|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US4673641A
(en)
|
1982-12-16 |
1987-06-16 |
Molecular Genetics Research And Development Limited Partnership |
Co-aggregate purification of proteins
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4740461A
(en)
|
1983-12-27 |
1988-04-26 |
Genetics Institute, Inc. |
Vectors and methods for transformation of eucaryotic cells
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US4959455A
(en)
|
1986-07-14 |
1990-09-25 |
Genetics Institute, Inc. |
Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
|
|
US4912040A
(en)
|
1986-11-14 |
1990-03-27 |
Genetics Institute, Inc. |
Eucaryotic expression system
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
ATE356869T1
(de)
|
1990-01-12 |
2007-04-15 |
Amgen Fremont Inc |
Bildung von xenogenen antikörpern
|
|
WO1993012227A1
(en)
|
1991-12-17 |
1993-06-24 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
DE122004000008I1
(de)
|
1991-06-14 |
2005-06-09 |
Genentech Inc |
Humanisierter Heregulin Antikörper.
|
|
DK0574048T3
(da)
|
1992-03-13 |
2002-12-16 |
Organon Teknika Bv |
Peptider og nucleinsyresekvenser relateret til Epstein-Barr-virus
|
|
US5625825A
(en)
|
1993-10-21 |
1997-04-29 |
Lsi Logic Corporation |
Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network
|
|
US5770565A
(en)
|
1994-04-13 |
1998-06-23 |
La Jolla Cancer Research Center |
Peptides for reducing or inhibiting bone resorption
|
|
US5688781A
(en)
|
1994-08-19 |
1997-11-18 |
Bristol-Myers Squibb Company |
Method for treating vascular leak syndrome
|
|
WO1996031598A1
(en)
|
1995-04-06 |
1996-10-10 |
Regeneron Pharmaceuticals, Inc. |
Tie-2 ligands, methods of making and uses thereof
|
|
DE69638058D1
(de)
|
1995-06-15 |
2009-11-26 |
Crucell Holland Bv |
Verpackungssysteme für humane rekombinante Adenoviren zur Gentherapie
|
|
US20030040463A1
(en)
|
1996-04-05 |
2003-02-27 |
Wiegand Stanley J. |
TIE-2 ligands, methods of making and uses thereof
|
|
AU5154098A
(en)
|
1996-10-31 |
1998-05-22 |
Duke University |
Soluble tie2 receptor
|
|
US6133426A
(en)
|
1997-02-21 |
2000-10-17 |
Genentech, Inc. |
Humanized anti-IL-8 monoclonal antibodies
|
|
DK1325932T5
(da)
|
1997-04-07 |
2005-10-03 |
Genentech Inc |
Anti-VEGF antistoffer
|
|
US5919813C1
(en)
|
1998-03-13 |
2002-01-29 |
Univ Johns Hopkins Med |
Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy
|
|
US5980929A
(en)
|
1998-03-13 |
1999-11-09 |
Johns Hopkins University, School Of Medicine |
Use of a protein tyrosine kinase pathway inhibitor in the treatment of retinal ischmemia or ocular inflammation
|
|
AR022303A1
(es)
|
1999-01-22 |
2002-09-04 |
Lundbeck & Co As H |
Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
|
|
ES2199804T3
(es)
|
1999-03-26 |
2004-03-01 |
Regeneron Pharmaceuticals, Inc. |
Modulacion de la permeabilidad vascular por medio de activadores del receptor tie2.
