JP2014531402A - 新規アニリン誘導体及びこれの用途(Novelanilinederivativesandusethereof) - Google Patents
新規アニリン誘導体及びこれの用途(Novelanilinederivativesandusethereof) Download PDFInfo
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- JP2014531402A JP2014531402A JP2014523855A JP2014523855A JP2014531402A JP 2014531402 A JP2014531402 A JP 2014531402A JP 2014523855 A JP2014523855 A JP 2014523855A JP 2014523855 A JP2014523855 A JP 2014523855A JP 2014531402 A JP2014531402 A JP 2014531402A
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- cancer
- dimethylphenyl
- maleamic
- amino
- enoic acid
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- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
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- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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Abstract
Description
前記R10乃至R14はそれぞれ水素、メチル、ハロゲン及びメコキシからなる群より選ばれたものである]。
R1乃至R5はそれぞれ水素、C1-C4の直鎖、枝の付いた又はシクロアルキル、ハロゲン、アルコキシ、ヒドロキシ及びカルボキシ基からなる群より選ばれたもので、
前記R10乃至R14はそれぞれ水素、メチル、ハロゲン及びメコキシからなる群より選ばれたものである]。
R1乃至R5はそれぞれ水素、C1-C4の直鎖、枝の付いた又はシクロアルキル、ハロゲン、アルコキシ及びヒドロキシからなる群より選ばれたもので、
前記R10乃至R14はそれぞれ水素、メチル、ハロゲン及びメコキシからなる群より選ばれたものである]。
R1乃至R5はそれぞれ水素、C1-C4の直鎖、枝の付いた又はシクロアルキル、ハロゲン、アルコキシ及びヒドロキシ及びカルボキシ基からなる群より選ばれたもので、
前記R10乃至R14はそれぞれ水素、メチル、ハロゲン及びメコキシからなる群より選ばれたものである]。
R1乃至R5はそれぞれ水素、C1-C4の直鎖、枝の付いた又はシクロアルキル、ハロゲン、アルコキシ、ヒドロキシ及びカルボキシル基からなる群より選ばれたもので、
前記R10乃至R14はそれぞれ水素、メチル、ハロゲン及びメコキシからなる群より選ばれたものであることを特徴とする。
4-[(3-エトキシ-1,3-ジオキソプロピル)アミノ]-ベンゾ酸
N1,N4-ビス(3,4-ジメチルフェニル)フマルアミド
N1,N4-ジ-m-トルイルフマルアミド
N1-(2,5-ジメチルフェニル)-N4-(3,4-ジメチルフェニル)マレアミド
N1,N4-ジ-m-トルイルマレアミド
N1-(3,4-ジメチルフェニル)-N4-(4-フルオロ-2-メチルフェニル)マレアミド
N1-(3,4-ジメチルフェニル)-N4-(3-フルオロ-4-メチルフェニル)マレアミド
N1-(3,5-ジクロロフェニル)-N4-(3,4-ジメチルフェニル)マレアミド
(Z)-4-[2,5-ジメチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸
(Z)-4-[3,5-ジメチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸
(Z)-4-[4-ブチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸
(Z)-4-オキソ-4-(m-トルイルアミノ)ブーツ-2-エノイク酸
(Z)-4-[(4-フルオロフェニル)アミノ]-4-オキソブーツ-2-エノイク酸
(Z)-4-[(3,5-ジクロロフェニル)アミノ]-4-オキソブーツ-2-エノイク酸
(Z)-4-[(2,4-ジクロロ -6-メチルフェニル)アミノ]-4-オキソブーツ-2-エノイク
N1-(3,4-ジメチルフェニル)-N4-(3,5-ジメチルフェニル)マレアミド
N1-(3-ブチルフェニル)-N4-(3,4-ジメチルフェニル)マレアミド
N1-(4-ブロモフェニル)-N4-(3,4-ジメチルフェニル)マレアミド
N1-(4-フルオロフェニル)-N4-(3,4-メトキシフェニル)マレアミド
N1-(3-エチルフェニル)-N4-(4-フルオロフェニル)マレアミド
(Z)-4-[(3 -フルオロ-4-メチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸
N1,N4-ビス(3,5-ジクロロフェニル)フマルアミド
N1,N4-ビス(4-ブロモフェニル)フマルアミド
N1,N4-ビス(3,4-ジクロロフェニル)フマルアミド
N1,N4-ビス(3-フルオロ-4-メチルフェニル)フマルアミド
N1,N4-ビス(4-メトキシフェニル)マレアミド
N1-(3-フルオロ-4-メトキシフェニル)-N4-(フルオロフェニル)マレアミド
