JP2015500387A5 - - Google Patents
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- Publication number
- JP2015500387A5 JP2015500387A5 JP2014547145A JP2014547145A JP2015500387A5 JP 2015500387 A5 JP2015500387 A5 JP 2015500387A5 JP 2014547145 A JP2014547145 A JP 2014547145A JP 2014547145 A JP2014547145 A JP 2014547145A JP 2015500387 A5 JP2015500387 A5 JP 2015500387A5
- Authority
- JP
- Japan
- Prior art keywords
- chemically modified
- kda
- molecular weight
- modified heparin
- heparin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 26
- 150000004676 glycans Polymers 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 150000004804 polysaccharides Polymers 0.000 claims 12
- 150000002016 disaccharides Chemical group 0.000 claims 6
- 229920000669 heparin Polymers 0.000 claims 6
- 230000001590 oxidative effect Effects 0.000 claims 6
- 229960002897 heparin Drugs 0.000 claims 5
- 239000007800 oxidant agent Substances 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
- 230000002378 acidificating effect Effects 0.000 claims 2
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical group O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 claims 2
- -1 disaccharide polysaccharides Chemical class 0.000 claims 2
- 230000007062 hydrolysis Effects 0.000 claims 2
- 238000006460 hydrolysis reaction Methods 0.000 claims 2
- 201000004792 malaria Diseases 0.000 claims 2
- 238000005160 1H NMR spectroscopy Methods 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 230000002429 anti-coagulating effect Effects 0.000 claims 1
- 239000004019 antithrombin Substances 0.000 claims 1
- FIHJKUPKCHIPAT-AHIGJZGOSA-N artesunate Chemical group C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2O[C@@H](OC(=O)CCC(O)=O)[C@@H]4C FIHJKUPKCHIPAT-AHIGJZGOSA-N 0.000 claims 1
- 229960004991 artesunate Drugs 0.000 claims 1
- IAJILQKETJEXLJ-LECHCGJUSA-N iduronic acid Chemical class O=C[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-LECHCGJUSA-N 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- SSOLNOMRVKKSON-UHFFFAOYSA-N proguanil Chemical compound CC(C)\N=C(/N)N=C(N)NC1=CC=C(Cl)C=C1 SSOLNOMRVKKSON-UHFFFAOYSA-N 0.000 claims 1
- 229960005385 proguanil Drugs 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SEPCT/SE2011/051538 | 2011-12-19 | ||
| PCT/SE2011/051538 WO2013095215A1 (en) | 2011-12-19 | 2011-12-19 | Low anticoagulant heparins |
| PCT/SE2012/051428 WO2013095276A1 (en) | 2011-12-19 | 2012-12-19 | Low anticoagulant heparins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018112162A Division JP2018154848A (ja) | 2011-12-19 | 2018-06-12 | 低抗凝固剤ヘパリン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500387A JP2015500387A (ja) | 2015-01-05 |
| JP2015500387A5 true JP2015500387A5 (cg-RX-API-DMAC7.html) | 2016-12-01 |
| JP6703806B2 JP6703806B2 (ja) | 2020-06-03 |
Family
ID=48668926
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547145A Active JP6703806B2 (ja) | 2011-12-19 | 2012-12-19 | 低抗凝固剤ヘパリン |
| JP2018112162A Pending JP2018154848A (ja) | 2011-12-19 | 2018-06-12 | 低抗凝固剤ヘパリン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018112162A Pending JP2018154848A (ja) | 2011-12-19 | 2018-06-12 | 低抗凝固剤ヘパリン |
Country Status (26)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013095279A1 (en) | 2011-12-19 | 2013-06-27 | Dilafor Ab | Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use |
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| GB2515315A (en) | 2013-06-19 | 2014-12-24 | Dilafor Ab | New Processes |
| EP3137099B1 (en) * | 2014-04-30 | 2019-09-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Dnase for use in treating vaso-occlusive crisis |
| EP2965764A1 (en) * | 2014-07-11 | 2016-01-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating vaso-occlusive crisis |
| CN105504097B (zh) * | 2015-12-30 | 2018-07-03 | 深圳市海普瑞药业集团股份有限公司 | 一种硫酸化肝素寡糖及其制备方法和应用 |
| CN108424474B (zh) * | 2017-02-15 | 2023-07-25 | 清华大学 | 去抗凝肝素衍生物及其用于炎症性肠病的治疗 |
| US12220500B2 (en) * | 2018-04-13 | 2025-02-11 | University Of Virginia Patent Foundation | Compositions and methods for preparing and using non-immunogenic fast annealing microporous annealed particle hydrogels |
| CN109481692A (zh) * | 2018-11-30 | 2019-03-19 | 东南大学 | 一种青蒿琥酯肝素衍生物及其药物组合物和应用 |
| WO2023192344A1 (en) * | 2022-03-29 | 2023-10-05 | The Penn State Research Foundation | Device and method for accelerating and guiding vascularization |
| US12444880B2 (en) | 2022-05-05 | 2025-10-14 | Tego Innovations, Inc. | Magnetic power distribution assembly |
| US20250353936A1 (en) * | 2022-06-06 | 2025-11-20 | Ihp Therapeutics Inc. | Chemically modified heparin |
| CN115448994B (zh) * | 2022-09-28 | 2023-08-01 | 山东大学 | 一种可中和抗凝低分子量肝素及其制备方法和应用 |
| US12059430B2 (en) | 2022-09-29 | 2024-08-13 | Adora Animal Health Corporation | Storage stable formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions |
| GB2625581A (en) * | 2022-12-21 | 2024-06-26 | Modus Therapeutics Ab | New medical use |
| GB2627263A (en) * | 2023-02-17 | 2024-08-21 | Modus Therapeutics Ab | New medical use |
| WO2024170746A1 (en) | 2023-02-17 | 2024-08-22 | Modus Therapeutics Ab | New medical use of sevuparin in the treatment of endotoxemia |
| CN116854838A (zh) * | 2023-06-30 | 2023-10-10 | 重庆望业药物研究有限公司 | 低分子多糖及其制备方法与应用 |
| GB202407366D0 (en) * | 2024-05-23 | 2024-07-10 | Glycos Biomedical Ltd | Preparation of medium molecular weight heparin |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1136620A (en) | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
| FR2614026B1 (fr) | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
| DE68906345T2 (de) * | 1988-10-07 | 1993-10-28 | Hoechst Ag | Antimalariazusammenstellungen, gebrauchmachend von Quinidin, Artemisinin und ihren Derivaten. |
| SE9002550D0 (sv) | 1990-08-01 | 1990-08-01 | Kabivitrum Ab | Heparinfragment |
| SE9003181D0 (sv) * | 1990-10-04 | 1990-10-04 | Kabivitrum Ab | Use of heparin fraction |
| US5280016A (en) * | 1991-03-29 | 1994-01-18 | Glycomed Incorporated | Non-anticoagulant heparin derivatives |
| US5250519A (en) * | 1991-03-29 | 1993-10-05 | Glycomed Incorporated | Non-anticoagulant heparin derivatives |
| JPH0532703A (ja) * | 1991-07-26 | 1993-02-09 | Terumo Corp | 低分子量ヘパリン誘導体の製造法 |
| AU5442594A (en) | 1992-10-13 | 1994-05-09 | Virginia Commonwealth University | Use of non-anticoagulant heparin for treating ischemia/reperfusion injury |
| US5527785A (en) * | 1993-05-14 | 1996-06-18 | The Regents Of The University Of California | Selectin receptor modulating compositions |
| ATE224918T1 (de) * | 1995-03-31 | 2002-10-15 | Hamilton Civic Hospitals Res | Zusammensetzung zur hemmung der thromboseentstehung |
| US5993810A (en) | 1996-03-15 | 1999-11-30 | Lebovitz; Shamir Israel | Method of softening or ripening the cervix of a female mammal using collagenase |
| US5767269A (en) | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
| WO1998016559A1 (fr) | 1996-10-15 | 1998-04-23 | Toray Industries, Inc. | Agent de maturation des canaux cervicaux |
| GB9711443D0 (en) | 1997-06-03 | 1997-07-30 | Leo Pharm Prod Ltd | Chemical suppositions |
| EP1033375A4 (en) * | 1997-11-20 | 2002-04-24 | Ikuo Yamashina | MODIFICATION OF LOW MOLECULAR MASS HEPARIN AND REMEDY FOR SKIN Ulcer |
| US6596705B1 (en) | 1998-02-09 | 2003-07-22 | The Regents Of The University Of California | Inhibition of L-selectin and P-selection mediated binding using heparin |
| EP1059304B1 (en) | 1998-02-26 | 2006-04-26 | Seikagaku Corporation | Novel polysaccharide derivatives, process for the production thereof and medicinal compositions containing the same as the active ingredient |
| US6028061A (en) * | 1998-06-18 | 2000-02-22 | Children's Medical Center Corp | Angiogenesis inhibitors and use thereof |
| EP1022289B1 (en) * | 1998-07-31 | 2004-07-07 | Seikagaku Corporation | Novel glycosaminoglycan and drug compositions containing the same |
| CZ20014665A3 (cs) * | 1999-06-30 | 2002-05-15 | Hamilton Civic Hospitals Research Development, Inc | Prostředek s obsahem heparinu se střední molekulovou hmotností |
| JP4897991B2 (ja) * | 1999-07-23 | 2012-03-14 | ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ | 超低分子量ヘパリン組成物 |
| IT1316986B1 (it) | 2000-01-25 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica. |
| JP4585072B2 (ja) * | 2000-02-29 | 2010-11-24 | 扶桑薬品工業株式会社 | ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物 |
| DK1319183T3 (da) * | 2000-09-12 | 2009-05-18 | Massachusetts Inst Technology | Fremgangsmåder og produkter relateret til heparin med lav molekylvægt |
| SE521676C2 (sv) | 2002-01-02 | 2003-11-25 | Dilafor Ab | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
| WO2003088980A1 (en) * | 2002-04-18 | 2003-10-30 | Embury Stephen H | Method and composition for preventing pain in sickle cell patients |
| US8071569B2 (en) * | 2002-09-20 | 2011-12-06 | Mousa Shaker A | Oxidized heparin fractions and their use in inhibiting angiogenesis |
| EP1582531A1 (en) | 2004-03-24 | 2005-10-05 | Aventis Pharma S.A. | Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products |
| EP2258349B1 (en) * | 2004-05-11 | 2014-07-16 | Egalet Ltd. | Swellable dosage form comprising gellan gum |
| US20060040896A1 (en) * | 2004-08-18 | 2006-02-23 | Paringenix, Inc. | Method and medicament for anticoagulation using a sulfated polysaccharide with enhanced anti-inflammatory activity |
| US7741311B2 (en) * | 2005-01-03 | 2010-06-22 | Shaker Mousa | Composition and method for treating occlusive vascular diseases, nerve regeneration, and wound healing |
| EP1906975A4 (en) * | 2005-07-22 | 2010-10-06 | Trf Pharma Inc | METHOD FOR THE TREATMENT OF SICKLE CELL DISEASE AND CONSEQUENCES OF SICKLE CELL DISEASE |
| EP1906974A4 (en) * | 2005-07-22 | 2010-06-23 | Univ California | HEPARINE COMPOSITIONS AND SELECTIN INHIBITION |
| EP2447285A3 (en) * | 2006-05-25 | 2013-01-16 | Momenta Pharmaceuticals, Inc. | Low molecular weight heparin composition and uses thereof |
| WO2009007224A1 (en) * | 2007-07-10 | 2009-01-15 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Low molecular weight heparin derivatives having neuroprotective activity |
| WO2009059284A2 (en) * | 2007-11-02 | 2009-05-07 | Momenta Pharmaceuticals, Inc. | Non-anticoagulant polysaccharide compositions |
| US8592393B2 (en) * | 2007-11-02 | 2013-11-26 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
| US8569262B2 (en) | 2007-11-02 | 2013-10-29 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
| WO2009073184A1 (en) | 2007-12-03 | 2009-06-11 | Florida State University Research Foundation, Inc. | Compositions for inducing labor and associated methods |
| JP5758797B2 (ja) * | 2008-04-04 | 2015-08-05 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション | アルキル化半合成グリコサミノグリカンエーテルならびにその製造および使用方法 |
| CA2767560A1 (en) * | 2008-07-25 | 2010-01-28 | Alphapharm Pty Ltd | Atovaquone with a particle size diameter range (d90) of greater than 3um to about 10um |
| CA2758520A1 (en) | 2009-04-16 | 2010-10-21 | Momenta Pharmaceuticals, Inc. | Methods of assessing activity of a polysaccharide composition |
| WO2011000032A1 (en) * | 2009-06-30 | 2011-01-06 | Walter And Eliza Hall Institute Of Medical Research | Sulfated polysaccharides having antiplasmodial activity and methods and products for identifying antiplasmodial activity |
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| WO2013095279A1 (en) | 2011-12-19 | 2013-06-27 | Dilafor Ab | Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use |
| CA2868479A1 (en) | 2012-03-26 | 2013-10-03 | Dilafor Ab | Method for treatment of labor arrest |
| CA2868444A1 (en) | 2012-03-26 | 2013-10-03 | Dilafor Ab | Combination treatment comprising sulphated glycosaminoglycans for inducing labor |
-
2011
- 2011-12-19 WO PCT/SE2011/051538 patent/WO2013095215A1/en not_active Ceased
-
2012
- 2012-12-19 PT PT128593845T patent/PT2794666T/pt unknown
- 2012-12-19 ES ES12859384.5T patent/ES2668273T3/es active Active
- 2012-12-19 CA CA2856918A patent/CA2856918C/en not_active Expired - Fee Related
- 2012-12-19 IN IN1056MUN2014 patent/IN2014MN01056A/en unknown
- 2012-12-19 EP EP12859384.5A patent/EP2794666B1/en active Active
- 2012-12-19 WO PCT/SE2012/051428 patent/WO2013095276A1/en not_active Ceased
- 2012-12-19 HU HUE12860938A patent/HUE037555T2/hu unknown
- 2012-12-19 PL PL12859384T patent/PL2794666T3/pl unknown
- 2012-12-19 HU HUE12859384A patent/HUE037554T2/hu unknown
- 2012-12-19 DK DK12860938.5T patent/DK2794667T3/en active
- 2012-12-19 CN CN201280062042.7A patent/CN104053675B/zh active Active
- 2012-12-19 WO PCT/SE2012/051429 patent/WO2013095277A1/en not_active Ceased
- 2012-12-19 RS RS20180574A patent/RS57214B1/sr unknown
- 2012-12-19 SM SM20180217T patent/SMT201800217T1/it unknown
- 2012-12-19 HR HRP20180726TT patent/HRP20180726T1/hr unknown
- 2012-12-19 PL PL12860938T patent/PL2794667T3/pl unknown
- 2012-12-19 RS RS20180552A patent/RS57213B1/sr unknown
- 2012-12-19 SM SM20180218T patent/SMT201800218T1/it unknown
- 2012-12-19 EP EP12860938.5A patent/EP2794667B1/en active Active
- 2012-12-19 DK DK12859384.5T patent/DK2794666T3/en active
- 2012-12-19 MY MYPI2014001796A patent/MY170069A/en unknown
- 2012-12-19 SI SI201231283T patent/SI2794667T1/en unknown
- 2012-12-19 PT PT128609385T patent/PT2794667T/pt unknown
- 2012-12-19 HR HRP20180725TT patent/HRP20180725T1/hr unknown
- 2012-12-19 MX MX2014006956A patent/MX358439B/es active IP Right Grant
- 2012-12-19 NO NO12859384A patent/NO2794666T3/no unknown
- 2012-12-19 SI SI201231282T patent/SI2794666T1/en unknown
- 2012-12-19 CA CA2856477A patent/CA2856477C/en active Active
- 2012-12-19 US US14/366,603 patent/US9480702B2/en active Active
- 2012-12-19 ES ES12860938.5T patent/ES2669055T3/es active Active
- 2012-12-19 NO NO12860938A patent/NO2794667T3/no unknown
- 2012-12-19 US US14/366,570 patent/US9480701B2/en active Active
- 2012-12-19 AU AU2012354226A patent/AU2012354226B2/en active Active
- 2012-12-19 JP JP2014547145A patent/JP6703806B2/ja active Active
- 2012-12-19 BR BR112014014673-0A patent/BR112014014673B1/pt active IP Right Grant
-
2014
- 2014-05-20 ZA ZA2014/03654A patent/ZA201403654B/en unknown
- 2014-05-29 TN TNP2014000236A patent/TN2014000236A1/en unknown
- 2014-05-29 TN TNP2014000237A patent/TN2014000237A1/en unknown
- 2014-06-01 IL IL232903A patent/IL232903A/en active IP Right Grant
- 2014-06-18 PH PH12014501387A patent/PH12014501387B1/en unknown
-
2018
- 2018-05-10 CY CY20181100483T patent/CY1120197T1/el unknown
- 2018-05-10 CY CY20181100482T patent/CY1120194T1/el unknown
- 2018-06-12 JP JP2018112162A patent/JP2018154848A/ja active Pending
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