JP2015180693A5 - - Google Patents

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Publication number
JP2015180693A5
JP2015180693A5 JP2015135207A JP2015135207A JP2015180693A5 JP 2015180693 A5 JP2015180693 A5 JP 2015180693A5 JP 2015135207 A JP2015135207 A JP 2015135207A JP 2015135207 A JP2015135207 A JP 2015135207A JP 2015180693 A5 JP2015180693 A5 JP 2015180693A5
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JP
Japan
Prior art keywords
aromatic
peptide
cationic peptide
isolated
dmt
Prior art date
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Granted
Application number
JP2015135207A
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English (en)
Japanese (ja)
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JP6166312B2 (ja
JP2015180693A (ja
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Publication of JP2015180693A publication Critical patent/JP2015180693A/ja
Publication of JP2015180693A5 publication Critical patent/JP2015180693A5/ja
Application granted granted Critical
Publication of JP6166312B2 publication Critical patent/JP6166312B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2015135207A 2003-02-04 2015-07-06 ミトコンドリア透過性転移の阻止方法 Expired - Lifetime JP6166312B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44477703P 2003-02-04 2003-02-04
US60/444,777 2003-02-04
US53569004P 2004-01-08 2004-01-08
US60/535,690 2004-01-08

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2013182343A Division JP5837542B2 (ja) 2003-02-04 2013-09-03 ミトコンドリア透過性転移の阻止方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017025764A Division JP2017095519A (ja) 2003-02-04 2017-02-15 ミトコンドリア透過性転移の阻止方法

Publications (3)

Publication Number Publication Date
JP2015180693A JP2015180693A (ja) 2015-10-15
JP2015180693A5 true JP2015180693A5 (OSRAM) 2016-06-09
JP6166312B2 JP6166312B2 (ja) 2017-07-19

Family

ID=32853391

Family Applications (7)

Application Number Title Priority Date Filing Date
JP2006503317A Expired - Lifetime JP4838114B2 (ja) 2003-02-04 2004-02-03 ミトコンドリア透過性転移の阻止方法
JP2010241738A Expired - Lifetime JP5775285B2 (ja) 2003-02-04 2010-10-28 ミトコンドリア透過性転移の阻止方法
JP2013182343A Expired - Lifetime JP5837542B2 (ja) 2003-02-04 2013-09-03 ミトコンドリア透過性転移の阻止方法
JP2014202889A Expired - Lifetime JP6126059B2 (ja) 2003-02-04 2014-10-01 ミトコンドリア透過性転移の阻止方法
JP2015135207A Expired - Lifetime JP6166312B2 (ja) 2003-02-04 2015-07-06 ミトコンドリア透過性転移の阻止方法
JP2017025764A Pending JP2017095519A (ja) 2003-02-04 2017-02-15 ミトコンドリア透過性転移の阻止方法
JP2019001256A Pending JP2019089773A (ja) 2003-02-04 2019-01-08 ミトコンドリア透過性転移の阻止方法

Family Applications Before (4)

Application Number Title Priority Date Filing Date
JP2006503317A Expired - Lifetime JP4838114B2 (ja) 2003-02-04 2004-02-03 ミトコンドリア透過性転移の阻止方法
JP2010241738A Expired - Lifetime JP5775285B2 (ja) 2003-02-04 2010-10-28 ミトコンドリア透過性転移の阻止方法
JP2013182343A Expired - Lifetime JP5837542B2 (ja) 2003-02-04 2013-09-03 ミトコンドリア透過性転移の阻止方法
JP2014202889A Expired - Lifetime JP6126059B2 (ja) 2003-02-04 2014-10-01 ミトコンドリア透過性転移の阻止方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2017025764A Pending JP2017095519A (ja) 2003-02-04 2017-02-15 ミトコンドリア透過性転移の阻止方法
JP2019001256A Pending JP2019089773A (ja) 2003-02-04 2019-01-08 ミトコンドリア透過性転移の阻止方法

Country Status (13)

