JP2015524822A5 - - Google Patents
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- Publication number
- JP2015524822A5 JP2015524822A5 JP2015525605A JP2015525605A JP2015524822A5 JP 2015524822 A5 JP2015524822 A5 JP 2015524822A5 JP 2015525605 A JP2015525605 A JP 2015525605A JP 2015525605 A JP2015525605 A JP 2015525605A JP 2015524822 A5 JP2015524822 A5 JP 2015524822A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- salt
- converting
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C1C(OC)=CC(*)=C(Cc(cccc2Cl)c2F)C1)=O Chemical compound CC(C1C(OC)=CC(*)=C(Cc(cccc2Cl)c2F)C1)=O 0.000 description 2
- RLCJXIYWSSMZDH-UHFFFAOYSA-N CC(c(c(OC)c1)cc(Cc(cccc2Cl)c2F)c1OC)=O Chemical compound CC(c(c(OC)c1)cc(Cc(cccc2Cl)c2F)c1OC)=O RLCJXIYWSSMZDH-UHFFFAOYSA-N 0.000 description 1
- FKHOOEDRXRLSTH-UHFFFAOYSA-N COc1cc(OC)c(Cc2cccc(Cl)c2F)cc1 Chemical compound COc1cc(OC)c(Cc2cccc(Cl)c2F)cc1 FKHOOEDRXRLSTH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261679475P | 2012-08-03 | 2012-08-03 | |
| US61/679,475 | 2012-08-03 | ||
| PCT/US2013/053295 WO2014022707A1 (en) | 2012-08-03 | 2013-08-01 | Process and intermediates for preparing integrase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524822A JP2015524822A (ja) | 2015-08-27 |
| JP2015524822A5 true JP2015524822A5 (enExample) | 2016-10-06 |
| JP6147856B2 JP6147856B2 (ja) | 2017-06-14 |
Family
ID=48980354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525605A Expired - Fee Related JP6147856B2 (ja) | 2012-08-03 | 2013-08-01 | インテグラーゼインヒビターを調製するためのプロセスおよび中間体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8877931B2 (enExample) |
| EP (1) | EP2880017B1 (enExample) |
| JP (1) | JP6147856B2 (enExample) |
| KR (1) | KR20150040340A (enExample) |
| CN (1) | CN104520275B (enExample) |
| AU (1) | AU2013296289B2 (enExample) |
| BR (1) | BR112015002275A2 (enExample) |
| CA (1) | CA2878699C (enExample) |
| EA (1) | EA026089B1 (enExample) |
| ES (1) | ES2608860T3 (enExample) |
| IL (1) | IL236618A (enExample) |
| IN (1) | IN2015DN01688A (enExample) |
| MX (1) | MX337094B (enExample) |
| NZ (1) | NZ630199A (enExample) |
| PT (1) | PT2880017T (enExample) |
| SG (1) | SG11201500812QA (enExample) |
| WO (1) | WO2014022707A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2893843C (en) | 2012-12-21 | 2018-09-04 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| NO2865735T3 (enExample) | 2013-07-12 | 2018-07-21 | ||
| DK3019503T3 (da) | 2013-07-12 | 2017-11-20 | Gilead Sciences Inc | Polycykliske-carbamoylpyridon-forbindelser og anvendelse deraf til behandling af hiv-infektioner |
| TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| NO2717902T3 (enExample) | 2014-06-20 | 2018-06-23 | ||
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| TWI738321B (zh) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| TR201905009T4 (tr) | 2015-04-02 | 2019-05-21 | Gilead Sciences Inc | Polisiklik-karbamoilpiridon bileşikleri ve bunların farmasötik kullanımları. |
| JP7312318B2 (ja) * | 2019-09-24 | 2023-07-20 | アシムケム ラボラトリーズ （ティエンジン） カンパニー リミテッド | ベンジル亜鉛ハライド及びその誘導体の連続製造方法 |
| CN112661698A (zh) * | 2021-01-14 | 2021-04-16 | 浙江海森药业股份有限公司 | 一种艾维雷韦的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904108D0 (sv) * | 1999-11-15 | 1999-11-15 | New Pharma Research Ab | Nya föreningar |
| EP1343766B1 (en) | 2000-12-14 | 2005-07-27 | The Procter & Gamble Company | Cyclization process step in the making of quinolones and naphthyridines |
