JP2015134813A5 - - Google Patents
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- JP2015134813A5 JP2015134813A5 JP2015075105A JP2015075105A JP2015134813A5 JP 2015134813 A5 JP2015134813 A5 JP 2015134813A5 JP 2015075105 A JP2015075105 A JP 2015075105A JP 2015075105 A JP2015075105 A JP 2015075105A JP 2015134813 A5 JP2015134813 A5 JP 2015134813A5
- Authority
- JP
- Japan
- Prior art keywords
- core
- positive
- cells
- microorganism
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 244000005700 microbiome Species 0.000 claims 65
- 239000000203 mixture Substances 0.000 claims 27
- 210000001744 T-lymphocyte Anatomy 0.000 claims 25
- 239000012634 fragment Substances 0.000 claims 20
- 210000004443 dendritic cell Anatomy 0.000 claims 17
- 239000006166 lysate Substances 0.000 claims 17
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical group OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims 17
- 241001465754 Metazoa Species 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 15
- 238000002360 preparation method Methods 0.000 claims 15
- 238000012360 testing method Methods 0.000 claims 15
- 238000009472 formulation Methods 0.000 claims 14
- 230000028996 humoral immune response Effects 0.000 claims 14
- 230000009089 cytolysis Effects 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 230000024932 T cell mediated immunity Effects 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 108010028495 asialoglycophorin Proteins 0.000 claims 7
- 241000282412 Homo Species 0.000 claims 6
- 210000002865 immune cell Anatomy 0.000 claims 6
- 230000028993 immune response Effects 0.000 claims 6
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 5
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 5
- 235000015872 dietary supplement Nutrition 0.000 claims 5
- 230000028327 secretion Effects 0.000 claims 5
- 241000606125 Bacteroides Species 0.000 claims 4
- VYZAMTAEIAYCRO-BJUDXGSMSA-N Chromium-51 Chemical compound [51Cr] VYZAMTAEIAYCRO-BJUDXGSMSA-N 0.000 claims 4
- 229910052693 Europium Inorganic materials 0.000 claims 4
- 102000028180 Glycophorins Human genes 0.000 claims 4
- 108091005250 Glycophorins Proteins 0.000 claims 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 4
- 239000003550 marker Substances 0.000 claims 4
- 125000000837 carbohydrate group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 238000002965 ELISA Methods 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000001124 body fluid Anatomy 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000001728 clone cell Anatomy 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 238000010166 immunofluorescence Methods 0.000 claims 2
- 238000011534 incubation Methods 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 239000002689 soil Substances 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000217846 Bacteroides caccae Species 0.000 claims 1
- 241001135228 Bacteroides ovatus Species 0.000 claims 1
- 241001569772 Celithemis elisa Species 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 210000000447 Th1 cell Anatomy 0.000 claims 1
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000012642 immune effector Substances 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000037452 priming Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 238000005728 strengthening Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06090209.5 | 2006-11-10 | ||
| EP06090209A EP1920782A1 (en) | 2006-11-10 | 2006-11-10 | Carboyhdrate specific cellular immunity inducing microorganisms and fractions thereof |
| EP06090208.7 | 2006-11-10 | ||
