JP2015166342A5 - - Google Patents

Info

Publication number

JP2015166342A5

JP2015166342A5 JP2015027127A JP2015027127A JP2015166342A5 JP 2015166342 A5 JP2015166342 A5 JP 2015166342A5 JP 2015027127 A JP2015027127 A JP 2015027127A JP 2015027127 A JP2015027127 A JP 2015027127A JP 2015166342 A5 JP2015166342 A5 JP 2015166342A5

Authority

JP

Japan

Prior art keywords

tablet

binder

tablet according

diluent

irbesartan

Prior art date

2015-02-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000011230 binding agent Substances 0.000 claims 6
• 239000003085 diluting agent Substances 0.000 claims 5
• 239000002947 C09CA04 - Irbesartan Substances 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 4
• YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 claims 4
• 229960002198 irbesartan Drugs 0.000 claims 4
• 239000000314 lubricant Substances 0.000 claims 4
• 239000007884 disintegrant Substances 0.000 claims 3
• WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 2
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
• 239000001913 cellulose Substances 0.000 claims 2
• 229920002678 cellulose Polymers 0.000 claims 2
• 239000008187 granular material Substances 0.000 claims 2
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
• 229960003943 hypromellose Drugs 0.000 claims 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
• 238000005550 wet granulation Methods 0.000 claims 2
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
• 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
• 229930195725 Mannitol Natural products 0.000 claims 1
• 229920002472 Starch Polymers 0.000 claims 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
• 229960004977 anhydrous lactose Drugs 0.000 claims 1
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
• 235000013539 calcium stearate Nutrition 0.000 claims 1
• 239000008116 calcium stearate Substances 0.000 claims 1
• 238000007906 compression Methods 0.000 claims 1
• 230000006835 compression Effects 0.000 claims 1
• 238000000748 compression moulding Methods 0.000 claims 1
• 229960001681 croscarmellose sodium Drugs 0.000 claims 1
• 229960000913 crospovidone Drugs 0.000 claims 1
• 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
• GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims 1
• 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
• 229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims 1
• 239000000391 magnesium silicate Substances 0.000 claims 1
• 235000019359 magnesium stearate Nutrition 0.000 claims 1
• 235000019793 magnesium trisilicate Nutrition 0.000 claims 1
• 229940099273 magnesium trisilicate Drugs 0.000 claims 1
• 229910000386 magnesium trisilicate Inorganic materials 0.000 claims 1
• 239000000594 mannitol Substances 0.000 claims 1
• 235000010355 mannitol Nutrition 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000011812 mixed powder Substances 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
• 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
• 229940069328 povidone Drugs 0.000 claims 1
• 239000000377 silicon dioxide Substances 0.000 claims 1
• 235000012239 silicon dioxide Nutrition 0.000 claims 1
• 229940045902 sodium stearyl fumarate Drugs 0.000 claims 1
• 239000008107 starch Substances 0.000 claims 1
• 235000019698 starch Nutrition 0.000 claims 1
• 239000000454 talc Substances 0.000 claims 1
• 229910052623 talc Inorganic materials 0.000 claims 1
• 235000012222 talc Nutrition 0.000 claims 1