Country Link
US (8) US7576061B2 (OSRAM)
EP (9) EP3842055A1 (OSRAM)
JP (7) JP4838114B2 (OSRAM)
CN (3) CN102617706A (OSRAM)
AU (1) AU2004209663B2 (OSRAM)
CA (1) CA2515080C (OSRAM)
CY (2) CY1114959T1 (OSRAM)
DK (3) DK1599216T3 (OSRAM)
ES (3) ES2605504T3 (OSRAM)
HU (1) HUE027110T2 (OSRAM)
PT (2) PT1599216E (OSRAM)
SI (1) SI2656854T1 (OSRAM)
WO (1) WO2004070054A2 (OSRAM)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2656854T1 (sl) * 2003-02-04 2015-09-30 Cornell Research Foundation, Inc. Uporabe aromatsko-kationskega peptida
US7704954B2 (en) 2003-05-01 2010-04-27 Cornell Research Foundation, Inc. Method and carrier complexes for delivering molecules to cells
CA3024434A1 (en) * 2004-01-23 2005-08-11 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
AU2014203126B2 (en) * 2005-09-16 2016-03-10 Cornell Research Foundation, Inc. Methods for reducing cd36 expression
CA2947343C (en) 2005-09-16 2019-04-30 Cornell Research Foundation, Inc. Methods for reducing cd36 expression
PT2252312E (pt) 2008-02-07 2014-07-17 Univ Cornell Métodos de prevenção ou tratamento de resistência a insulina
CN107802821A (zh) 2008-02-26 2018-03-16 康奈尔大学 用于防止和治疗急性肾损伤的方法
DE102008061044A1 (de) * 2008-12-11 2010-06-17 Henkel Ag & Co. Kgaa Zusammensetzung mit antioxidativ wirksamen Peptiden
EP3563862B1 (en) * 2009-03-20 2021-05-05 The General Hospital Corporation d/b/a Massachusetts General Hospital D-arg-2'6'-dimethyltyrosine-lys-phe-nh2 for use in the prevention of secondary complications of burn injuries
CN105031605A (zh) * 2009-08-12 2015-11-11 康奈尔大学 预防或治疗代谢综合症的方法
SMT202300433T1 (it) 2009-08-24 2024-01-10 Stealth Biotherapeutics Inc Peptide per l'uso nella prevenzione o nel trattamento della degenerazione maculare
US20110082084A1 (en) 2009-10-05 2011-04-07 Szeto Hazel H Methods for the prevention or treatment of heart failure
AU2010339414A1 (en) * 2009-12-31 2012-07-19 Stealth Peptides International, Inc. Methods for performing a coronary artery bypass graft procedure
CA2786280A1 (en) * 2009-12-31 2011-07-07 Stealth Peptides International, Inc. Methods for the prevention or treatment of vessel occlusion injury
EP2848628A1 (en) * 2010-01-25 2015-03-18 Cornell University Aromatic-cationic peptides and uses of same
CA2790823A1 (en) * 2010-02-26 2011-09-01 University Of Florida Research Foundation, Inc. Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy
WO2011116007A1 (en) * 2010-03-15 2011-09-22 Stealth Peptides International, Inc. Combination therapies using cyclosporine and aromatic cationic peptides
US20110245182A1 (en) 2010-04-06 2011-10-06 Perricone Nicholas V Topical Uses of Szeto-Schiller Peptides
US20110245183A1 (en) 2010-04-06 2011-10-06 Perricone Nicholas V Topical Uses of Szeto-Schiller Peptides
JP2013532124A (ja) * 2010-05-03 2013-08-15 ステルス ペプチドズ インターナショナル インコーポレイテッド 芳香族系陽イオンペプチド及びその使用
EP3539554A1 (en) * 2010-07-09 2019-09-18 Stealth Peptides International, Inc. Methods for the prevention or treatment of no-reflow following ischemia/reperfusion injury
WO2014137496A1 (en) * 2013-03-08 2014-09-12 The Administrators Of The Tulane Educational Fund Mu opioid receptor agonist analogs of the endomorphins
US20160176930A1 (en) 2010-07-09 2016-06-23 The Administrators Of The Tulane Educational Fund Mu opioid receptor agonist analogs of the endomorphins
US20120083452A1 (en) * 2010-09-30 2012-04-05 Perricone Nicholas V Topical Anesthetic Uses of Szeto-Schiller Peptides
WO2012129427A2 (en) * 2011-03-24 2012-09-27 Cornell University Aromatic-cationic peptides and uses of same
CA2849073A1 (en) * 2011-09-19 2013-03-28 Gencia Corporation Modified creatine compounds
CN106913860A (zh) 2011-09-29 2017-07-04 梅约医学教育与研究基金会 芳族阳离子肽和使用它们的方法
