JP2015516812A - 多能性細胞のデノボ生成 - Google Patents

多能性細胞のデノボ生成 Download PDF

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Publication number
JP2015516812A
JP2015516812A JP2015509109A JP2015509109A JP2015516812A JP 2015516812 A JP2015516812 A JP 2015516812A JP 2015509109 A JP2015509109 A JP 2015509109A JP 2015509109 A JP2015509109 A JP 2015509109A JP 2015516812 A JP2015516812 A JP 2015516812A
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cells
cell
pluripotent
stress
stem
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JP2015516812A5 (enExample
Inventor
エー． バカンティ、チャールズ
エー． バカンティ、チャールズ
ピー． バカンティ、マーチン
ピー． バカンティ、マーチン
宏司 小島
宏司 小島
晴子 小保方
晴子 小保方
照彦 若山
照彦 若山
芳樹 笹井
芳樹 笹井
大和　雅之
雅之 大和
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The Brigham and Women's Hospital Inc
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The Brigham and Women's Hospital Inc
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Publication of JP2015516812A publication Critical patent/JP2015516812A/ja
Publication of JP2015516812A5 publication Critical patent/JP2015516812A5/ja
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JP2015509109A 2012-04-24 2013-04-24 多能性細胞のデノボ生成 Pending JP2015516812A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261637631P 2012-04-24 2012-04-24
US61/637,631 2012-04-24
US201361779533P 2013-03-13 2013-03-13
US61/779,533 2013-03-13
PCT/US2013/037996 WO2013163296A1 (en) 2012-04-24 2013-04-24 Generating pluripotent cells de novo

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018117481A Division JP2018183145A (ja) 2012-04-24 2018-06-20 多能性細胞のデノボ生成

Publications (2)

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JP2015516812A true JP2015516812A (ja) 2015-06-18
JP2015516812A5 JP2015516812A5 (enExample) 2016-06-16

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JP2015509109A Pending JP2015516812A (ja) 2012-04-24 2013-04-24 多能性細胞のデノボ生成
JP2018117481A Withdrawn JP2018183145A (ja) 2012-04-24 2018-06-20 多能性細胞のデノボ生成
JP2020122035A Withdrawn JP2020182480A (ja) 2012-04-24 2020-07-16 多能性細胞のデノボ生成
JP2022175459A Pending JP2023002805A (ja) 2012-04-24 2022-11-01 多能性細胞のデノボ生成
JP2025061922A Pending JP2025106394A (ja) 2012-04-24 2025-04-03 多能性細胞のデノボ生成

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JP2018117481A Withdrawn JP2018183145A (ja) 2012-04-24 2018-06-20 多能性細胞のデノボ生成
JP2020122035A Withdrawn JP2020182480A (ja) 2012-04-24 2020-07-16 多能性細胞のデノボ生成
JP2022175459A Pending JP2023002805A (ja) 2012-04-24 2022-11-01 多能性細胞のデノボ生成
JP2025061922A Pending JP2025106394A (ja) 2012-04-24 2025-04-03 多能性細胞のデノボ生成

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US (1) US11963977B2 (enExample)
EP (2) EP2844738A4 (enExample)
JP (5) JP2015516812A (enExample)
KR (2) KR20150045935A (enExample)
CN (2) CN104718283A (enExample)
AU (2) AU2013251649B2 (enExample)
CA (1) CA2885576A1 (enExample)
ES (1) ES2972525T3 (enExample)
RU (1) RU2696071C2 (enExample)
SG (2) SG10201809901SA (enExample)
WO (1) WO2013163296A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019508068A (ja) * 2016-03-11 2019-03-28 ステムオン インコーポレーテッドＳｔｅｍｏｎ Ｉｎｃ． 物理的刺激による環境流入を用いた細胞のリプログラミング方法
JP2019508069A (ja) * 2016-03-11 2019-03-28 ステムオン インコーポレーテッドＳｔｅｍｏｎ Ｉｎｃ． 細胞のリプログラミング装置
JP2022546578A (ja) * 2019-09-04 2022-11-04 ブイセル セラピューティックス，インコーポレイテッド 癌を処置するためのワクチンおよびストレスリプログラミングによるその作製方法

