JP2015516812A5 - - Google Patents
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- JP2015516812A5 JP2015516812A5 JP2015509109A JP2015509109A JP2015516812A5 JP 2015516812 A5 JP2015516812 A5 JP 2015516812A5 JP 2015509109 A JP2015509109 A JP 2015509109A JP 2015509109 A JP2015509109 A JP 2015509109A JP 2015516812 A5 JP2015516812 A5 JP 2015516812A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- pluripotent
- cytoplasm
- acth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000004027 cell Anatomy 0.000 claims 97
- 238000000034 method Methods 0.000 claims 80
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 claims 14
- 101800000414 Corticotropin Proteins 0.000 claims 14
- 102100027467 Pro-opiomelanocortin Human genes 0.000 claims 14
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims 14
- 229960000258 corticotropin Drugs 0.000 claims 14
- 210000000805 cytoplasm Anatomy 0.000 claims 13
- 230000035882 stress Effects 0.000 claims 12
- 210000000130 stem cell Anatomy 0.000 claims 8
- 239000002771 cell marker Substances 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 6
- 210000003470 mitochondria Anatomy 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 4
- 238000002659 cell therapy Methods 0.000 claims 3
- 230000001973 epigenetic effect Effects 0.000 claims 3
- 230000001747 exhibiting effect Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 102000000905 Cadherin Human genes 0.000 claims 2
- 108050007957 Cadherin Proteins 0.000 claims 2
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims 2
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 claims 2
- 101150072501 Klf2 gene Proteins 0.000 claims 2
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 2
- 101710150336 Protein Rex Proteins 0.000 claims 2
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 2
- 101150086694 SLC22A3 gene Proteins 0.000 claims 2
- 101150111019 Tbx3 gene Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims 2
- 230000003204 osmotic effect Effects 0.000 claims 2
- 206010063601 Exposure to extreme temperature Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 108010089610 Nuclear Proteins Proteins 0.000 claims 1
- 102000007999 Nuclear Proteins Human genes 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 238000011130 autologous cell therapy Methods 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 230000007910 cell fusion Effects 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000003833 cell viability Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 210000002308 embryonic cell Anatomy 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000009894 physiological stress Effects 0.000 claims 1
- 230000003169 placental effect Effects 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- -1 transcripts Proteins 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 238000001665 trituration Methods 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261637631P | 2012-04-24 | 2012-04-24 | |
| US61/637,631 | 2012-04-24 | ||
| US201361779533P | 2013-03-13 | 2013-03-13 | |
| US61/779,533 | 2013-03-13 | ||
| PCT/US2013/037996 WO2013163296A1 (en) | 2012-04-24 | 2013-04-24 | Generating pluripotent cells de novo |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018117481A Division JP2018183145A (ja) | 2012-04-24 | 2018-06-20 | 多能性細胞のデノボ生成 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015516812A JP2015516812A (ja) | 2015-06-18 |
| JP2015516812A5 true JP2015516812A5 (enExample) | 2016-06-16 |
