JP2014526562A5 - - Google Patents
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- Publication number
- JP2014526562A5 JP2014526562A5 JP2014532075A JP2014532075A JP2014526562A5 JP 2014526562 A5 JP2014526562 A5 JP 2014526562A5 JP 2014532075 A JP2014532075 A JP 2014532075A JP 2014532075 A JP2014532075 A JP 2014532075A JP 2014526562 A5 JP2014526562 A5 JP 2014526562A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- disorder
- superoxide dismutase
- agent according
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 35
- 229940124597 therapeutic agent Drugs 0.000 claims 35
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 29
- 108010012715 Superoxide dismutase Proteins 0.000 claims 29
- 239000003446 ligand Substances 0.000 claims 23
- 238000009472 formulation Methods 0.000 claims 17
- 230000003278 mimic effect Effects 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 238000002512 chemotherapy Methods 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 238000001959 radiotherapy Methods 0.000 claims 6
- 230000007935 neutral effect Effects 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 3
- 208000019693 Lung disease Diseases 0.000 claims 3
- 208000032376 Lung infection Diseases 0.000 claims 3
- 208000012902 Nervous system disease Diseases 0.000 claims 3
- 208000026106 cerebrovascular disease Diseases 0.000 claims 3
- 125000003963 dichloro group Chemical group Cl* 0.000 claims 3
- 208000010643 digestive system disease Diseases 0.000 claims 3
- 230000003176 fibrotic effect Effects 0.000 claims 3
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 208000026278 immune system disease Diseases 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 208000030159 metabolic disease Diseases 0.000 claims 3
- 239000005022 packaging material Substances 0.000 claims 3
- 208000017520 skin disease Diseases 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000007975 buffered saline Substances 0.000 claims 2
- 150000007942 carboxylates Chemical class 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000000451 tissue damage Effects 0.000 claims 2
- 231100000827 tissue damage Toxicity 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims 1
- 244000299906 Cucumis sativus var. sativus Species 0.000 claims 1
- 125000002579 carboxylato group Chemical group [O-]C(*)=O 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 239000008176 lyophilized powder Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000003860 storage Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161539365P | 2011-09-26 | 2011-09-26 | |
| US61/539,365 | 2011-09-26 | ||
| PCT/US2012/056921 WO2013048965A1 (en) | 2011-09-26 | 2012-09-24 | Methods for treatment of diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017172825A Division JP6382416B2 (ja) | 2011-09-26 | 2017-09-08 | 疾患の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526562A JP2014526562A (ja) | 2014-10-06 |
| JP2014526562A5 true JP2014526562A5 (enExample) | 2015-11-12 |
| JP6267638B2 JP6267638B2 (ja) | 2018-01-24 |
Family
ID=47911939
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014532075A Active JP6267638B2 (ja) | 2011-09-26 | 2012-09-24 | 疾患の治療方法 |
| JP2017172825A Active JP6382416B2 (ja) | 2011-09-26 | 2017-09-08 | 疾患の治療方法 |
| JP2018145207A Active JP6736618B2 (ja) | 2011-09-26 | 2018-08-01 | 疾患の治療方法 |
| JP2020121417A Active JP7562125B2 (ja) | 2011-09-26 | 2020-07-15 | 疾患の治療方法 |
| JP2022200192A Active JP7697688B2 (ja) | 2011-09-26 | 2022-12-15 | 疾患の治療方法 |
| JP2025094341A Pending JP2025131753A (ja) | 2011-09-26 | 2025-06-05 | 疾患の治療方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017172825A Active JP6382416B2 (ja) | 2011-09-26 | 2017-09-08 | 疾患の治療方法 |
| JP2018145207A Active JP6736618B2 (ja) | 2011-09-26 | 2018-08-01 | 疾患の治療方法 |
| JP2020121417A Active JP7562125B2 (ja) | 2011-09-26 | 2020-07-15 | 疾患の治療方法 |
| JP2022200192A Active JP7697688B2 (ja) | 2011-09-26 | 2022-12-15 | 疾患の治療方法 |
| JP2025094341A Pending JP2025131753A (ja) | 2011-09-26 | 2025-06-05 | 疾患の治療方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US9149483B2 (enExample) |
| EP (1) | EP2760874A4 (enExample) |
| JP (6) | JP6267638B2 (enExample) |
| CN (2) | CN103906756B (enExample) |
| AU (5) | AU2012316397B2 (enExample) |
| CA (2) | CA2849456C (enExample) |
| HK (1) | HK1199261A1 (enExample) |
