PH12014501760A1 - Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro[5.5]undecanes - Google Patents
Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro[5.5]undecanesInfo
- Publication number
- PH12014501760A1 PH12014501760A1 PH12014501760A PH12014501760A PH12014501760A1 PH 12014501760 A1 PH12014501760 A1 PH 12014501760A1 PH 12014501760 A PH12014501760 A PH 12014501760A PH 12014501760 A PH12014501760 A PH 12014501760A PH 12014501760 A1 PH12014501760 A1 PH 12014501760A1
- Authority
- PH
- Philippines
- Prior art keywords
- undecanes
- diaza
- spiro
- oxo
- hydroxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000000707 stereoselective effect Effects 0.000 title abstract 2
- CGBQPXGVSMMBHA-UHFFFAOYSA-N 9-hydroxy-1,4-diazaspiro[5.5]undecan-5-one Chemical class C1CC(O)CCC21C(=O)NCCN2 CGBQPXGVSMMBHA-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12154688 | 2012-02-09 | ||
| PCT/EP2013/052287 WO2013117568A1 (de) | 2012-02-09 | 2013-02-06 | Verfahren zur stereoselektiven synthese von 1,4-geschützten 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12014501760A1 true PH12014501760A1 (en) | 2014-11-10 |
| PH12014501760B1 PH12014501760B1 (en) | 2014-11-10 |
Family
ID=47678813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12014501760A PH12014501760B1 (en) | 2012-02-09 | 2014-08-05 | Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro[5.5]undecanes |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8629146B2 (enExample) |
| EP (1) | EP2812317B1 (enExample) |
| JP (1) | JP6105631B2 (enExample) |
| KR (1) | KR20140128318A (enExample) |
| CN (1) | CN104080775A (enExample) |
| AU (1) | AU2013218119A1 (enExample) |
| BR (1) | BR112014019196A8 (enExample) |
| CA (1) | CA2862520A1 (enExample) |
| CL (1) | CL2014001823A1 (enExample) |
| EA (1) | EA201400882A1 (enExample) |
| IL (1) | IL233370A (enExample) |
| MX (1) | MX2014009033A (enExample) |
| PH (1) | PH12014501760B1 (enExample) |
| WO (1) | WO2013117568A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2289881A1 (de) * | 2009-08-06 | 2011-03-02 | Boehringer Ingelheim International GmbH | Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4575507A (en) * | 1985-05-29 | 1986-03-11 | Pfizer Inc. | Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| PL371188A1 (en) | 2002-03-30 | 2005-06-13 | Boehringer Ingelheim Pharma Gmbh & Co.Kg | 4-(n-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors |
| KR20080077009A (ko) | 2005-12-12 | 2008-08-20 | 베링거 인겔하임 인터내셔날 게엠베하 | 바이사이클릭 헤테로사이클, 당해 화합물을 함유하는 약제,이의 용도 및 이의 제조방법 |
| EP2245026B1 (de) | 2008-02-07 | 2012-08-01 | Boehringer Ingelheim International GmbH | Spirocyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| EP2289881A1 (de) | 2009-08-06 | 2011-03-02 | Boehringer Ingelheim International GmbH | Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen |
| PE20141012A1 (es) | 2011-02-01 | 2014-09-10 | Boehringer Ingelheim Int | Dimaleato de 9-[4-(3-cloro-2-fluoro-fenilamino)-7-metoxi-quinazolin-6-iloxi]-1,4-diaza-espiro[5.5]undecan-5-ona, su uso como medicamento y su preparacion |
-
2013
- 2013-02-06 KR KR1020147021922A patent/KR20140128318A/ko not_active Withdrawn
- 2013-02-06 JP JP2014556029A patent/JP6105631B2/ja active Active
- 2013-02-06 EA EA201400882A patent/EA201400882A1/ru unknown
- 2013-02-06 MX MX2014009033A patent/MX2014009033A/es not_active Application Discontinuation
- 2013-02-06 AU AU2013218119A patent/AU2013218119A1/en not_active Abandoned
- 2013-02-06 CA CA2862520A patent/CA2862520A1/en not_active Abandoned
- 2013-02-06 EP EP13703045.8A patent/EP2812317B1/de active Active
- 2013-02-06 WO PCT/EP2013/052287 patent/WO2013117568A1/de not_active Ceased
- 2013-02-06 BR BR112014019196A patent/BR112014019196A8/pt not_active IP Right Cessation
- 2013-02-06 CN CN201380006918.0A patent/CN104080775A/zh active Pending
- 2013-02-07 US US13/761,211 patent/US8629146B2/en active Active
-
2014
- 2014-06-25 IL IL233370A patent/IL233370A/en not_active IP Right Cessation
- 2014-07-09 CL CL2014001823A patent/CL2014001823A1/es unknown
- 2014-08-05 PH PH12014501760A patent/PH12014501760B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20130211081A1 (en) | 2013-08-15 |
| BR112014019196A2 (enExample) | 2017-06-20 |
| CA2862520A1 (en) | 2013-08-15 |
| JP6105631B2 (ja) | 2017-03-29 |
| IL233370A0 (en) | 2014-08-31 |
| WO2013117568A1 (de) | 2013-08-15 |
| IL233370A (en) | 2015-04-30 |
| JP2015506966A (ja) | 2015-03-05 |
| KR20140128318A (ko) | 2014-11-05 |
| CL2014001823A1 (es) | 2015-03-06 |
| EP2812317A1 (de) | 2014-12-17 |
| MX2014009033A (es) | 2014-10-17 |
| US8629146B2 (en) | 2014-01-14 |
| CN104080775A (zh) | 2014-10-01 |
| PH12014501760B1 (en) | 2014-11-10 |
| EP2812317B1 (de) | 2016-02-03 |
| BR112014019196A8 (pt) | 2017-07-11 |
| AU2013218119A1 (en) | 2014-07-17 |
| EA201400882A1 (ru) | 2015-01-30 |
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