|
|
US6455035B1
(en)
|
1999-03-26 |
2002-09-24 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of use thereof
|
|
EP1046715A1
(en)
|
1999-04-23 |
2000-10-25 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Interaction of vascular-endothelial protein-tyrosine phosphatase with the angiopoietin receptor tie-2
|
|
AU5062500A
(en)
|
1999-04-26 |
2000-11-10 |
Amersham Pharmacia Biotech Ab |
Primers for identifying typing or classifying nucleic acids
|
|
CA2372053C
(en)
|
1999-04-28 |
2008-09-02 |
Board Of Regents, The University Of Texas System |
Compositions and methods for cancer treatment by selectively inhibiting vegf
|
|
WO2000070030A1
(en)
|
1999-05-19 |
2000-11-23 |
Amgen Inc. |
Crystal of a lymphocyte kinase-ligand complex and methods of use
|
|
US7070959B1
(en)
|
1999-06-08 |
2006-07-04 |
Regeneron Pharmaceuticals, Inc. |
Modified chimeric polypeptides with improved pharmacokinetic properties
|
|
US6589758B1
(en)
|
2000-05-19 |
2003-07-08 |
Amgen Inc. |
Crystal of a kinase-ligand complex and methods of use
|
|
AU784231B2
(en)
|
2000-06-23 |
2006-02-23 |
Schering Aktiengesellschaft |
Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/tie receptor function and their use (II)
|
|
US6316109B1
(en)
|
2000-09-21 |
2001-11-13 |
Ppg Industries Ohio, Inc. |
Aminoplast-based crosslinkers and powder coating compositions containing such crosslinkers
|
|
HUP0303085A2
(hu)
|
2000-09-27 |
2003-12-29 |
The Procter & Gamble Co. |
Melanokortin receptor ligandumok és ezeket tartalmazó gyógyszerkészítmények
|
|
US6455026B1
(en)
|
2001-03-23 |
2002-09-24 |
Agy Therapeutics, Inc. |
Use of protein tyrosine phosphatase zeta as a biomolecular target in the treatment and visualization of brain tumors
|
|
CA2461896C
(en)
|
2001-09-28 |
2012-09-18 |
Santen Pharmaceutical Co., Ltd. |
Injections for eye tissues containing drug bonded to polyethylene glycol
|
|
US20050260132A1
(en)
|
2001-10-17 |
2005-11-24 |
Daniel Chin |
Monoclonal antibodies directed to receptor protein tyrosine phosphatase zeta
|
|
WO2003034990A2
(en)
|
2001-10-25 |
2003-05-01 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of use thereof
|
|
WO2003047611A2
(en)
|
2001-12-04 |
2003-06-12 |
DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung |
Ptp10d, tec and edtp involved in triglycerid-metabolism
|
|
US20030158083A1
(en)
|
2002-02-08 |
2003-08-21 |
The Procter & Gamble Company |
Method of effecting angiogenesis by modulating the function of a novel endothelia phosphatase
|
|
US20030215899A1
(en)
|
2002-02-13 |
2003-11-20 |
Ceptyr, Inc. |
Reversible oxidation of protein tyrosine phosphatases
|
|
AU2003229627A1
(en)
|
2002-04-08 |
2003-10-20 |
Max-Planck-Gesellschaft Zur |
Ve-ptp as regulator of ve-cadherin mediated processes or disorders
|
|
RU2376029C2
(ru)
|
2002-04-25 |
2009-12-20 |
Юниверсити Оф Коннектикут Хелт Сентер |
Применение белков теплового шока для улучшения терапевтического эффекта невакцинного лечебного воздействия
|
|
WO2003092611A2
(en)
|
2002-05-03 |
2003-11-13 |
Regeneron Pharmaceuticals, Inc. |
Methods of inducing formation of functional and organized lymphatic vessels
|
|
US7507568B2
(en)
|
2002-09-25 |
2009-03-24 |
The Proctor & Gamble Company |
Three dimensional coordinates of HPTPbeta
|
|
US7226755B1
(en)
|
2002-09-25 |
2007-06-05 |