| WO (1) | WO2013048965A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2725023T3 (es) | 2006-10-12 | 2019-09-18 | Galera Labs Llc | Métodos para el tratamiento de la mucositis oral |
| HK1199261A1 (en) * | 2011-09-26 | 2015-06-26 | Galera Labs, Llc | Methods for treatment of diseases |
| TWI746449B (zh) * | 2015-07-20 | 2021-11-21 | 美商Ａｉ治療公司 | 使用阿吡莫德治療癌症之方法 |
| LT3334744T (lt) * | 2015-08-11 | 2020-07-27 | Galera Labs, Llc | Pentaaza makrociklinio žiedo kompleksai, turintys peroralinį biologinį prieinamumą |
| WO2017192740A2 (en) * | 2016-05-03 | 2017-11-09 | Galera Labs, Llc | Combination therapy for cancer treatment |
| CN109906081A (zh) | 2016-09-01 | 2019-06-18 | 加莱拉实验室有限责任公司 | 利用五氮杂大环络合物和抗坏血酸类化合物的联合癌症疗法 |
| AU2018221043A1 (en) | 2017-02-15 | 2019-09-12 | Galera Labs, Llc | Pentaaza macrocyclic ring complexes for local intestinal delivery |
| IL269915B (en) | 2017-04-13 | 2022-09-01 | Galera Labs Llc | Cancer immunotherapy combined with a macrocyclic ring pentase complex |
| KR20200118823A (ko) * | 2018-01-31 | 2020-10-16 | 갈레라 랩스, 엘엘씨 | 펜타아자 마크로시클릭 고리 복합체 및 백금-기재 항암제를 사용한 조합 암 요법 |
| JP7770026B2 (ja) * | 2019-10-10 | 2025-11-14 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー | マンガン含有配位錯体の水性製剤の製造方法、製剤および処置方法 |
| WO2021163397A1 (en) * | 2020-02-13 | 2021-08-19 | Teva Pharmaceuticals International Gmbh | Solid state forms of avasopasem manganese and process for preparation thereof |
| WO2025259817A1 (en) * | 2024-06-12 | 2025-12-18 | Galera Labs, Llc | Methods for reduced tissue damage from radiopharmaceuticals with superoxide-reducing agent |
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| LT3334744T (lt) | 2015-08-11 | 2020-07-27 | Galera Labs, Llc | Pentaaza makrociklinio žiedo kompleksai, turintys peroralinį biologinį prieinamumą |
| WO2017192740A2 (en) | 2016-05-03 | 2017-11-09 | Galera Labs, Llc | Combination therapy for cancer treatment |
| CN109906081A (zh) | 2016-09-01 | 2019-06-18 | 加莱拉实验室有限责任公司 | 利用五氮杂大环络合物和抗坏血酸类化合物的联合癌症疗法 |
| US20190350867A1 (en) | 2016-12-27 | 2019-11-21 | Soon Kap Hahn | Prevention of local tumor recurrence following surgery using sustained and/or delayed release of medicaments contained in micro-particles |
| AU2018221043A1 (en) | 2017-02-15 | 2019-09-12 | Galera Labs, Llc | Pentaaza macrocyclic ring complexes for local intestinal delivery |
| SG11201909495PA (en) | 2017-04-13 | 2019-11-28 | Galera Labs Llc | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| IL269915B (en) | 2017-04-13 | 2022-09-01 | Galera Labs Llc | Cancer immunotherapy combined with a macrocyclic ring pentase complex |
| EP3388082A1 (en) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| KR20200118823A (ko) | 2018-01-31 | 2020-10-16 | 갈레라 랩스, 엘엘씨 | 펜타아자 마크로시클릭 고리 복합체 및 백금-기재 항암제를 사용한 조합 암 요법 |
-
2012
- 2012-09-24 HK HK14112775.0A patent/HK1199261A1/xx unknown
- 2012-09-24 CN CN201280053322.1A patent/CN103906756B/zh active Active
- 2012-09-24 CN CN202010082500.XA patent/CN111467351A/zh active Pending
- 2012-09-24 US US13/625,617 patent/US9149483B2/en active Active
- 2012-09-24 EP EP20120835035 patent/EP2760874A4/en active Pending
- 2012-09-24 CA CA2849456A patent/CA2849456C/en active Active
- 2012-09-24 WO PCT/US2012/056921 patent/WO2013048965A1/en not_active Ceased
- 2012-09-24 AU AU2012316397A patent/AU2012316397B2/en not_active Ceased
- 2012-09-24 CA CA3120505A patent/CA3120505C/en active Active
- 2012-09-24 JP JP2014532075A patent/JP6267638B2/ja active Active
-
2015
- 2015-08-27 US US14/837,831 patent/US10137133B2/en active Active
-
2016
- 2016-10-20 AU AU2016247160A patent/AU2016247160B2/en not_active Ceased
-
2017
- 2017-09-08 JP JP2017172825A patent/JP6382416B2/ja active Active
-
2018
- 2018-08-01 JP JP2018145207A patent/JP6736618B2/ja active Active
- 2018-10-31 US US16/176,958 patent/US10493081B2/en active Active
-
2019
- 2019-02-27 AU AU2019201392A patent/AU2019201392B2/en active Active
- 2019-11-12 US US16/680,844 patent/US11826373B2/en active Active
-
2020
- 2020-07-15 JP JP2020121417A patent/JP7562125B2/ja active Active
- 2020-10-05 AU AU2020244613A patent/AU2020244613C1/en active Active
-
2022
- 2022-12-15 JP JP2022200192A patent/JP7697688B2/ja active Active
-
2023
- 2023-03-31 AU AU2023201978A patent/AU2023201978A1/en not_active Abandoned
- 2023-10-18 US US18/381,524 patent/US20250017944A1/en not_active Abandoned
-
2025
- 2025-06-05 JP JP2025094341A patent/JP2025131753A/ja active Pending
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