N1,N4-ビス(4-フルオロ-2-メチルフェニル)マレアミド
N1-(2,5-ジメチルフェニル)-N3-(3-メトキシフェニル)-2-メチルマロンアミド
N1-(4-フルオロフェニル)-N4-(m-トルイル)マレアミド
N1-(3,5-ジメチルフェニル)-N3-(3-メトキシフェニル)-2-メチルマロンアミド
エチル3-(アントラセン-2-イルアミノ)-2-メチル-3-オキソプロパン酸エステル
エチル3-[ (2-クロロ-4-ヒドロキシフェニル)アミノ]-3-オキソプロパン酸エステル
エチル3-[(2-クロロ-4-ヒドロキシフェニル)アミノ]-2-メチル-3-オキソプロパン酸エステル
AIMP2-DX2抑制剤探索
本発明化合物がAIMP2-DX2活性に及ぼす影響調査
本発明の化合物の肺癌抑制in vitro効果
肺癌細胞株NCI-H460を10%牛胎児血清、1%ペニシリンを含むストレプトマイシンのRPMI(HyQ RPMI-1640,Hyclone)培地で培養した。WI-26細胞株を10%牛胎児血清、1%ペニシリンを含むストレプトマイシンのDEMD(Dulbeccos modified Eagles medium,,Hyclone)で培養した。本発明の化合物が細胞周期に及ぼす影響を調べるために、細胞を2%FBSを含む培地で本発明の化合物を処理して培養し、細胞を集めてFACS分析した。
本発明の化合物が肺癌抑制in vivo効果
本発明の化合物の肺癌抑制効果
Claims (6)
- 前記化学式1で示されるアニリン誘導体は
N1,N4-ビス(3,4-ジメチルフェニル)フマルアミド、
N1,N4-ジ-m-トルイルフマルアミド、
N1-(2,5-ジメチルフェニル)-N4-(3,4-ジメチルフェニル)マレアミド、
N1,N4-ジ-m-トルイルマレアミド、
N1-(3,4-ジメチルフェニル)-N4-(4-フルオロ-2-メチルフェニル)マレアミド、
N1-(3,4-ジメチルフェニル)-N4-(3-フルオロ-4-メチルフェニル)マレアミド、
N1-(3,5-ジクロロフェニル)-N4-(3,4-ジメチルフェニル)マレアミド、
(Z)-4-[2,5-ジメチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
(Z)-4-[3,5-ジメチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
(Z)-4-[4-ブチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
(Z)-4-オキソ-4-(m-トルイルアミノ)ブーツ-2-エノイク酸、
(Z)-4-[(4-フルオロフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
(Z)-4-[(3,5-ジクロロフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
(Z)-4-[(2,4-ジクロロ -6-メチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
N1-(3,4-ジメチルフェニル)-N4-(3,5-ジメチルフェニル)マレアミド、
N1-(3-ブチルフェニル)-N4-(3,4-ジメチルフェニル)マレアミド、
N1-(4-ブロモフェニル)-N4-(3,4-ジメチルフェニル)マレアミド、
N1-(4-フルオロフェニル)-N4-(3,4-メトキシフェニル)マレアミド、
N1-(3-エチルフェニル)-N4-(4-フルオロフェニル)マレアミド、
(Z)-4-[(3 -フルオロ-4-メチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
N1,N4-ビス(3,5-ジクロロフェニル)フマルアミド、
N1,N4-ビス(4-ブロモフェニル)フマルアミド、
N1,N4-ビス(3,4-ジクロロフェニル)フマルアミド、
N1,N4-ビス(3-フルオロ-4-メチルフェニル)フマルアミド、
N1,N4-ビス(4-メトキシフェニル)マレアミド、
N1-(3-フルオロ-4-メトキシフェニル)-N4-(フルオロフェニル)マレアミド、
N1,N4-ビス(4-フルオロ-2-メチルフェニル)マレアミド、
N1-(2,5-ジメチルフェニル)-N3-(3-メトキシフェニル)-2-メチルマロンアミド、
N1-(4-フルオロフェニル)-N4-(m-トルイル)マレアミド、
N1-(3,5-ジメチルフェニル)-N3-(3-メトキシフェニル)-2-メチルマロンアミド、
エチル3-(アントラセン-2-イルアミノ)-2-メチル-3-オキソプロパン酸エステル、
エチル3-[ (2-クロロ-4-ヒドロキシフェニル)アミノ]-3-オキソプロパン酸エスル、
エチル3-[(2-クロロ-4-ヒドロキシフェニル)アミノ]-2-メチル-3-オキソプロパン酸エステル、
からなる群より選ばれた一つ以上のアニリン誘導体であることを特徴とする第1項記載のアニリン誘導体又はこれの薬学的に許容される塩。 - 前記化学式1で示されるアニリン誘導体は
N1,N4-ビス(3,4-ジメチルフェニル)フマルアミド、
N1,N4-ジ-m-トルイルフマルアミド、
N1-(2,5-ジメチルフェニル)-N4-(3,4-ジメチルフェニル)マレアミド、
N1,N4-ジ-m-トルイルマレアミド、
N1-(3,4-ジメチルフェニル)-N4-(4-フルオロ-2-メチルフェニル)マレアミド、
N1-(3,4-ジメチルフェニル)-N4-(3-フルオロ-4-メチルフェニル)マレアミド、
N1-(3,5-ジクロロフェニル)-N4-(3,4-ジメチルフェニル)マレアミド、
