JP2015506673A5 - - Google Patents
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- JP2015506673A5 JP2015506673A5 JP2014546024A JP2014546024A JP2015506673A5 JP 2015506673 A5 JP2015506673 A5 JP 2015506673A5 JP 2014546024 A JP2014546024 A JP 2014546024A JP 2014546024 A JP2014546024 A JP 2014546024A JP 2015506673 A5 JP2015506673 A5 JP 2015506673A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- molecule encoding
- cell
- rna molecule
- rna molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 14
- 230000008672 reprogramming Effects 0.000 claims 7
- 102000009027 Albumins Human genes 0.000 claims 5
- 108010088751 Albumins Proteins 0.000 claims 5
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 claims 4
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 4
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 4
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 2
- ZAYHVCMSTBRABG-JXOAFFINSA-N 5-methylcytidine Chemical group O=C1N=C(N)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 ZAYHVCMSTBRABG-JXOAFFINSA-N 0.000 claims 2
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 102100037362 Fibronectin Human genes 0.000 claims 2
- 108010067306 Fibronectins Proteins 0.000 claims 2
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 2
- 108010085895 Laminin Proteins 0.000 claims 2
- 102000007547 Laminin Human genes 0.000 claims 2
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims 2
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 2
- 102000009092 Proto-Oncogene Proteins c-myc Human genes 0.000 claims 2
- 108010087705 Proto-Oncogene Proteins c-myc Proteins 0.000 claims 2
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims 2
- 108010031318 Vitronectin Proteins 0.000 claims 2
- 102100035140 Vitronectin Human genes 0.000 claims 2
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 claims 2
- 239000003610 charcoal Substances 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000003456 ion exchange resin Substances 0.000 claims 2
- 229920003303 ion-exchange polymer Polymers 0.000 claims 2
- 229920000729 poly(L-lysine) polymer Polymers 0.000 claims 2
- 108010055896 polyornithine Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- PTJWIQPHWPFNBW-GBNDHIKLSA-N pseudouridine Chemical group O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-GBNDHIKLSA-N 0.000 claims 2
- 210000004927 skin cell Anatomy 0.000 claims 2
- BYKRNSHANADUFY-UHFFFAOYSA-M sodium octanoate Chemical compound [Na+].CCCCCCCC([O-])=O BYKRNSHANADUFY-UHFFFAOYSA-M 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161566948P | 2011-12-05 | 2011-12-05 | |
| US61/566,948 | 2011-12-05 | ||
| US201161569595P | 2011-12-12 | 2011-12-12 | |
| US61/569,595 | 2011-12-12 | ||
| US201261637570P | 2012-04-24 | 2012-04-24 | |
| US61/637,570 | 2012-04-24 | ||
| US13/465,490 | 2012-05-07 | ||
| US13/465,490 US8497124B2 (en) | 2011-12-05 | 2012-05-07 | Methods and products for reprogramming cells to a less differentiated state |
| US201261664494P | 2012-06-26 | 2012-06-26 | |
| US61/664,494 | 2012-06-26 | ||
| PCT/US2012/067966 WO2013086008A1 (en) | 2011-12-05 | 2012-12-05 | Methods and products for transfecting cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016213019A Division JP6294944B2 (ja) | 2011-12-05 | 2016-10-31 | 細胞に形質移入するための方法および製品 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015506673A JP2015506673A (ja) | 2015-03-05 |
| JP2015506673A5 true JP2015506673A5 (enExample) | 2016-01-28 |
| JP6073916B2 JP6073916B2 (ja) | 2017-02-01 |
Family
ID=48574831
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546024A Active JP6073916B2 (ja) | 2011-12-05 | 2012-12-05 | 細胞に形質移入するための方法および製品 |
| JP2016213019A Active JP6294944B2 (ja) | 2011-12-05 | 2016-10-31 | 細胞に形質移入するための方法および製品 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016213019A Active JP6294944B2 (ja) | 2011-12-05 | 2016-10-31 | 細胞に形質移入するための方法および製品 |
Country Status (12)
| Country | Link |
|---|---|
| US (17) | US9422577B2 (enExample) |
| EP (3) | EP2788033B1 (enExample) |
| JP (2) | JP6073916B2 (enExample) |
| KR (5) | KR20250035015A (enExample) |
| CN (2) | CN111893140A (enExample) |
| AU (7) | AU2012347919B2 (enExample) |
| BR (1) | BR112014013664A2 (enExample) |
| CA (2) | CA3188654A1 (enExample) |
| DK (1) | DK3260140T3 (enExample) |
| MX (5) | MX354995B (enExample) |
| RU (3) | RU2691027C2 (enExample) |
| WO (1) | WO2013086008A1 (enExample) |
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| MX2014007233A (es) | 2011-12-16 | 2015-02-04 | Moderna Therapeutics Inc | Composiciones de nucleosidos, nucleotidos y acidos nucleicos modificados. |
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| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
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| CN108103027B (zh) * | 2018-02-02 | 2021-12-24 | 中国医学科学院血液病医院（血液学研究所） | 高效率血细胞重编程同时实现基因编辑的方法 |
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