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3260140B1 (en) 2011-12-05 2021-02-03 Factor Bioscience Inc. Methods and products for transfecting cells
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
CA2890110C (en) 2012-11-01 2023-05-02 Factor Bioscience Inc. Methods and products for expressing proteins in cells
CA3106271A1 (en) 2013-01-25 2014-07-31 Xcell Biosciences, Inc. Methods, compositions, kits, and systems for selective enrichment of target cells
EP2955223B1 (en) 2013-02-08 2019-12-18 Kyoto University Production methods for megakaryocytes and platelets
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
CA2906815A1 (en) 2013-03-15 2014-09-18 Ocata Therapeutics, Inc. Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
WO2014201254A1 (en) 2013-06-12 2014-12-18 University Of Washington Through Its Center For Commercialization Methods for maturing cardiomyocytes and uses thereof
KR102415811B1 (ko) 2014-01-31 2022-07-04 팩터 바이오사이언스 인크. 핵산 제조 및 송달을 위한 방법 및 산물
JP2017513517A (ja) * 2014-03-19 2017-06-01 ブイセル セラピューティックス，インコーポレイテッド 多能性細胞に関連する方法
WO2016089178A1 (ko) * 2014-12-04 2016-06-09 가톨릭관동대학교산학협력단 에너지를 이용한 다능성 세포 유도 장치 및 방법
KR101798726B1 (ko) * 2014-12-04 2017-11-16 가톨릭관동대학교기술지주 주식회사 에너지를 이용한 다능성 세포 유도 장치 및 방법
US11241505B2 (en) 2015-02-13 2022-02-08 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
US20180066223A1 (en) 2015-04-17 2018-03-08 Xcell Biosciences, Inc. Cancer cell enrichment system
ES3063334T3 (en) * 2015-06-18 2026-04-16 Yeda Res & Dev Conditioning protocols and use of same for tissue regeneration
WO2017155166A1 (ko) * 2016-03-11 2017-09-14 가톨릭관동대학교기술지주 주식회사 물리적 자극에 의한 환경유입을 이용한 세포 리프로그래밍 방법
WO2017155167A1 (ko) * 2016-03-11 2017-09-14 가톨릭관동대학교산학협력단 세포 리프로그래밍 장치
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10426796B2 (en) 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
IL264439B2 (en) 2016-08-17 2024-08-01 Factor Bioscience Inc non-viral, cell-free composition comprising a synthetic messenger RNA (MRNA) encoding a gene-editing protein for use in treating cancer, and a synthetic RNA encoding a gene-editing protein for use in treatment
CA3043166A1 (en) * 2016-11-07 2018-05-11 K2 Research Holdings, Llc Production and therapeutic uses of epinul pluripotent cells and differentiated cells derived therefrom
WO2018172335A1 (en) * 2017-03-20 2018-09-27 Ifom Fondazione Istituto Firc Di Oncologia Molecolare Method of generating 2 cell-like stem cells
AU2018281936A1 (en) * 2017-06-10 2020-01-30 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
CN107729932B (zh) * 2017-10-10 2019-07-26 杭州智微信息科技有限公司 骨髓细胞标记方法和系统
KR102416171B1 (ko) 2018-10-02 2022-07-06 주식회사 스템온 세포의 리프로그래밍을 유도하는 리프로좀 및 그 제조 방법
CA3145425A1 (en) 2019-07-03 2021-01-07 Factor Bioscience Inc. Cationic lipids and uses thereof
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
US12091684B2 (en) 2020-02-14 2024-09-17 Hackensack Meridian Health, Inc. Platelet-derived mitochondria treatment and method of generating multipotent cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009057831A1 (ja) * 2007-10-31 2009-05-07 Kyoto University 核初期化方法
WO2011007900A1 (ja) * 2009-07-15 2011-01-20 Dezawa Mari 生体組織から単離できる多能性幹細胞
WO2011125948A1 (ja) * 2010-04-02 2011-10-13 独立行政法人理化学研究所 Ｅｓ細胞の製造方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
FR2687404B1 (fr) 1992-02-19 1994-05-20 Centre Nal Recherc Scientifique Peptides immunologiquement apparentes aux proteines d'un agent viral et leurs applications biologiques.
AU4543193A (en) 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5672346A (en) 1992-07-27 1997-09-30 Indiana University Foundation Human stem cell compositions and methods
KR950703640A (ko) 1992-10-09 1995-09-20 가일 케이,나우톤. 간 보존 세포(liver reserve cells)
US5753431A (en) * 1993-10-13 1998-05-19 Northeastern Ohio University Cholesterol 7 α-hydroxdylase gene regulatory elements and transcription factors
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
GB9502022D0 (en) 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
US20020151050A1 (en) 2000-10-30 2002-10-17 Vacanti Charles A. Isolation of spore-like cells from tissues exposed to extreme conditions
GB0113118D0 (en) 2001-05-31 2001-07-18 Intercytex Ltd Stem Cells
US7575321B2 (en) 2003-10-30 2009-08-18 Welch Allyn, Inc. Apparatus and method of diagnosis of optically identifiable ophthalmic conditions
EP1709151B1 (en) * 2003-12-02 2016-04-13 Celavie Biosciences, LLC Compositions and methods for propagation of neural progenitor cells
EP1789540B9 (en) * 2004-09-03 2012-02-22 Moraga Biotechnology Inc. Non-embryonic totipotent blastomer-like stem cells and methods therefor
US20060084167A1 (en) 2004-10-16 2006-04-20 Cohenford Menashi A Formation of Hybrid Cells by Fusion of Lineage Committed Cells with Stem Cells
WO2006113534A1 (en) * 2005-04-15 2006-10-26 The Johns Hopkins University Immortilization of cells including neuronal cells
FR2885368A1 (fr) * 2005-05-04 2006-11-10 Fred Zacouto Systemes et procedes de regeneration cellulaire et utilisations de telles cellules regenerees
WO2007030693A2 (en) * 2005-09-08 2007-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for promoting stem cell proliferation and survival
US20070087437A1 (en) * 2005-10-14 2007-04-19 Jifan Hu Methods for rejuvenating cells in vitro and in vivo
US8278104B2 (en) * 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US20070190646A1 (en) * 2006-02-10 2007-08-16 The Trustees Of The University Of Pennsylvania Regulating stem cell differentiation by controlling matrix elasticity
US20090252711A1 (en) * 2006-05-11 2009-10-08 Andrew Craig Boquest Stem Cells And Methods Of Making And Using Stem Cells
US20100135970A1 (en) 2006-10-27 2010-06-03 Caritas St. Elizabeth Medical Center Of Boston, In Methods for Reprogramming Adult Somatic Cells and Uses Thereof
MX348010B (es) * 2007-04-07 2017-05-23 Whitehead Inst Biomedical Res Reprogramacion de celulas somaticas.
WO2009058884A1 (en) * 2007-10-30 2009-05-07 Le Centre Nationale De La Recherche Scientifique Method for conducting an assay for neutralizing antibodies
US20090280518A1 (en) * 2008-05-12 2009-11-12 Massachusetts Institute Of Technology System for high throughput measurement of mechanical properties of cells
EP2492715B1 (en) * 2009-10-06 2019-01-09 Canon Kabushiki Kaisha Rear attachment lens, imaging optical system, and image pickup apparatus
KR20120002134A (ko) 2010-06-30 2012-01-05 서울대학교산학협력단 지방 기질 세포의 역분화를 유도하는 방법
US9260697B2 (en) 2010-07-09 2016-02-16 The Gid Group, Inc. Apparatus and methods relating to collecting and processing human biological material containing adipose

