JP2015501285A5 - - Google Patents
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- Publication number
- JP2015501285A5 JP2015501285A5 JP2014526247A JP2014526247A JP2015501285A5 JP 2015501285 A5 JP2015501285 A5 JP 2015501285A5 JP 2014526247 A JP2014526247 A JP 2014526247A JP 2014526247 A JP2014526247 A JP 2014526247A JP 2015501285 A5 JP2015501285 A5 JP 2015501285A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- αvβ8
- antibody
- cdr sequences
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161524708P | 2011-08-17 | 2011-08-17 | |
| US61/524,708 | 2011-08-17 | ||
| US201261646111P | 2012-05-11 | 2012-05-11 | |
| US61/646,111 | 2012-05-11 | ||
| PCT/US2012/051373 WO2013026004A2 (en) | 2011-08-17 | 2012-08-17 | Antibodies that bind integrin alpha-v beta-8 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015501285A JP2015501285A (ja) | 2015-01-15 |
| JP2015501285A5 true JP2015501285A5 (enExample) | 2015-10-08 |
| JP6093360B2 JP6093360B2 (ja) | 2017-03-08 |
Family
ID=47715714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014526247A Expired - Fee Related JP6093360B2 (ja) | 2011-08-17 | 2012-08-17 | インテグリンα−ｖβ−８と結合する抗体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9492569B2 (enExample) |
| EP (1) | EP2744823B1 (enExample) |
| JP (1) | JP6093360B2 (enExample) |
| KR (1) | KR102010098B1 (enExample) |
| CN (1) | CN103857696B (enExample) |
| AU (1) | AU2012296362B2 (enExample) |
| BR (1) | BR112014003501B1 (enExample) |
| CA (1) | CA2846240C (enExample) |
| ES (1) | ES2643397T3 (enExample) |
| MX (1) | MX350335B (enExample) |
| RU (1) | RU2614252C2 (enExample) |
| SG (1) | SG2014014237A (enExample) |
| WO (1) | WO2013026004A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011103490A2 (en) * | 2010-02-18 | 2011-08-25 | The Regents Of The University Of California | INTEGRIN αVβ8 NEUTRALIZING ANTIBODY |
| EP3003390B1 (en) | 2013-06-06 | 2021-07-07 | Pierre Fabre Médicament | Anti-c10orf54 antibodies and uses thereof |
| ES2779412T3 (es) * | 2014-06-17 | 2020-08-17 | Medimmune Ltd | Anticuerpos Alfa-V Beta-8 mejorados |
| EP3009147A1 (en) | 2014-10-16 | 2016-04-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating resistant glioblastoma |
| WO2017182834A1 (en) | 2016-04-19 | 2017-10-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method for treating resistant glioblastoma |
| CN109862913B (zh) | 2016-09-29 | 2023-09-05 | 加利福尼亚大学董事会 | 用于免疫疗法的αvβ8整联蛋白复合物的中和抗体 |
| EP3630185A4 (en) * | 2017-05-30 | 2020-06-17 | The Board of Trustees of the Leland Stanford Junior University | TREATMENT OF A NEUROINFLAMMATIONAL DISEASE |
| CN112823167B (zh) | 2018-09-07 | 2025-07-15 | 辉瑞大药厂 | 抗-αvβ8抗体和组合物及其用途 |
| BR112021009325A2 (pt) * | 2018-11-14 | 2021-09-14 | Arch Oncology, Inc. | Anticorpo monoclonal, ou fragmento de ligação ao antígeno do mesmo; anticorpo biespecífico; método para prevenir ou tratar um câncer suscetível em um ser humano; método de ensaio de expressão de sirp¿ em células tumorais e/ou imunes; e; composição farmacêutica |
| WO2020210650A1 (en) | 2019-04-12 | 2020-10-15 | Medimmune, Llc | Neutralization of tgf-beta or alpha-v-beta-8 integrin for s. aureus infections |
| TWI854088B (zh) | 2020-01-27 | 2024-09-01 | 英商梅迪繆思有限公司 | 用於治療腎臟疾病之抗αｖβ８整聯蛋白抗體 |
| WO2024056668A1 (en) * | 2022-09-12 | 2024-03-21 | Institut National de la Santé et de la Recherche Médicale | New anti-itgb8 antibodies and its uses thereof |
| KR20250167591A (ko) * | 2023-03-31 | 2025-12-01 | 제넨테크, 인크. | 항-알파 v 베타 8 인테그린 항체 및 사용 방법 |
| WO2024258908A1 (en) * | 2023-06-12 | 2024-12-19 | University Of Washington | De novo designed alpha (v) beta (8) integrin selective minibinder |
| CN117143241B (zh) * | 2023-10-26 | 2024-02-23 | 迈威(上海)生物科技股份有限公司 | 与人整合素蛋白itgav/itgb8特异性结合的单克隆抗体 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| EP0575554A1 (en) * | 1991-03-14 | 1993-12-29 | Genentech, Inc. | Novel beta integrin subunit |
| ATE244306T1 (de) * | 1994-12-20 | 2003-07-15 | Merck Patent Gmbh | Monoklonaler antikörper gegen das alpha-v- integrin |
| US6160099A (en) * | 1998-11-24 | 2000-12-12 | Jonak; Zdenka Ludmila | Anti-human αv β3 and αv β5 antibodies |
| WO2004043989A2 (en) * | 2002-11-07 | 2004-05-27 | Medarex, Inc. | Human monoclonal antibodies to heparanase |
| KR101224235B1 (ko) * | 2003-04-11 | 2013-01-25 | 메디뮨 엘엘씨 | 재조합 ｉｌ９ 항체 및 그의 용도 |
| JP4653660B2 (ja) * | 2003-09-04 | 2011-03-16 | 独立行政法人理化学研究所 | ＴＧＦ−β活性化制御領域の切断面を認識する抗体 |
| ES2689328T3 (es) | 2004-01-07 | 2018-11-13 | Novartis Vaccines And Diagnostics, Inc. | Anticuerpo monoclonal M-CSF-específico y usos del mismo |
| US20110250203A1 (en) * | 2008-08-29 | 2011-10-13 | Symphogen A/S | Anti-cd5 antibodies |
| BR112012003686B1 (pt) * | 2009-08-19 | 2021-09-21 | Merck Patent Gmbh | Anticorpos monoclonais, seu uso para detecção de complexos de integrina em material ffpe, e polinucleotídeo |
| WO2011103490A2 (en) * | 2010-02-18 | 2011-08-25 | The Regents Of The University Of California | INTEGRIN αVβ8 NEUTRALIZING ANTIBODY |
-
2012
- 2012-08-17 MX MX2014001850A patent/MX350335B/es active IP Right Grant
- 2012-08-17 EP EP12823966.2A patent/EP2744823B1/en not_active Not-in-force
- 2012-08-17 KR KR1020147006624A patent/KR102010098B1/ko not_active Expired - Fee Related
- 2012-08-17 CA CA2846240A patent/CA2846240C/en active Active
- 2012-08-17 BR BR112014003501-6A patent/BR112014003501B1/pt not_active IP Right Cessation
- 2012-08-17 RU RU2014109928A patent/RU2614252C2/ru active
- 2012-08-17 US US14/239,124 patent/US9492569B2/en active Active
- 2012-08-17 ES ES12823966T patent/ES2643397T3/es active Active
- 2012-08-17 WO PCT/US2012/051373 patent/WO2013026004A2/en not_active Ceased
- 2012-08-17 CN CN201280048486.5A patent/CN103857696B/zh not_active Expired - Fee Related
- 2012-08-17 AU AU2012296362A patent/AU2012296362B2/en not_active Ceased
- 2012-08-17 SG SG2014014237A patent/SG2014014237A/en unknown
- 2012-08-17 JP JP2014526247A patent/JP6093360B2/ja not_active Expired - Fee Related
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