ATE240728T1 - Neue verbindungen nutlich als neuroschützende mittel - Google Patents
Neue verbindungen nutlich als neuroschützende mittelInfo
- Publication number
- ATE240728T1 ATE240728T1 AT97909975T AT97909975T ATE240728T1 AT E240728 T1 ATE240728 T1 AT E240728T1 AT 97909975 T AT97909975 T AT 97909975T AT 97909975 T AT97909975 T AT 97909975T AT E240728 T1 ATE240728 T1 AT E240728T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds useful
- new compounds
- neuroprotective agents
- agents
- neuroprotective
- Prior art date
Links
- 239000004090 neuroprotective agent Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 150000000183 1,3-benzoxazoles Chemical class 0.000 abstract 1
- RQCBPOPQTLHDFC-UHFFFAOYSA-N 2-phenyl-1,3-oxazole Chemical class C1=COC(C=2C=CC=CC=2)=N1 RQCBPOPQTLHDFC-UHFFFAOYSA-N 0.000 abstract 1
- 150000004866 oxadiazoles Chemical class 0.000 abstract 1
- 150000002918 oxazolines Chemical class 0.000 abstract 1
- 150000003557 thiazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Liquid Crystal Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2756096P | 1996-10-07 | 1996-10-07 | |
| PCT/US1997/017963 WO1998015274A1 (en) | 1996-10-07 | 1997-10-06 | Novel compounds useful as neuro-protective agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240728T1 true ATE240728T1 (de) | 2003-06-15 |
Family
ID=21838447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97909975T ATE240728T1 (de) | 1996-10-07 | 1997-10-06 | Neue verbindungen nutlich als neuroschützende mittel |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US6156748A (de) |
| EP (1) | EP0971709B1 (de) |
| CN (1) | CN1239889A (de) |
| AT (1) | ATE240728T1 (de) |
| AU (1) | AU721355B2 (de) |
| CA (1) | CA2270661A1 (de) |
| CZ (1) | CZ166399A3 (de) |
| DE (1) | DE69722258T2 (de) |
| DK (1) | DK0971709T3 (de) |
| EA (1) | EA001713B1 (de) |
| ES (1) | ES2199353T3 (de) |
| HU (1) | HUP9904682A3 (de) |
| ID (1) | ID21472A (de) |
| IL (1) | IL129748A (de) |
| NO (1) | NO313193B1 (de) |
| NZ (1) | NZ335610A (de) |
| PT (1) | PT971709E (de) |
| TR (1) | TR199901559T2 (de) |
| WO (1) | WO1998015274A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5952360A (en) * | 1997-08-28 | 1999-09-14 | Eli Lilly And Company | Method for treating neuropathic pain |
| US5942530A (en) * | 1997-08-28 | 1999-08-24 | Eli Lilly And Company | Method for treating pain |
| AU9034798A (en) * | 1997-08-28 | 1999-03-16 | Eli Lilly And Company | Method for treating pain |
| TR200100352T2 (tr) * | 1997-10-06 | 2001-06-21 | Eli Lilly And Company | Nöro-koruyucu maddeler olarak yararlı yeni bileşikler |
| IT1300055B1 (it) * | 1998-04-17 | 2000-04-05 | Boehringer Ingelheim Italia | Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici |
| WO2001021577A2 (en) | 1999-09-20 | 2001-03-29 | Takeda Chemical Industries, Ltd. | Melanin concentrating hormone antagonist |
| FR2812546B1 (fr) * | 2000-08-01 | 2008-11-21 | Sod Conseils Rech Applic | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
| TWI292316B (en) * | 1999-10-11 | 2008-01-11 | Sod Conseils Rech Applic | Pharmaceutical composition of thiazole derivatives intended to inhibit mao and/or lipidic peroxidation and/or to act as modulators of sodium channels and the use thereof |
