JP2015511931A5 - - Google Patents
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- Publication number
- JP2015511931A5 JP2015511931A5 JP2014519203A JP2014519203A JP2015511931A5 JP 2015511931 A5 JP2015511931 A5 JP 2015511931A5 JP 2014519203 A JP2014519203 A JP 2014519203A JP 2014519203 A JP2014519203 A JP 2014519203A JP 2015511931 A5 JP2015511931 A5 JP 2015511931A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- amino acid
- acid sequence
- hvr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 31
- 239000003814 drug Substances 0.000 claims 21
- 229940119218 CD83 agonist Drugs 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 6
- 210000004443 dendritic cell Anatomy 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 3
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 3
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 3
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000011664 signaling Effects 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
- 102000043136 MAP kinase family Human genes 0.000 claims 2
- 108091054455 MAP kinase family Proteins 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000026731 phosphorylation Effects 0.000 claims 2
- 238000006366 phosphorylation reaction Methods 0.000 claims 2
- 230000000770 proinflammatory effect Effects 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 206010050245 Autoimmune thrombocytopenia Diseases 0.000 claims 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 1
- 102100035793 CD83 antigen Human genes 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102000005636 Cyclic AMP Response Element-Binding Protein Human genes 0.000 claims 1
- 108010045171 Cyclic AMP Response Element-Binding Protein Proteins 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims 1
- 206010021263 IgA nephropathy Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000014158 Interleukin-12 Subunit p40 Human genes 0.000 claims 1
- 108010011429 Interleukin-12 Subunit p40 Proteins 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000003782 Raynaud disease Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 206010043561 Thrombocytopenic purpura Diseases 0.000 claims 1
- 201000007023 Thrombotic Thrombocytopenic Purpura Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 102000009634 interleukin-1 receptor antagonist activity proteins Human genes 0.000 claims 1
- 108040001669 interleukin-1 receptor antagonist activity proteins Proteins 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 210000000066 myeloid cell Anatomy 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014519203A JP6198730B2 (ja) | 2011-07-01 | 2012-06-29 | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161504127P | 2011-07-01 | 2011-07-01 | |
| US61/504,127 | 2011-07-01 | ||
| JP2011285585 | 2011-12-27 | ||
| JP2011285585A JP2013040160A (ja) | 2011-07-01 | 2011-12-27 | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
| PCT/US2012/045142 WO2013006505A1 (en) | 2011-07-01 | 2012-06-29 | Use of anti-cd83 agonist antibodies for treating autoimmune diseases |
| JP2014519203A JP6198730B2 (ja) | 2011-07-01 | 2012-06-29 | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511931A JP2015511931A (ja) | 2015-04-23 |
| JP2015511931A5 true JP2015511931A5 (enExample) | 2015-08-20 |
| JP6198730B2 JP6198730B2 (ja) | 2017-09-20 |
Family
ID=47888898
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011285585A Pending JP2013040160A (ja) | 2011-07-01 | 2011-12-27 | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
| JP2014519203A Expired - Fee Related JP6198730B2 (ja) | 2011-07-01 | 2012-06-29 | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011285585A Pending JP2013040160A (ja) | 2011-07-01 | 2011-12-27 | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9562097B2 (enExample) |
| EP (1) | EP2726509B1 (enExample) |
| JP (2) | JP2013040160A (enExample) |
| KR (1) | KR20140051272A (enExample) |
| CN (1) | CN103906766B (enExample) |
| AU (1) | AU2012279175B2 (enExample) |
| BR (1) | BR112013033968A2 (enExample) |
| CA (1) | CA2840426A1 (enExample) |
| MX (1) | MX2014000142A (enExample) |
| RU (1) | RU2014103498A (enExample) |
| WO (1) | WO2013006505A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013150592A (ja) * | 2011-07-01 | 2013-08-08 | Genentech Inc | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
| JP2013040160A (ja) | 2011-07-01 | 2013-02-28 | Genentech Inc | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
| DK2951208T3 (da) | 2013-02-01 | 2020-01-13 | Kira Biotech Pty Ltd | Anti-cd83 antistoffer og anvendelse deraf |
| EP3209695A4 (en) * | 2014-10-23 | 2018-05-30 | DendroCyte BioTech Pty Ltd | Cd83 binding proteins and uses thereof |
| US9982057B2 (en) | 2014-11-17 | 2018-05-29 | Pelican Therapeutics, Inc. | Human TNFRSF25 antibody |
| CN104610452B (zh) * | 2015-01-27 | 2018-11-20 | 中国科学技术大学先进技术研究院 | 抗人cd83单克隆抗体及其制备、鉴定和应用 |
| AU2017278192A1 (en) | 2016-06-09 | 2018-12-13 | Pelican Therapeutics, Inc. | Anti-TNFRSF25 antibodies |
| CN111148759B (zh) * | 2017-09-30 | 2023-09-19 | 合肥立方制药股份有限公司 | 结合至纤维连接蛋白b结构域的蛋白 |
| KR20200130324A (ko) * | 2018-02-23 | 2020-11-18 | 에이치 리 모피트 캔서 센터 앤드 리서어치 인스티튜트 아이엔씨 | Cd83-결합 키메라 항원 수용체 |
| CA3147835A1 (en) * | 2019-08-16 | 2021-02-25 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Chimeric antigen receptors for treating myeloid malignancies |
| JP7701908B2 (ja) * | 2019-08-16 | 2025-07-02 | エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド | 抗ｃｄ３８キメラ抗原受容体を発現する制御性ｔ細胞 |
| WO2021127212A2 (en) * | 2019-12-18 | 2021-06-24 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Systems and methods for producing efficacious regulatory t cells |
| EP3895723A1 (en) * | 2020-04-16 | 2021-10-20 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Scd83 for wound healing, hair growth, and skin and hair care |
| EP4598572A1 (en) * | 2022-10-04 | 2025-08-13 | Emergent Product Development Gaithersburg Inc. | Novel vsv virus formulations |
| DE102024110866A1 (de) * | 2024-04-18 | 2025-10-23 | Christian Arnold | Pharmazeutische Zusammensetzung zur Heilung einer Wunde |
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| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
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| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
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| JP2013040160A (ja) | 2011-07-01 | 2013-02-28 | Genentech Inc | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
-
2011
- 2011-12-27 JP JP2011285585A patent/JP2013040160A/ja active Pending
-
2012
- 2012-06-29 US US14/129,053 patent/US9562097B2/en not_active Expired - Fee Related
- 2012-06-29 WO PCT/US2012/045142 patent/WO2013006505A1/en not_active Ceased
- 2012-06-29 AU AU2012279175A patent/AU2012279175B2/en not_active Ceased
- 2012-06-29 JP JP2014519203A patent/JP6198730B2/ja not_active Expired - Fee Related
- 2012-06-29 CA CA2840426A patent/CA2840426A1/en not_active Abandoned
- 2012-06-29 KR KR1020147002210A patent/KR20140051272A/ko not_active Withdrawn
- 2012-06-29 BR BR112013033968A patent/BR112013033968A2/pt not_active IP Right Cessation
- 2012-06-29 CN CN201280042210.6A patent/CN103906766B/zh not_active Expired - Fee Related
- 2012-06-29 RU RU2014103498/10A patent/RU2014103498A/ru not_active Application Discontinuation
- 2012-06-29 MX MX2014000142A patent/MX2014000142A/es unknown
- 2012-06-29 EP EP12807315.2A patent/EP2726509B1/en not_active Not-in-force
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