JP2014530816A - Ｗｎｔ経路関連疾患のための抗体および方法 - Google Patents
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
- C12Y603/02019—Ubiquitin-protein ligase (6.3.2.19), i.e. ubiquitin-conjugating enzyme
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020506701A (ja) * | 2017-01-26 | 2020-03-05 | スロゼン， インコーポレイテッド | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
| JP2020514303A (ja) * | 2017-01-11 | 2020-05-21 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Ｒ−スポンジン（ｒｓｐｏ）サロゲート分子 |
| JP2021530223A (ja) * | 2018-07-09 | 2021-11-11 | スロゼン， インコーポレイテッド | 組織特異性Ｗｎｔシグナル増強分子及びその使用 |
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| JP5931336B2 (ja) | 2007-07-02 | 2016-06-08 | オンコメッド ファーマシューティカルズ インコーポレイテッド | がんを処置および診断するための組成物および方法 |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| CN106167526A (zh) | 2011-07-15 | 2016-11-30 | 昂考梅德药品有限公司 | Rspo结合剂和其应用 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| RU2017120287A (ru) | 2012-02-28 | 2018-11-15 | АйАрЭм ЭлЭлСи | ОТБОР БОЛЬНЫХ РАКОМ ДЛЯ ВВЕДЕНИЯ ИНГИБИТОРОВ СИГНАЛЬНОГО ПУТИ Wnt НА ОСНОВАНИИ СТАТУСА МУТАЦИИ RNF43 |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
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| CA2878868A1 (en) | 2012-07-13 | 2014-01-16 | Austin L. Gurney | Rspo3 binding agents and uses thereof |
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| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
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| EP3865511A1 (en) | 2016-04-14 | 2021-08-18 | F. Hoffmann-La Roche AG | Anti-rspo3 antibodies and methods of use |
| US11773171B2 (en) | 2017-12-19 | 2023-10-03 | Surrozen Operating, Inc. | WNT surrogate molecules and uses thereof |
| US11746150B2 (en) | 2017-12-19 | 2023-09-05 | Surrozen Operating, Inc. | Anti-LRP5/6 antibodies and methods of use |
| CA3085596A1 (en) | 2017-12-19 | 2019-06-27 | Surrozen, Inc. | Anti-frizzled antibodies and methods of use |
| US20220064337A1 (en) * | 2018-12-19 | 2022-03-03 | Surrozen, Inc. | Antigen binding formats for receptor complexes |
| US20220041753A1 (en) * | 2018-12-27 | 2022-02-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Bispecific antibody for membrane clearance of target receptors |
| EP3986912A1 (en) | 2019-06-21 | 2022-04-27 | Regeneron Pharmaceuticals, Inc. | Treatment of decreased bone mineral density with zinc and ring finger 3 (znrf3) inhibitors |
| AU2020376928A1 (en) * | 2019-11-01 | 2022-05-19 | The Regents Of The University Of California | Degradation of surface proteins using bispecific binding agent |
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| CA3169792A1 (en) * | 2020-03-05 | 2021-09-10 | Umc Utrecht Holding B.V. | Membrane ubiquitin ligases to target protein degradation |
| CN111920951B (zh) * | 2020-07-17 | 2022-12-06 | 上海交通大学医学院附属瑞金医院 | Znrf3/rnf43在制备调节能量代谢药物中的应用 |
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| WO2022169872A1 (en) * | 2021-02-03 | 2022-08-11 | Genentech, Inc. | Multispecific binding protein degrader platform and methods of use |
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- 2012-10-12 EP EP19209759.0A patent/EP3653222A1/en not_active Withdrawn
- 2012-10-12 ES ES12794776T patent/ES2769786T3/es active Active
- 2012-10-12 CN CN201810805989.1A patent/CN109111523B/zh active Active
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2016
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020514303A (ja) * | 2017-01-11 | 2020-05-21 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Ｒ−スポンジン（ｒｓｐｏ）サロゲート分子 |
| JP2023026539A (ja) * | 2017-01-11 | 2023-02-24 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Ｒ－スポンジン（ｒｓｐｏ）サロゲート分子 |
| JP7617603B2 (ja) | 2017-01-11 | 2025-01-20 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Ｒ－スポンジン（ｒｓｐｏ）サロゲート分子 |
| JP2020506701A (ja) * | 2017-01-26 | 2020-03-05 | スロゼン， インコーポレイテッド | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
| JP2023078467A (ja) * | 2017-01-26 | 2023-06-06 | スロゼン オペレーティング， インコーポレイテッド | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
| JP7305543B2 (ja) | 2017-01-26 | 2023-07-10 | スロゼン オペレーティング， インコーポレイテッド | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
| JP7635291B2 (ja) | 2017-01-26 | 2025-02-25 | スロゼン オペレーティング， インコーポレイテッド | 組織特異的Ｗｎｔシグナル増強分子およびその使用 |
| JP2021530223A (ja) * | 2018-07-09 | 2021-11-11 | スロゼン， インコーポレイテッド | 組織特異性Ｗｎｔシグナル増強分子及びその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2769786T3 (es) | 2020-06-29 |
| EP3653222A1 (en) | 2020-05-20 |
| WO2013054307A3 (en) | 2013-11-21 |
| CN104080471B (zh) | 2018-08-10 |
| CN109111523B (zh) | 2022-06-07 |
| JP2020200332A (ja) | 2020-12-17 |
| US20140328859A1 (en) | 2014-11-06 |
| CN104080471A (zh) | 2014-10-01 |
| US9296826B2 (en) | 2016-03-29 |
| JP2018016634A (ja) | 2018-02-01 |
| EP2766033A2 (en) | 2014-08-20 |
| EP2766033B1 (en) | 2019-11-20 |
| WO2013054307A9 (en) | 2013-10-03 |
| WO2013054307A2 (en) | 2013-04-18 |
| US20180066067A1 (en) | 2018-03-08 |
| JP7079298B2 (ja) | 2022-06-01 |
| CN109111523A (zh) | 2019-01-01 |
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