JP2015508775A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015508775A5 JP2015508775A5 JP2014557765A JP2014557765A JP2015508775A5 JP 2015508775 A5 JP2015508775 A5 JP 2015508775A5 JP 2014557765 A JP2014557765 A JP 2014557765A JP 2014557765 A JP2014557765 A JP 2014557765A JP 2015508775 A5 JP2015508775 A5 JP 2015508775A5
- Authority
- JP
- Japan
- Prior art keywords
- halo
- aliphatic
- compound
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261600070P | 2012-02-17 | 2012-02-17 | |
| US61/600,070 | 2012-02-17 | ||
| PCT/US2013/026113 WO2013123169A1 (en) | 2012-02-17 | 2013-02-14 | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508775A JP2015508775A (ja) | 2015-03-23 |
| JP2015508775A5 true JP2015508775A5 (cg-RX-API-DMAC10.html) | 2017-03-16 |
| JP6122877B2 JP6122877B2 (ja) | 2017-04-26 |
Family
ID=48982730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014557765A Expired - Fee Related JP6122877B2 (ja) | 2012-02-17 | 2013-02-14 | ユビキチン活性化酵素のピラゾロピリミジニル阻害剤 |
Country Status (30)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| UA116534C2 (uk) | 2012-02-17 | 2018-04-10 | Мілленніум Фармасьютікалз, Інк. | Піразолопіримідинілові інгібітори убіквітинактивуючого ферменту |
| CN104684559A (zh) | 2012-08-03 | 2015-06-03 | 米伦纽姆医药公司 | 针对Uba6的吲哚取代的吡咯并嘧啶基抑制剂 |
| EP3016934B1 (en) | 2013-07-02 | 2018-01-10 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of sumo activating enzyme |
| MX376054B (es) | 2014-07-01 | 2025-03-07 | Takeda Pharmaceuticals Co | Compuestos de heteroarilo utiles como inhibidores de enzima activadora de sumo. |
| EP3212650B1 (en) * | 2014-10-29 | 2021-02-17 | Millennium Pharmaceuticals, Inc. | Administration of ubiquitin-activating enzyme inhibitor and chemotherapeutic agents |
| JP6697453B2 (ja) * | 2014-10-29 | 2020-05-20 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ユビキチン活性化酵素阻害物質及び放射線の投与 |
| MA54092A (fr) | 2018-10-30 | 2021-09-08 | Kronos Bio Inc | Composés, compositions et procédés de modulation de l'activité de cdk9 |
| CN117412973A (zh) * | 2021-05-31 | 2024-01-16 | 上海瑛派药业有限公司 | 含氮稠合杂芳双环化合物作为usp1抑制剂及其应用 |
| WO2023021498A1 (en) * | 2021-08-16 | 2023-02-23 | Moya Bio Ltd. | Fused azole and furan based nucleoside analogs and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003073989A2 (en) | 2002-02-28 | 2003-09-12 | Biota, Inc. | Nucleoside 5'-monophosphate mimics and their prodrugs |
| ATE362474T1 (de) | 2002-09-04 | 2007-06-15 | Schering Corp | Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen |
| US7563798B2 (en) | 2002-09-04 | 2009-07-21 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7196092B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| CN1310918C (zh) | 2002-09-04 | 2007-04-18 | 先灵公司 | 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶 |
| WO2004087707A1 (en) | 2003-03-31 | 2004-10-14 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
| JP2005008581A (ja) * | 2003-06-20 | 2005-01-13 | Kissei Pharmaceut Co Ltd | 新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途 |
| EP1680431A1 (en) | 2003-10-17 | 2006-07-19 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors |
| EP1758873A1 (en) | 2004-06-22 | 2007-03-07 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| SI1848718T1 (sl) | 2005-02-04 | 2012-12-31 | Millennium Pharmaceuticals, Inc. | Inhibitorji E1 aktivacijskih enzimov |
| AR055206A1 (es) | 2005-10-06 | 2007-08-08 | Schering Corp | Pirazolo[1, 5 - a]pirimidinas como inhibidoras de proteina quinasa, composiciones farmaceuticas y combinaciones con agentes citostaticos que las comprenden y su uso en la fabricacion de un medicamento para el tratamiento del cancer. |
| SI1989206T1 (sl) * | 2006-02-02 | 2012-11-30 | Millennium Pharm Inc | Inhibitorji e aktivirajočih enzimov |
| WO2007099021A1 (en) * | 2006-02-28 | 2007-09-07 | Sez Ag | Device and method for liquid treating disc-like articles |
| KR20150036358A (ko) * | 2006-08-08 | 2015-04-07 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Ｅ１ 활성화 효소의 억제제로서 유용한 헤테로아릴 화합물 |
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| CA2691987C (en) | 2007-06-12 | 2016-08-16 | Achaogen, Inc. | Antibacterial agents |
| TW201434851A (zh) * | 2007-08-02 | 2014-09-16 | Millennium Pharm Inc | 合成ｅ１活化酶抑制劑之方法 |
| WO2009082691A1 (en) | 2007-12-21 | 2009-07-02 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
| WO2010086040A1 (en) | 2009-01-29 | 2010-08-05 | Biomarin Iga, Ltd. | Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy |
| WO2010088518A2 (en) | 2009-01-31 | 2010-08-05 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
| WO2010132110A1 (en) | 2009-05-14 | 2010-11-18 | Millennium Pharmaceuticals, Inc. | Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
| JP5879273B2 (ja) | 2010-03-01 | 2016-03-08 | ジーティーエックス・インコーポレイテッド | 癌を処置するための化合物 |
| US20120077814A1 (en) | 2010-09-10 | 2012-03-29 | Zhong Wang | Sulfonamide, sulfamate, and sulfamothioate derivatives |
| US8809356B2 (en) | 2011-08-24 | 2014-08-19 | Millennium Pharmaceuticals, Inc. | Inhibitors of NEDD8-activating enzyme |
| UA116534C2 (uk) | 2012-02-17 | 2018-04-10 | Мілленніум Фармасьютікалз, Інк. | Піразолопіримідинілові інгібітори убіквітинактивуючого ферменту |
| CN104684559A (zh) | 2012-08-03 | 2015-06-03 | 米伦纽姆医药公司 | 针对Uba6的吲哚取代的吡咯并嘧啶基抑制剂 |
| EP3016934B1 (en) | 2013-07-02 | 2018-01-10 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of sumo activating enzyme |
| MX376054B (es) | 2014-07-01 | 2025-03-07 | Takeda Pharmaceuticals Co | Compuestos de heteroarilo utiles como inhibidores de enzima activadora de sumo. |
-
2013
- 2013-02-14 UA UAA201409297A patent/UA116534C2/uk unknown
- 2013-02-14 CA CA2864672A patent/CA2864672C/en active Active
- 2013-02-14 JP JP2014557765A patent/JP6122877B2/ja not_active Expired - Fee Related
- 2013-02-14 SG SG10201606581RA patent/SG10201606581RA/en unknown
- 2013-02-14 EP EP13748707.0A patent/EP2814791A4/en not_active Withdrawn
- 2013-02-14 KR KR1020147025556A patent/KR20140123104A/ko not_active Ceased
- 2013-02-14 BR BR112014020365-2A patent/BR112014020365B1/pt not_active IP Right Cessation
- 2013-02-14 MX MX2014009944A patent/MX352963B/es active IP Right Grant
- 2013-02-14 EP EP16205139.5A patent/EP3173413B1/en active Active
- 2013-02-14 US US13/767,314 patent/US9290500B2/en active Active
- 2013-02-14 CN CN201380009784.8A patent/CN104136399B/zh active Active
- 2013-02-14 EA EA201400831A patent/EA035020B1/ru not_active IP Right Cessation
- 2013-02-14 SG SG11201404757WA patent/SG11201404757WA/en unknown
- 2013-02-14 GE GEAP201313560A patent/GEP201706687B/en unknown
- 2013-02-14 NZ NZ628969A patent/NZ628969A/en not_active IP Right Cessation
- 2013-02-14 EP EP19170607.6A patent/EP3536692B1/en active Active
- 2013-02-14 HK HK15102227.4A patent/HK1201817A1/xx unknown
- 2013-02-14 PE PE2014001278A patent/PE20142244A1/es active IP Right Grant
- 2013-02-14 WO PCT/US2013/026113 patent/WO2013123169A1/en not_active Ceased
- 2013-02-14 ES ES16205139T patent/ES2739150T3/es active Active
- 2013-02-15 AR ARP130100480A patent/AR092797A1/es unknown
- 2013-02-15 UY UY0001034629A patent/UY34629A/es not_active Application Discontinuation
- 2013-02-18 TW TW102105676A patent/TWI593688B/zh not_active IP Right Cessation
-
2014
- 2014-08-07 IL IL234016A patent/IL234016A0/en unknown
- 2014-08-11 TN TNP2014000351A patent/TN2014000351A1/fr unknown
- 2014-08-12 CR CR20140380A patent/CR20140380A/es unknown
- 2014-08-13 PH PH12014501832A patent/PH12014501832A1/en unknown
- 2014-08-14 CL CL2014002181A patent/CL2014002181A1/es unknown
- 2014-08-15 DO DO2014000187A patent/DOP2014000187A/es unknown
- 2014-08-20 ZA ZA2014/06103A patent/ZA201406103B/en unknown
- 2014-09-10 MA MA37338A patent/MA35932B1/fr unknown
- 2014-09-16 CO CO14205517A patent/CO7071135A2/es unknown
- 2014-09-17 EC ECIEPI201419113A patent/ECSP14019113A/es unknown
-
2016
- 2016-02-19 US US15/048,007 patent/US9663525B2/en active Active
-
2017
- 2017-04-17 US US15/488,800 patent/US9796725B2/en active Active
- 2017-09-08 US US15/699,818 patent/US10202389B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6122877B2 (ja) | ユビキチン活性化酵素のピラゾロピリミジニル阻害剤 | |
| TWI798635B (zh) | 吡啶並嘧啶酮類化合物及其應用 | |
| JP7058636B2 (ja) | サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤 | |
| JP2015508775A5 (cg-RX-API-DMAC10.html) | ||
| EP2382207B1 (en) | Pi3k/mtor kinase inhibitors | |
| JP2022078315A (ja) | Ｍｋ２阻害剤およびその使用 | |
| TW202509040A (zh) | 三環類化合物及其用途 | |
| TWI580679B (zh) | 雜芳基並嘧啶類衍生物、其製備方法和用途 | |
| CN106928219B (zh) | 含氮稠杂环化合物、制备方法、中间体、组合物和应用 | |
| US9156853B2 (en) | AKT inhibitor compounds for treatment of cancer | |
| CN114369097B (zh) | 杂芳环类AhR抑制剂 | |
| HK1238244A1 (en) | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme | |
| HK1222388B (en) | Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors | |
| HK1222388A1 (en) | Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |