AU2012296362B2 - Antibodies that bind integrin alpha-v beta-8 - Google Patents
Antibodies that bind integrin alpha-v beta-8 Download PDFInfo
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- AU2012296362B2 AU2012296362B2 AU2012296362A AU2012296362A AU2012296362B2 AU 2012296362 B2 AU2012296362 B2 AU 2012296362B2 AU 2012296362 A AU2012296362 A AU 2012296362A AU 2012296362 A AU2012296362 A AU 2012296362A AU 2012296362 B2 AU2012296362 B2 AU 2012296362B2
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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| US61/646,111 | 2012-05-11 | ||
| PCT/US2012/051373 WO2013026004A2 (en) | 2011-08-17 | 2012-08-17 | Antibodies that bind integrin alpha-v beta-8 |
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| EP4219560A3 (en) * | 2010-02-18 | 2023-08-23 | The Regents of The University of California | Integrin alpha v beta 8 neutralizing antibody |
| SG11201509982UA (enExample) | 2013-06-06 | 2016-04-28 | Igenica Biotherapeutics Inc | |
| PT3157561T (pt) * | 2014-06-17 | 2020-03-25 | Univ California | Anticorpos contra alfa-v beta-8 melhorados |
| EP3009147A1 (en) | 2014-10-16 | 2016-04-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating resistant glioblastoma |
| WO2017182834A1 (en) | 2016-04-19 | 2017-10-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method for treating resistant glioblastoma |
| US10954304B2 (en) | 2016-09-29 | 2021-03-23 | The Regents Of The University Of California | Neutralizing antibodies to the αvβ8 integrin complex for immunotherapy |
| JP7370252B2 (ja) * | 2017-05-30 | 2023-10-27 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 神経炎症性疾患の治療 |
| BR112021004287A2 (pt) * | 2018-09-07 | 2021-08-03 | Pfizer Inc. | anticorpos anti-avss8 e composições e usos dos mesmos |
| WO2020102422A1 (en) * | 2018-11-14 | 2020-05-22 | Arch Oncology, Inc. | THERAPEUTIC SIRPα ANTIBODIES |
| WO2020210650A1 (en) | 2019-04-12 | 2020-10-15 | Medimmune, Llc | Neutralization of tgf-beta or alpha-v-beta-8 integrin for s. aureus infections |
| TWI854088B (zh) * | 2020-01-27 | 2024-09-01 | 英商梅迪繆思有限公司 | 用於治療腎臟疾病之抗αｖβ８整聯蛋白抗體 |
| CN120225559A (zh) * | 2022-09-12 | 2025-06-27 | 国家健康与医学研究院 | 新型抗itgb8抗体及其用途 |
| WO2024206788A1 (en) * | 2023-03-31 | 2024-10-03 | Genentech, Inc. | Anti-alpha v beta 8 integrin antibodies and methods of use |
| WO2024258908A1 (en) * | 2023-06-12 | 2024-12-19 | University Of Washington | De novo designed alpha (v) beta (8) integrin selective minibinder |
| CN117143241B (zh) * | 2023-10-26 | 2024-02-23 | 迈威(上海)生物科技股份有限公司 | 与人整合素蛋白itgav/itgb8特异性结合的单克隆抗体 |
Citations (1)
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|---|---|---|---|---|
| US5635601A (en) * | 1991-03-14 | 1997-06-03 | Genentech, Inc. | Beta-8 integrin subunit antibodies |
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|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE69531187T2 (de) * | 1994-12-20 | 2004-04-22 | Merck Patent Gmbh | Monoklonaler Antikörper gegen das Alpha-V-Integrin |
| US6160099A (en) * | 1998-11-24 | 2000-12-12 | Jonak; Zdenka Ludmila | Anti-human αv β3 and αv β5 antibodies |
| WO2004043989A2 (en) | 2002-11-07 | 2004-05-27 | Medarex, Inc. | Human monoclonal antibodies to heparanase |
| AU2004229501B2 (en) | 2003-04-11 | 2011-08-18 | Medimmune, Llc | Recombinant IL-9 antibodies and uses thereof |
| US7803553B2 (en) * | 2003-09-04 | 2010-09-28 | Riken | Methods of use of antibodies which recognize a protease cleavage site of an LAP fragment of TGF-β |
| EP3476861A1 (en) | 2004-01-07 | 2019-05-01 | Novartis Vaccines and Diagnostics, Inc. | M-csf-specific monoclonal antibody and uses thereof |
| WO2010022737A1 (en) * | 2008-08-29 | 2010-03-04 | Symphogen A/S | Anti-cd5 antibodies |
| SG178348A1 (en) * | 2009-08-19 | 2012-03-29 | Merck Patent Gmbh | Antibodies for the detection of integrin complexes in ffpe material |
| EP4219560A3 (en) * | 2010-02-18 | 2023-08-23 | The Regents of The University of California | Integrin alpha v beta 8 neutralizing antibody |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635601A (en) * | 1991-03-14 | 1997-06-03 | Genentech, Inc. | Beta-8 integrin subunit antibodies |
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| JP2015501285A (ja) | 2015-01-15 |
| JP6093360B2 (ja) | 2017-03-08 |
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| EP2744823B1 (en) | 2017-08-02 |
| US20140271478A1 (en) | 2014-09-18 |
| CN103857696B (zh) | 2017-07-04 |
| KR102010098B1 (ko) | 2019-08-13 |
| CN103857696A (zh) | 2014-06-11 |
| MX2014001850A (es) | 2014-12-08 |
| BR112014003501B1 (pt) | 2022-02-08 |
| WO2013026004A2 (en) | 2013-02-21 |
| AU2012296362A1 (en) | 2014-03-13 |
| MX350335B (es) | 2017-09-04 |
| EP2744823A2 (en) | 2014-06-25 |
| RU2614252C2 (ru) | 2017-03-24 |
| EP2744823A4 (en) | 2015-08-12 |
| CA2846240A1 (en) | 2013-02-21 |
| US9492569B2 (en) | 2016-11-15 |
| CA2846240C (en) | 2021-01-12 |
| SG2014014237A (en) | 2014-07-30 |
| BR112014003501A2 (pt) | 2017-03-01 |
| KR20140054238A (ko) | 2014-05-08 |
| RU2014109928A (ru) | 2015-09-27 |
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