Family
ID=49483852
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509109A Pending JP2015516812A (ja) | 2012-04-24 | 2013-04-24 | 多能性細胞のデノボ生成 |
| JP2018117481A Withdrawn JP2018183145A (ja) | 2012-04-24 | 2018-06-20 | 多能性細胞のデノボ生成 |
| JP2020122035A Withdrawn JP2020182480A (ja) | 2012-04-24 | 2020-07-16 | 多能性細胞のデノボ生成 |
| JP2022175459A Pending JP2023002805A (ja) | 2012-04-24 | 2022-11-01 | 多能性細胞のデノボ生成 |
| JP2025061922A Pending JP2025106394A (ja) | 2012-04-24 | 2025-04-03 | 多能性細胞のデノボ生成 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018117481A Withdrawn JP2018183145A (ja) | 2012-04-24 | 2018-06-20 | 多能性細胞のデノボ生成 |
| JP2020122035A Withdrawn JP2020182480A (ja) | 2012-04-24 | 2020-07-16 | 多能性細胞のデノボ生成 |
| JP2022175459A Pending JP2023002805A (ja) | 2012-04-24 | 2022-11-01 | 多能性細胞のデノボ生成 |
| JP2025061922A Pending JP2025106394A (ja) | 2012-04-24 | 2025-04-03 | 多能性細胞のデノボ生成 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11963977B2 (enExample) |
| EP (2) | EP2844738A4 (enExample) |
| JP (5) | JP2015516812A (enExample) |
| KR (2) | KR20150045935A (enExample) |
| CN (2) | CN112048466A (enExample) |
| AU (2) | AU2013251649B2 (enExample) |
| CA (1) | CA2885576A1 (enExample) |
| ES (1) | ES2972525T3 (enExample) |
| RU (1) | RU2696071C2 (enExample) |
| SG (2) | SG11201407768QA (enExample) |
| WO (1) | WO2013163296A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2691027C2 (ru) | 2011-12-05 | 2019-06-07 | Фэктор Байосайенс Инк. | Способы и препараты для трансфекции клеток |
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| EP2914728B1 (en) | 2012-11-01 | 2020-07-08 | Factor Bioscience Inc. | Methods and products for expressing proteins in cells |
| WO2014117021A2 (en) | 2013-01-25 | 2014-07-31 | Xcell Biosciences, Inc. | Methods, compositions, kits, and systems for selective enrichment of target cells |
| US20160002599A1 (en) | 2013-02-08 | 2016-01-07 | Kyoto University | Production methods for megakaryocytes and platelets |
| KR102527507B1 (ko) | 2013-03-15 | 2023-04-28 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 만능 줄기 세포로부터 제조된 광수용기 및 광수용기 전구체 |
| US11241460B2 (en) | 2013-03-15 | 2022-02-08 | Astellas Institute For Regenerative Medicine | Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells |
| WO2014201254A1 (en) | 2013-06-12 | 2014-12-18 | University Of Washington Through Its Center For Commercialization | Methods for maturing cardiomyocytes and uses thereof |
| CN105940110A (zh) | 2014-01-31 | 2016-09-14 | 菲克特生物科学股份有限公司 | 用于核酸产生和递送的方法和产品 |
| ES3006707T3 (en) * | 2014-03-19 | 2025-03-18 | Vcell Therapeutics Inc | Methods relating to pluripotent cells |
| WO2016089178A1 (ko) * | 2014-12-04 | 2016-06-09 | 가톨릭관동대학교산학협력단 | 에너지를 이용한 다능성 세포 유도 장치 및 방법 |
| US11773387B2 (en) * | 2014-12-04 | 2023-10-03 | Stemon Inc. | Device and method for inducing pluripotent cells using energy |
| WO2016131052A1 (en) | 2015-02-13 | 2016-08-18 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| US10668109B2 (en) * | 2015-06-18 | 2020-06-02 | Yeda Research And Development Co. Ltd. | Conditioning protocols and use of same for tissue regeneration |
| KR101855967B1 (ko) * | 2016-03-11 | 2018-05-10 | 가톨릭관동대학교산학협력단 | 물리적 자극에 의한 환경유입을 이용한 세포 리프로그래밍 방법 |
| WO2017155166A1 (ko) * | 2016-03-11 | 2017-09-14 | 가톨릭관동대학교기술지주 주식회사 | 물리적 자극에 의한 환경유입을 이용한 세포 리프로그래밍 방법 |
| WO2017155167A1 (ko) * | 2016-03-11 | 2017-09-14 | 가톨릭관동대학교산학협력단 | 세포 리프로그래밍 장치 |
| KR102050852B1 (ko) * | 2016-03-11 | 2019-12-03 | 주식회사 스템온 | 세포 리프로그래밍 장치 |
