JP2014530861A5 - - Google Patents
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- Publication number
- JP2014530861A5 JP2014530861A5 JP2014537216A JP2014537216A JP2014530861A5 JP 2014530861 A5 JP2014530861 A5 JP 2014530861A5 JP 2014537216 A JP2014537216 A JP 2014537216A JP 2014537216 A JP2014537216 A JP 2014537216A JP 2014530861 A5 JP2014530861 A5 JP 2014530861A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- kinase inhibitor
- tor kinase
- use according
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161549034P | 2011-10-19 | 2011-10-19 | |
| US61/549,034 | 2011-10-19 | ||
| US201261591401P | 2012-01-27 | 2012-01-27 | |
| US61/591,401 | 2012-01-27 | ||
| US201261647233P | 2012-05-15 | 2012-05-15 | |
| US61/647,233 | 2012-05-15 | ||
| US201261653436P | 2012-05-31 | 2012-05-31 | |
| US61/653,436 | 2012-05-31 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016234951A Division JP6360136B2 (ja) | 2011-10-19 | 2016-12-02 | Torキナーゼ阻害剤を用いたがんの処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014530861A JP2014530861A (ja) | 2014-11-20 |
| JP2014530861A5 true JP2014530861A5 (enExample) | 2015-11-12 |
Family
ID=47116477
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537216A Pending JP2014530861A (ja) | 2011-10-19 | 2012-10-18 | Torキナーゼ阻害剤を用いたがんの処置 |
| JP2016234951A Active JP6360136B2 (ja) | 2011-10-19 | 2016-12-02 | Torキナーゼ阻害剤を用いたがんの処置 |
| JP2018117932A Pending JP2018162286A (ja) | 2011-10-19 | 2018-06-21 | Torキナーゼ阻害剤を用いたがんの処置 |
| JP2020117028A Pending JP2020169203A (ja) | 2011-10-19 | 2020-07-07 | Torキナーゼ阻害剤を用いたがんの処置 |
| JP2021078559A Pending JP2021107461A (ja) | 2011-10-19 | 2021-05-06 | Torキナーゼ阻害剤を用いたがんの処置 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016234951A Active JP6360136B2 (ja) | 2011-10-19 | 2016-12-02 | Torキナーゼ阻害剤を用いたがんの処置 |
| JP2018117932A Pending JP2018162286A (ja) | 2011-10-19 | 2018-06-21 | Torキナーゼ阻害剤を用いたがんの処置 |
| JP2020117028A Pending JP2020169203A (ja) | 2011-10-19 | 2020-07-07 | Torキナーゼ阻害剤を用いたがんの処置 |
| JP2021078559A Pending JP2021107461A (ja) | 2011-10-19 | 2021-05-06 | Torキナーゼ阻害剤を用いたがんの処置 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9493466B2 (enExample) |
| EP (3) | EP3466423B1 (enExample) |
| JP (5) | JP2014530861A (enExample) |
| KR (1) | KR101978537B1 (enExample) |
| CN (2) | CN103998036B (enExample) |
| BR (1) | BR112014009755B1 (enExample) |
| CA (1) | CA2852921C (enExample) |
| EA (2) | EA030664B1 (enExample) |
| ES (2) | ES2894958T3 (enExample) |
| IL (3) | IL232128B (enExample) |
| IN (1) | IN2014CN02887A (enExample) |
| MX (4) | MX357833B (enExample) |
| MY (1) | MY183661A (enExample) |
| PH (1) | PH12014500869A1 (enExample) |
| SG (3) | SG10201912850WA (enExample) |
| TW (4) | TWI708605B (enExample) |
| UA (1) | UA115319C2 (enExample) |
| WO (1) | WO2013059396A2 (enExample) |
| ZA (2) | ZA201402771B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| EP2945636B1 (en) | 2013-01-16 | 2017-06-28 | Signal Pharmaceuticals, LLC | Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith |
| EP2961408A1 (en) * | 2013-02-28 | 2016-01-06 | Signal Pharmaceuticals, LLC | Treatment of cancer with tor kinase inhibitors |
| AU2014254057A1 (en) | 2013-04-17 | 2015-11-05 | Signal Pharmaceuticals, Llc | Combination therapy comprising a TOR kinase inhibitor and N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer |
| MX368286B (es) * | 2013-04-17 | 2019-09-27 | Signal Pharm Llc | Terapia de combinacion que comprende un inhibidor de tor cinasa y un compuesto de quinazolinona 5-sustituida para tratar cancer. |
| ES2944478T3 (es) * | 2013-04-17 | 2023-06-21 | Signal Pharm Llc | 1-etil-7-(2-metil-6-(1H-1,2,4-triazol-3-il)piridin-3-il)-3,4-dihidropirazino[2,3-b]pirazin-2(1H)-ona para tratar el glioblastoma multiforme |