WO2013059071A1 (en) * 2011-10-17 2013-04-25 Cornell University Aromatic-cationic peptides and uses of same
CN107312066A (zh) 2011-12-09 2017-11-03 康德生物医疗技术公司 芳香族阳离子肽及其用途
WO2013149172A1 (en) * 2012-03-30 2013-10-03 Stealth Peptides International, Inc. Methods and compositions for the prevention and treatment neuropathy
CN104661670A (zh) * 2012-08-02 2015-05-27 康肽德生物医药技术有限公司 用于治疗动脉粥样硬化的方法
WO2014066419A2 (en) * 2012-10-22 2014-05-01 Stealth Peptides International, Inc. Methods for reducing risks associated with heart failure and factors associated therewith
CN110339339A (zh) * 2013-03-01 2019-10-18 康德生物医疗技术公司 治疗线粒体疾病的方法
CN115990242A (zh) 2013-03-01 2023-04-21 康德生物医疗有限公司 预防或治疗巴斯综合征的方法和组合物
US9850278B2 (en) 2013-04-25 2017-12-26 Carmel-Haifa University Economic Corp. Synthetic anti-inflammatory peptides and use thereof
CA2916977A1 (en) 2013-06-26 2014-12-31 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions
US20160193278A1 (en) * 2013-08-01 2016-07-07 Stealth Biotherapeutics Corp Methods and compositions for preventing or treating leber's hereditary optic neuropathy
US20160166633A1 (en) 2013-08-02 2016-06-16 Stealth Bio Therapeutics Corp Methods and compositions for the prevention and treatment of friedreich's ataxia
CA2925757A1 (en) * 2013-09-30 2015-04-02 Cornell University Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity
CN106536056B (zh) 2014-06-13 2021-07-16 儿童医学中心公司 分离线粒体的产品和方法
HUE054626T2 (hu) 2014-06-25 2021-09-28 Flamma Spa Eljárás D-arginil-2,6-dimetil-L-tirozil-L-lizil-L-fenilalaninamid elõállítására
US10112976B2 (en) 2014-06-30 2018-10-30 Flamma S.P.A. Process for the production of D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
WO2016004093A2 (en) * 2014-07-01 2016-01-07 Stealth Biotherapeutics Corp Therapeutic compositions including galectin-3 inhibitors and uses thereof
CN104306954B (zh) * 2014-09-25 2016-08-24 中山大学 Wry三肽在制备治疗阿尔茨海默症药物中的用途
EP3473253A1 (en) 2014-10-29 2019-04-24 University Of Maryland Methods of treating age-related symptoms in mammals and compositions therefor
WO2017015660A1 (en) * 2015-07-23 2017-01-26 Salk Institute For Biological Studies Prevention and treatment of aging and neurodegenerative diseases
CA3006698A1 (en) * 2015-11-30 2017-06-08 Peter Schiller Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome
EP4653048A2 (en) 2016-01-15 2025-11-26 The Children's Medical Center Corporation Therapeutic use of mitochondria and combined mitochondrial agents
CN115160402A (zh) 2016-03-11 2022-10-11 隐形生物治疗公司 结晶盐形式
AU2017249218B2 (en) 2016-04-11 2020-08-27 Arcuate Therapeutics, Inc. Chiral peptides
US11099347B2 (en) 2016-11-30 2021-08-24 Daicel Corporation Lens module for imaging device, and method for producing lens module
WO2018187400A1 (en) 2017-04-05 2018-10-11 Stealth Biotherapeutics Corp. Crystalline salt forms of boc-d-arg-dmt-lys-(boc)-phe-nh2
CN115109116A (zh) 2017-08-17 2022-09-27 凯瑞康宁生物工程（武汉）有限公司 活性氧清除剂衍生物的制备及用途
EP3988561B1 (en) 2017-09-04 2023-06-07 XWPharma Ltd. Preparation and use of reactive oxygen species scavenger
JP6958860B2 (ja) * 2017-11-07 2021-11-02 学校法人自治医科大学 ミトコンドリアの機能障害の改善剤、及びミトコンドリアの機能障害に起因する疾患又は症状の予防又は治療薬、並びにそれらの用途
US10676506B2 (en) 2018-01-26 2020-06-09 Stealth Biotherapeutics Corp. Crystalline bis- and tris-hydrochloride salt of elamipretide
US12404300B2 (en) 2018-12-18 2025-09-02 Stealth Biotherapeutics Inc. Mitochondria-targeting peptides
US20220347212A1 (en) * 2019-05-02 2022-11-03 Children`S Medical Center Corporation Prophylactic and therapeutic use of mitochondria and combined mitochondrial agents
EP3771467A1 (en) 2019-07-30 2021-02-03 Fundacio Institut de Recerca de l'Hospital de la Santa Creu i sant Pau Ss-31 for the prevention and/or treatment of aneurysm
KR102666922B1 (ko) 2020-09-09 2024-05-20 소셜 프로핏 네트워크 미토콘드리아에 비오틴의 전달을 위한 방법 및 조성물
