AU2012316397B2 - Methods for treatment of diseases - Google Patents
Methods for treatment of diseasesInfo
- Publication number
- AU2012316397B2 AU2012316397B2 AU2012316397A AU2012316397A AU2012316397B2 AU 2012316397 B2 AU2012316397 B2 AU 2012316397B2 AU 2012316397 A AU2012316397 A AU 2012316397A AU 2012316397 A AU2012316397 A AU 2012316397A AU 2012316397 B2 AU2012316397 B2 AU 2012316397B2
- Authority
- AU
- Australia
- Prior art keywords
- superoxide dismutase
- administered
- patient
- dismutase mimetic
- ligands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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| AU2019215032A1 (en) * | 2018-01-31 | 2020-09-10 | Board Of Regents Of The University Of Texas System | Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009043454A2 (en) * | 2007-09-11 | 2009-04-09 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
| US20110136756A1 (en) * | 2008-05-22 | 2011-06-09 | Keene Jeffery L | Combination antitumor therapy |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001212A (en) | 1973-10-03 | 1977-01-04 | E. I. Du Pont De Nemours And Company | Macrocyclic polyamines |
| US3930867A (en) | 1974-01-07 | 1976-01-06 | E. I. Du Pont De Nemours And Company | Macrocyclic polyamines as sensitizers for silver halide emulsions |
| JPS61226751A (ja) | 1985-03-30 | 1986-10-08 | Konishiroku Photo Ind Co Ltd | ハロゲン化銀写真感光材料用処理液及びその処理方法 |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5096724A (en) | 1988-06-03 | 1992-03-17 | Aquanautics Corporation | Methods, compositions, and systems for ligand extraction |
| GB9001245D0 (en) | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
| CA2072934C (en) | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| DE69224839T2 (de) | 1991-07-19 | 1998-10-08 | Monsanto Co | Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren. |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| US6204259B1 (en) | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| NZ283279A (en) | 1994-04-22 | 1998-01-26 | Monsanto Co | Magnetic resonance imaging compounds comprising paramagnetic metals, compositions and use thereof |
| US6245758B1 (en) | 1994-05-13 | 2001-06-12 | Michael K. Stern | Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor |
| JPH0840941A (ja) | 1994-07-29 | 1996-02-13 | Kanegafuchi Chem Ind Co Ltd | 炎症性腸疾患治療製剤 |
| US6525041B1 (en) | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| CA2229799A1 (en) * | 1995-08-17 | 1997-02-27 | Monsanto Company | Bioconjugates of manganese complexes and their application as catalysts |
| US5976498A (en) | 1995-08-17 | 1999-11-02 | Neumann; William L. | Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands |
| CA2229781A1 (en) | 1995-08-17 | 1997-02-27 | Monsanto Company | Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands |
| US20020128248A1 (en) | 1997-06-20 | 2002-09-12 | Metaphore Pharmaceuticals, Inc | SODm therapy for prevention and/or treatment of inflammatory disease |
| US6180620B1 (en) * | 1997-06-20 | 2001-01-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
| US20050171198A1 (en) | 1997-06-20 | 2005-08-04 | Metaphore Pharmaceuticals, Inc. | SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease |
| US20060270639A1 (en) | 1997-06-20 | 2006-11-30 | Daniela Salvemini | Combinations of superoxide dismutase mimetics and nonsteroidal analgesic/anti-inflammatory drugs |
| US6214817B1 (en) * | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
| JP2991172B2 (ja) | 1997-10-24 | 1999-12-20 | 日本電気株式会社 | 半導体装置 |
| EP1045851B1 (en) | 1997-11-03 | 2003-04-23 | Duke University | Substituted porphyrins |
| GB9817845D0 (en) | 1998-08-17 | 1998-10-14 | Glaxo Group Ltd | Chemical compounds |
| US6040330A (en) | 1999-01-08 | 2000-03-21 | Bionumerik Pharmaceuticals, Inc. | Pharmaceutical formulations of taxanes |
| DE60037768T2 (de) * | 1999-05-27 | 2009-01-15 | Pharmacia Corp.(N.D.Ges.D.Staates Delaware) | Biomaterialien, modifiziert mit Superoxid-Dismutase Imitatoren |