The Procter & Gamble Company |
HPTPbeta as a target in treatment of angiogenesis mediated disorders
|
|
US6930117B2
(en)
|
2002-11-09 |
2005-08-16 |
The Procter & Gamble Company |
N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
|
|
US20040167183A1
(en)
|
2003-02-20 |
2004-08-26 |
The Procter & Gamble Company |
Phenethylamino sulfamic acids
|
|
US7718377B2
(en)
|
2003-05-29 |
2010-05-18 |
Kyoto Pharmaceutical Industries, Ltd. |
Insulin resistance curative and method of screening the same
|
|
AR046510A1
(es)
|
2003-07-25 |
2005-12-14 |
Regeneron Pharma |
Composicion de un antagonista de vegf y un agente anti-proliferativo
|
|
US7758859B2
(en)
|
2003-08-01 |
2010-07-20 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
US20050059639A1
(en)
|
2003-09-11 |
2005-03-17 |
Wei Edward T. |
Ophthalmic compositions and method for treating eye discomfort and pain
|
|
US20050158320A1
(en)
|
2003-11-12 |
2005-07-21 |
Nichols M. J. |
Combinations for the treatment of proliferative diseases
|
|
US8298532B2
(en)
|
2004-01-16 |
2012-10-30 |
Regeneron Pharmaceuticals, Inc. |
Fusion polypeptides capable of activating receptors
|
|
RS54199B1
(sr)
|
2004-03-15 |
2015-12-31 |
Janssen Pharmaceutica Nv |
Postupak za dobijanje intermedijera jedinjenja korisnih kao modulatori opioidnih receptora
|
|
US7771742B2
(en)
|
2004-04-30 |
2010-08-10 |
Allergan, Inc. |
Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
|
|
ATE456579T1
(de)
|
2004-07-20 |
2010-02-15 |
Genentech Inc |
Angiopoietin-like 4 protein hemmer kombinationen und deren verwendung
|
|
EP2457578B1
(en)
|
2004-09-28 |
2015-08-19 |
Aprogen, Inc. |
Chimeric molecule comprising angiopoietin-1 and a coiled-coil domain for use in treating penile erectile dysfunction
|
|
JP4884395B2
(ja)
|
2004-12-21 |
2012-02-29 |
アストラゼネカ エービー |
アンジオポエチン−2に対する抗体およびそれらの使用
|
|
RU2007135216A
(ru)
|
2005-02-23 |
2009-03-27 |
Мерримак Фармасьютикалз, Инк. (Us) |
Биспецифические связывающие агенты для модулирования биологической активности
|
|
US20120237442A1
(en)
|
2005-04-06 |
2012-09-20 |
Ibc Pharmaceuticals, Inc. |
Design and Construction of Novel Multivalent Antibodies
|
|
JO2787B1
(en)
|
2005-04-27 |
2014-03-15 |
امجين إنك, |
Alternative amide derivatives and methods of use
|
|
US7893040B2
(en)
|
2005-07-22 |
2011-02-22 |
Oculis Ehf |
Cyclodextrin nanotechnology for ophthalmic drug delivery
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
WO2007033216A2
(en)
|
2005-09-12 |
2007-03-22 |
Beth Israel Deaconess Medical Center |
Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state
|
|
US20070134234A1
(en)
|
2005-09-29 |
2007-06-14 |
Viral Logic Systems Technology Corp. |
Immunomodulatory compositions and uses therefor
|
|
US8168584B2
(en)
|
2005-10-08 |
2012-05-01 |
Potentia Pharmaceuticals, Inc. |
Methods of treating age-related macular degeneration by compstatin and analogs thereof
|
|
US20090123474A1
(en)
|
2005-12-15 |
2009-05-14 |
Astrazeneca Ab |
Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or fltl antagonist for treating cancer
|
|
EP1981520A2
(en)
|
2006-01-30 |
2008-10-22 |
(OSI) Eyetech, Inc. |
Combination therapy for the treatment of neovascular disorders
|
|
US7588924B2
(en)
|
2006-03-07 |
2009-09-15 |
Procter & Gamble Company |
Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
|
|
SG172686A1
(en)
|
2006-03-08 |
2011-07-28 |
Archemix Corp |
Complement binding aptamers and anti-c5 agents useful in the treatment of ocular disorders
|
|
WO2007113648A2
(en)
|
2006-04-05 |
2007-10-11 |
Pfizer Products Inc. |
Ctla4 antibody combination therapy
|
|
AU2007237096C1
(en)
|
2006-04-07 |
2012-12-13 |
EyePoint Pharmaceuticals, Inc. |
Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof
|
|
US7608261B2
(en)
|
2006-06-16 |
2009-10-27 |
Regeneron Pharmacuticals, Inc. |
VEGF antagonist formulations suitable for intravitreal administration
|
|
US8846685B2
(en)
|
2006-06-27 |
2014-09-30 |
Aerpio Therapeutics Inc. |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7795444B2
(en)
|
2006-06-27 |
2010-09-14 |
Warner Chilcott Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US20130023542A1
(en)
|
2006-06-27 |
2013-01-24 |
Aerpio Therapeutics Inc. |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7589212B2
(en)
|
2006-06-27 |
2009-09-15 |
Procter & Gamble Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7622593B2
(en)
|
2006-06-27 |
2009-11-24 |
The Procter & Gamble Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
DK2076290T3
(en)
|
2006-10-27 |
2017-01-23 |
Sunnybrook Health Sciences Center |
MULTIMERIC TIE 2 AGONISTS AND APPLICATIONS THEREOF IN STIMULATING ANGIOGENESIS
|
|
US8642067B2
(en)
|
2007-04-02 |
2014-02-04 |
Allergen, Inc. |
Methods and compositions for intraocular administration to treat ocular conditions
|
|
WO2008127727A1
(en)
|
2007-04-13 |
2008-10-23 |
Kinex Pharmaceuticals, Llc |
Biaryl compositions and methods for modulating a kinase cascade
|
|
US11078262B2
(en)
|
2007-04-30 |
2021-08-03 |
Allergan, Inc. |
High viscosity macromolecular compositions for treating ocular conditions
|
|
WO2009003110A2
(en)
|
2007-06-26 |
2008-12-31 |
Children's Medical Center Corporation |
Metap-2 inhibitor polymersomes for therapeutic administration
|
|
US20090002289A1
(en)
*
|
2007-06-28 |
2009-01-01 |
Boundary Net, Incorporated |
Composite display
|
|
JP5171948B2
(ja)
|
2007-06-29 |
2013-03-27 |
メルク・シャープ・アンド・ドーム・コーポレーション |
Mdl−1の使用
|
|
RU2010120674A
(ru)
|
2007-10-22 |
2011-11-27 |
Шеринг Корпорейшн (US) |
Полностью человеческие анти-vegf-антитела и способы их применения
|
|
US9403789B2
(en)
|
2008-02-21 |
2016-08-02 |
Sequoia Pharmaceuticals, Inc. |
Benzofuran-containing amino acid inhibitors of cytochrome P450
|
|
US8293714B2
(en)
|
2008-05-05 |
2012-10-23 |
Covx Technology Ireland, Ltd. |
Anti-angiogenic compounds
|
|
KR101737466B1
(ko)
|
2008-06-25 |
2017-05-18 |
에스바테크 - 어 노바티스 컴파니 엘엘씨 |
Vegf를 억제하는 안정하고 가용성인 항체
|
|
CN102272148A
(zh)
|
2008-11-03 |
2011-12-07 |
分子组合公司 |
抑制vegf-a受体相互作用的结合蛋白
|
|
CN108635350A
(zh)
|
2009-01-12 |
2018-10-12 |
爱尔皮奥治疗有限公司 |
治疗血管渗漏综合征的方法
|
|
US9096555B2
(en)
|
2009-01-12 |
2015-08-04 |
Aerpio Therapeutics, Inc. |
Methods for treating vascular leak syndrome
|
|
WO2010097800A1
(en)
|
2009-02-26 |
2010-09-02 |
Muhammad Abdulrazik |
Synergistic combination of bioactive compounds for lowering of intraocular pressure
|
|
CN102340991B
(zh)
|
2009-03-03 |
2014-02-26 |
爱尔康研究有限公司 |
向眼部递送受体酪氨酸激酶抑制性(RTKi)化合物的药物组合物
|
|
MX2011008680A
(es)
|
2009-03-03 |
2011-09-08 |
Alcon Res Ltd |
Composicion farmaceutica para el suministro de compuestos inhibidores de la tirosina cinasa receptora (rtki) para los ojos.
|
|
US8883832B2
(en)
|
2009-07-06 |
2014-11-11 |
Aerpio Therapeutics Inc. |
Compounds, compositions, and methods for preventing metastasis of cancer cells
|
|
CA2748765C
(en)
|
2009-07-06 |
2014-07-22 |
Akebia Therapeutics Inc. |
Compounds, compositions, and methods for preventing metastasis of cancer cells
|
|
ES2644998T3
(es)
|
2009-11-06 |
2017-12-01 |
Aerpio Therapeutics Inc. |
Métodos para aumentar la estabilización del factor-1 alfa inducible por hipoxia
|
|
AU2010325969B2
(en)
|
2009-12-02 |
2016-10-20 |
Imaginab, Inc. |
J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen
|
|
CN102711756A
(zh)
*
|
2010-01-14 |
2012-10-03 |
株式会社三和化学研究所 |
用于预防或治疗伴有眼内血管生成及/或眼内血管通透性增高的疾病的药物
|
|
IL323000A
(en)
|
2010-03-05 |
2025-10-01 |
Univ Johns Hopkins |
Compositions and methods for antibodies and fusion proteins targeted for immune modulation
|
|
TWI510246B
(zh)
|
2010-04-30 |
2015-12-01 |
Molecular Partners Ag |
抑制vegf-a受體交互作用的經修飾結合性蛋白質
|
|
EP3311835B1
(en)
|
2010-07-12 |
2021-03-24 |
Threshold Pharmaceuticals Inc. |
Administration of hypoxia activated prodrugs and antiangiogenic agents for the treatment of cancer
|
|
US20180092883A1
(en)
|
2010-10-07 |
2018-04-05 |
Aerpio Therapeutics, Inc. |
Phosphatase inhibitors for treating ocular diseases
|
|
PH12013500577B1
(en)
|
2010-10-07 |
2019-06-28 |
Aerpio Therapeutics Inc |
Compositions and methods for treating ocular edema, neovascularization and related diseases
|
|
CN103249422A
(zh)
|
2010-12-02 |
2013-08-14 |
丸善制药株式会社 |
Tie2活化剂、血管内皮生长因子抑制剂、血管生成抑制剂、血管成熟剂、血管正常化剂及血管稳定剂、以及药物组合物
|
|
CA2824422A1
(en)
|
2011-01-13 |
2012-07-19 |
Regeneron Pharmaceuticals, Inc. |
Use of a vegf antagonist to treat angiogenic eye disorders
|
|
WO2012109673A1
(en)
|
2011-02-11 |
2012-08-16 |
Psivida Us, Inc. |
Methods of treating macular edema using antiedema therapeutics
|
|
EP3505182A1
(en)
|
2011-10-13 |
2019-07-03 |
Aerpio Therapeutics, Inc. |
Methods for treating vascular leak syndrome and cancer
|
|
HK1201196A1
(en)
|
2011-10-13 |
2015-08-28 |
Aerpio Therapeutics, Inc. |
Treatment of ocular disease
|
|
CN104870011A
(zh)
|
2011-11-03 |
2015-08-26 |
托莱拉医疗股份有限公司 |
选择性抑制t细胞应答的抗体和方法
|
|
US20130190324A1
(en)
|
2011-12-23 |
2013-07-25 |
The Regents Of The University Of Colorado, A Body Corporate |
Topical ocular drug delivery
|
|
CA2870341A1
(en)
|
2012-04-13 |
2013-10-17 |
The Johns Hopkins University |
Treatment of ischemic retinopathies
|
|
PT2846836T
(pt)
|
2012-05-07 |
2019-10-29 |
Allergan Inc |
Método de tratamento de dmi em doentes refratários à terapia anti-vegf
|
|
UA120029C2
(uk)
|
2012-07-13 |
2019-09-25 |
Рош Глікарт Аг |
Спосіб зниження в'язкості біспецифічного антитіла до vegf/ang-2 та застосування такого антитіла для лікування судинних очних захворювань
|
|
MX360824B
(es)
|
2012-07-31 |
2018-11-15 |
Univ Texas |
Una combinación para inducir la formación de células beta de células de mamífero y uso de la misma.