| US10426796B2 (en) | 2016-06-13 | 2019-10-01 | SMART SURGICAL, Inc. | Compositions for biological systems and methods for preparing and using the same |
| US10456423B2 (en) | 2016-06-13 | 2019-10-29 | SMART SURGICAL, Inc. | Compositions for biological systems and methods for preparing and using the same |
| IL308824A (en) | 2016-08-17 | 2024-01-01 | Factor Bioscience Inc | Nucleic acid products and methods of administration thereof |
| EP3555262A4 (en) * | 2016-11-07 | 2020-05-13 | K2 Research Holdings, LLC | PRODUCTION AND THERAPEUTIC USES OF EPINUL PLURIPOTENT CELLS AND DIFFERENTIATED CELLS DERIVED THEREFROM |
| EP3601530A1 (en) * | 2017-03-20 | 2020-02-05 | IFOM Fondazione Istituto Firc di Oncologia Molecolare | Method of generating 2 cell-like stem cells |
| AU2018281936A1 (en) * | 2017-06-10 | 2020-01-30 | SMART SURGICAL, Inc. | Compositions for biological systems and methods for preparing and using the same |
| CN107729932B (zh) * | 2017-10-10 | 2019-07-26 | 杭州智微信息科技有限公司 | 骨髓细胞标记方法和系统 |
| KR102416171B1 (ko) | 2018-10-02 | 2022-07-06 | 주식회사 스템온 | 세포의 리프로그래밍을 유도하는 리프로좀 및 그 제조 방법 |
| JP7699552B2 (ja) | 2019-07-03 | 2025-06-27 | ファクター バイオサイエンス インコーポレイテッド | カチオン性脂質及びその使用 |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| WO2021046186A1 (en) * | 2019-09-04 | 2021-03-11 | Vcell Therapeutics, Inc. | Vaccine for treatment of cancer and method of making by stress reprogramming |
| EP4103694A4 (en) | 2020-02-14 | 2024-03-20 | Hackensack Meridian Health, Inc. | TREATMENT MITOCHONDRIA FROM THROMBOCYTES AND METHOD FOR GENERATING MULTIPOTENT CELLS |
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| US4963489A (en) | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
| FR2687404B1 (fr) | 1992-02-19 | 1994-05-20 | Centre Nal Recherc Scientifique | Peptides immunologiquement apparentes aux proteines d'un agent viral et leurs applications biologiques. |
| AU4543193A (en) | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
| US5672346A (en) | 1992-07-27 | 1997-09-30 | Indiana University Foundation | Human stem cell compositions and methods |
| PT671923E (pt) | 1992-10-09 | 2001-10-30 | Advanced Tissue Sciences Inc | Celulas de reserva do figado |
| US5753431A (en) * | 1993-10-13 | 1998-05-19 | Northeastern Ohio University | Cholesterol 7 α-hydroxdylase gene regulatory elements and transcription factors |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| GB9502022D0 (en) | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| WO2002057428A1 (en) | 2000-10-30 | 2002-07-25 | University Of Massachusetts | Isolation of spore-like cells from tissues exposed to extreme conditions |
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| US7575321B2 (en) | 2003-10-30 | 2009-08-18 | Welch Allyn, Inc. | Apparatus and method of diagnosis of optically identifiable ophthalmic conditions |
| US7632681B2 (en) * | 2003-12-02 | 2009-12-15 | Celavie Biosciences, Llc | Compositions and methods for propagation of neural progenitor cells |
| ES2364878T3 (es) * | 2004-09-03 | 2011-09-15 | Moraga Biotechnology Inc. | Células madre de tipo blastómero totipotenciales no embrionarias y procedimientos de las mismas. |
| US20060084167A1 (en) | 2004-10-16 | 2006-04-20 | Cohenford Menashi A | Formation of Hybrid Cells by Fusion of Lineage Committed Cells with Stem Cells |
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| FR2885368A1 (fr) * | 2005-05-04 | 2006-11-10 | Fred Zacouto | Systemes et procedes de regeneration cellulaire et utilisations de telles cellules regenerees |
