JP2015506966A5 - - Google Patents
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- Publication number
- JP2015506966A5 JP2015506966A5 JP2014556029A JP2014556029A JP2015506966A5 JP 2015506966 A5 JP2015506966 A5 JP 2015506966A5 JP 2014556029 A JP2014556029 A JP 2014556029A JP 2014556029 A JP2014556029 A JP 2014556029A JP 2015506966 A5 JP2015506966 A5 JP 2015506966A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- tautomer
- protecting group
- group selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 11
- 125000006239 protecting group Chemical group 0.000 claims 7
- 150000003839 salts Chemical group 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 5
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 claims 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 4
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 4
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 3
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 3
- 230000000707 stereoselective effect Effects 0.000 claims 2
- 0 *N(CCN1)C(CC2)(CCC22OCCO2)C1=O Chemical compound *N(CCN1)C(CC2)(CCC22OCCO2)C1=O 0.000 description 1
- XCTHNNBOOMATKA-UHFFFAOYSA-N O=C(CC1)CCC1(C(NCC1)=O)N1I Chemical compound O=C(CC1)CCC1(C(NCC1)=O)N1I XCTHNNBOOMATKA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12154688.1 | 2012-02-09 | ||
| EP12154688 | 2012-02-09 | ||
| PCT/EP2013/052287 WO2013117568A1 (de) | 2012-02-09 | 2013-02-06 | Verfahren zur stereoselektiven synthese von 1,4-geschützten 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecane |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015506966A JP2015506966A (ja) | 2015-03-05 |
| JP2015506966A5 true JP2015506966A5 (enExample) | 2016-03-24 |
| JP6105631B2 JP6105631B2 (ja) | 2017-03-29 |
Family
ID=47678813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014556029A Active JP6105631B2 (ja) | 2012-02-09 | 2013-02-06 | １，４−保護９−ヒドロキシ−５−オキソ−１，４−ジアザ−スピロ［５．５］ウンデカンの立体選択的合成方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8629146B2 (enExample) |
| EP (1) | EP2812317B1 (enExample) |
| JP (1) | JP6105631B2 (enExample) |
| KR (1) | KR20140128318A (enExample) |
| CN (1) | CN104080775A (enExample) |
| AU (1) | AU2013218119A1 (enExample) |
| BR (1) | BR112014019196A8 (enExample) |
| CA (1) | CA2862520A1 (enExample) |
| CL (1) | CL2014001823A1 (enExample) |
| EA (1) | EA201400882A1 (enExample) |
| IL (1) | IL233370A (enExample) |
| MX (1) | MX2014009033A (enExample) |
| PH (1) | PH12014501760A1 (enExample) |
| WO (1) | WO2013117568A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2289881A1 (de) * | 2009-08-06 | 2011-03-02 | Boehringer Ingelheim International GmbH | Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4575507A (en) * | 1985-05-29 | 1986-03-11 | Pfizer Inc. | Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use |
| ATE557008T1 (de) | 2002-03-30 | 2012-05-15 | Boehringer Ingelheim Pharma | 4- ( n-phenylamino ) -chinazoline/chinoline als tyrosinkinaseinhibitoren |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| CA2631813A1 (en) | 2005-12-12 | 2007-06-21 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for the production thereof |
| PT2245026E (pt) | 2008-02-07 | 2012-10-15 | Boehringer Ingelheim Int | Heterociclos espirocíclicos, produtos farmacêuticos contendo estes compostos, sua utilização e processo para a sua preparação |
| EP2289881A1 (de) | 2009-08-06 | 2011-03-02 | Boehringer Ingelheim International GmbH | Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen |
| PE20141012A1 (es) * | 2011-02-01 | 2014-09-10 | Boehringer Ingelheim Int | Dimaleato de 9-[4-(3-cloro-2-fluoro-fenilamino)-7-metoxi-quinazolin-6-iloxi]-1,4-diaza-espiro[5.5]undecan-5-ona, su uso como medicamento y su preparacion |
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2013
- 2013-02-06 JP JP2014556029A patent/JP6105631B2/ja active Active
- 2013-02-06 KR KR1020147021922A patent/KR20140128318A/ko not_active Withdrawn
- 2013-02-06 EP EP13703045.8A patent/EP2812317B1/de active Active
- 2013-02-06 CA CA2862520A patent/CA2862520A1/en not_active Abandoned
- 2013-02-06 MX MX2014009033A patent/MX2014009033A/es not_active Application Discontinuation
- 2013-02-06 WO PCT/EP2013/052287 patent/WO2013117568A1/de not_active Ceased
- 2013-02-06 EA EA201400882A patent/EA201400882A1/ru unknown
- 2013-02-06 BR BR112014019196A patent/BR112014019196A8/pt not_active IP Right Cessation
- 2013-02-06 CN CN201380006918.0A patent/CN104080775A/zh active Pending
- 2013-02-06 AU AU2013218119A patent/AU2013218119A1/en not_active Abandoned
- 2013-02-07 US US13/761,211 patent/US8629146B2/en active Active
-
2014
- 2014-06-25 IL IL233370A patent/IL233370A/en not_active IP Right Cessation
- 2014-07-09 CL CL2014001823A patent/CL2014001823A1/es unknown
- 2014-08-05 PH PH12014501760A patent/PH12014501760A1/en unknown