| EP06090208.7A EP1920781B1 (en) | 2006-11-10 | 2006-11-10 | Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535633A Division JP2010508834A (ja) | 2006-11-10 | 2007-11-12 | 炭水化物に対する細胞性免疫を活性化し得る微生物またはその部分 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015134813A JP2015134813A (ja) | 2015-07-27 |
| JP2015134813A5 true JP2015134813A5 (OSRAM) | 2015-12-03 |
Family
ID=39200183
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535633A Withdrawn JP2010508834A (ja) | 2006-11-10 | 2007-11-12 | 炭水化物に対する細胞性免疫を活性化し得る微生物またはその部分 |
| JP2009535632A Expired - Fee Related JP5771355B2 (ja) | 2006-11-10 | 2007-11-12 | 微生物およびその部分が誘導する炭水化物特異的細胞性免疫 |
| JP2015075105A Withdrawn JP2015134813A (ja) | 2006-11-10 | 2015-04-01 | 炭水化物に対する細胞性免疫を活性化し得る微生物またはその部分 |
| JP2015074801A Withdrawn JP2015133979A (ja) | 2006-11-10 | 2015-04-01 | 微生物およびその部分が誘導する炭水化物特異的細胞性免疫 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535633A Withdrawn JP2010508834A (ja) | 2006-11-10 | 2007-11-12 | 炭水化物に対する細胞性免疫を活性化し得る微生物またはその部分 |
| JP2009535632A Expired - Fee Related JP5771355B2 (ja) | 2006-11-10 | 2007-11-12 | 微生物およびその部分が誘導する炭水化物特異的細胞性免疫 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015074801A Withdrawn JP2015133979A (ja) | 2006-11-10 | 2015-04-01 | 微生物およびその部分が誘導する炭水化物特異的細胞性免疫 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9494587B2 (OSRAM) |
| EP (4) | EP1920781B1 (OSRAM) |
| JP (4) | JP2010508834A (OSRAM) |
| KR (2) | KR20090080554A (OSRAM) |
| CN (1) | CN101573138B (OSRAM) |
| AU (2) | AU2007316820B2 (OSRAM) |
| BR (2) | BRPI0719005A2 (OSRAM) |
| CA (2) | CA2668603A1 (OSRAM) |
| EA (1) | EA025395B1 (OSRAM) |
| ES (1) | ES2715045T3 (OSRAM) |
| IL (2) | IL198567A0 (OSRAM) |
| MX (1) | MX2009005004A (OSRAM) |
| NO (1) | NO20091748L (OSRAM) |
| NZ (1) | NZ577559A (OSRAM) |
| PL (1) | PL1920781T3 (OSRAM) |
| RU (1) | RU2460074C2 (OSRAM) |
| WO (2) | WO2008055703A2 (OSRAM) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2620261T3 (es) | 2006-09-10 | 2017-06-28 | Glycotope Gmbh | Uso de células humanas de origen leucémico mieloide para expresión de anticuerpos |
| PL1920781T3 (pl) * | 2006-11-10 | 2015-06-30 | Glycotope Gmbh | Kompozycje zawierające core-1-dodatnie mikroorganizmy i ich zastosowanie w leczeniu lub profilaktyce nowotworów |
| JP2011520435A (ja) * | 2008-05-13 | 2011-07-21 | グリコトープ ゲーエムベーハー | 発酵プロセス |
| EP2119365B1 (de) | 2008-05-13 | 2017-08-16 | Glycotope GmbH | Fermentationsprozess |
| AU2010281507A1 (en) * | 2009-07-27 | 2012-03-01 | The University Of North Carolina At Chapel Hill | Enterococcus and fecal Bacteroides for rapid water quality assessment |
| GB2475226A (en) | 2009-11-03 | 2011-05-18 | Genetic Analysis As | Universal Prokaryote 16S ribosome PCR primer pair |
| AU2011261528A1 (en) * | 2010-06-01 | 2013-01-10 | Moore Research Enterprises Llc | Cellular constituents from Bacteroides, compositions thereof, and therapeutic methods employing Bacteroides or cellular constituents thereof |
| WO2012045150A1 (en) * | 2010-10-04 | 2012-04-12 | British Columbia Cancer Agency Branch | Detection of fusobacterium in a gastrointestinal sample to diagnose gastrointestinal cancer |
| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| IN2014CN02038A (OSRAM) * | 2011-08-22 | 2015-05-29 | Glycotope Gmbh | |
| ES2686313T3 (es) * | 2011-08-22 | 2018-10-17 | Glycotope Gmbh | Microorganismos que portan un antígeno tumoral |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| WO2014001658A1 (fr) * | 2012-06-26 | 2014-01-03 | Centre Hospitalier Régional Universitaire De Lille | Méthode de diagnostic in vitro d'une infection fongique invasive par spectrométrie de masse maldi-tof |
