JP2014522235A5 - - Google Patents

Info

Publication number

JP2014522235A5

JP2014522235A5 JP2014509496A JP2014509496A JP2014522235A5 JP 2014522235 A5 JP2014522235 A5 JP 2014522235A5 JP 2014509496 A JP2014509496 A JP 2014509496A JP 2014509496 A JP2014509496 A JP 2014509496A JP 2014522235 A5 JP2014522235 A5 JP 2014522235A5

Authority

JP

Japan

Prior art keywords

amino acid

variant

subtilisin

subtilisin variant

protease

Prior art date

2012-05-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000787 Subtilisin Proteins 0.000 claims 21
• 125000003275 alpha amino acid group Chemical group 0.000 claims 13
• 108091005804 Peptidases Proteins 0.000 claims 7
• 239000004365 Protease Substances 0.000 claims 7
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 7
• 238000010998 test method Methods 0.000 claims 5
• 241000193422 Bacillus lentus Species 0.000 claims 4
• 238000006467 substitution reaction Methods 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 241000193744 Bacillus amyloliquefaciens Species 0.000 claims 2
• 108010056079 Subtilisins Proteins 0.000 claims 2
• 102000005158 Subtilisins Human genes 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• -1 perhydrolase Proteins 0.000 claims 2
• ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 claims 1
• 108010065511 Amylases Proteins 0.000 claims 1
• 102000013142 Amylases Human genes 0.000 claims 1
• 101000642797 Bacillus amyloliquefaciens Subtilisin BPN' Proteins 0.000 claims 1
• 108700038091 Beta-glucanases Proteins 0.000 claims 1
• 102100032487 Beta-mannosidase Human genes 0.000 claims 1
• 108010059892 Cellulase Proteins 0.000 claims 1
• 108010023736 Chondroitinases and Chondroitin Lyases Proteins 0.000 claims 1
• 102000011413 Chondroitinases and Chondroitin Lyases Human genes 0.000 claims 1
• 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 108090000371 Esterases Proteins 0.000 claims 1
• 108010003272 Hyaluronate lyase Proteins 0.000 claims 1
• 102000001974 Hyaluronidases Human genes 0.000 claims 1
• 108010029541 Laccase Proteins 0.000 claims 1
• 108090001060 Lipase Proteins 0.000 claims 1
• 102000004882 Lipase Human genes 0.000 claims 1
• 239000004367 Lipase Substances 0.000 claims 1
• 102000003820 Lipoxygenases Human genes 0.000 claims 1
• 108090000128 Lipoxygenases Proteins 0.000 claims 1
• 102000005741 Metalloproteases Human genes 0.000 claims 1
• 108010006035 Metalloproteases Proteins 0.000 claims 1
• 108090000854 Oxidoreductases Proteins 0.000 claims 1
• 102000004316 Oxidoreductases Human genes 0.000 claims 1
• 102000003992 Peroxidases Human genes 0.000 claims 1
• 108010064785 Phospholipases Proteins 0.000 claims 1
• 102000015439 Phospholipases Human genes 0.000 claims 1
• 108010059820 Polygalacturonase Proteins 0.000 claims 1
• 101710180309 Protease 4 Proteins 0.000 claims 1
• 102000003425 Tyrosinase Human genes 0.000 claims 1
• 108060008724 Tyrosinase Proteins 0.000 claims 1
• 108090000637 alpha-Amylases Proteins 0.000 claims 1
• 108010084650 alpha-N-arabinofuranosidase Proteins 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 235000019418 amylase Nutrition 0.000 claims 1
• 229940025131 amylases Drugs 0.000 claims 1
• 108010055059 beta-Mannosidase Proteins 0.000 claims 1
• 239000007844 bleaching agent Substances 0.000 claims 1
• 229940106157 cellulase Drugs 0.000 claims 1
• 238000004140 cleaning Methods 0.000 claims 1
• 108010005400 cutinase Proteins 0.000 claims 1
• YERABYSOHUZTPQ-UHFFFAOYSA-P endo-1,4-beta-Xylanase Chemical compound C=1C=CC=CC=1C[N+](CC)(CC)CCCNC(C(C=1)=O)=CC(=O)C=1NCCC[N+](CC)(CC)CC1=CC=CC=C1 YERABYSOHUZTPQ-UHFFFAOYSA-P 0.000 claims 1
• 229940088598 enzyme Drugs 0.000 claims 1
• 108010093305 exopolygalacturonase Proteins 0.000 claims 1
• 239000004744 fabric Substances 0.000 claims 1
• 108010002430 hemicellulase Proteins 0.000 claims 1
• 229940059442 hemicellulase Drugs 0.000 claims 1
• 229960002773 hyaluronidase Drugs 0.000 claims 1
• 108010059345 keratinase Proteins 0.000 claims 1
• 108010062085 ligninase Proteins 0.000 claims 1
• 235000019421 lipase Nutrition 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 108010087558 pectate lyase Proteins 0.000 claims 1
• 229940072417 peroxidase Drugs 0.000 claims 1
• 108040007629 peroxidase activity proteins Proteins 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 230000002797 proteolythic effect Effects 0.000 claims 1
• 108010038851 tannase Proteins 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1