| SG11201508527VA (en) | 2013-04-17 | 2015-11-27 | Signal Pharm Llc | Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one |
| KR102242505B1 (ko) * | 2013-04-17 | 2021-04-20 | 시그날 파마소티칼 엘엘씨 | 암 치료용 tor 키나제 억제제 및 시티딘 유사체를 포함하는 병용 요법 |
| TW201526897A (zh) * | 2013-04-17 | 2015-07-16 | Signal Pharm Llc | 使用tor激酶抑制劑組合療法以治療癌症之方法 |
| NZ629411A (en) | 2013-04-17 | 2017-06-30 | Signal Pharm Llc | Treatment of cancer with dihydropyrazino-pyrazines |
| BR112015026257B1 (pt) * | 2013-04-17 | 2022-12-20 | Signal Pharmaceuticals, Llc | Uso de um composto dihidropirazino-pirazina e enzalutamida, composição farmacêutica que os compreende, e kit |
| JP6401250B2 (ja) | 2013-05-29 | 2018-10-10 | シグナル ファーマシューティカルズ,エルエルシー | 7−(6−(2−ヒドロキシプロパン−2−イル)ピリジン−3−イル)−1−((trans)−4−メトキシシクロヘキシル)−3,4−ジヒドロピラジノ[2,3−b]ピラジン−2(1H)−オン、その固体形態の医薬組成物、及びその使用方法 |
| MX2016004212A (es) * | 2013-10-04 | 2016-07-11 | Signal Pharm Llc | Inhibidor de tor cinasa en la prevencion o tratamiento de cancer caracterizado por mutaciones genicas. |
| US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
| US9512129B2 (en) | 2014-04-16 | 2016-12-06 | Signal Pharmaceuticals, Llc | Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| US9737535B2 (en) | 2014-04-16 | 2017-08-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines |
| NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
| AU2015289929A1 (en) | 2014-07-14 | 2017-03-02 | Signal Pharmaceuticals, Llc | Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof |
| JP6964343B2 (ja) | 2015-11-20 | 2021-11-10 | フォーマ セラピューティクス,インコーポレイテッド | ユビキチン特異的プロテアーゼ1阻害剤としてのプリノン |
| CN108602825A (zh) * | 2016-02-05 | 2018-09-28 | 中央研究院 | 具有抗癌活性的嘌呤化合物 |
| WO2018013430A2 (en) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus infection |
| HUE054548T2 (hu) | 2016-12-20 | 2021-09-28 | Astrazeneca Ab | Amino-triazolopiridin vegyületek és azok alkalmazása rák kezelésében |
| EP3641772B1 (en) | 2017-06-22 | 2023-08-02 | Celgene Corporation | Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection |
| JP7258899B2 (ja) * | 2017-11-01 | 2023-04-17 | ジュノー セラピューティクス インコーポレイテッド | T細胞組成物を作製するための方法 |
| EP3762385B1 (en) | 2018-03-09 | 2025-02-12 | Recurium IP Holdings, LLC | Substituted 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones |
| CN110526907B (zh) * | 2018-05-23 | 2021-04-23 | 四川大学 | 苯并噁嗪酮类衍生物及其应用 |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| WO2021021986A1 (en) * | 2019-07-31 | 2021-02-04 | Ribon Therapeutics, Inc. | Heterobicyclic amides as inhibitors of cd38 |
| CN114728978A (zh) * | 2019-11-22 | 2022-07-08 | 南京明德新药研发有限公司 | 作为dna-pk抑制剂的嘧啶并吡咯类螺环化合物及其衍生物 |
| JP7383818B2 (ja) * | 2019-11-25 | 2023-11-20 | ザイ ラボ (シャンハイ) カンパニー、リミテッド. | Dna-pk阻害剤としてのピリミドイミダゾル系化合物 |
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-
2012
- 2012-10-18 SG SG10201912850WA patent/SG10201912850WA/en unknown
- 2012-10-18 SG SG11201401630SA patent/SG11201401630SA/en unknown
- 2012-10-18 MX MX2017002007A patent/MX357833B/es unknown
- 2012-10-18 MX MX2020004689A patent/MX384385B/es unknown
- 2012-10-18 MY MYPI2017000252A patent/MY183661A/en unknown
- 2012-10-18 TW TW106118908A patent/TWI708605B/zh active
- 2012-10-18 MX MX2018008536A patent/MX373925B/es unknown
- 2012-10-18 BR BR112014009755-0A patent/BR112014009755B1/pt active IP Right Grant
- 2012-10-18 ES ES18207204T patent/ES2894958T3/es active Active
- 2012-10-18 EP EP18207204.1A patent/EP3466423B1/en active Active
- 2012-10-18 EA EA201490814A patent/EA030664B1/ru not_active IP Right Cessation
- 2012-10-18 TW TW109119519A patent/TWI758746B/zh active
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