ATE497009T1 - 3-nichttranslatierte hybridbereiche mit eignung zur effizienten proteinexpression in säugerzellen - Google Patents
3-nichttranslatierte hybridbereiche mit eignung zur effizienten proteinexpression in säugerzellenInfo
- Publication number
- ATE497009T1 ATE497009T1 AT05819306T AT05819306T ATE497009T1 AT E497009 T1 ATE497009 T1 AT E497009T1 AT 05819306 T AT05819306 T AT 05819306T AT 05819306 T AT05819306 T AT 05819306T AT E497009 T1 ATE497009 T1 AT E497009T1
- Authority
- AT
- Austria
- Prior art keywords
- hybrid
- region
- efficient
- protein expression
- translated
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 241000124008 Mammalia Species 0.000 title 1
- 108020005345 3' Untranslated Regions Proteins 0.000 abstract 2
- 108091036066 Three prime untranslated region Proteins 0.000 abstract 2
- 108020004999 messenger RNA Proteins 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 230000008488 polyadenylation Effects 0.000 abstract 1
- 230000010473 stable expression Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000010474 transient expression Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2005/013316 WO2007068265A1 (en) | 2005-12-12 | 2005-12-12 | Hybrid 3’ untranslated regions suitable for efficient protein expression in mammalian cells |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE497009T1 true ATE497009T1 (de) | 2011-02-15 |
Family
ID=35892431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05819306T ATE497009T1 (de) | 2005-12-12 | 2005-12-12 | 3-nichttranslatierte hybridbereiche mit eignung zur effizienten proteinexpression in säugerzellen |
Country Status (8)
Country | Link |
---|---|
US (1) | US9017965B2 (de) |
EP (1) | EP1974042B1 (de) |
AT (1) | ATE497009T1 (de) |
AU (1) | AU2005339232A1 (de) |
CA (1) | CA2632900A1 (de) |
DE (1) | DE602005026186D1 (de) |
IL (1) | IL191995A0 (de) |
WO (1) | WO2007068265A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102135745B1 (ko) * | 2011-12-07 | 2020-07-21 | 아이크노스 사이언스 에스. 아. | 발현 카세트 |
RU2717986C2 (ru) * | 2013-12-30 | 2020-03-27 | Куревак Аг | Искусственные молекулы нуклеиновой кислоты |
US11254951B2 (en) | 2014-12-30 | 2022-02-22 | Curevac Ag | Artificial nucleic acid molecules |
EP3842537A1 (de) * | 2013-12-30 | 2021-06-30 | CureVac AG | Künstliche nukleinsäuremoleküle |
DE202015010000U1 (de) | 2014-12-12 | 2023-07-03 | CureVac SE | Artifizielle Nukleinsäuremoleküle für eine verbesserte Proteinexpression |
WO2016107877A1 (en) | 2014-12-30 | 2016-07-07 | Curevac Ag | Artificial nucleic acid molecules |
WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
JPWO2021075567A1 (de) * | 2019-10-17 | 2021-04-22 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7598079B2 (en) | 1998-12-24 | 2009-10-06 | Novation Pharmaceuticals, Inc. | Assay for identifying compounds which affect stability of mRNA |
-
2005
- 2005-12-12 DE DE602005026186T patent/DE602005026186D1/de active Active
- 2005-12-12 CA CA002632900A patent/CA2632900A1/en not_active Abandoned
- 2005-12-12 AT AT05819306T patent/ATE497009T1/de not_active IP Right Cessation
- 2005-12-12 EP EP05819306A patent/EP1974042B1/de active Active
- 2005-12-12 US US12/097,169 patent/US9017965B2/en not_active Expired - Fee Related
- 2005-12-12 WO PCT/EP2005/013316 patent/WO2007068265A1/en active Application Filing
- 2005-12-12 AU AU2005339232A patent/AU2005339232A1/en not_active Abandoned
-
2008
- 2008-06-05 IL IL191995A patent/IL191995A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE602005026186D1 (de) | 2011-03-10 |
US9017965B2 (en) | 2015-04-28 |
AU2005339232A1 (en) | 2007-06-21 |
EP1974042B1 (de) | 2011-01-26 |
WO2007068265A1 (en) | 2007-06-21 |
IL191995A0 (en) | 2008-12-29 |
US20090181427A1 (en) | 2009-07-16 |
CA2632900A1 (en) | 2007-06-21 |
EP1974042A1 (de) | 2008-10-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE497009T1 (de) | 3-nichttranslatierte hybridbereiche mit eignung zur effizienten proteinexpression in säugerzellen | |
Dayer et al. | A brief history of IL-1 and IL-1 Ra in rheumatology | |
BRPI0514396A2 (pt) | polipeptìdeos dependentes de vitamina k modificada | |
CY1112323T1 (el) | Παραγωγη και καθαρισμος της il-29 | |
EA201301350A1 (ru) | Модифицированные полипептиды фактора vii и их применение | |
CL2012000063A1 (es) | Polipéptido factor ix (fix) o un fragmento del mismo porque comprende la modificación de un aminoácido; vector; célula; método para expresar el polipéptido fix; composición farmacéutica; uso de la composición para tratar enfermedades trombóticas, hemorrágicas y coagulación intravascular diseminada (cid) (div. sol. 1796-07). | |
DE602004030315D1 (de) | Induzierbare sirna expressionskonstrukte zur gezielten genabschaltung | |
Herlihy et al. | Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent | |
ATE529442T1 (de) | Verbesserte humane interferon-moleküle und ihre verwendungen | |
EA200802289A1 (ru) | Направляемые к мишени антителами цитокины для терапии | |
DE59903410D1 (de) | Hybridprotein zur hemmung der mastzelldegranulation und dessen verwendung | |
BRPI0510475B8 (pt) | adenovírus quimérico recombinante, uso do mesmo no tratamento de câncer e métodos de inibição de crescimento de uma célula de câncer, de fornecimento de uma proteína terapêutica a uma célula e para o isolamento do adenovírus | |
ECSP088262A (es) | Proteínas de fusión de albúmina | |
WO2008070357A3 (en) | Smoothened polypeptides and methods of use | |
MXPA05007781A (es) | Constructos de fusion y uso de los mismos para producir anticuerpos con afinidad incrementada de enlace al receptor fc y funcion efectora. | |
IN2012DN02981A (de) | ||
WO2011036443A3 (en) | Si protease c- terminal polypeptides and uses thereof for treating inflammation or coagulation disorders | |
AR113492A2 (es) | Furina recombinante libre de proteínas sustancialmente animal y métodos para producirla | |
DE60207053D1 (de) | Rekombinante gelatineartige proteine zur verwendung als plasmaexpander | |
ATE510920T1 (de) | Dna-sequenzen zur regulation der transkription | |
DE60138715D1 (de) | Tnf-rezeptor-ähnliche moleküle und deren anwendungen | |
HRP20200744T1 (hr) | Organizacija ekspresijskog vektora, novi postupci generiranja proizvodnje stanica i njihova uporaba za rekombinantnu proizvodnju polipeptida | |
MX2022011805A (es) | Vectores de adn no virales y usos de estos para expresar agentes terapéuticos con factor ix. | |
MX2021011039A (es) | Vectores de adn no virales y usos de estos para expresar agentes terapéuticos con fviii. | |
ATE338826T1 (de) | Rekombinante virale vektoren zur tetracyclinregulierbaren genexpression |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |