JP2015187156A5 - - Google Patents

Download PDF

Info

Publication number
JP2015187156A5
JP2015187156A5 JP2015125342A JP2015125342A JP2015187156A5 JP 2015187156 A5 JP2015187156 A5 JP 2015187156A5 JP 2015125342 A JP2015125342 A JP 2015125342A JP 2015125342 A JP2015125342 A JP 2015125342A JP 2015187156 A5 JP2015187156 A5 JP 2015187156A5
Authority
JP
Japan
Prior art keywords
compound
medicament according
administered
medicament
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015125342A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015187156A (ja
JP6194335B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2015187156A publication Critical patent/JP2015187156A/ja
Publication of JP2015187156A5 publication Critical patent/JP2015187156A5/ja
Application granted granted Critical
Publication of JP6194335B2 publication Critical patent/JP6194335B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2015125342A 2002-05-17 2015-06-23 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物 Expired - Lifetime JP6194335B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38084202P 2002-05-17 2002-05-17
US60/380,842 2002-05-17
US42460002P 2002-11-06 2002-11-06
US60/424,600 2002-11-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2009116367A Division JP5839770B2 (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017095838A Division JP2017132817A (ja) 2002-05-17 2017-05-12 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Publications (3)

Publication Number Publication Date
JP2015187156A JP2015187156A (ja) 2015-10-29
JP2015187156A5 true JP2015187156A5 (enExample) 2016-02-04
JP6194335B2 JP6194335B2 (ja) 2017-09-06

Family

ID=29553516

Family Applications (8)

Application Number Title Priority Date Filing Date
JP2004505051A Pending JP2005530784A (ja) 2002-05-17 2003-05-16 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2006288966A Pending JP2007008966A (ja) 2002-05-17 2006-10-24 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2009116363A Withdrawn JP2009191072A (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2009116367A Expired - Lifetime JP5839770B2 (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2012273326A Expired - Lifetime JP5830005B2 (ja) 2002-05-17 2012-12-14 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2013038222A Withdrawn JP2013126999A (ja) 2002-05-17 2013-02-28 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2015125342A Expired - Lifetime JP6194335B2 (ja) 2002-05-17 2015-06-23 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2017095838A Pending JP2017132817A (ja) 2002-05-17 2017-05-12 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Family Applications Before (6)

Application Number Title Priority Date Filing Date
JP2004505051A Pending JP2005530784A (ja) 2002-05-17 2003-05-16 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2006288966A Pending JP2007008966A (ja) 2002-05-17 2006-10-24 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2009116363A Withdrawn JP2009191072A (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2009116367A Expired - Lifetime JP5839770B2 (ja) 2002-05-17 2009-05-13 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2012273326A Expired - Lifetime JP5830005B2 (ja) 2002-05-17 2012-12-14 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物
JP2013038222A Withdrawn JP2013126999A (ja) 2002-05-17 2013-02-28 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017095838A Pending JP2017132817A (ja) 2002-05-17 2017-05-12 癌および他の疾患を治療および管理するための免疫調節性化合物を用いた方法および組成物

Country Status (19)

Country Link
EP (9) EP2272513A1 (enExample)
JP (8) JP2005530784A (enExample)
KR (2) KR100822149B1 (enExample)
CN (13) CN102429908A (enExample)
AT (1) ATE459357T1 (enExample)
AU (1) AU2003234626B2 (enExample)
CA (10) CA2752122A1 (enExample)
CY (3) CY1110013T1 (enExample)
DE (1) DE60331537D1 (enExample)
DK (1) DK1505973T3 (enExample)
ES (2) ES2521672T3 (enExample)
IL (9) IL165254A0 (enExample)
LU (1) LU92642I2 (enExample)
MX (1) MXPA04011311A (enExample)
NZ (5) NZ536907A (enExample)
PT (2) PT2105135E (enExample)
SI (1) SI1505973T1 (enExample)
WO (1) WO2003097052A2 (enExample)
ZA (3) ZA200503656B (enExample)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
EP1389203B8 (en) 2001-02-27 2010-03-10 The Governement of the United States of America, represented by The Secretary Department of Health and Human services Analogs of thalidomide as angiogenesis inhibitors
EP2272513A1 (en) * 2002-05-17 2011-01-12 Celgene Corporation Pharmaceutical compositions for treating cancer
US7393862B2 (en) * 2002-05-17 2008-07-01 Celgene Corporation Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
US11116782B2 (en) 2002-10-15 2021-09-14 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
US7189740B2 (en) 2002-10-15 2007-03-13 Celgene Corporation Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
US8404716B2 (en) 2002-10-15 2013-03-26 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
MXPA05004488A (es) * 2002-10-31 2005-07-26 Celgene Corp Composicion para el tratamiento de la degeneracion macular.
US7785601B2 (en) * 2002-12-31 2010-08-31 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
WO2005016326A2 (en) * 2003-07-11 2005-02-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Analogs of thalidomide as potential angiogenesis inhibitors
UA83504C2 (en) 2003-09-04 2008-07-25 Селджин Корпорейшн Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
WO2005028436A2 (en) 2003-09-17 2005-03-31 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Thalidomide analogs as tnf-alpha modulators
US20050100529A1 (en) * 2003-11-06 2005-05-12 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
NZ548049A (en) * 2003-12-02 2009-01-31 Celgene Corp Methods and compositions for the treatment and management of hemoglobinopathy and anemia
US20050143344A1 (en) * 2003-12-30 2005-06-30 Zeldis Jerome B. Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
US9421175B2 (en) 2004-03-17 2016-08-23 Lars Michael Larsen Prevention of retinopathy by inhibition of the visual cycle
MXPA06010699A (es) * 2004-03-22 2006-12-15 Celgene Corp Metodos de usos y composiciones que contienen compuestos inmunomoduladores para el tratamiento y manejo de enfermedades o alteraciones de la piel.
CN1968695A (zh) * 2004-04-14 2007-05-23 细胞基因公司 含有用于治疗和控制骨髓发育不良综合征的免疫调节化合物的组合物和使用方法
ZA200704784B (en) * 2004-11-12 2008-10-29 Celgene Corp Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases
CA2588597A1 (en) * 2004-11-23 2006-06-01 Celgene Corporation Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury
JP2009507030A (ja) * 2005-09-01 2009-02-19 セルジーン・コーポレーション ワクチン及び抗感染症療法のための免疫調節性化合物の免疫学的使用
EP1960551A2 (en) * 2005-12-01 2008-08-27 Medical Prognosis Institute Methods and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
CA2648216C (en) 2006-04-13 2016-06-07 Michael Gutschow Tetrahalogenated compounds useful as inhibitors of angiogenesis
CA2652888A1 (en) * 2006-05-26 2007-12-06 Celgene Corporation Methods and compositions using immunomodulatory compounds in combination therapy
CL2007002218A1 (es) * 2006-08-03 2008-03-14 Celgene Corp Soc Organizada Ba Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa.
PT2641601T (pt) * 2006-08-07 2016-10-14 Dana Farber Cancer Inst Inc Métodos de tratamento de mieloma múltiplo utilizando terapias de combinação baseadas em huluc63 com bortezomib
EP2081561A2 (en) * 2006-10-19 2009-07-29 Celgene Corporation Methods and compositions using immunomodulatory compounds for the treatment and management of spirochete and other obligate intracellular bacterial diseases
RU2348420C2 (ru) * 2007-04-17 2009-03-10 ФГУ Ростовский научно-исследовательский онкологический институт Росздрава Способ лечения местно-распространенного рака легкого
CA2700617C (en) * 2007-09-28 2018-11-06 Celgene Cellular Therapeutics Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
UA104579C2 (uk) * 2007-12-10 2014-02-25 Байокрист Фармасьютикалз, Инк. Спосіб лікування раку кровотворної системи із застосуванням фородезину у комбінації з ритуксимабом
WO2009097120A1 (en) * 2008-01-29 2009-08-06 Celgene Corporation Methods using immunomodulatory compounds for modulating level of cd59
RU2398525C1 (ru) * 2009-03-25 2010-09-10 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" Способ лечения рака легкого
CN101696205B (zh) 2009-11-02 2011-10-19 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
US8841325B2 (en) * 2009-11-24 2014-09-23 Celgene Corporation Immunomodulatory compounds for the restoration of vitamin D sensitivity in vitamin D resistant tumor cells
SG10201501062SA (en) 2010-02-11 2015-04-29 Celgene Corp Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
AU2011224166B2 (en) * 2010-03-12 2014-08-21 Celgene Corporation Methods for the treatment of non-Hodgkin's lymphomas using lenalidomide, and gene and protein biomarkers as a predictor
CA2844109C (en) * 2010-08-18 2018-11-06 Theresa Deisher Compositions and methods to inhibit stem cell binding to active germinal centers in lymphatic tissues
US10426740B1 (en) 2010-08-18 2019-10-01 Avm Biotechnology, Llc Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues
WO2012062366A1 (en) * 2010-11-11 2012-05-18 Ingo Schmidt-Wolf Compositions comprising wnt inhibitors for treating cancer
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds
US9694015B2 (en) * 2012-09-10 2017-07-04 Celgene Corporation Methods for the treatment of locally advanced breast cancer
CA2907908A1 (en) * 2013-04-02 2014-10-09 Celgene Corporation Methods and compositions using 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment and management of central nervous system cancers
GB201322626D0 (en) * 2013-12-19 2014-02-05 Immutep S A Combined preparations for the treatment of cancer
CN104231068A (zh) * 2014-01-27 2014-12-24 苏州发士达生物科技有限公司 人白细胞介素ii突变体及其应用
JP6616934B2 (ja) * 2014-05-22 2019-12-04 株式会社 資生堂 レナリドミドの光学分割方法
US10034872B2 (en) 2014-08-22 2018-07-31 Celgene Corporation Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
US10570457B2 (en) 2014-09-26 2020-02-25 Medical Prognosis Institute A/S Methods for predicting drug responsiveness
GB201500374D0 (en) 2015-01-09 2015-02-25 Immutep S A Combined preparations for the treatment of cancer
CN107249502A (zh) * 2015-01-20 2017-10-13 斯里瓦特桑·拉加万 自照明式面颊牵开器
US11000536B2 (en) 2015-04-30 2021-05-11 Nant Holdings Ip, Llc Patient treatment via teratogenic pharmaceutical compounds
SI3313528T1 (sl) * 2015-06-29 2021-11-30 Bristol-Myers Squibb Company Imunoterapevtski režim odmerjanja, ki vsebujejo pomalidomid in protitelo anti-CS1 za zdravljenje raka
CN108472366B (zh) * 2015-10-21 2023-03-17 泰克利森有限公司 用于免疫介导的癌症疗法的组合物和方法
CN105388237B (zh) * 2015-12-28 2017-02-01 成都百裕金阁莱药业有限公司 阿普斯特中3‑乙酰氨基邻苯二甲酸的检测方法
US9725769B1 (en) 2016-10-07 2017-08-08 Oncology Venture ApS Methods for predicting drug responsiveness in cancer patients
AU2017258901A1 (en) 2016-12-30 2018-07-19 Allarity Therapeutics Europe ApS Methods for predicting drug responsiveness in cancer patients
EP3577109A4 (en) 2017-01-31 2020-11-18 Arvinas Operations, Inc. CEREMONY LIGANDS AND BIFUNCTIONAL COMPOUNDS CONTAINING THEM
ES2954311T3 (es) 2017-04-01 2023-11-21 Avm Biotechnology Llc Reemplazo de un preacondicionamiento citotóxico antes de una inmunoterapia celular
CN110662762A (zh) 2017-05-24 2020-01-07 诺华股份有限公司 抗体细胞因子移植蛋白和用于治疗癌症的方法
KR20200078498A (ko) * 2017-10-26 2020-07-01 신바이어스 파마 아게 레날리도마이드 즉시 방출 제형
FI3784663T3 (fi) 2018-04-23 2023-10-06 Celgene Corp Substituoituja 4-aminoisoindoliini-1,3-dioniyhdisteitä ja niiden käyttö lymfooman hoitamiseksi
SG11202011568XA (en) * 2018-05-23 2020-12-30 Celgene Corp Treating multiple myeloma and the use of biomarkers for 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1- oxoisoindolin-4-yl)oxy)methyl)benzyl) piperazin-1-yl)-3-fluorobenzonitrile
US20210317109A1 (en) * 2018-09-07 2021-10-14 Medshine Discovery Inc. Tricyclic substituted piperidine dione compound
EP3488851A1 (en) 2018-10-03 2019-05-29 AVM Biotechnology, LLC Immunoablative therapies
CA3151738A1 (en) * 2019-10-04 2021-04-08 Teru Hideshima Immunomodulatory imide drugs as zeta-chain-associated protein kinase 70 (zap70) agonists and uses thereof
CA3154504A1 (en) 2019-10-21 2021-04-29 Maria Soraya Carrancio ANTON Methods of treating hematological malignancies using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino )isoindoline-1,3-dione
IL292305A (en) * 2019-10-21 2022-06-01 Celgene Corp Methods for the treatment of hematological cancer and the use of associated biomarkers for 2-(2,6-deoxypyridin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isodonyl 1,3-discussion
EP4077309A1 (en) 2019-12-19 2022-10-26 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228601A (en) 1964-02-20 1966-01-11 Monarch Marking Systems Inc Controls for marking machine
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4994443A (en) 1982-12-20 1991-02-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US5001116A (en) 1982-12-20 1991-03-19 The Children's Medical Center Corporation Inhibition of angiogenesis
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5391485A (en) 1985-08-06 1995-02-21 Immunex Corporation DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues
JPS63500636A (ja) 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするdna
US4810643A (en) 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5360352A (en) 1992-12-24 1994-11-01 The Whitaker Corporation Wire retainer for current mode coupler
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US6114355A (en) 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US5698579A (en) 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US5635517B1 (en) 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US5798368A (en) 1996-08-22 1998-08-25 Celgene Corporation Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
US6281230B1 (en) * 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
PT2177517E (pt) 1996-07-24 2011-11-10 Celgene Corp 2-(2,6-dioxopiperidin-3-il)-ftalimida amino-substituída para redução dos níveis de tnf-alfa
JP4214537B2 (ja) 1996-08-12 2009-01-28 セルジーン コーポレーション 新規な免疫治療薬とこの薬物を使用してサイトカインレベルを抵減する方法
DE69734290T2 (de) * 1996-11-05 2006-07-06 The Children's Medical Center Corp., Boston Mittel zur hemmung von angiogenese enthaltend thalodomid und einen nsaid
US5874448A (en) 1997-11-18 1999-02-23 Celgene Corporation Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels
US6020358A (en) * 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels
WO2000059473A1 (en) * 1999-04-01 2000-10-12 Inex Pharmaceuticals Corp. Compositions and methods for treating lymphoma
CA2402643A1 (en) * 2000-03-17 2001-09-27 Cell Therapeutics, Inc. Polyglutamic acid-camptothecin conjugates and methods of preparation
ATE322266T1 (de) * 2000-05-15 2006-04-15 Celgene Corp Pharmazeutische zusammensetzungen zur behandlung von krebs welche thalidomid und topoisomerase inhibitoren enthalten
US6458810B1 (en) * 2000-11-14 2002-10-01 George Muller Pharmaceutically active isoindoline derivatives
NZ526683A (en) 2000-11-30 2008-03-28 Childrens Medical Center Synthesis of 4-amino-thalidomide and its enantiomers that are suitable for inhibiting angiogenesis
US20030045552A1 (en) 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
EP2272513A1 (en) * 2002-05-17 2011-01-12 Celgene Corporation Pharmaceutical compositions for treating cancer
US7323479B2 (en) * 2002-05-17 2008-01-29 Celgene Corporation Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline

Similar Documents

Publication Publication Date Title
CY1123595T1 (el) Παραγωγα χολικου οξεος ως αγωνιστες fxr/tgr5
JP2015508103A5 (enExample)
JP2014507446A5 (enExample)
JP2017525713A5 (enExample)
JP2017518334A5 (enExample)
JP2017504611A5 (enExample)
SG11202103057RA (en) Pharmaceutical composition for oral administration comprising aminopyrimidine derivative or its salt
EA201400056A1 (ru) Вещества, связывающие ядерные рецепторы
JP2016515561A5 (enExample)
JP2016534063A5 (enExample)
JP2017528503A5 (enExample)
JP2016518337A5 (enExample)
MY193177A (en) Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use therepf
JP2013522326A5 (enExample)
JP2019516735A5 (enExample)
JP2012513416A5 (enExample)
CA2921436C (en) Formulations of (s)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
FI3182996T3 (fi) Menetelmiä multippelin myelooman hoitamiseksi immuunivastetta muuntavilla yhdisteillä yhdistelmässä vasta-aineiden kanssa
NZ625592A (en) Compositions and methods for the treatment of hepatic diseases and disorders
MA37455A1 (fr) Utilisation d'un dérivé de pyrazole dans le traitement d'exacerbations aigues d'une maladie pulmonaire obstructive chronique
MX2016008362A (es) Combinaciones farmaceuticas.
EA202092829A1 (ru) Композиции тофацитиниба с контролируемым высвобождением
JP2016532632A5 (enExample)
JP2014148552A5 (enExample)
JP2017527551A5 (enExample)