|
|
EP2890389A1
(en)
|
2012-08-28 |
2015-07-08 |
Novartis AG |
Use of a vegf antagonist in treating ocular vascular proliferative diseases
|
|
MY177912A
(en)
|
2012-10-11 |
2020-09-25 |
Ascendis Pharma Ophthalmology Div A/S |
Vegf neutralizing prodrugs for the treatment of ocular conditions
|
|
EP3721872B1
(en)
|
2012-11-08 |
2025-01-22 |
Clearside Biomedical Inc. |
Methods for the treatment of ocular disease in human subjects
|
|
WO2014079709A1
(en)
|
2012-11-23 |
2014-05-30 |
Ab Science |
Use of small molecule inhibitors/activators in combination with (deoxy)nucleoside or (deoxy)nucleotide analogs for treatment of cancer and hematological malignancies or viral infections
|
|
US20150050277A1
(en)
|
2013-03-15 |
2015-02-19 |
Aerpio Therapeutics Inc. |
Compositions and methods for treating ocular diseases
|
|
GB2516561B
(en)
|
2013-03-15 |
2016-03-09 |
Aerpio Therapeutics Inc |
Compositions, formulations and methods for treating ocular diseases
|
|
DK2983695T3
(da)
|
2013-04-11 |
2019-09-02 |
Sunnybrook Res Inst |
Fremgangsmåder, anvendelser og sammensætninger af tie2- agonister
|
|
JP2016522250A
(ja)
|
2013-06-20 |
2016-07-28 |
ノバルティス アーゲー |
黄斑浮腫の治療におけるvegfアンタゴニストの使用
|
|
WO2014203182A1
(en)
|
2013-06-20 |
2014-12-24 |
Novartis Ag |
Use of a vegf antagonist in treating choroidal neovascularisation
|
|
WO2015002893A1
(en)
|
2013-07-02 |
2015-01-08 |
The Trustees Of Columbia University In The City Of New York |
Clearance of bioactive lipids from membrane structures by cyclodextrins
|
|
AU2014288847A1
(en)
|
2013-07-11 |
2016-01-28 |
Novartis Ag |
Use of a VEGF antagonist in treating retinopathy of prematurity
|
|
US20160168240A1
(en)
|
2013-07-11 |
2016-06-16 |
Sergey AKSENOV |
Use of vegf antagonist in treating chorioretinal neovascular and permeability disorders in paediatric patients
|
|
EP2832746B1
(en)
|
2013-07-29 |
2018-07-18 |
Samsung Electronics Co., Ltd |
Anti-Ang2 antibody
|
|
US10617755B2
(en)
|
2013-08-30 |
2020-04-14 |
Genentech, Inc. |
Combination therapy for the treatment of glioblastoma
|
|
US20160252526A1
(en)
|
2013-10-01 |
2016-09-01 |
Sphingotec Gmbh |
A method for predicting the risk of getting a major adverse cardiac event
|
|
AU2014337135B2
(en)
|
2013-10-18 |
2019-09-19 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions comprising a combination of a VEGF antagonist and an anti-CTLA-4 antibody
|
|
LT3062811T
(lt)
|
2013-11-01 |
2019-05-10 |
Regeneron Pharmaceuticals, Inc. |
Intervencijos angiopoietino pagrindu cerebrinės maliarijos gydymui
|
|
DK3065761T3
(da)
|
2013-11-05 |
2020-02-17 |
Allergan Inc |
Fremgangsmåde til behandling af tilstande af øjet med en anti-vegf darpin
|
|
AU2015204674B2
(en)
|
2014-01-10 |
2020-09-03 |
Anaptysbio, Inc. |
Antibodies directed against interleukin-33 (IL-33)
|
|
ES2739625T3
(es)
|
2014-02-19 |
2020-02-03 |
Aerpio Therapeutics Inc |
Proceso para la preparación de N-bencil-3-hidroxi-4-sustituido-piridin-2-(1H)-onas
|
|
CN106456614A
(zh)
|
2014-03-14 |
2017-02-22 |
爱尔皮奥治疗有限公司 |
HPTP‑β抑制剂
|
|
JP2015199733A
(ja)
|
2014-04-04 |
2015-11-12 |
国立大学法人東北大学 |
眼圧降下剤
|
|
US9719135B2
(en)
|
2014-07-03 |
2017-08-01 |
Mannin Research Inc. |
Conditional angiopoietin-1/angiopoietin-2 double knock-out mice with defective ocular drainage system
|
|
WO2016022813A1
(en)
|
2014-08-07 |
2016-02-11 |
Aerpio Therapeutics, Inc. |
Combination of immunotherapies with activators of tie-2
|
|
SG11201701016WA
(en)
|
2014-09-16 |
2017-03-30 |
Ovascience Inc |