| US6448239B1 (en) | 1999-06-03 | 2002-09-10 | Trustees Of Princeton University | Peroxynitrite decomposition catalysts and methods of use thereof |
| JP2003502372A (ja) | 1999-06-23 | 2003-01-21 | エリック・エフ・バーンスタイン | 創傷治癒および光傷害の防止におけるニトロキシドの使用 |
| WO2001058458A1 (en) | 2000-02-08 | 2001-08-16 | Rice University | Optically-active nanoparticles for use in therapeutic and diagnostic methods |
| US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
| AU2000265525A1 (en) | 2000-08-29 | 2002-03-13 | Mepha Ag | Medicament for treating intestinal diseases |
| US6589948B1 (en) * | 2000-11-28 | 2003-07-08 | Eukarion, Inc. | Cyclic salen-metal compounds: reactive oxygen species scavengers useful as antioxidants in the treatment and prevention of diseases |
| US7166910B2 (en) | 2000-11-28 | 2007-01-23 | Knowles Electronics Llc | Miniature silicon condenser microphone |
| US20020072512A1 (en) | 2000-12-08 | 2002-06-13 | Metaphore Pharmaceuticals, Inc | Method of preventing and treating HIV-mediated central nervous system damage |
| ATE464061T1 (de) * | 2001-01-05 | 2010-04-15 | Metaphore Pharmaceuticals Inc | Zusammensetzungen und verfahren zur erhöhung der zytokin-aktivität und zur behandlung der hypotension assoziiert mit der verabreichung von zytokinen |
| CA2436245C (en) * | 2001-01-19 | 2013-04-23 | National Jewish Medical And Research Center | Medicament for protection in radiotherapy |
| AU2002236861A1 (en) | 2001-01-26 | 2002-08-06 | Metaphore Pharmaceuticals, Inc. | Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes |
| CA2439971A1 (en) | 2001-03-02 | 2002-09-12 | Metaphore Pharmaceuticals, Inc. | Chromatography of metal complexes |
| US20040137638A1 (en) * | 2002-03-04 | 2004-07-15 | Slomczynska Urszula J. | Chromatography of metal complexes |
| WO2002100395A1 (en) | 2001-06-08 | 2002-12-19 | Genzyme Corporation | Bismuth salts of anti-oxidants and radical scavengers for prevention and treatment of mucous membrane ulcers |
| US20040132706A1 (en) | 2001-10-05 | 2004-07-08 | Daniela Salvemini | Composition comprising a catalyst for the dismutation of superoxide and use of the composition for preventing and treating hypotension |
| CN100506277C (zh) | 2001-11-01 | 2009-07-01 | Uab研究基金会 | 肿瘤坏死因子相关细胞凋亡诱导配体受体的选择性抗体和其它治疗剂的联合体系 |
| SI1463563T1 (sl) * | 2001-12-14 | 2009-06-30 | Alcon Inc | Superoksidni dizmutazni mimetiki za zdravljenje očesnih motenj in bolezni |
| WO2003088986A1 (en) | 2002-04-16 | 2003-10-30 | Isis Innovation Limited | Curcumin for the prevention and/or treatment of tissue damage |
| US20050101581A1 (en) | 2002-08-28 | 2005-05-12 | Reading Christopher L. | Therapeutic treatment methods 2 |
| US6781231B2 (en) | 2002-09-10 | 2004-08-24 | Knowles Electronics Llc | Microelectromechanical system package with environmental and interference shield |
| US6798047B1 (en) | 2002-12-26 | 2004-09-28 | Amkor Technology, Inc. | Pre-molded leadframe |
| WO2005042718A2 (en) | 2003-10-31 | 2005-05-12 | Metaphore Pharmaceuticals, Inc. | Compositions and methods for treating, preventing, reversing and inhibiting pain |
| FR2863892B1 (fr) | 2003-12-18 | 2007-05-11 | Univ Paris Descartes | Utilisation de mimetiques de la superoxyde dismutase et de la glutathion reductase comme anti-cancereux |
| WO2005070126A2 (en) | 2004-01-08 | 2005-08-04 | The Regents Of The University Of Colorado | Methods and compositions for treating human diseases and wounds with ucp and fas inhibitors |
| EA010834B1 (ru) | 2004-03-29 | 2008-12-30 | Инотек Фармасьютикалз Корпорейшн | Пиридилзамещённые порфириновые соединения и способы их применения |
| US7262498B2 (en) | 2004-10-19 | 2007-08-28 | Hewlett-Packard Development Company, L.P. | Assembly with a ring and bonding pads formed of a same material on a substrate |
| US20070148154A1 (en) | 2004-12-17 | 2007-06-28 | Universite Rene Descartes (Paris V) | Use of superoxide dismutase mimetics and reductase gultatione in the form of anticancer drugs |
