JP2015501642A5 - - Google Patents
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- Publication number
- JP2015501642A5 JP2015501642A5 JP2014545423A JP2014545423A JP2015501642A5 JP 2015501642 A5 JP2015501642 A5 JP 2015501642A5 JP 2014545423 A JP2014545423 A JP 2014545423A JP 2014545423 A JP2014545423 A JP 2014545423A JP 2015501642 A5 JP2015501642 A5 JP 2015501642A5
- Authority
- JP
- Japan
- Prior art keywords
- genomic dna
- promoter
- expression cassette
- dna sequence
- gapdh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 60
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 60
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 44
- 239000002773 nucleotide Substances 0.000 claims 38
- 125000003729 nucleotide group Chemical group 0.000 claims 38
- 238000011144 upstream manufacturing Methods 0.000 claims 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 108091033319 polynucleotide Proteins 0.000 claims 16
- 102000040430 polynucleotide Human genes 0.000 claims 16
- 239000002157 polynucleotide Substances 0.000 claims 16
- 239000013604 expression vector Substances 0.000 claims 15
- 241000124008 Mammalia Species 0.000 claims 13
- 239000012634 fragment Substances 0.000 claims 8
- 239000003623 enhancer Substances 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 6
- 108020004999 messenger RNA Proteins 0.000 claims 6
- 230000008488 polyadenylation Effects 0.000 claims 6
- 238000013518 transcription Methods 0.000 claims 6
- 230000035897 transcription Effects 0.000 claims 6
- 101100006921 Homo sapiens NCAPD2 gene Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000002068 genetic effect Effects 0.000 claims 3
- 230000010076 replication Effects 0.000 claims 3
- 108091029430 CpG site Proteins 0.000 claims 2
- 108091034057 RNA (poly(A)) Proteins 0.000 claims 2
- 108091081024 Start codon Proteins 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 101001066129 Homo sapiens Glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 102000047486 human GAPDH Human genes 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161567675P | 2011-12-07 | 2011-12-07 | |
| US61/567,675 | 2011-12-07 | ||
| PCT/IB2012/056977 WO2013084157A1 (en) | 2011-12-07 | 2012-12-05 | Expression cassette |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017092184A Division JP2017200476A (ja) | 2011-12-07 | 2017-05-08 | 発現カセット |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015501642A JP2015501642A (ja) | 2015-01-19 |
| JP2015501642A5 true JP2015501642A5 (enExample) | 2016-01-28 |
Family
ID=47561694
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014545423A Pending JP2015501642A (ja) | 2011-12-07 | 2012-12-05 | 発現カセット |
| JP2017092184A Pending JP2017200476A (ja) | 2011-12-07 | 2017-05-08 | 発現カセット |
| JP2019124927A Active JP7096790B2 (ja) | 2011-12-07 | 2019-07-04 | 発現カセット |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017092184A Pending JP2017200476A (ja) | 2011-12-07 | 2017-05-08 | 発現カセット |
| JP2019124927A Active JP7096790B2 (ja) | 2011-12-07 | 2019-07-04 | 発現カセット |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20130344604A1 (enExample) |
| EP (1) | EP2788483B1 (enExample) |
| JP (3) | JP2015501642A (enExample) |
| KR (1) | KR102135745B1 (enExample) |
| CN (1) | CN104093834A (enExample) |
| AU (2) | AU2012348558A1 (enExample) |
| BR (1) | BR112014013597A2 (enExample) |
| CA (1) | CA2856479A1 (enExample) |
| EA (1) | EA037273B1 (enExample) |
| ES (1) | ES2679291T3 (enExample) |
| HK (1) | HK1202578A1 (enExample) |
| IL (1) | IL232845A0 (enExample) |
| MX (1) | MX362393B (enExample) |
| SG (1) | SG11201402477VA (enExample) |
| WO (1) | WO2013084157A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX377591B (es) * | 2014-10-15 | 2025-03-10 | Amgen Inc | Elementos promotores y reguladores para mejorar la expresión de genes heterólogos en células hospederas. |
| CA2967060A1 (en) * | 2014-11-10 | 2016-05-19 | Murdoch Childrens Research Institute | Vectors and methods for targeted integration in loci comprising constitutively expressed genes |
| CN106868044A (zh) * | 2017-02-15 | 2017-06-20 | 扬州大学 | 一种转基因动物毛色报告基因表达盒、表达载体及应用 |
| JP7520719B2 (ja) * | 2018-03-21 | 2024-07-23 | アルデブロン，エル．エル．シー． | 生成が改良されたウイルス及び非ウイルスのナノプラスミドベクター |
| CN114540352A (zh) * | 2022-02-16 | 2022-05-27 | 艾瑞生命科学技术(常州)有限公司 | 一种多核苷酸、载体元件及表达载体和宿主细胞及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3584341D1 (de) * | 1984-08-24 | 1991-11-14 | Upjohn Co | Rekombinante dna-verbindungen und expression von polypeptiden wie tpa. |
| KR20000006334A (ko) * | 1998-06-26 | 2000-01-25 | 이선경 | 바이러스코딩염기서열이전혀없는고효율레트로바이러스벡터 |
| US20040005639A1 (en) * | 2000-08-10 | 2004-01-08 | Ryoichi Ishitani | Glycerylaldehyde-3-phosphate dehyrogenase promoter inducing cell death |
| ATE497009T1 (de) * | 2005-12-12 | 2011-02-15 | King Faisal Specialist Hospital And Res Ct | 3-nichttranslatierte hybridbereiche mit eignung zur effizienten proteinexpression in säugerzellen |
-
2012
- 2012-12-05 HK HK15102932.0A patent/HK1202578A1/xx unknown
- 2012-12-05 CA CA2856479A patent/CA2856479A1/en not_active Abandoned
- 2012-12-05 SG SG11201402477VA patent/SG11201402477VA/en unknown
- 2012-12-05 BR BR112014013597-5A patent/BR112014013597A2/pt not_active Application Discontinuation
- 2012-12-05 EP EP12816132.0A patent/EP2788483B1/en active Active
- 2012-12-05 CN CN201280069001.0A patent/CN104093834A/zh active Pending
- 2012-12-05 US US14/003,410 patent/US20130344604A1/en not_active Abandoned
- 2012-12-05 AU AU2012348558A patent/AU2012348558A1/en not_active Abandoned
- 2012-12-05 JP JP2014545423A patent/JP2015501642A/ja active Pending
- 2012-12-05 KR KR1020147018672A patent/KR102135745B1/ko active Active
- 2012-12-05 ES ES12816132.0T patent/ES2679291T3/es active Active
- 2012-12-05 WO PCT/IB2012/056977 patent/WO2013084157A1/en not_active Ceased
- 2012-12-05 EA EA201491034A patent/EA037273B1/ru unknown
- 2012-12-05 MX MX2014006869A patent/MX362393B/es active IP Right Grant
-
2014
- 2014-05-28 IL IL232845A patent/IL232845A0/en unknown
-
2017
- 2017-05-08 JP JP2017092184A patent/JP2017200476A/ja active Pending
- 2017-07-18 US US15/653,243 patent/US20180163225A1/en not_active Abandoned
-
2018
- 2018-06-18 AU AU2018204332A patent/AU2018204332B2/en active Active
-
2019
- 2019-04-29 US US16/397,006 patent/US20200087679A1/en not_active Abandoned
- 2019-07-04 JP JP2019124927A patent/JP7096790B2/ja active Active
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