) 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US7291362B2 (en) * 2004-01-20 2007-11-06 3M Innovative Properties Company Method and apparatus for controlling coating width
US7690325B2 (en) * 2004-04-30 2010-04-06 Bioforce Nanosciences, Inc. Method and apparatus for depositing material onto a surface
US20060105453A1 (en) * 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
US7170050B2 (en) * 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US7315019B2 (en) * 2004-09-17 2008-01-01 Pacific Biosciences Of California, Inc. Arrays of optical confinements and uses thereof
EP1693337A1 (de) * 2005-02-18 2006-08-23 Infineon Technologies AG Makroporöser Träger für chemische Amplifikationsreaktionen
US7682816B2 (en) * 2005-04-07 2010-03-23 454 Life Sciences Corporation Thin film coated microwell arrays and methods of using same
CN1996009B (zh) * 2007-01-10 2010-05-19 博奥生物有限公司 一种用于多样品分析的微流体器件和使用方法
JP5095247B2 (ja) * 2007-03-22 2012-12-12 株式会社城北精工所 コーティングダイ
CN106443039B (zh) 2010-06-28 2018-04-24 生命科技公司 用于转移液体样品的系统和方法

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04301608A (ja) * 1991-03-29 1992-10-26 Hitachi Cable Ltd 合成樹脂光伝送体の製造方法
JPH05126716A (ja) * 1991-11-06 1993-05-21 Dainippon Printing Co Ltd 前進及び後退接触角測定方法
JP2001519449A (ja) * 1997-10-03 2001-10-23 ミネソタ マイニング アンド マニュファクチャリング カンパニー ポリマーのコロナ処理
JP2004517175A (ja) * 2000-12-29 2004-06-10 エヌ・ケー・ティー リサーチ アンド イノベーション アクティーゼルスカブ 化合物を固定する基質の調製方法、その基質およびその使用方法
JP2002214232A (ja) * 2001-01-12 2002-07-31 Toray Ind Inc 選択結合性物質固定化フィルム及びそれを用いた被検物質の測定方法
US20040171135A1 (en) * 2001-03-23 2004-09-02 President And Fellows Of Harvard College Selective deposition of materials on countoured surfaces
JP2002335960A (ja) * 2001-05-15 2002-11-26 Moritex Corp Ｐｃｒ用マイクロプレート及びそれを用いたｐｃｒ法
US20030047688A1 (en) * 2001-08-07 2003-03-13 Faris Gregory W. Optical microfluidic devices and methods
JP2005536727A (ja) * 2002-08-23 2005-12-02 バイオトローブ・インク 毛管作用移送ピン
JP2011203272A (ja) * 2002-12-26 2011-10-13 Meso Scale Technologies Llc アッセイカートリッジ及び同アッセイカートリッジを用いた方法
JP2007515263A (ja) * 2003-03-31 2007-06-14 アイトゲノシッシュ テヒニッシュ ホーホシューレ チューリッヒ 制御された界面化学勾配
JP2007521458A (ja) * 2003-07-14 2007-08-02 キアゲン サイエンシス インコーポレイテッド 異なる湿潤性を有する試料提示器具
JP2007529015A (ja) * 2004-03-12 2007-10-18 バイオトローブ， インコーポレイテッド ナノリットルのアレイローディング
JP2008509398A (ja) * 2004-08-04 2008-03-27 バイオトローブ， インコーポレイテッド ディスペンサーアレイのロケーションを登録するための方法およびシステム
JP2009509144A (ja) * 2005-09-15 2009-03-05 バイオトローブ， インコーポレイテッド マイクロ流体アレイアッセイのためのサーマルサイクラ
JP2010510777A (ja) * 2006-11-24 2010-04-08 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 液滴中においてサンプルを処理するための装置、およびそれを使用する方法
US20100298163A1 (en) * 2008-01-04 2010-11-25 The Royal Institution For The Advancement Of Learning/Mcgill University Microfluidic microarray system and method for the multiplexed analysis of biomolecules
WO2011157895A1 (en) * 2010-06-15 2011-12-22 Åbo Akademi University Method for manufacturing a sheet-like reaction plate, reaction plate and its use

Also Published As

Publication number Publication date
US11493526B2 (en) 2022-11-08
US10627420B2 (en) 2020-04-21
EP2825312A2 (en) 2015-01-21
SG11201405788UA (en) 2014-11-27
KR20150022751A (ko) 2015-03-04
EP2825311B1 (en) 2020-07-29
US20150072897A1 (en) 2015-03-12
US20200319221A1 (en) 2020-10-08
CN104334273B (zh) 2016-12-07
US20150051118A1 (en) 2015-02-19
WO2013138724A3 (en) 2014-04-24
IN2014DN08164A (show.php) 2015-05-01
US10627421B2 (en) 2020-04-21
KR20150003737A (ko) 2015-01-09
WO2013138746A1 (en) 2013-09-19
RU2014141635A (ru) 2016-05-10
IN2014DN08136A (show.php) 2015-05-01
CN104334275A (zh) 2015-02-04
JP2015511016A (ja) 2015-04-13
AU2013231955A1 (en) 2014-10-30
WO2013138724A2 (en) 2013-09-19
RU2014141634A (ru) 2016-05-10
EP2825312B1 (en) 2020-04-29
US20230030218A1 (en) 2023-02-02
CN104334273A (zh) 2015-02-04
AU2013231889A1 (en) 2014-10-30
CN104334275B (zh) 2016-08-24
SG11201405787SA (en) 2014-11-27
EP2825311A1 (en) 2015-01-21

Similar Documents

Publication Publication Date Title
US20230030218A1 (en) Coated Substrate for Biological Reaction Systems
JP7574265B2 (ja) フローセルパッケージおよびその製造方法
AU2021204165B2 (en) Flow Cells With Hydrogel Coating
JP7304158B2 (ja) フローセル用保護表面被膜
US12337324B2 (en) Microreactor array platform
JP7123928B2 (ja) 樹脂膜とパターン化ポリマー層を含むアレイ
KR20190009345A (ko) 패턴화된 소수성 표면을 사용한 자가 조립된 패터닝
EP1643249A1 (en) Bio-chip
US20210011013A1 (en) Novel Biochip Substrate, Preparation Method and Application Thereof
JP2009528037A (ja) 核酸増幅用基材
KR102900855B1 (ko) 헤테로폴리머를 포함하는 플로우 셀
CN114561455A (zh) 一种芯片表面化学修饰方法
Ventimiglia et al. The biophysics of nucleic acids sensing by hybridization on a lab-on-chip device
Dugas et al. The immobilisation of DNA strands on silica surface by means of chemical grafting
US20080085512A1 (en) Array assay devices and methods for making and using the same

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160222

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20161221

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170105

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170802