| US8217166B2 (en) | 2005-05-05 | 2012-07-10 | Galera Therapeutics, Llc | Polyethylene glycolated superoxide dismutase mimetics |
| WO2006083508A2 (en) | 2005-01-10 | 2006-08-10 | Metaphore Pharmaceuticals Inc. | Combinations of superoxide dismutase mimetics and nonsteroidal analgesic/anti-inflammatory drugs |
| WO2006078713A2 (en) | 2005-01-19 | 2006-07-27 | Metaphore Pharmaceuticals, Inc. | Methotrexate combinations for treating inflammatory diseases |
| AU2006230292A1 (en) | 2005-03-31 | 2006-10-05 | Schering Corporation | Spirocyclic thrombin receptor antagonists |
| CN2870352Y (zh) | 2005-12-23 | 2007-02-14 | 瑞声声学科技(深圳)有限公司 | 微机电系统传声器扣合式封装结构 |
| US20100158857A1 (en) | 2006-05-23 | 2010-06-24 | University Of Utah Research Foundation | Compositions and methods for the inhibition of endothelial nitric oxide synthase activity |
| US20080139525A1 (en) | 2006-08-31 | 2008-06-12 | The Brigham And Women's Hospital, Inc. | Antioxidant therapies |
| US20080161324A1 (en) | 2006-09-14 | 2008-07-03 | Johansen Lisa M | Compositions and methods for treatment of viral diseases |
| PL2056675T3 (pl) * | 2006-10-12 | 2019-08-30 | Galera Labs, Llc | Metody leczenia zapalenia błony śluzowej jamy ustnej |
| TWI333264B (en) | 2007-01-10 | 2010-11-11 | Advanced Semiconductor Eng | Packaging structure and method of mems microphone |
| US20090221622A1 (en) | 2008-02-29 | 2009-09-03 | Eagle Pharmaceuticals, Inc. | Topotecan ready to use solutions |
| AU2009241514A1 (en) | 2008-04-15 | 2009-11-05 | Intermune, Inc. | Novel inhibitors of hepatitis C virus replication |
| CN102822198B (zh) | 2010-03-12 | 2016-08-31 | 艾伯维生物医疗股份有限公司 | Ctla4蛋白和其用途 |
| US20120207687A1 (en) | 2011-01-14 | 2012-08-16 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Topical formulations of targeted nitroxide agents |
| AU2012316397B2 (en) * | 2011-09-26 | 2016-07-21 | Galera Labs, Llc | Methods for treatment of diseases |
| US9238659B2 (en) | 2012-11-19 | 2016-01-19 | The University Of Hong Kong | Method of using binuclear gold (I) compounds for cancer treatment |
| US10597415B2 (en) | 2015-08-11 | 2020-03-24 | Galera Labs, Llc | Pentaaza macrocyclic ring complexes possessing oral bioavailability |
| WO2017192740A2 (en) | 2016-05-03 | 2017-11-09 | Galera Labs, Llc | Combination therapy for cancer treatment |
| CA3035766A1 (en) | 2016-09-01 | 2018-03-08 | Galera Labs, Llc | Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound |
| US20190350867A1 (en) | 2016-12-27 | 2019-11-21 | Soon Kap Hahn | Prevention of local tumor recurrence following surgery using sustained and/or delayed release of medicaments contained in micro-particles |
| JP2020507598A (ja) | 2017-02-15 | 2020-03-12 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーＧａｌｅｒａ Ｌａｂｓ， Ｌｌｃ | 局所腸送達のためのペンタアザマクロ環錯体 |
| IL295620B2 (en) | 2017-04-13 | 2024-01-01 | Galera Labs Llc | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| EP3388082A1 (en) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| WO2018191676A1 (en) | 2017-04-13 | 2018-10-18 | Galera Labs, Llc | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| AU2019215032A1 (en) | 2018-01-31 | 2020-09-10 | Board Of Regents Of The University Of Texas System | Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent |
-
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- 2012-09-24 CN CN202010082500.XA patent/CN111467351A/zh active Pending
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- 2019-11-12 US US16/680,844 patent/US11826373B2/en active Active
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- 2020-10-05 AU AU2020244613A patent/AU2020244613C1/en active Active
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- 2023-03-31 AU AU2023201978A patent/AU2023201978A1/en not_active Abandoned
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009043454A2 (en) * | 2007-09-11 | 2009-04-09 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
| US20110136756A1 (en) * | 2008-05-22 | 2011-06-09 | Keene Jeffery L | Combination antitumor therapy |
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