| RU2380362C2 (ru) * | 1999-10-11 | 2010-01-27 | Сосьете Де Консей Де Решерш З | Производные пятичленных гетероциклов, способ их получения и их применение в качестве лекарственных средств |
| CA2407149C (en) | 2000-04-28 | 2010-10-12 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
| AU2002237298B2 (en) * | 2001-02-08 | 2006-08-03 | Karo Bio Ab | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands |
| US7091357B2 (en) * | 2001-12-26 | 2006-08-15 | University Of Kentucky Research Foundation | Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies |
| US7179808B2 (en) | 2002-07-03 | 2007-02-20 | Janssen Pharmaceutica N.V. | Substituted heteroaryl and heterocyclic compounds useful in treating inflammatory disorders |
| EP3479838A1 (de) | 2003-02-04 | 2019-05-08 | Cornell Research Foundation, Inc. | Verwendung von aromatisch kationischem peptid |
| WO2005072295A2 (en) * | 2004-01-23 | 2005-08-11 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
| TW200505913A (en) | 2003-03-28 | 2005-02-16 | Hoffmann La Roche | Novel oxazole derivatives, their manufacture and use as pharmaceutical agents |
| US7353897B2 (en) * | 2003-07-23 | 2008-04-08 | Fernandez Dennis S | Telematic method and apparatus with integrated power source |
| US8637559B2 (en) | 2005-11-15 | 2014-01-28 | Otsuka Pharmaceutical Co., Ltd. | Oxazole compound and pharmaceutical composition |
| EA025178B1 (ru) | 2010-09-06 | 2016-11-30 | Айгис Аг | Проточный аккумулятор и способ преобразования электрической энергии с его использованием |
| WO2016179369A1 (en) | 2015-05-07 | 2016-11-10 | Impact Labs Llc | Device for minimizing impact of collisions for a helmet |
| CN112826794B (zh) | 2019-11-06 | 2022-02-11 | 上海交通大学医学院 | 一种靶向修复神经血管病变的纳米复合物及其制备与应用 |
| WO2024040267A2 (en) * | 2022-08-19 | 2024-02-22 | Mitokinin, Inc. | Direct synthesis of n-(3-substituted-chroman-4-yl)-7h- pyrrolo[2,3-d]pyrimidin-4-amines and derivatives thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4636516A (en) * | 1981-02-19 | 1987-01-13 | Yamanouchi Pharmaceutical Co., Ltd. | 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds |
| DE3425118A1 (de) * | 1984-07-07 | 1986-01-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue redox-indikatoren |
| GB8531608D0 (en) * | 1985-12-23 | 1986-02-05 | Beecham Group Plc | Treatment |
| DE3621775A1 (de) * | 1986-03-13 | 1988-01-07 | Thomae Gmbh Dr K | Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3903993A1 (de) * | 1989-02-10 | 1990-08-16 | Basf Ag | Diarylsubstituierte heterocyclische verbindungen, ihre herstellung und arzneimittel daraus |
| EP0382199A1 (de) * | 1989-02-08 | 1990-08-16 | Takeda Chemical Industries, Ltd. | Oxazol-Verbindungen und ihre Verwendung |
| DE122008000051I1 (de) * | 1990-11-30 | 2009-02-05 | Teijin Ltd | 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel |
| US5633271A (en) * | 1992-05-26 | 1997-05-27 | E. I. Du Pont De Nemours And Company | Arthropodicidal oxazolines and thiazolines |
| DE4304197A1 (de) * | 1993-02-12 | 1994-08-18 | Bayer Ag | Substituierte Oxazole |
| US5428048A (en) * | 1993-11-08 | 1995-06-27 | American Home Products Corporation | Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-arteriosclerotic agents |