| TW200300349A (en) | 2001-11-19 | 2003-06-01 | Sankyo Co | A 4-oxoqinoline derivative |
| EP1510510A1 (en) | 2002-05-31 | 2005-03-02 | Banyu Pharmaceutical Co., Ltd. | Method of substituent introduction through halogen-metal exchange reaction |
| US6803469B2 (en) | 2002-08-05 | 2004-10-12 | The Procter & Gamble Company | Process for preparing quinolone antibiotic intermediates |
| TW200409759A (en) | 2002-09-25 | 2004-06-16 | Wyeth Corp | Substituted 4-(indazol-3-yl)phenols |
| WO2004046115A1 (ja) | 2002-11-20 | 2004-06-03 | Japan Tobacco Inc. | ４−オキソキノリン化合物及びそのｈｉｖインテグラーゼ阻害剤としての利用 |
| EP1582523A1 (en) | 2004-04-02 | 2005-10-05 | Ludwig-Maximilians-Universität München | Method of preparing organomagnesium compounds |
| EP1582524B1 (en) | 2004-04-02 | 2008-08-13 | Ludwig Maximilians Universität | Method of preparing organomagnesium compounds |
| WO2005113509A1 (en) | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| MY134672A (en) | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| EP2229945A1 (en) | 2004-05-21 | 2010-09-22 | Japan Tobacco, Inc. | Combinations comprising a 4-isoquinolone derivative and anti-HIV agents |
| WO2007063869A1 (ja) | 2005-11-30 | 2007-06-07 | Japan Tobacco Inc. | 高純度キノロン化合物の製造方法 |
| US20090233964A1 (en) | 2005-12-30 | 2009-09-17 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| IN2014CN00532A (enExample) | 2006-03-06 | 2015-04-03 | Japan Tobacco Inc | |
| KR101023635B1 (ko) | 2006-03-06 | 2011-03-22 | 니뽄 다바코 산교 가부시키가이샤 | 4-옥소퀴놀린 화합물 제조 방법 |
| TW200811153A (en) | 2006-06-23 | 2008-03-01 | Japan Tobacco Inc | 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| BRPI0716752A2 (pt) | 2006-09-12 | 2013-09-17 | Gilead Sciences Inc | processo e intermediÁrios para preparo de inibidores de intergrase |
| BRPI0813955A2 (pt) | 2007-06-29 | 2017-05-09 | Gilead Sciences Inc | composições terapêuticas e o uso das mesmas |
| NZ582086A (en) | 2007-06-29 | 2012-07-27 | Gilead Sciences Inc | Therapeutic compositions and the use thereof |
| AR068403A1 (es) * | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
-
2013
- 2013-08-01 NZ NZ630199A patent/NZ630199A/en not_active IP Right Cessation
- 2013-08-01 SG SG11201500812QA patent/SG11201500812QA/en unknown
- 2013-08-01 WO PCT/US2013/053295 patent/WO2014022707A1/en not_active Ceased
- 2013-08-01 EA EA201590018A patent/EA026089B1/ru not_active IP Right Cessation
- 2013-08-01 US US13/956,905 patent/US8877931B2/en active Active
- 2013-08-01 MX MX2015001506A patent/MX337094B/es active IP Right Grant
- 2013-08-01 KR KR20157005620A patent/KR20150040340A/ko not_active Abandoned
- 2013-08-01 AU AU2013296289A patent/AU2013296289B2/en not_active Ceased
- 2013-08-01 EP EP13748229.5A patent/EP2880017B1/en active Active
- 2013-08-01 CA CA2878699A patent/CA2878699C/en not_active Expired - Fee Related
- 2013-08-01 IN IN1688DEN2015 patent/IN2015DN01688A/en unknown
- 2013-08-01 BR BR112015002275A patent/BR112015002275A2/pt not_active IP Right Cessation
- 2013-08-01 ES ES13748229.5T patent/ES2608860T3/es active Active
- 2013-08-01 PT PT137482295T patent/PT2880017T/pt unknown
- 2013-08-01 JP JP2015525605A patent/JP6147856B2/ja not_active Expired - Fee Related
- 2013-08-01 CN CN201380041287.6A patent/CN104520275B/zh not_active Expired - Fee Related
-
2015
- 2015-01-11 IL IL236618A patent/IL236618A/en not_active IP Right Cessation