| CN102813916B (zh) * | 2012-09-05 | 2015-03-11 | 北京希普生国际生物医学研究院 | 一种快速获取树突状细胞疫苗的制备方法及其应用 |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| EP2818056A1 (en) * | 2013-06-25 | 2014-12-31 | Biosearch S.A. | Probiotic bacteria comprising metals, metal nanoparticles and uses thereof |
| CN105579053B (zh) * | 2013-08-06 | 2021-08-31 | 达特茅斯学院理事会 | 非糖基化溶葡球菌素变体蛋白 |
| BR112016020009A2 (pt) | 2014-04-10 | 2017-10-17 | Obi Pharma Inc | anticorpo, composição farmacêutica, método para inibir a proliferação de células cancerígenas, hibridoma |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| CN104546933A (zh) * | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 粪拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| CN104546932A (zh) * | 2014-09-30 | 2015-04-29 | 深圳华大基因科技有限公司 | 卵形拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用 |
| LT3065748T (lt) | 2014-12-23 | 2018-03-12 | 4D Pharma Research Limited | Bacteroides thetaiotaomicron padermė ir jos panaudojimas uždegimo sumažinimui |
| EP3193901B1 (en) | 2014-12-23 | 2018-04-04 | 4D Pharma Research Limited | Pirin polypeptide and immune modulation |
| US10076556B2 (en) * | 2015-01-29 | 2018-09-18 | Oxyrase, Inc. | Methods for inhibiting tumor growth |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| SMT202200174T1 (it) | 2015-06-15 | 2022-05-12 | 4D Pharma Res Limited | Composizioni comprendenti ceppi batterici |
| PL3307288T3 (pl) | 2015-06-15 | 2019-12-31 | 4D Pharma Research Limited | Kompozycje zawierające szczepy bakteryjne |
| SG10201912323VA (en) | 2015-06-15 | 2020-02-27 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| HK1254843B (zh) | 2015-11-20 | 2020-04-17 | 希杰生物科技株式会社 | 包含细菌菌株的组合物 |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| EP3520801A1 (en) | 2016-03-04 | 2019-08-07 | 4D Pharma Plc | Compositions comprising bacterial blautia strains for treating visceral hypersensitivity |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
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| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商４Ｄ製藥有限公司 | 包含細菌菌株之組合物 |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
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| EP1529060B1 (de) * | 2002-07-22 | 2014-09-10 | Glycotope GmbH | Verfahren zur herstellung eines immunstimulatorischen muzins (muc1) |
| DK1530628T3 (da) | 2002-08-16 | 2011-01-10 | Glycotope Gmbh | Fremgangsmåde til fremstilling af temperaturinducerede tumorcellelysater til anvendelse som immunogene forbindelser |
| WO2004029621A2 (en) * | 2002-09-26 | 2004-04-08 | Novartis Ag | Tcell mediator/modulator assay based upon tcell restricted transgenic mouse |
| DE10256900A1 (de) | 2002-11-29 | 2004-06-24 | Nemod Immuntherapie Ag | Tumorspezifische Erkennungsmoleküle |
| JP4762887B2 (ja) * | 2003-02-27 | 2011-08-31 | ノースウエスト バイオセラピューティクス，インコーポレイティド | 付加的なサイトカインの非存在下でｇｍ−ｃｓｆを用いる単球樹状前駆細胞からの樹状細胞の産生 |
| GB0315991D0 (en) | 2003-07-08 | 2003-08-13 | Dakocytomation Denmark As | Standard |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| PT1654353E (pt) | 2003-08-18 | 2013-08-23 | Glycotope Gmbh | Linhas de células tumorais nm f9 (dsm acc2606) e nm d4 (dsm acc2605), suas utilizações |
| FR2861080B1 (fr) | 2003-10-20 | 2006-02-17 | Lab Francais Du Fractionnement | Anticorps presentant un taux de fucose et de galactose optimise |
| US20050203010A1 (en) * | 2003-11-14 | 2005-09-15 | Atgen Co., Ltd. | Novel peptides conferring environmental stress resistance and fusion proteins including said peptides |