| US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
| AU9034798A (en) * | 1997-08-28 | 1999-03-16 | Eli Lilly And Company | Method for treating pain |
| US5942530A (en) * | 1997-08-28 | 1999-08-24 | Eli Lilly And Company | Method for treating pain |
| US5952360A (en) * | 1997-08-28 | 1999-09-14 | Eli Lilly And Company | Method for treating neuropathic pain |
| TR200100352T2 (tr) * | 1997-10-06 | 2001-06-21 | Eli Lilly And Company | Nöro-koruyucu maddeler olarak yararlı yeni bileşikler |
-
1997
- 1997-10-06 US US08/944,468 patent/US6156748A/en not_active Expired - Fee Related
- 1997-10-06 ID IDW990301A patent/ID21472A/id unknown
- 1997-10-06 DE DE69722258T patent/DE69722258T2/de not_active Expired - Fee Related
- 1997-10-06 PT PT97909975T patent/PT971709E/pt unknown
- 1997-10-06 WO PCT/US1997/017963 patent/WO1998015274A1/en not_active Ceased
- 1997-10-06 AU AU47459/97A patent/AU721355B2/en not_active Ceased
- 1997-10-06 ES ES97909975T patent/ES2199353T3/es not_active Expired - Lifetime
- 1997-10-06 EA EA199900362A patent/EA001713B1/ru not_active IP Right Cessation
- 1997-10-06 EP EP97909975A patent/EP0971709B1/de not_active Expired - Lifetime
- 1997-10-06 CA CA002270661A patent/CA2270661A1/en not_active Abandoned
- 1997-10-06 AT AT97909975T patent/ATE240728T1/de not_active IP Right Cessation
- 1997-10-06 IL IL12974897A patent/IL129748A/xx not_active IP Right Cessation
- 1997-10-06 HU HU9904682A patent/HUP9904682A3/hu unknown
- 1997-10-06 CZ CZ991663A patent/CZ166399A3/cs unknown
- 1997-10-06 TR TR1999/01559T patent/TR199901559T2/xx unknown
- 1997-10-06 DK DK97909975T patent/DK0971709T3/da active
- 1997-10-06 CN CN97180378A patent/CN1239889A/zh active Pending
- 1997-10-06 NZ NZ335610A patent/NZ335610A/xx unknown
-
1999
- 1999-05-07 NO NO19992226A patent/NO313193B1/no not_active IP Right Cessation
- 1999-08-04 US US09/368,236 patent/US6166216A/en not_active Expired - Fee Related
-
2000
- 2000-11-17 US US09/715,987 patent/US6380213B1/en not_active Expired - Fee Related
-
2001
- 2001-11-28 US US09/996,005 patent/US6423709B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6156748A (en) | 2000-12-05 |
| ES2199353T3 (es) | 2004-02-16 |
| IL129748A (en) | 2003-11-23 |
| HUP9904682A3 (en) | 2001-09-28 |
| HUP9904682A2 (hu) | 2000-05-28 |
| US20020065274A1 (en) | 2002-05-30 |
| EP0971709A1 (de) | 2000-01-19 |
| AU721355B2 (en) | 2000-06-29 |
| NO313193B1 (no) | 2002-08-26 |
| DE69722258T2 (de) | 2004-03-18 |
| EP0971709A4 (de) | 2001-04-11 |
| DK0971709T3 (da) | 2003-09-22 |
| IL129748A0 (en) | 2000-02-29 |
| EA199900362A1 (ru) | 2000-02-28 |
| US6423709B1 (en) | 2002-07-23 |
| WO1998015274A1 (en) | 1998-04-16 |
| AU4745997A (en) | 1998-05-05 |
| EA001713B1 (ru) | 2001-08-27 |
| US6166216A (en) | 2000-12-26 |
| CZ166399A3 (cs) | 1999-11-17 |
| DE69722258D1 (de) | 2003-06-26 |
| EP0971709B1 (de) | 2003-05-21 |
| PT971709E (pt) | 2003-09-30 |
| CN1239889A (zh) | 1999-12-29 |
| US6380213B1 (en) | 2002-04-30 |
| NZ335610A (en) | 2000-10-27 |
| CA2270661A1 (en) | 1998-04-16 |
| NO992226D0 (no) | 1999-05-07 |
| NO992226L (no) | 1999-05-27 |
| TR199901559T2 (xx) | 1999-09-21 |
| ID21472A (id) | 1999-06-17 |
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