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009057831A1 (ja) * 2007-10-31 2009-05-07 Kyoto University 核初期化方法
WO2011007900A1 (ja) * 2009-07-15 2011-01-20 Dezawa Mari 生体組織から単離できる多能性幹細胞
WO2011125948A1 (ja) * 2010-04-02 2011-10-13 独立行政法人理化学研究所 Ｅｓ細胞の製造方法

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ALEJANDRO DE LOS ANGELES, ET AL., NATURE, vol. 525, JPN6017007339, September 2015 (2015-09-01), pages 6 - 9, ISSN: 0003510116 *
DAIJIRO KONNO, ET AL., NATURE, vol. 525, JPN6017007341, September 2015 (2015-09-01), pages 4 - 5, ISSN: 0003510117 *
HARUKO OBOKATA, ET AL., NATURE, vol. 505, JPN6017007325, January 2014 (2014-01-01), pages 641 - 647, ISSN: 0003510111 *
HARUKO OBOKATA, ET AL., NATURE, vol. 505, JPN6017007328, January 2014 (2014-01-01), pages 676 - 680, ISSN: 0003510112 *
HARUKO OBOKATA, ET AL., NATURE, vol. 511, JPN6017007330, July 2014 (2014-07-01), pages 112, ISSN: 0003510113 *
HARUKO OBOKATA, ET AL., NATURE, vol. 511, JPN6017007333, July 2014 (2014-07-01), pages 112, ISSN: 0003510114 *
HITOSHI NIWA, ET AL., SCIENTIFIC REPORT, vol. 6:28003, JPN6017007344, June 2016 (2016-06-01), pages 1 - 9, ISSN: 0003510118 *
NATURE, vol. 511, JPN6017007336, July 2014 (2014-07-01), pages 5 - 6, ISSN: 0003510115 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019508068A (ja) * 2016-03-11 2019-03-28 ステムオン インコーポレーテッドＳｔｅｍｏｎ Ｉｎｃ． 物理的刺激による環境流入を用いた細胞のリプログラミング方法
JP2019508069A (ja) * 2016-03-11 2019-03-28 ステムオン インコーポレーテッドＳｔｅｍｏｎ Ｉｎｃ． 細胞のリプログラミング装置
JP2021019646A (ja) * 2016-03-11 2021-02-18 ステムオン インコーポレーテッドＳｔｅｍｏｎ Ｉｎｃ． 物理的刺激による環境流入を用いた細胞のリプログラミング方法
JP7219618B2 (ja) 2016-03-11 2023-02-08 ステムオン インコーポレーテッド 物理的刺激による環境流入を用いた細胞のリプログラミング方法
JP7648124B2 (ja) 2016-03-11 2025-03-18 ステムオン インコーポレーテッド 物理的刺激による環境流入を用いた細胞のリプログラミング方法
JP2022546578A (ja) * 2019-09-04 2022-11-04 ブイセル セラピューティックス，インコーポレイテッド 癌を処置するためのワクチンおよびストレスリプログラミングによるその作製方法

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