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| US20070087437A1 (en) | 2005-10-14 | 2007-04-19 | Jifan Hu | Methods for rejuvenating cells in vitro and in vivo |
| US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US20070190646A1 (en) * | 2006-02-10 | 2007-08-16 | The Trustees Of The University Of Pennsylvania | Regulating stem cell differentiation by controlling matrix elasticity |
| WO2008038148A2 (en) * | 2006-05-11 | 2008-04-03 | Andrew Craig Boquest | Stem cells and methods of making and using stem cells |
| US20100135970A1 (en) * | 2006-10-27 | 2010-06-03 | Caritas St. Elizabeth Medical Center Of Boston, In | Methods for Reprogramming Adult Somatic Cells and Uses Thereof |
| EP2626416A3 (en) * | 2007-04-07 | 2013-12-18 | The Whitehead Institute for Biomedical Research | Reprogramming of somatic cells |
| ES2409356T3 (es) * | 2007-10-30 | 2013-06-26 | Le Centre National De La Recherche Scientifique (Cnrs) | Método de realización de un ensayo para neutralizar anticuerpos |
| AU2008297024B2 (en) | 2007-10-31 | 2014-08-28 | Kyoto University | Nuclear reprogramming method |
| US20090280518A1 (en) * | 2008-05-12 | 2009-11-12 | Massachusetts Institute Of Technology | System for high throughput measurement of mechanical properties of cells |
| US9550975B2 (en) | 2009-07-15 | 2017-01-24 | Mari Dezawa | SSEA-3 pluripotent stem cell isolated from body tissue |
| EP2312341B1 (en) * | 2009-10-06 | 2019-05-29 | Canon Kabushiki Kaisha | Rear attachment lens and imaging optical system including the same |
| EP2554659A4 (en) | 2010-04-02 | 2013-09-25 | Riken | PROCESS FOR PREPARING ES CELLS |
| KR20120002134A (ko) | 2010-06-30 | 2012-01-05 | 서울대학교산학협력단 | 지방 기질 세포의 역분화를 유도하는 방법 |
| EP2590695B1 (en) | 2010-07-09 | 2024-11-20 | GID BIO, Inc. | Apparatus and methods relating to collecting and processing human biological material containing adipose |
-
2013
- 2013-04-24 KR KR1020147032963A patent/KR20150045935A/ko not_active Ceased
- 2013-04-24 US US14/397,080 patent/US11963977B2/en active Active
- 2013-04-24 EP EP13780959.6A patent/EP2844738A4/en not_active Ceased
- 2013-04-24 EP EP18203532.9A patent/EP3483261B1/en active Active
- 2013-04-24 SG SG11201407768QA patent/SG11201407768QA/en unknown
- 2013-04-24 WO PCT/US2013/037996 patent/WO2013163296A1/en not_active Ceased
- 2013-04-24 JP JP2015509109A patent/JP2015516812A/ja active Pending
- 2013-04-24 AU AU2013251649A patent/AU2013251649B2/en active Active
- 2013-04-24 KR KR1020207019169A patent/KR20200084916A/ko not_active Ceased
- 2013-04-24 RU RU2014147093A patent/RU2696071C2/ru active
- 2013-04-24 CN CN202010907822.3A patent/CN112048466A/zh active Pending
- 2013-04-24 SG SG10201809901SA patent/SG10201809901SA/en unknown
- 2013-04-24 CA CA2885576A patent/CA2885576A1/en active Pending
- 2013-04-24 ES ES18203532T patent/ES2972525T3/es active Active
- 2013-04-24 CN CN201380033613.9A patent/CN104718283A/zh active Pending
-
2018
- 2018-06-20 JP JP2018117481A patent/JP2018183145A/ja not_active Withdrawn
-
2019
- 2019-06-05 AU AU2019203943A patent/AU2019203943B2/en active Active
-
2020
- 2020-07-16 JP JP2020122035A patent/JP2020182480A/ja not_active Withdrawn
-
2022
- 2022-11-01 JP JP2022175459A patent/JP2023002805A/ja active Pending
-
2025
- 2025-04-03 JP JP2025061922A patent/JP2025106394A/ja active Pending
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