Anti-vasa antibodies, and methods of production and use thereof
|
|
WO2016049183A1
(en)
|
2014-09-24 |
2016-03-31 |
Aerpio Therapeutics, Inc. |
Ve-ptp extracellular domain antibodies delivered by a gene therapy vector
|
|
TWI806150B
(zh)
|
2014-11-07 |
2023-06-21 |
瑞士商諾華公司 |
穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
|
|
US20160144025A1
(en)
|
2014-11-25 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and formulations for treating vascular eye diseases
|
|
AU2015360496B2
(en)
|
2014-12-11 |
2021-09-30 |
Bayer Healthcare Llc |
Treatment of age related macular degeneration with a small active choroidal neovascularization lesion
|
|
WO2016115092A1
(en)
|
2015-01-12 |
2016-07-21 |
La Jolla Institute For Allergy And Immunology |
Methods for targeting host vascular mechanism for therapeutic protection against hemorrhagic fever
|
|
PH12017501792B1
(en)
|
2015-04-02 |
2022-07-20 |
Molecular Partners Ag |
Recombinant binding proteins and their use
|
|
EP3341021A4
(en)
|
2015-08-27 |
2019-03-13 |
Celldex Therapeutics, Inc. |
ANTI-ALK ANTIBODIES AND METHOD OF USE THEREOF
|
|
MX387804B
(es)
|
2015-09-23 |
2025-03-19 |
Aerpio Therapeutics Inc |
Metodos para tratar presion intraocular con activadores de tie-2
|
|
SG10201911226QA
(en)
|
2015-09-23 |
2020-01-30 |
Genentech Inc |
Optimized variants of anti-vegf antibodies
|
|
US10894823B2
(en)
|
2016-03-24 |
2021-01-19 |
Gensun Biopharma Inc. |
Trispecific inhibitors for cancer treatment
|
|
WO2018007314A1
(en)
|
2016-07-04 |
2018-01-11 |
F. Hoffmann-La Roche Ag |
Novel antibody format
|
|
WO2018017714A1
(en)
|
2016-07-20 |
2018-01-25 |
Aerpio Therapeutics, Inc. |
HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß)
|
|
CN110177563A
(zh)
|
2016-10-04 |
2019-08-27 |
阿斯克雷佩西治疗公司 |
用于激活tie2信号传导的化合物和方法
|
|
IT201600120314A1
(it)
|
2016-11-28 |
2018-05-28 |
Nuovo Pignone Tecnologie Srl |
Turbo-compressore e metodo di funzionamento di un turbo-compressore
|
|
US10426817B2
(en)
|
2017-01-24 |
2019-10-01 |
Macregen, Inc. |
Treatment of age-related macular degeneration and other eye diseases with apolipoprotein mimetics
|
|
WO2018218215A1
(en)
|
2017-05-26 |
2018-11-29 |
The Johns Hopkins University |
Multifunctional antibody-ligand traps to modulate immune tolerance
|
|
TW201904610A
(zh)
|
2017-06-14 |
2019-02-01 |
德商拜耳製藥公司 |
用於治療新生血管型青光眼之非抗體vegf拮抗劑
|
|
CN107602702A
(zh)
|
2017-09-22 |
2018-01-19 |
生标(上海)医疗器械科技有限公司 |
一种同时靶向人p185和血管内皮生长因子的抗体及其应用
|
|
EP4609914A3
(en)
|
2017-11-30 |
2025-10-15 |
Regeneron Pharmaceuticals, Inc. |
Use of a vegf antagonist to treat angiogenic eye disorders
|
|
TWI731310B
(zh)
|
2018-02-28 |
2021-06-21 |
圓祥生命科技股份有限公司 |
結合檢查點阻礙物作為標的治療的雙功能性蛋白質、其藥物複合體、其醫藥組成物、其核酸、及其用途
|
|
CN111867631A
(zh)
|
2018-03-16 |
2020-10-30 |
诺华股份有限公司 |
治疗眼部疾病的方法
|
|
US10276202B1
(en)
|
2018-04-23 |
2019-04-30 |
Western Digital Technologies, Inc. |
Heat-assisted magnetic recording (HAMR) medium with rhodium or rhodium-based alloy heat-sink layer
|
|
IL318714A
(en)
|
2018-05-10 |
2025-03-01 |
Regeneron Pharma |
Formulations that include high concentrations of VEGF receptor fusion protein
|
|
AU2019269628A1
(en)
|
2018-05-17 |
2020-12-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Receptor inhibition by phosphatase recruitment
|
|
US11066476B2
(en)
|
2018-09-14 |
2021-07-20 |
Shanghai tongji hospital |
Asymmetric bispecific antibody
|
|
EP3856245A4
(en)
|
2018-09-24 |
2022-10-26 |
EyePoint Pharmaceuticals, Inc. |
MULTISPECIFIC ANTIBODIES THAT TARGET HPTP - ß (VE-PTP) AND VEGF
|