(Z)-4-[2,5-ジメチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
(Z)-4-[3,5-ジメチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
(Z)-4-[4-ブチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
(Z)-4-オキソ-4-(m-トルイルアミノ)ブーツ-2-エノイク酸、
(Z)-4-[(4-フルオロフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
(Z)-4-[(3,5-ジクロロフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
(Z)-4-[(2,4-ジクロロ -6-メチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
N1-(3,4-ジメチルフェニル)-N4-(3,5-ジメチルフェニル)マレアミド、
N1-(3-ブチルフェニル)-N4-(3,4-ジメチルフェニル)マレアミド、
N1-(4-ブロモフェニル)-N4-(3,4-ジメチルフェニル)マレアミド、
N1-(4-フルオロフェニル)-N4-(3,4-メトキシフェニル)マレアミド、
N1-(3-エチルフェニル)-N4-(4-フルオロフェニル)マレアミド、
(Z)-4-[(3 -フルオロ-4-メチルフェニル)アミノ]-4-オキソブーツ-2-エノイク酸、
N1,N4-ビス(3,5-ジクロロフェニル)フマルアミド、
N1,N4-ビス(4-ブロモフェニル)フマルアミド、
N1,N4-ビス(3,4-ジクロロフェニル)フマルアミド、
N1,N4-ビス(3-フルオロ-4-メチルフェニル)フマルアミド、
N1,N4-ビス(4-メトキシフェニル)マレアミド、
N1-(3-フルオロ-4-メトキシフェニル)-N4-(フルオロフェニル)マレアミド、
N1,N4-ビス(4-フルオロ-2-メチルフェニル)マレアミド、
N1-(2,5-ジメチルフェニル)-N3-(3-メトキシフェニル)-2-メチルマロンアミド、
N1-(4-フルオロフェニル)-N4-(m-トルイル)マレアミド、
N1-(3,5-ジメチルフェニル)-N3-(3-メトキシフェニル)-2-メチルマロンアミド、
エチル3-(アントラセン-2-イルアミノ)-2-メチル-3-オキソプロパン酸エステル、
エチル3-[ (2-クロロ-4-ヒドロキシフェニル)アミノ]-3-オキソプロパン酸エスル、
エチル3-[(2-クロロ-4-ヒドロキシフェニル)アミノ]-2-メチル-3-オキソプロパン酸エステル、
からなる群より選ばれた一つ以上の化合物であることを特徴とする第3項記載の癌の予防又は治療用薬学的組成物。 - 前記癌は、乳房癌、大腸癌、肺癌、小細胞肺癌、胃癌、肝臓癌、血液癌、骨癌、膵臓癌、皮膚癌、頭部又は頸部癌、皮膚又は眼球内黒色腫、子宮癌、卵巣癌、直腸癌、肛門付近癌、結腸癌、ラッパ管癌腫、子宮内膜癌症、子宮頸部癌、膣癌、陰門癌腫、ホジキン病、食道癌、小腸癌、内分泌癌、甲状腺癌、副甲状腺癌、副腎癌、軟組織肉腫、尿道癌、陰茎癌、前立腺癌、慢性又は急性白血病、リンパ球リンパ腫、膀胱癌、腎臓又は輸尿管癌、腎臓細胞癌腫、腎臓骨盤癌腫、CNS腫瘍、1次CNSリンパ腫、脊髄腫瘍、脳間神経膠症及び脳下垂体腺腫からなる群より選ばれた一つ以上の疾病であることを特徴とする第3項記載の癌の予防又は治療用薬学的組成物。
- 前記癌は肺癌であることを特徴とする第3項記載の癌の予防又は治療用薬学的組成物。
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WO2014179943A1 (zh) * | 2013-05-08 | 2014-11-13 | Yang Yongliang | 一种马来酰胺化合物、其制备方法及其用途 |
KR101762433B1 (ko) * | 2013-06-05 | 2017-07-28 | 재단법인 의약바이오컨버젼스연구단 | 신규한 말레인산 유도체 및 이의 제조방법 및 이를 포함하는 항암용 조성물 |
KR101514320B1 (ko) | 2013-06-14 | 2015-04-22 | 재단법인 의약바이오컨버젼스연구단 | 신규한 암 예방 또는 치료용 약학적 조성물 |
KR101831435B1 (ko) * | 2016-03-10 | 2018-02-22 | 재단법인 의약바이오컨버젼스연구단 | Aimp2-dx2 단백질에 특이적으로 결합하는 항체 |
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JP2019512693A (ja) * | 2016-03-07 | 2019-05-16 | メディシナル バイオコンバージェンス リサーチ センター | Aimp2−dx2とhsp70との結合を阻害する抗がん剤スクリーニング方法 |
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US20140142333A1 (en) | 2014-05-22 |
CN103889412A (zh) | 2014-06-25 |
KR20130016134A (ko) | 2013-02-14 |
EP2739279A4 (en) | 2015-08-12 |
WO2013019093A2 (en) | 2013-02-07 |
WO2013019093A3 (en) | 2013-04-25 |
EP2739279A2 (en) | 2014-06-11 |
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