JP2015500875A - マグノロール類似体を製造するための方法 - Google Patents
マグノロール類似体を製造するための方法 Download PDFInfo
- Publication number
- JP2015500875A JP2015500875A JP2014548744A JP2014548744A JP2015500875A JP 2015500875 A JP2015500875 A JP 2015500875A JP 2014548744 A JP2014548744 A JP 2014548744A JP 2014548744 A JP2014548744 A JP 2014548744A JP 2015500875 A JP2015500875 A JP 2015500875A
- Authority
- JP
- Japan
- Prior art keywords
- biphenyl
- dimethoxy
- diol
- dipropyl
- dialkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 4
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical class OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 title abstract description 19
- IMHDGJOMLMDPJN-UHFFFAOYSA-N biphenyl-2,2'-diol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1O IMHDGJOMLMDPJN-UHFFFAOYSA-N 0.000 claims description 22
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 18
- OYAQUBKYAKSHOA-UHFFFAOYSA-N tetrahydro-magnolol Natural products CCCC1=CC=C(O)C(C=2C(=CC=C(CCC)C=2)O)=C1 OYAQUBKYAKSHOA-UHFFFAOYSA-N 0.000 claims description 16
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 14
- VGMKUVCDINAAFC-UHFFFAOYSA-N 1-methoxy-2-(2-methoxyphenyl)benzene Chemical group COC1=CC=CC=C1C1=CC=CC=C1OC VGMKUVCDINAAFC-UHFFFAOYSA-N 0.000 claims description 11
- 239000004305 biphenyl Substances 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 7
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- LEKCGNXOZIPHEL-UHFFFAOYSA-N 1-[4-methoxy-3-(2-methoxy-5-propanoylphenyl)phenyl]propan-1-one Chemical group CCC(=O)C1=CC=C(OC)C(C=2C(=CC=C(C=2)C(=O)CC)OC)=C1 LEKCGNXOZIPHEL-UHFFFAOYSA-N 0.000 claims description 5
- SNWRWIMOUATIKJ-UHFFFAOYSA-N 1-methoxy-2-(2-methoxy-5-propylphenyl)-4-propylbenzene Chemical group CCCC1=CC=C(OC)C(C=2C(=CC=C(CCC)C=2)OC)=C1 SNWRWIMOUATIKJ-UHFFFAOYSA-N 0.000 claims description 5
- 230000001335 demethylating effect Effects 0.000 claims description 5
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 claims description 5
- 230000001035 methylating effect Effects 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 claims description 4
- 239000003054 catalyst Substances 0.000 claims description 3
- 125000004122 cyclic group Chemical group 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000000010 aprotic solvent Substances 0.000 claims description 2
- 239000012736 aqueous medium Substances 0.000 claims description 2
- 150000007529 inorganic bases Chemical class 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 4
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 241000218378 Magnolia Species 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 description 3
- 239000002260 anti-inflammatory agent Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000031709 bromination Effects 0.000 description 3
- 238000005893 bromination reaction Methods 0.000 description 3
- 238000010511 deprotection reaction Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- FCTQSFVLYRQKTR-UHFFFAOYSA-N 4-bromo-2-(5-bromo-2-hydroxyphenyl)phenol Chemical compound OC1=CC=C(Br)C=C1C1=CC(Br)=CC=C1O FCTQSFVLYRQKTR-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000010520 demethylation reaction Methods 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 239000012044 organic layer Substances 0.000 description 2
- 238000005863 Friedel-Crafts acylation reaction Methods 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- BHELZAPQIKSEDF-UHFFFAOYSA-N allyl bromide Chemical compound BrCC=C BHELZAPQIKSEDF-UHFFFAOYSA-N 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- DMLAVOWQYNRWNQ-UHFFFAOYSA-N azobenzene Chemical compound C1=CC=CC=C1N=NC1=CC=CC=C1 DMLAVOWQYNRWNQ-UHFFFAOYSA-N 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
- C07C37/003—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by hydrogenation of an unsaturated part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2011/066053 WO2013095364A1 (en) | 2011-12-20 | 2011-12-20 | Processes for making magnolol analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015500875A true JP2015500875A (ja) | 2015-01-08 |
| JP2015500875A5 JP2015500875A5 (enExample) | 2015-02-19 |
Family
ID=45498120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548744A Ceased JP2015500875A (ja) | 2011-12-20 | 2011-12-20 | マグノロール類似体を製造するための方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9045397B2 (enExample) |
| EP (1) | EP2794535B1 (enExample) |
| JP (1) | JP2015500875A (enExample) |
| CN (1) | CN104066702B (enExample) |
| AR (1) | AR089311A1 (enExample) |
| AU (1) | AU2011383725B2 (enExample) |
| BR (1) | BR112014015031A2 (enExample) |
| CA (1) | CA2858817A1 (enExample) |
| MX (1) | MX2014007554A (enExample) |
| PH (1) | PH12014501327A1 (enExample) |
| RU (1) | RU2014129908A (enExample) |
| SG (1) | SG11201402852SA (enExample) |
| TW (1) | TW201331173A (enExample) |
| WO (1) | WO2013095364A1 (enExample) |
| ZA (1) | ZA201404278B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9676690B2 (en) | 2013-01-23 | 2017-06-13 | Colgate-Palmolive Company | Processes for making magnolol derivatives |
| CN105622603A (zh) * | 2015-05-28 | 2016-06-01 | 广州牌牌生物科技有限公司 | 多核化合物、其制备方法以及其应用 |
| CN109053387B (zh) * | 2018-09-19 | 2021-07-09 | 九江学院 | 一种厚朴酚的合成方法 |
| US12311044B2 (en) | 2018-12-18 | 2025-05-27 | Conopco, Inc. | Antimicrobial composition |
| CN114956977B (zh) * | 2022-06-09 | 2024-03-26 | 朗捷睿(苏州)生物科技有限公司 | 一种联苯类化合物、药物组合物及其制备方法和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004292392A (ja) * | 2003-03-27 | 2004-10-21 | T Hasegawa Co Ltd | ジアルキルビスフェノール類の製法 |
| JP2007326798A (ja) * | 2006-06-07 | 2007-12-20 | T Hasegawa Co Ltd | ジ−置換ビスフェノールの製造方法 |
| WO2010073124A2 (en) * | 2008-12-26 | 2010-07-01 | Actavis Group Ptc Ehf | Processes for preparing highly pure rotigotine or a pharmaceutically acceptable salt thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106391C (zh) | 1999-04-12 | 2003-04-23 | 李安荣 | 厚朴酚系列化合物及其合成方法和以该化合物为活性成分的药物组合物 |
| WO2001082922A1 (en) * | 2000-04-27 | 2001-11-08 | The Procter & Gamble Company | Oral compositions comprising polyphenol herbal extracts |
| US6500409B1 (en) | 2000-05-10 | 2002-12-31 | Colgate Palmolive Company | Synergistic antiplaque/antigingivitis oral composition |
| US7795233B2 (en) | 2004-11-19 | 2010-09-14 | Miyagi Ken | Composition comprising double stranded RNA that inhibits expression of NEU3 and method for treating cancer |
| US7973185B2 (en) | 2004-12-08 | 2011-07-05 | Richter Gedeon Nyrt. | Process for the preparation of phenolic hydroxy-substituted compounds |
| MY148519A (en) * | 2004-12-29 | 2013-04-30 | Colgate Palmolive Co | Oral compositions containing biphenol antibacterial compounds |
| US8071077B2 (en) * | 2004-12-29 | 2011-12-06 | Colgate-Palmolive Company | Oral compositions containing biphenol antibacterial compounds |
| US7608741B2 (en) | 2005-05-30 | 2009-10-27 | Korea Institute Of Oriental Medicine | Mass separation method of magnolol from Magnoliae cortex radix |
| WO2008006581A2 (en) | 2006-07-14 | 2008-01-17 | Dsm Ip Assets B.V. | Compositions and use thereof for the treatment, co-treatment or prevention of imflammatory disorders |
| CN101293816B (zh) | 2008-06-24 | 2011-09-28 | 江南大学 | 厚朴酚的合成方法 |
| TWI422382B (zh) | 2010-02-24 | 2014-01-11 | Colgate Palmolive Co | 加強木蘭活性物之溶解度及傳送的組成物 |
| TWI459957B (zh) | 2010-02-24 | 2014-11-11 | Colgate Palmolive Co | 口腔保健組成物 |
| RU2510938C1 (ru) | 2010-02-25 | 2014-04-10 | Колгейт-Палмолив Компани | Синтез магнолола и его аналогов |
-
2011
- 2011-12-20 BR BR112014015031A patent/BR112014015031A2/pt not_active IP Right Cessation
- 2011-12-20 MX MX2014007554A patent/MX2014007554A/es unknown
- 2011-12-20 EP EP11810738.2A patent/EP2794535B1/en not_active Not-in-force
- 2011-12-20 AU AU2011383725A patent/AU2011383725B2/en not_active Ceased
- 2011-12-20 SG SG11201402852SA patent/SG11201402852SA/en unknown
- 2011-12-20 US US14/365,676 patent/US9045397B2/en active Active
- 2011-12-20 RU RU2014129908A patent/RU2014129908A/ru unknown
- 2011-12-20 JP JP2014548744A patent/JP2015500875A/ja not_active Ceased
- 2011-12-20 CN CN201180075810.8A patent/CN104066702B/zh not_active Expired - Fee Related
- 2011-12-20 WO PCT/US2011/066053 patent/WO2013095364A1/en not_active Ceased
- 2011-12-20 CA CA2858817A patent/CA2858817A1/en not_active Abandoned
-
2012
- 2012-12-18 AR ARP120104804A patent/AR089311A1/es unknown
- 2012-12-19 TW TW101148202A patent/TW201331173A/zh unknown
-
2014
- 2014-06-10 ZA ZA2014/04278A patent/ZA201404278B/en unknown
- 2014-06-11 PH PH12014501327A patent/PH12014501327A1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004292392A (ja) * | 2003-03-27 | 2004-10-21 | T Hasegawa Co Ltd | ジアルキルビスフェノール類の製法 |
| JP2007326798A (ja) * | 2006-06-07 | 2007-12-20 | T Hasegawa Co Ltd | ジ−置換ビスフェノールの製造方法 |
| WO2010073124A2 (en) * | 2008-12-26 | 2010-07-01 | Actavis Group Ptc Ehf | Processes for preparing highly pure rotigotine or a pharmaceutically acceptable salt thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201331173A (zh) | 2013-08-01 |
| AU2011383725A1 (en) | 2014-06-19 |
| AR089311A1 (es) | 2014-08-13 |
| EP2794535B1 (en) | 2016-04-20 |
| CN104066702B (zh) | 2016-01-20 |
| US9045397B2 (en) | 2015-06-02 |
| PH12014501327A1 (en) | 2014-09-15 |
| WO2013095364A1 (en) | 2013-06-27 |
| RU2014129908A (ru) | 2016-02-10 |
| ZA201404278B (en) | 2015-12-23 |
| SG11201402852SA (en) | 2014-10-30 |
| AU2011383725B2 (en) | 2015-03-12 |
| CA2858817A1 (en) | 2013-06-27 |
| BR112014015031A2 (pt) | 2017-06-13 |
| EP2794535A1 (en) | 2014-10-29 |
| US20140343328A1 (en) | 2014-11-20 |
| CN104066702A (zh) | 2014-09-24 |
| MX2014007554A (es) | 2014-08-01 |
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