| EP1725673A1 (en) | 2004-02-13 | 2006-11-29 | Glycotope Gmbh | Sialytated glycoproteins-process conditions and an efficient method for their production |
| BRPI0512921A (pt) * | 2004-07-01 | 2008-04-22 | Den Kgl Veterinaer Og Landboho | processo para tratamento e profilaxia de ms |
| WO2006012616A2 (en) * | 2004-07-26 | 2006-02-02 | The Research Foundation Of State University Of New York At Buffalo Stor Intellectual Property Division | Therapeutic use of anti-tf-antigen antibody |
| AU2006275510B2 (en) * | 2005-08-01 | 2013-02-21 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada. | Low fiber yellow canola seeds comprising high oleic, low linolenic oil |
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| PL1920781T3 (pl) * | 2006-11-10 | 2015-06-30 | Glycotope Gmbh | Kompozycje zawierające core-1-dodatnie mikroorganizmy i ich zastosowanie w leczeniu lub profilaktyce nowotworów |
| JP2011520435A (ja) * | 2008-05-13 | 2011-07-21 | グリコトープ ゲーエムベーハー | 発酵プロセス |
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| ES2686313T3 (es) * | 2011-08-22 | 2018-10-17 | Glycotope Gmbh | Microorganismos que portan un antígeno tumoral |
-
2006
- 2006-11-10 PL PL06090208T patent/PL1920781T3/pl unknown
- 2006-11-10 EP EP06090208.7A patent/EP1920781B1/en active Active
- 2006-11-10 EP EP06090209A patent/EP1920782A1/en not_active Withdrawn
-
2007
- 2007-11-12 EA EA200970471A patent/EA025395B1/ru not_active IP Right Cessation
- 2007-11-12 EP EP07819754A patent/EP2101814A1/en not_active Withdrawn
- 2007-11-12 KR KR1020097011972A patent/KR20090080554A/ko not_active Abandoned
- 2007-11-12 BR BRPI0719005-0A patent/BRPI0719005A2/pt not_active IP Right Cessation
- 2007-11-12 CA CA002668603A patent/CA2668603A1/en not_active Abandoned
- 2007-11-12 ES ES07819755T patent/ES2715045T3/es active Active
- 2007-11-12 JP JP2009535633A patent/JP2010508834A/ja not_active Withdrawn
- 2007-11-12 MX MX2009005004A patent/MX2009005004A/es active IP Right Grant
- 2007-11-12 CN CN200780049283.7A patent/CN101573138B/zh not_active Expired - Fee Related
- 2007-11-12 AU AU2007316820A patent/AU2007316820B2/en not_active Ceased
- 2007-11-12 AU AU2007316819A patent/AU2007316819B2/en not_active Ceased
- 2007-11-12 JP JP2009535632A patent/JP5771355B2/ja not_active Expired - Fee Related
- 2007-11-12 US US12/514,248 patent/US9494587B2/en not_active Expired - Fee Related
- 2007-11-12 WO PCT/EP2007/009766 patent/WO2008055703A2/en not_active Ceased
- 2007-11-12 NZ NZ577559A patent/NZ577559A/en not_active IP Right Cessation
- 2007-11-12 BR BRPI0718796-3A2A patent/BRPI0718796A2/pt not_active IP Right Cessation
- 2007-11-12 RU RU2009122204/10A patent/RU2460074C2/ru not_active IP Right Cessation
- 2007-11-12 US US12/514,200 patent/US8592165B2/en not_active Expired - Fee Related
- 2007-11-12 CA CA002668704A patent/CA2668704A1/en not_active Abandoned
- 2007-11-12 KR KR1020157011383A patent/KR20150054014A/ko not_active Abandoned
- 2007-11-12 WO PCT/EP2007/009765 patent/WO2008055702A1/en not_active Ceased
- 2007-11-12 EP EP07819755.5A patent/EP2099480B2/en active Active
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2009
- 2009-05-04 NO NO20091748A patent/NO20091748L/no not_active Application Discontinuation
- 2009-05-05 IL IL198567A patent/IL198567A0/en unknown
- 2009-05-07 IL IL198626A patent/IL198626A/en not_active IP Right Cessation
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2015
- 2015-04-01 JP JP2015075105A patent/JP2015134813A/ja not_active Withdrawn
- 2015-04-01 JP JP2015074801A patent/JP2015133979A/ja not_active Withdrawn
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