CN117881411A (zh) 2021-06-01 2024-04-12 艾迪雅生物有限责任公司 用于眼部药物的延长释放药物递送系统和使用方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
ES2085865T3 (es) 1988-06-30 1996-06-16 Astra Ab Analogos de dermorfina, sus metodos de preparacion, composiciones farmaceuticas, y metodos de tratamiento terapeutico que los emplean.
US5602100A (en) 1988-06-30 1997-02-11 Astra Ab Dermorphin analogs having pharmacological activity
US5747641A (en) * 1989-12-21 1998-05-05 Biogen Inc Tat-derived transport polypeptide conjugates
DE69129294T2 (de) * 1990-01-17 1998-10-01 The Regents Of The University Of California, Oakland, Calif. Zusammensetzung zur verbesserung der lebenserhaltung biologischer materialien
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5674534A (en) 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
IS4261A (is) 1994-02-21 1995-08-22 Astra Aktiebolag Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra
DE69630918T2 (de) * 1995-06-09 2004-10-28 Hisamitsu Pharmaceutical Co., Inc., Tosu Matrix für Iontophorese
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
ATE240728T1 (de) * 1996-10-07 2003-06-15 Lilly Co Eli Neue verbindungen nutlich als neuroschützende mittel
US5885958A (en) * 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
JP2002505077A (ja) * 1997-12-10 2002-02-19 ワシントン大学 抗病原体システムおよびその使用方法
EP1071414A1 (en) * 1998-04-24 2001-01-31 Mitokor Compounds and methods for treating mitochondria-associated diseases
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
GB9905503D0 (en) * 1999-03-10 1999-05-05 Adprotech Plc Novel compound formulations and methods of delivery
SE9900961D0 (sv) 1999-03-16 1999-03-16 Astra Ab Novel compounds
US6503713B1 (en) * 1999-10-04 2003-01-07 University Of Medicine And Dentistry Of New Jersey Methods for identifying RNA binding compounds
US6759520B1 (en) * 1999-10-28 2004-07-06 The New England Medical Center Hospitals, Inc. Chimeric analgesic peptides
US20050192215A1 (en) 2000-01-21 2005-09-01 Malabika Ghosh Methods and materials relating to novel polypeptides and polynucleotides
US7498297B2 (en) * 2000-07-18 2009-03-03 Cornell Research Foundation Medicinal uses of mu-opioid receptor agonists
US6900178B2 (en) * 2000-09-12 2005-05-31 University Of Kentucky Research Foundation Protection against ischemia and reperfusion injury
JP2004523490A (ja) * 2000-11-28 2004-08-05 ギルフォード ファーマシュウティカルズ インコーポレイテッド 二置換カルボサイクリックサイクロフィリン結合化合物とその用途
US6545097B2 (en) * 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
WO2002059080A2 (en) * 2001-01-25 2002-08-01 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
US20030077826A1 (en) * 2001-02-02 2003-04-24 Lena Edelman Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC)
JP4125125B2 (ja) * 2001-02-16 2008-07-30 コーディス・コーポレイション ステントデリバリ装置の製造方法
AU2002252372A1 (en) * 2001-03-16 2002-10-03 Sts Biopolymers, Inc. Stent with medicated multi-layer hydrid polymer coating
JPWO2002102833A1 (ja) * 2001-06-15 2004-09-30 千寿製薬株式会社 新規エンドモルフィン誘導体
SI2656854T1 (sl) 2003-02-04 2015-09-30 Cornell Research Foundation, Inc. Uporabe aromatsko-kationskega peptida
CN101440124B (zh) * 2003-02-04 2012-07-18 科内尔研究基金会 用于防止线粒体通透性改变的方法
US7704954B2 (en) 2003-05-01 2010-04-27 Cornell Research Foundation, Inc. Method and carrier complexes for delivering molecules to cells
JP2005005762A (ja) * 2003-06-09 2005-01-06 Fujitsu Ltd 送信電力制御方法及び装置
WO2005032481A2 (en) 2003-09-30 2005-04-14 Scios Inc. Quinazoline derivatives as medicaments
CA3024434A1 (en) * 2004-01-23 2005-08-11 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
CA2947343C (en) 2005-09-16 2019-04-30 Cornell Research Foundation, Inc. Methods for reducing cd36 expression

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